安氏Ⅰ类拥挤伴融合牙的矫治设计

目的结合临床病例探讨安氏Ⅰ类拥挤伴下颌融合牙的临床处理,以期获得比较有效的处理下颌融合牙病例的常用治疗方法。方法收集本科近三年来临床上安氏Ⅰ类拥挤拌下颌前牙有融合牙者12例(男5例,女7例),根据牙弓的拥挤程度,面型突度、患者主观要求等,决定是采用拔牙或非拔牙的矫治方案,再通过计算 Bolton 指数的前牙比和全牙比,确定如何拔牙以及如何邻面去釉。结果根据不同的适应证,分别采用不同的矫治设计方法:非拔牙矫治患者,主要采用上颌邻面去釉的方法,磨去的量主要以Bolton 指数来指导;拔牙病例中,多采用上下颌非对称拔牙(上颌两颗,下颌一颗),再通过计算 Bolton 指数来适当行下颌下齿的领面去釉。最后所有患者均获得满意的临床矫治效果。结论对于安氏Ⅰ数拥挤伴下颌融合牙患者,根据其临床条件可选择拔牙或非拔牙的矫治方案,两者均可取得健康,美观的临床疗效。     

用Bolton指数指导矫治下颌个别牙先天缺失症

目的：探索用Bolton指数指导矫治下颌个别牙先天缺失症。方法：临床选择26例（男10，女16）安氏I类和Ⅱ类错He患者，以Bolton指数前牙比公式为依据，实施方丝弓矫治技术结合邻面去釉、下颌个别牙义齿修复及拔牙矫治等方法进行治疗。结果：根据不同的适应证，分别采用上述4种不同的矫治方法，使最后的矫治结果Bolton指数前牙比均达到正常值，临床矫治效果满意。结论：依据Bolton指数能很好地指导矫治个别下切牙缺失症的患者。     

用Bolton指数和牙冠宽度百分比指导邻面去釉

目的 :探讨用Bolton指数和牙冠宽度百分比指导邻面去釉。方法 :临床选择需邻面去釉辅助矫治的错牙合患者 43例 ,以Bolton指数和牙冠宽度百分比为依据进行邻面去釉。结果 :通过矫治 ,所有患者Bolton指数正常或接近正常 ,牙冠宽度百分比正常 ,上下牙弓间关系正常 ,临床矫治效果满意。结论 :依据Bolton指数和牙冠宽度百分比能很好地指导邻面去釉。     

邻面去釉在正畸治疗中的应用

目的　评价邻面去釉在正畸临床治疗中的疗效。方法　选择“边缘病例”或Bolton指数异常病例共 5 7例 ,采用邻面去釉法进行矫治并比较矫治前后结果。结果　 5 7例均取得满意疗效 ,矫治简化、疗程缩短且疗效稳定。结论　邻面去釉是正畸治疗中不可忽略的治疗手段     

邻面去釉在正畸治疗中的应用

目的 评价邻面去釉在正畸临床治疗中的疗效。方法 选择“边缘病例”或Bolton指数异常病例共57例,将矫治前后进行比较。结果 57例均取得满意疗效,矫治简化、疗程缩短且疗效稳定。结论 邻面去釉是正畸治疗中不可忽略的治疗手段。     

伴有个别前牙缺失的错畸形矫治方法研究

目的 :探讨不同部位的个别前牙缺失临床矫治的最佳方法。方法 :选择临床上个别上或下前牙缺失的患者 4 0例 ,根据前牙缺失的具体牙位及缺失牙数分为 6组。根据患者的临床资料、Bolton指数、排牙试验等方法进行分析、设计并筛选出最佳治疗方案。结果 :通过有选择性的补偿拔牙 ,邻牙移动替代 ,邻面去釉及必要的修复治疗等方法 ,患者可获得较为理想的牙弓 ,颌面形态及良好的咬合功能。结论 :伴有个别前牙缺失病例的矫治在正畸临床上是一个难点 ,通过周密的分析、设计、有效的临床矫治 ,仍然可以获得较为理想的效果。     

安氏Ⅰ类下颌前牙区融合牙的矫治设计

目的:本研究结合临床探讨安氏Ⅰ类下颌前牙区融合牙的临床处理方法。方法:临床选择20例(男8,女12)安氏Ⅰ类下颌前牙区融合牙患者,以Bolton指数前牙比公式为依据,根据牙弓的拥挤程度,面型突度等临床条件,采用拔牙及非拔牙的矫治方法。结果:根据不同的适应证,分别采用上述不同的矫治设计方法,使最后的临床矫治效果满意。20例患者中13例采用拔牙矫治,5例采用非拔牙矫治,2例采用修复治疗。时间最长为22个月,最短为12个月,平均为16个月。结论:对于安氏Ⅰ类下颌前牙区颌融合牙的患者,根据其临床条件可选择拔牙和非拔牙矫治方法,两者均可取得健康,美观的临床效果。     

拔除下切牙矫治在改善Bohon指数中的作用

目的：探讨拔除下颌切牙进行矫治,通过改变Bolton指数来进行代偿治疗中的作用。方法：采用回顾性研究的方法,对9例由于各种原因需拔除单个下颌切牙或配合拔除其它牙齿进行矫治的病例进行分析比较。结果：9个病例矫治时间为19-23个月,均采用直丝弓矫治技术。治疗结束后拔牙间隙均全部关闭,前牙覆胎覆盖关系基本正常,后牙咬耠关系较好。结论：部分上颌需要减数的成人骨性Ⅱ类病例,下颌可以考虑拔除一个下切牙矫治;某些轻、中度的成人骨性Ⅲ类患者也可拔除一个下切牙结合上颌邻面去釉进行矫治。拔除下颌切牙矫治在诊断设计时应权衡利弊,严格控制适应症,以获得良好、稳定的矫治效果。     

中重度牙列拥挤的非拔牙矫治

目的：探讨中重度牙列拥挤非拔牙矫治的临床效果。方法：选择面型较好、牙列拥挤度在5～10mm的病例14例，进行方丝弓或直丝弓非拔牙矫治，非拔牙矫治的方法包括推磨牙向远中、扩大牙弓、唇向开展前牙和邻面去釉。术前术后均拍摄X线头影测量片进行分析。结果：采用非拔牙矫治的14例中重度拥挤患者经固定矫治器治疗后均达到满意的治疗效果，牙齿排列整齐，咬合关系正常，面型良好。结论：中重度牙列拥挤非拔牙矫治是可能的，应行综合分析决定矫治方案。     

邻面去釉方法在正畸中的应用

邻面去釉是通过邻面釉质磨削、再成形，获得间隙或调整牙齿的大小，达到矫治目的的一种方法。主要应用于“边缘病例”或Ｂｏｌｔｏｎ指数异常病例。近些年由于拔牙矫治比率增加，该方法颇受一些学者推崇〔１，２〕。自１９９３年我们应用该方法治疗２８例患者，取得良好效果。１　临床资料本组患者２８例，男１１例，女１７例；年龄１６～３９岁，平均２３．７岁；疗程２～１５月，平均８．８月，自然调整病例２例；２８例中边缘病例１１例，牙弓轻度前突９例，Ｂｏｌｔｏｎ指数异常８例。矫治前后常规模型分析，头影测量，照像。矫治结束半…     

柠檬精油对牙周致病菌抑制作用及其安全性初步研究

目的:探讨柠檬精油对牙周致病菌的体外抗菌活性及对细胞增殖的影响。方法:采用微量液体稀释法测定柠檬精油对Pg、Fn、Aa、Pi的最小抑菌浓度(minimal inhibitory concentration,MIC)及最小杀菌浓度(minimum bactericidal concentration,MBC);以较低浓度的MIC为标准稀释LEO作为实验组,采用MTT法测定柠檬精油对HUVECs的毒性作用,明确抑菌浓度下LEO的安全性。结果:柠檬精油对牙周主要致病菌均有抑菌作用,Pg、Fn、Aa、Pi的MIC分别是9.0 g/L、4.5 g/L、4.5 g/L、9.0 g/L,Aa、Fn的 MBC是9.0 g/L,Pg、Pi的MBC未测得。1/2MIC、1/20MIC浓度的LEO能够抑制人脐静脉内皮细胞的生长,而低于1/200MIC浓度的LEO则对人脐静脉内皮细胞的生长没有影响,其中1/200MIC浓度的LEO作用明显优于0.02%的CHX。结论:体外环境中,柠檬精油对牙周致病菌Pg、Fn、Aa、Pi具有抗菌活性,低浓度应用对机体相对安全。     

Oral cancer: molecular technologies for risk assessment and diagnosis

Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.     

Computer-assisted planning for maxillofacial prosthodontic rehabilitation

Computerized tomography (CT) planning and the use of CT derived surgical templates for implant placement have shown promise for restoring function within months after surgical reconstruction of acquired post-oncologic defects.     

Stimulated whole saliva components in children with Down syndrome

The authors report on the components of stimulated whole saliva from children with Down syndrome—including pH, flow rate, sialic acid and protein concentrations, and amylase and peroxidase activity. Saliva samples were collected from 35 children aged 6–10 years. Of the participants, 17 had Down syndrome and 18 did not. To stimulate saliva production, the children chewed a piece of parafilm for 10 minutes before the sample was collected. Soon after collecting the saliva sample, the authors measured pH using a portable pH-meter. Sialic acid levels were determined with a thiobarbituric acid assay. Protein content was determined with Folin's phenol reagent. Amylase was assayed and the authors measured the maltose produced by the breakdown of starch and peroxidase using ortho-dianisidine.
No statistically significant difference was observed in levels of sialic acid (free and total) between the two groups. Protein concentration was about 36% higher in the group with Down syndrome. However, the salivary flow rate, pH, and amylase and peroxidase activities were lower among the children with Down syndrome.     

Effect of Pingyangmycin on human venous malformation endothelial cells

Purpose: Venous malformations are common vascular anomalies with a propensity of the head and neck. Intralesional injection of Pingyangmycin (PYM, bleomycin A5 hydrochloride) is a widely used sclerotherapy method for the treatment of venous malformation.     

牙髓再生的研究现状

目前,根管治疗术在临床上已得到了广泛的应用并成功的保存了患牙,但其仍有许多术后并发症。随着组织工程技术在口腔领域的应用,构建一种组织工程化牙髓进行牙髓-牙本质复合体的再生治疗成为可能。近年来国内外已有很多关于牙髓再生的研究,并且已经取得了一定成果。本文将对目前国内外牙髓再生的研究进展现状作一综述。     

Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life

Dysphagia is one of the most important complications encountered in amyotrophic lateral sclerosis (ALS). Our aim was to determine whether oropharyngeal dysphagia impacted the quality of life (QoL) of patients with ALS. Thirty consecutive patients were recruited (31–82 years, 18 men). Swallowing function was evaluated using a standardised videofluoroscopic barium swallow. All the patients completed a specific questionnaire on quality of life in dysphagia (SWAL‐QoL) immediately after the videofluoroscopy. The results of dysphagia outcome severity scale separated 14 patients with oropharyngeal dysphagia and 16 with normal swallowing function. There was no difference in the average age, weight and body mass index of the two groups (dysphagic patients: 68 ± 11 kg versus non‐dysphagic patients: 69 ± 14 kg). Most of the dysphagic patients had a bulbar affection based on their Norris scores which determine the importance of cranial nerves illness (20 ± 8), significantly lower than those of the non‐dysphagic patients (35 ± 5) (P < 0·0001). There was no difference in the neurological peripheral symptoms evaluated by Amyotrophic Lateral Sclerosis Functional Rating Scale scores (dysphagic patients: 26 ± 7 versus non‐dysphagic patients: 27 ± 8) (ns). The swallowing quality of life questionnaire revealed that the dysphagic patients had significant burden (P < 0·001). They were affected by the necessity to applied a food selection (P < 0·01), by the increase in eating duration (P < 0·05) and described a decrease in eating desire (P < 0·05). They complained of fear regarding the risk of dysphagia (P < 0·05). They also described difficulties with oral communication (P < 0·001). All of those complained about dysphagia which impacted directly mental health (P < 0·05) and social life (P < 0·05). In conclusion, oropharyngeal dysphagia is a common symptom accompanying ALS, which alters the patient's QoL, especially social health.     

拔牙位点保存用复合温敏凝胶的构建及体外表征

目的:制备多壁碳纳米管/羟基磷灰石/壳聚糖复合温敏凝胶,探讨其作为拔牙位点保存材料的理化性能。方法:采用原位沉积方法制备多壁碳纳米管/羟基磷灰石(MWNT/ HA简称HAC)复合无机材料,将其分散至壳聚糖温敏凝胶中,制备壳聚糖/多壁碳纳米管/羟基磷灰石(CS /MWNT/HA简称CS/HAC)复合温敏凝胶,以成胶时间、孔径、孔隙率、机械强度及降解性能为指标优化配方设计,并表征复合温敏凝胶的微观形貌及理化性能。结果:以10 g/L的HAC作为补强成分加入到壳聚糖溶液中,能够在不影响成胶并保证一定孔隙率(84%)的前提下,提高材料的机械性能(抗压强度0.441 MPa),所获复合温敏凝胶具有适宜的临床操作时间(12 min),并具有可控的降解速率。结论:负载HAC的复合温敏凝胶具有良好的成型性,并具有较好的机械性能,在拔牙位点保存领域具有良好的应用前景。     

替牙期骨性Ⅲ类错牙合患者颞下颌关节特征的锥形束CT研究

目的:采用锥形束CT(CBCT)研究替牙期骨性Ⅲ类错牙合患者颞下颌关节的影像学特征,探讨Ⅲ类功能状态下,颞下颌关节的生长、改建机制。方法:从就诊于昆明医科大学附属口腔医院正畸科的患者中选取符合纳入标准的替牙期骨性Ⅲ类错牙合患者及骨性Ⅰ类错牙合患者各20名,使用NNT viewer 5.3图像处理软件进行三维重建及线距和角度的测量,并进行统计学分析。结果:替牙期骨性Ⅲ类错牙合患者组和替牙期骨性Ⅰ类错牙合患者组对比结果为:矢状面双侧关节前间隙偏小、双侧关节上间隙偏小、双侧关节结节斜度偏小;冠状面双侧关节内间隙偏小,双侧关节上间隙偏小,双侧关节外间隙偏小,右侧髁状突角度偏小;横截面右侧髁状突前后径偏小。结论:替牙期骨性Ⅲ类错牙合患者颞下颌关节发育不充分,呈现髁状突,关节窝深度,关节结节斜度;冠状面关节内、外间隙均较小的特征。骨性Ⅲ类错牙合患者髁状突在关节窝中处于前置近关节窝顶位置。骨性Ⅲ类错牙合患者颞下颌关节影像学特征与其功能状态相适应。