Prospective,single-center cohort study analyzing the efcacy of complete laparoscopic resection on recurrent hepatocellular carcinoma

Background: Laparoscopic hepatectomy is increasingly being used to treat hepatocellular carcinoma (HCC). How?ever, few studies have examined the treatment of recurrent HCC in patients who received a prior hepatectomy. The present prospective study compared the clinical efcacy of laparoscopic surgery with conventional open surgery in HCC patients with postoperative tumor recurrence. Methods: We conducted a prospective study of 64 patients, all of whom had undergone open surgery once before, who were diagnosed with recurrent HCC between June 2014 and November 2014. The laparoscopic group (n = 31)underwent laparoscopic hepatectomy, and the control group (n tion time, intraoperative blood loss, surgical margins, postoperative pain scores, postoperative time until the patient= 33) underwent conventional open surgery. Opera?could walk, anal exsufation time, length of hospital stay, and inpatient costs were compared between the two groups. The patients were followed up for 1 year after surgery, and relapse?free survival was compared between the two groups. Results: All surgeries were successfully completed. No conversion to open surgery occurred in the laparoscopic group, and no serious postoperative complications occurred in either group. No significant difference in inpatient costs was found between the laparoscopic group and the control group (P = 0.079), but significant differencesbetween the two groups were observed for operation time (116.7 ± 37.5 vs. 148.2 ± 46.7 min, P = 0.031), intraopera?tive blood loss (117.5 ± 35.5 vs. 265.9 ± 70.3 mL, P = 0.012), postoperative time until the patient could walk (1.6 ± 0.6vs. 2.2 ± 0.8 days, P < 0.05), anal exsufation time (2.1 ± 0.3 vs. 2.8 ± 0.7 days, P = 0.041), visual analogue scale pain score (P < 0.05), postoperative hepatic function (P < 0.05), and length of hospital stay (4.5 ± 1.3 vs. 6.0 ± 1.2 days,P= 0.014). During the 1?year postoperative follow?up period, 6 patients in each group had recurrent HCC on the side of the initial operation, but no significant difference between groups was observed in the recurrence rate or relapse?free survival. In the laparoscopic group, operation time, postoperative time until the patient could walk, anal exsufation time, and inpatient costs were not different (P > 0.05) between the patients with contralateral HCC recur?rence (n = 18) and those with ipsilateral HCC recurrence (n = 13). However, intraoperative blood loss was signifi?cantly less (97.7 ± 14.0 vs. 186.3 ± 125.6 mL, P = 0.012) and the hospital stay was significantly shorter (4.2 ± 0.7 vs. 6.1 ± 1.7 days, P = 0.021) for the patients with contralateral recurrence than for those with ipsilateral recurrence. Conclusions: For the patients who previously underwent conventional open surgical resection of HCC, complete laparoscopic resection was safe and effective for recurrent HCC and resulted in a shorter operation time, less intraop?erative blood loss, and a faster postoperative recovery than conventional open surgery. Laparoscopic resection was especially advantageous for the patients with contralateral HCC recurrence.     

腹腔镜与开腹肝肿瘤切除术临床疗效的对比分析

背景与目的:随着腹腔镜技术在肝脏外科中的应用日渐广泛,腹腔镜肝切除的安全性和可行性逐步得到了认可,该研究旨在探讨腹腔镜肝肿瘤切除术与开腹肝肿瘤切除术的可行性与临床疗效.方法:回顾性分析复旦大学附属肿瘤医院2015年3月—2016年3月37例接受腹腔镜肝肿瘤切除术与74例接受传统开腹肝肿瘤切除术患者的临床资料,计量资料采用Wilcoxon秩和检验,统计值为Z,计数资料采用Fisher精确概率检验;分析手术时间、术中出血量、手术后胃肠道恢复时间、手术后引流管拔管时间、住院时间、术后并发症和住院费用等临床资料.腹腔镜组:男性20例,女性17例,年龄18~76岁(中位年龄55岁);开腹组:男性42例,女性32例,年龄26~74岁(中位年龄54岁).切肝方式为超声刀+单极电凝,结合腹腔镜下切割缝合器.腹腔镜组的手术方式包括:局部切除13例;行肝段或肝叶解剖性切除24例.开腹组的手术方式包括:局部切除33例;行肝段或肝叶解剖性切除41例.结果:手术平均用时:腹腔镜组为149 min(40~204 min),开腹组为142 min(45~190 min).术中出血量:腹腔镜组为220 mL(30~570 mL),开腹组为360 mL(90~970 mL).平均住院时间:腹腔镜组为4.9 d(3.0~6.0 d),开腹组为6.8 d(5.0~9.0 d).手术后胃肠道恢复平均时间:腹腔镜组为1.1 d,开腹组为2.3 d.手术后引流管拔管时间:腹腔镜组为3.1 d,开腹组为5.8 d.平均住院费用:腹腔镜组为38760元,开腹组为39145元.手术后并发症:腹腔镜组为8.1%(3/37),开腹组为9.5%(7/74).结论:腹腔镜肝切除术是一种安全、有效、微创的手术,可安全用于局部、肝段及半肝切除术,值得推广使用.     

Laparoscopic hepatectomy for liver neoplasms in 15 cases

Objective

The aim of our study was to retrospectively analyze 15 patients’ clinical materials with laparoscopic resection of liver neoplasms.

Methods

From December 2007, a total of 15 patients with liver neoplasms were performed with laparoscopic hepatectomy, and their clinical materials, perioperative dates, postoperative complications, postoperative recovery and short-term curative effects were analyzed and summarized respectively.

Results

Laparoscopic hepatectomy (LH) were performed in 15 patients, including 1 case underwent laparoscopic hepatic left lobectomy, 1 case of left lateral hepatectomy, 13 cases of partial liver resection. Fourteen cases of total laparoscopic liver resections for liver neoplasms, 1 case of hand-assisted laparoscopic liver resection of the tumor, there was no conversion to open approach. Of the 15 patients with liver neoplasms, 13 cases of hepatic neoplasms with the maximum diameter was 8 cm × 8 cm × 9 cm, 9 cases of the borderline micro hepatocellular carcinoma (MHCC) with the diameter not more than 2 cm, 3 cases of hepatic benign tumor. The mean operation time was (120 ± 30) min, and the intraoperative average hemorrhage was 100 mL, beginning to eat and get out of bed following 1–2 days of operation. The average postoperative hospitalization was 8 days, WBC, ALT, AST, albumin, bilirubin returned to normal after one week of operation. There were no postoperative complications such as hemorrhage, bile leakage or air embolism etc. Twelve patients with HCC were confirmed by postoperative pathology, 1 case of liver smooth muscle lipoma, 2 case of hepatic hemangioma. By one year of followed-up in 12 cases of HCC, the longest survival was 38 months, and no recurrence or death, 1 year survival rate was 100%.

Conclusion

Among the choice of cases, the advantages of LH for liver neoplasms compared with open surgery were less trauma, faster recovery and less blood loss. it is safe and effective for choosing a reasonable surgical indication, especially for peripheral micro hepatocellular carcinoma.     

快速康复外科理念在腹腔镜肝切除术围手术期中的应用

目的 探讨快速康复外科理念应用于腹腔镜肝切除术围手术期是否可以加速患者术后恢复,减少围手术期应激反应,是否可以降低术后并发症发生率.方法 收集46例行腹腔镜肝切除术的肝癌患者的临床资料,分为快速康复组(FTS组)及传统组,比较患者住院天数、住院费用,围手术期的应激反应及术后并发生发生率,评价快速康复理念的意义及价值.结果 两组手术时间及术中出血量比较,差异均无统计学意义(P﹥0.05);FTS组术后排气时间、引流管拔除时间及住院时间短于传统组,住院费用少于传统组,差异有统计学意义(P﹤0.05);FTS组术后C反应蛋白、白蛋白、胆碱酯酶及谷丙转氨酶均低于传统组;FTS组及传统组术后并发症发生率比较,差异无统计学意义(P﹥0.05).结论 FTS理念应用于腹腔镜肝切除术患者围手术期可以缩短术后住院时间,减少住院费用,减轻患者围手术期的应激反应,促进术后肝功能的恢复.     

侧俯卧位与侧卧位胸腔镜食管癌根治术的临床对照研究

目的：探讨侧俯卧位及侧卧位胸腔镜食管癌根治术的安全性、可行性及近期临床疗效。方法：选择我院2013年3月至2015年10月施行侧俯卧位胸腔镜食管癌根治术40例（试验组）与同期施行侧卧位食管癌根治术42例（对照组）,比较两组患者临床疗效。结果：侧俯卧位胸腔镜组手术时间（5.10±0.74）h 显著短于侧卧位胸腔镜组（5.76±0.96）h（P =0.001）;侧俯卧位胸腔镜组术中出血量（125.75±44.94）ml、术后胸腔引流时间（5.05±1.69）天、术后住院时间（12.73±5.01）天、术后并发症发生率12.5%（5/40）,比侧卧位组术中出血量（131.67±56.22）ml、术后胸腔引流时间（4.90±1.53）天、术后住院时间（11.95±4.17）天、术后并发症发生率11.9%（5/42）,差异无统计学意义（P >0.05）。结论：侧俯卧位胸腔镜食管切除术在技术上是安全、微创、可行的,在一定程度上可以缩短手术时间。     

Digital intelligent technology assisted three-dimensional laparoscopic extended left hepatectomy with resection of the middle hepatic vein(Video)

IntroductionDigital intelligent technology represented by three-dimensional (3D) visualization technology and surgical navigation system may provide preoperative and intraoperative anatomical information more accurately than CT and MRI [1]. Besides, the fusion of 3D model with surgical visual field through surgical navigation system may also compensate for the defects of visual fields and tactile sense to some extent in laparoscopic liver surgery [2].VideoA 49-year-old male patient with a tumor mainly located at the left inner area of liver and oppressing the middle hepatic vein (MHV). We formulated preoperative planning by using the Medical Image 3D Visualization System (MI3DVS, software copyright No: 2008SR18798) [3]. It was acknowledged that the right hepatic vein (RHV) was strong enough to drain the right anterior hepatic sector. Ultimately, 3D laparoscopic extended left hepatectomy with resection of the MHV was selected as the optimal operation scheme for the patient due to the RHV would avoid hepatic venous congestion in segment V and VIII after resection of the MHV, and more liver parenchyma than left trisegmentectomy would be retained. The operation was performed under assistance of the Laparoscopic Hepatectomy Navigation System (LHNS, software copyright No. 2018SR840555) [4].ResultsThe total operation time was 180 min, estimated blood loss of 200 ml. The final histopathological diagnosis showed an 8*6*6-cm-sized hepatocellular carcinoma. And the patient was discharged on postoperative day 6 without any complications.ConclusionDigital intelligent technology may be helpful to formulate preoperative planning and identify intraoperative important anatomical structures in 3D laparoscopic extended left hepatectomy with resection of the MHV.     

腹腔镜肝海绵状血管瘤切除7例报道

目的：探讨腹腔镜肝海绵状血管瘤（肝血管瘤）切除的可行性及方法。方法：回顾性分析我院采用超声刀为主要切肝器械,并结合pringle法阻断第一肝门,完成腹腔镜肝血管瘤切除7例。包括局部切除4例,左外叶切除3例。结果：全部顺利完成手术,无中转开腹。手术时间75—225min,（156±47．9）min,术中出血200～1200ml,（460．0±302．5）ml,术后住院时间3-10d,（6．6±3．0）d,除一例出现广泛皮下气肿外,其余病例未发生严重并发症。术后病理均证实为肝海绵状血管瘤。结论：腹腔镜下肝海绵状血管瘤切除对于经选择的病例是安全可行的。     

腹腔镜手术和开放D2根治术治疗胃癌的围术期情况和远期疗效分析

目的 探讨腹腔镜手术和开放D2根治术治疗胃癌的围术期情况和远期疗效.方法 105例胃癌患者根据手术方式的不同分为腹腔镜组55例和开放组50例.分析所有患者的手术时间、术中出血量、淋巴结清扫数目、术中转开腹率、术后并发症等围术期指标和术后3年的复发率、存活率.结果 腹腔镜组患者的手术时间长于开放组,术中出血量少于开放组,切口长度短于开放组,且P均＜0.05;腹腔镜组患者的术后进食时间、术后下床活动时间、术后住院时间均短于开放组(P＜0.05).腹腔镜组患者的术后并发症总发生率与开放组相比,差异无统计学意义(P＞0.05).腹腔镜组和开放组的复发率和术后3年存活率相比较,差异无统计学意义(P＞0.05).结论 胃癌腹腔镜手术和开放手术在手术时间、术中出血量、切口长度、术后进食时间、术后下床活动时间、术后住院时间等方面存在差异,但术后并发症发生率、复发率和术后3年存活率两者基本相当.     

肝癌腹腔镜及开腹治疗的临床疗效比较

目的:比较腹腔镜及开腹肝癌切除术的治疗效果.方法:选取2012年4月至2014年12月的22例腹腔镜肝癌切除术(腔镜组)与57例开腹肝癌切除术(开腹组)患者,对比两者的相关临床资料.结果:两组均顺利完成肝癌切除术.腔镜组术中出血量、拔管时间、术后引流量、术后住院时间均明显少于开腹组(P＜0.05),而手术时间两组无明显差异(P＞0.05),治疗后腔镜组并发症发生率、复发率、生存率依次为4.5％、0％、100％,开腹组依次为10.5％、5.3％、94.7％,两组并发症发生率差别无意义(P＞0.05),腔镜组较开腹组生存率高、复发率低(P＜0.05).术后腹腔镜组AST、ALT、ALB以及TBIL水平均明显优于开腹组(P＜0.05).结论:腹腔镜肝癌切除术安全可靠,与开腹手术比较,具有手术创伤小,术后恢复快,住院时间短的优点.     

保留回盲部的完全腹腔镜右侧横结肠癌根治术的可行性及安全性分析北大核心

目的:探讨保留回盲部的完全腹腔镜右侧横结肠癌根治术的可行性、安全性及近期疗效。方法:回顾性分析中国医学科学院北京协和医学院肿瘤医院2018年01月至2020年12月行保留回盲部的完全腹腔镜右侧横结肠癌根治术患者27例的临床资料,统计并分析患者的临床病理特征、手术情况、术后恢复及围手术期并发症等资料。结果:27例患者均成功完成保留回盲部的完全腹腔镜右侧横结肠癌根治术,中位手术时间为120.0 min,中位术中出血量为20.0 mL。标本中位近端切缘长度为12.0 cm,中位远端切缘长度为11.0 cm,中位淋巴结检出数目为27.0枚。患者中位术后下地时间、进食时间、排气时间和住院时间分别为18.0 h、13.0 h、32.0 h和6.0 d,中位住院费用为71618.5元。随访过程中,仅1例患者术后出现切口感染,1例患者术后出现淋巴漏,保守治疗后均痊愈。患者术后1月、3月、6月及1年腹泻发生率分别为22.2%、7.4%、3.7%及3.7%。所有患者均未出现吻合口狭窄、吻合口漏、吻合口出血、肠梗阻等严重并发症。随访期间无患者出现肿瘤复发或者转移。结论:保留回盲部的完全腹腔镜右侧横结肠癌根治术切实可行,近期疗效较为满意,可能有助于降低结肠癌术后腹泻的发生率。     

自制极简PORT在单孔腹腔镜子宫肌瘤切除术中的应用初步探讨

目的:初步探讨自制极简入路通道（PORT）在单孔腹腔镜子宫肌瘤切除术中应用的可行性及安全性。方法:回顾性分析空军军医大学西京医院妇产科于2017年3月至2018年12月共完成的46例单孔腹腔镜子宫肌瘤切除术患者,其中24例使用商品化PORT,22例使用我科自制极简PORT,所有患者均配合使用常规腹腔镜器械顺利完成手术。比较两组患者年龄、体质量数、手术时间、术中出血量、子宫肌瘤直径、术中及术后相关并发症、手术前后血红蛋白差值、术后排气时间、术后疼痛模拟评分、住院时间、术后随访情况等指标。结果:所有患者均顺利完成手术,无中转开腹或增加穿刺孔,无并发症发生。商品化PORT组和自制极简PORT组患者的一般资料具有可比性。手术相关指标包括手术时间［（75±56.9）min vs （74±55.7）min］、术中出血量［（55±67.9）ml vs （56±65.8）ml］、子宫肌瘤直径［（6±2.8）cm vs （6±3.4）cm］,两组比较无明显统计学差异（P＞0.05）。术后恢复指标包括术后排气时间［（12.6±4.4）h vs （13.5±3.4）h］、术后疼痛模拟评分［（2.1±1.3）分 vs （2.0±1.2）分］、住院时间［（3.4±2.8）d vs （3.5±2.6）d］,同样无统计学差异（P＞0.05）。两组手术效果相同,但术中使用自制极简PORT几乎不增加耗材。结论:自制极简PORT在单孔腹腔镜子宫肌瘤切除术中的应用安全性好,效果确切,节约成本,值得推广。     

腹腔镜与开腹Miles手术治疗低位直肠癌的临床研究

目的 对比分析腹腔镜与开腹Miles手术治疗低位直肠癌的疗效.方法 选择83例低位直肠癌患者,依据随机数字表法将患者分为腹腔镜组(n=42)和开腹组(n=41),观察记录两组患者的术中指标、术后恢复情况及术后并发症发生率.结果 腹腔镜组与开腹组患者的手术时间和淋巴结清扫数目比较,差异均无统计学意义(P﹥0.05);但腹腔镜组患者的术中出血量少于开腹组(P﹤0.05),胃肠道功能恢复时间、自主排尿时间、术后下床活动时间、术后住院时间、进食恢复时间均明显短于开腹组(P﹤0.01),并发症总发生率低于对照组(P﹤0.05).结论 腹腔镜Miles手术治疗低位直肠癌能达到开腹Miles手术的切除范围,且术中出血量少、创伤小、术后恢复快、住院时间短、术后并发症发生率低,值得临床推广应用.     

超选择性肾动脉栓塞联合经腹腹腔镜肾部分切除术在老年T1b期肾癌中的应用

目的:探讨DSA超选择性肾动脉栓塞联合经腹腹腔镜肾部分切除术治疗老年T1b期肾癌的安全性及可行性。方法:选择2016年1月至2018年1月于辽宁省肿瘤医院因罹患T1b期肾癌而行肾部分切除术的22例老年患者,进行回顾性研究。术前1~12 h先在介入手术室行DSA超选择性肾肿瘤靶动脉栓塞,然后再行经腹腹腔镜下零缺血肾部分切除术。对于术中手术时间、术中出血量、输血情况、术后胃肠道功能恢复所需时间、术后引流管拔除时间、术后并发症、术后住院时间、术后组织病理学指标等进行统计分析,并且术后进行随访统计肿瘤的复发和转移情况。结果:所有手术均成功完成,无中转改开放病例,无死亡病例,仅1例因肿瘤切除过程中出血较多,采用动脉夹暂时阻断肾动脉主干,阻断时间约为14 min。术中手术时间为（152.22±7.34） min,术中出血量为（102.27±66.82） ml,术后胃肠道功能恢复时间为（1.45±0.60） d,腹腔引流管拔除时间为（2.91±0.75） d,术后住院时间为（6.27±1.12） d,术后并发症发生率为9.09%,术中和术后输血率分别为4.54%和4.54%。所有患者均术后随访12~36个月,暂未发现肿瘤复发与转移。结论:超选择性肾动脉栓塞联合经腹腹腔镜肾部分切除术治疗老年T1b期肾癌安全、可行。     

Radio-frequency ablation (RFA) assisted endoscopic hepatectomy for hepatocellular carcinoma

We introduced a new therapeutic approach for hepatocellular carcinoma (HCC); Radio-frequency ablation (RFA) assisted endoscopic hepatectomy (RFA-assisted EH). Seven patients with HCC, smaller than 3 cm and located on the surface of the liver, were entered into this study. RFA on the hepatic cutting line was achieved with a 2 cm Cool-tip needle at a 1-cm interval. RFA power was gradually increased to 100 W in a minute and ablation was stopped once an impedance-out state was attained of RFA power. Hepatic resection was achieved with various items in a coagulative hepatic parenchyma. If necessary, additional RFA could be performed during the hepatectomy. Patients' characteristics were described as follows; average age: 64 years, 5 males and 2 females, liver damage A: 5, B: 2, average tumor size: 27 mm, and average tumor number: 1.3 Two thoracoscopic and 5 laparoscopic approaches were selected. One application of RFA could make an elliptical coagulative area (2 cm x 1 cm). RFA was achieved eleven times on the hepatic cutting line and three times during the hepatectomy. The average operating time and blood loss was 256 minutes and 96 g, respectively. No blood product was needed. The average postoperative hospital stay was 11 days and no operative complication was encountered. All of the patients were well and without recurrence during the observation period (average: 6 months). We positively recommend RFA-assisted EH for HCC due to its perfect radicality and safety.     

腹腔镜肝切除治疗肝脏恶性肿瘤的临床效果

目的：探讨腹腔镜肝切除治疗肝脏恶性肿瘤的临床效果。方法按照手术方式不同将98例肝脏恶性肿瘤患者分为实验组（腹腔镜手术）50例和对照组（开腹手术）48例,比较2组近期疗效。结果实验组患者术中出血量、术后进食时间及住院时间均明显低于对照组,差异有统计学意义（P＜0．05）;实验组患者术中输血率、术后使用杜冷丁率以及术后并发症发生率均明显低于对照组,差异有统计学意义（P＜0．05）。2组患者术后1 d WBC、ALT、AST水平均显著升高,与同组术前比较,差异有统计学意义（P＜0．05）;2组患者术后5 d WBC、ALT、AST水平均显著下降,与同组术后1 d比较,差异有统计学意义（P＜0．05）;实验组患者术后5 d WBC、ALT、AST水平均显著低于对照组,差异有统计学意义（P＜0．05）。结论腹腔镜肝切除治疗肝脏恶性肿瘤创伤小、术中出血量低、使用杜冷丁率低、术后恢复时间短、并发症少,近期疗效显著,可作为临床优选治疗方案。     

Pure laparoscopic versus open major hepatectomy for hepatocellular carcinoma with liver F4 cirrhosis without routine Pringle maneuver – A propensity analysis in a single center

Background/Aim: Laparoscopic hepatectomy has been gaining popularity but its evidence in major hepatectomy for cirrhotic liver is lacking. We studied the long-term outcomes of the pure laparoscopic approach versus the open approach in major hepatectomy without Pringle maneuver in patients with hepatocellular carcinoma (HCC) and cirrhosis using the propensity score analysis.MethodsWe reviewed patients diagnosed with HCC and cirrhosis who underwent major hepatectomy as primary treatment. The outcomes of patients who received the laparoscopic approach were compared with those of propensity-case-matched patients (ratio, 4:1) who received the open approach. The matching was made on the following factors: tumor size, tumor number, age, sex, hepatitis serology, HCC staging, comorbidity, and liver function.ResultsTwenty-four patients underwent pure laparoscopic major hepatectomy for HCC with cirrhosis. Ninety-six patients who underwent open major hepatectomy were matched by propensity scores. The laparoscopic group had less median blood loss (300 ml vs 645 ml, p = 0.001), shorter median hospital stay (6 days vs 10 days, p = 0.002), and lower rates of overall complication (12.5% vs 39.6%, p = 0.012), pulmonary complication (4.2% vs 25%, p = 0.049) and pleural effusion (p = 0.026). The 1-year, 3-year and 5-year overall survival rates in the laparoscopic group vs the open group were 95.2%, 89.6% and 89.6% vs 87.5%, 72.0% and 62.8% (p = 0.211). Correspondingly, the disease-free survival rates were 77.1%, 71.2% and 71.2% vs 75.8%, 52.7% and 45.5% (p = 0.422).ConclusionsThe two groups had similar long-term survival. The laparoscopic group had favorable short-term outcomes. Laparoscopic major hepatectomy without routine Pringle maneuver for HCC with cirrhosis is a safe treatment option at specialized centers.     

不同手术方式在结肠癌治疗中的效果分析和预后比较

目的 比较传统开腹手术和腹腔镜手术治疗结肠癌的疗效及预后.方法 回顾性分析92例结肠癌患者的临床资料,根据手术方式不同将患者分为腹腔镜组和传统开腹组,每组各46例.比较两组患者的术中和术后指标及预后情况.结果 腹腔镜组患者的手术切口长度明显短于传统开腹组,术中出血量明显少于传统开腹组,手术时间明显长于传统开腹组,差异均有统计学意义(P﹤0.001);腹腔镜组患者的术后体温恢复时间、开始进食时间和住院时间均明显短于传统开腹组(P﹤0.001).腹腔镜组患者的术后并发症总发生率低于传统开腹组(P﹤0.05);两组患者术后1年的局部复发率和远处转移率比较,差异均无统计学意义(P﹥0.05).结论 腹腔镜手术治疗结肠癌具有术中出血量少、创伤小、术后并发症发生率低等优点,且患者术后恢复时间短、速度快,预后效果良好,值得临床推广应用.     

腹腔镜下规则性肝切除与肝肿瘤剥除术治疗肝血管瘤的临床疗效比较

目的 比较腹腔镜下规则性肝切除与肝肿瘤剥除术治疗肝血管瘤的临床效果.方法 回顾性分析60例肝血管瘤患者的临床资料,其中31例在腹腔镜下行规则性肝切除术为A组,29例腹腔镜下行肝肿瘤剥除术为B组.比较两组手术时间、术中出血量、住院时间、术后并发症及复发率.结果 A组手术时间、术中出血量、住院时间分别为(153.96±37.13)min、(440.08±110.03)ml、(9.03±2.01)d,B组分别为(92.06±27.44)min、(327.21±130.51)ml、(7.17±3.14)d,B组手术时间、术中出血量明显少于A组(P<0.05).两组术后多数出现谷丙转氨酶(ALT)、谷草转氨酶(AST)一过性升高,同时A组出现1例胆漏,均未见切口感染、脂肪液化及死亡等情况发生,术后并发症比较无统计学意义(P>0.05).两组术后随访(13.97±3.09)个月,A、B组复发率分别为6.5%、3.4%,两组比较无统计学意义(P>0.05).结论 治疗肝血管瘤倾向于选择腹腔镜下肝肿瘤剥除术,具有创伤小、恢复快、预后好的优点,但具体选择何种术式仍需根据肿瘤实际情况而定.     

HCC术中放疗的安全性研究

目的 采用队列研究方法探讨IOERT在Ⅰ期HCC治疗中的安全性。方法 2010—2012年间初次病理诊断为Ⅰ期HCC的16例患者接受了IOERT。采用队列研究方法筛选同期行单纯根治术的87例Ⅰ期HCC患者,根据肿瘤大小(>5 cm与≤5 cm)及切缘情况(近切缘与切缘阴性)进行1∶2配对,共32例为对照组。评价两组患者术中、术后不良事件,反映肝功能的生化、凝血象及血常规等指标变化,以及与IOERT相关的不良反应。独立样本t检验组间差异。结果 IOERT组与对照组相比,手术时间明显延长[(275.4±71.55) min和(184.7±64.74) min,P=0.000],术中不良事件发生率稍高(18.75%和6.25%,P=1.000),手术并发症发生率稍低(12.50%和28.12%,P=0.460),围手术期死亡率分别为0和6%(P=0.440)。反映肝功能的实验室指标两组均相近(P>0.05),术后均降至1级或恢复正常。中位术后住院时间、外科住院时间、切口愈合时间及切口愈合级别两组也相似(P>0.05)。IOERT组无放射性肝炎发生。结论 IOERT作为早期HCC术后的辅助治疗,对术后康复及肝功能等无影响,IORT剂量15~16 Gy是安全可行的。     

Morbidity and mortality of laparoscopic vs. open radiofrequency ablation for hepatic malignancies.

AIMS: Surgical radiofrequency ablation (RFA) of hepatic malignancies is associated with superior oncological outcome as compared to percutaneous RFA. The aim of this prospective non-randomized cohort study was to compare morbidity and mortality of laparoscopic (LRFA) vs. open (ORFA) radiofrequency ablation of liver cancer. METHODS: Between October 1999 and November 2006, RFA was performed in 154 consecutive patients (percutaneous 12, LRFA 93, ORFA 49) for a total of 291 hepatic tumours (HCC 81, colorectal metastases 157, other 53). Seventy-four patients simultaneously underwent additional surgery. Laparoscopic RFA was performed in 45/54 patients with HCC, and in 44/54 patients with cirrhosis. Laparotomy was performed in 14/22 patients who underwent simultaneous colorectal resection, and in 12/22 patients with hepatic resection. RESULTS: Postoperative complications occurred in 25 patients with subsequent mortality in 2. As compared with LRFA, ORFA was associated with significantly (p<0.01) higher intra-operative blood loss (median 20 (range 0-1700) vs. 10 (0-900) ml), longer duration of surgery (180 (25-440) vs. 75 (30-390) min), more postoperative complications (17 vs. 8), and longer postoperative hospital stay (8 (1-127) vs. 4 (1-51) d). According to the therapy-oriented severity grading system (TOSGS) classification, postoperative complications in the ORFA-group were more severe than those in the LRFA-group (p<0.01). These findings were consistent in patients without simultaneous colorectal and/or hepatic resection and in patients with liver tumours measuring 3cm or less. In univariate analysis the following factors were significantly (p<0.01) related to the presence of postoperative complications: simultaneous colorectal resection, laparotomy, duration of surgery, tumour location in right liver, liver segment 7 (p=0.01), absence of cirrhosis (p=0.02), liver segment 8 (p=0.03), and metastatic liver cancer (p=0.04). CONCLUSION: LRFA for hepatic malignancies seems preferable above ORFA, provided good patient selection, surgical expertise, and long-term oncological control.