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脑缺血大鼠大脑皮层存活素及血管内皮生长因子的表达 总被引:2,自引:1,他引:1
目的 探讨存活素(Survivin)对大鼠脑缺血区神经细胞凋亡抑制的影响和介导血管内皮生长因子(VEGF)阳性表达的微血管修复再通的作用.方法 18只Wistar大鼠随机分为缺血组、盐水组、假手术组、正常组,建立局灶脑缺血模型,采用PV-6000两步免疫组织化学染色法检测,光学显微镜观察大脑皮层Survivin及VEGF阳性细胞并计数.结果 缺血组、盐水组、假手术组、正常组Survivin阳性表达数分别为67.32±7.34、23.63±4.63、18.21±2.17、2.56±0.11,VEGF阳性表达数分另1为47.83±5.04、19.33±4.10、14.12±1.21、1.47±0.03,缺血组Survivin和VEGF阳性表达明显高于其他3组(P<0.05),缺血组大脑皮层神经元和室管膜上皮细胞等处Survivin阳性细胞表达明显.结论 脑缺血大鼠大脑皮层Survivin阳性细胞的表达可抑制或减慢细胞调亡,介导VEGF促进微血管修复的形成过程. 相似文献
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目的探讨存活素(Survivin)对大鼠脑缺血区神经细胞凋亡抑制的影响和介导血管内皮生长因子(VEGF)阳性表达的微血管修复再通的作用。方法18只Wistar大鼠随机分为缺血组、盐水组、假手术组、正常组,建立局灶脑缺血模型,采用PV-6000两步免疫组织化学染色法检测,光学显微镜观察大脑皮层Survivin及VEGF阳性细胞并计数。结果缺血组、盐水组、假手术组、正常组Survivin阳性表达数分别为67.32±7.34、23.63±4.63、18.21±2.17、2.56±0.11,VEGF阳性表达数分别为47.83±5.04、19.33±4.10、14.12±1.21、1.47±0.03,缺血组Survivin和VEGF阳性表达明显高于其他3组(P〈0.05),缺血组大脑皮层神经元和室管膜上皮细胞等处Survivin阳性细胞表达明显。结论脑缺血大鼠大脑皮层Survivin阳性细胞的表达可抑制或减慢细胞调亡,介导VEGF促进微血管修复的形成过程。 相似文献
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血管内皮细胞冷损伤模型的建立 总被引:1,自引:0,他引:1
目的建立在细胞水平进行冷冻损伤研究的细胞冷损伤实验模型。方法在不加任何低温保护剂的条件下将体外培养的大鼠主动脉血管内皮细胞(VEC),以1℃·min1、10℃·min1和20℃·min1的冷冻速率冷冻至-40℃,或以1℃·min1的冷冻速率分别冻至0℃、-10℃、-20℃和-40℃,在冻后1d和3d观察VEC生长情况以及乳酸脱氢酶(LDH)活性的变化,分析冷冻速率和冷冻温度与VEC损伤程度的关系。结果VEC活存率1℃·min1组为80.0%,10℃·min1组为61.5%,20℃·min1组为42.3%。在冻后1d和3dVEC生长率(%)分别为:0℃组91.7,95.1;-10℃组57.7,54.2;-20℃组20.5,16.8;-40℃组5.4,4.4。冷冻至0℃、-10℃、-20℃和-40℃,冻后1dVCE培养液中LDH活性(U·L-1)依次为:141.6±15.3,270.2±18.6,328.9±29.6,359.8±28.0。结论本实验建立了以1℃·min-1的速率冷冻至0℃的轻度冷损伤模型、冷冻至-10℃的中度冷损伤模型和冷冻至-20℃或-40℃的重度冷损伤模型。对冷冻损伤反应较为适宜的细胞冷冻模型是中度冷损伤模型或重度中的-20℃冷损伤模型。 相似文献
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目的:建立全小肠切除大鼠模型。方法;保留距Treitz韧带及距回盲部1cm的小肠,切除中间段全部小肠,行空-回肠端端吻合术。术后行肠内营养(EN)10天。结果:40只大鼠中术后生存率1周为100%,4周为58%,8周为30%,12周为25%,与预实验组相比有明显差异(P<0.01)。结论:该全小肠切除大鼠模型创建方法切实可行。 相似文献
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目的:探讨短暂性脑缺血发作(TIA)与动脉粥样硬化病变的关系,评价颈部血管超声在TIA中的应用价值.方法:选取收治的TIA患者128例作为观察组,选取相同时期128例无该病的受检人员作为对照组,均已采取颈部血管超声检查,回顾性分析其特征,比较两组内膜增厚、管腔狭窄、颈动脉血流动力学及粥样斑块检出情况等.结果:超声对于观察组颈动脉病斑块检出率及血管狭窄情况明显高于对照组,差异均具有统计学意义(P<0.05).结论:TIA的发生与颈动脉粥样硬化密切相关,颈动脉超声检查能为临床有效地预防和治疗TIA的发生提供客观依据. 相似文献
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目的:通过对短暂性脑缺血发作(TIA)患者行全脑血管造影检查,了解缺血性脑血管痛患者的血管学资料,为临床提供依据。方法:选择164例TIA患者行仝脑血管造影检查。结果:前循环组共有血管狭窄222处;后循环组共有血管狭窄206处。前循环组全脑血管造影阴性例数为10例,后循环组为42例,两组比较差异有统计学意义。结论:前循环责任血管病变以颈内动脉虹吸部和大脑中动脉的水平段为多;后循环狭窄病变则以推动脉起始部、大脑后动脉和基底动脉较多。 相似文献
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目的探讨重组人促红细胞生成素(rhEPO)对大鼠慢性脑缺血后血管生成的作用。方法SD人鼠随机分为假手术组、缺血模型组、依达拉奉组(阳性对照,10mg/kg)、灭活rhEPO鼻腔给药组(24u·40μl^-1,加热灭活)和rhEPO鼻腔给药组(12、24、48u·40μl^-1)。以大脑中动脉栓塞诱导夫鼠局灶性腑缺仇,手术当日术前30min和术后2h各给药1次,第2天起隔天1次至术后14天。缺血后35天,应用免疫组织化学方法检测缺血侧CD31、HF-1α、VEGF和Flk-1继白表达的细胞数目。结果假手术组无CD31、HF一1α、VEGF和Flk-1蛋白表达,缺血模型组较假手术组表达明显增加,依达拉奉组和rhEPO(24和48u·40μl^-1)鼻腔给药组缺血侧大脑CD31、HF—lα和VECF赁自的表达与缺血模型纰比较明显增高。另外,rhEPO(24u·40μl^-1)鼻腔给药使受体Flk-1上调,而rhEPO(48u·40μl^-1)鼻腔给药使受体Flk一1下调。结论 rhEPO鼻腔给药可通过HIF-1α途径增强VEGF蛋白的表达、促进血管生成发挥对大鼠慢性脑缺J缸的保护作用。 相似文献
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目的探讨16排CT血管成像在下肢阻塞性病变诊断中的价值。方法对32例临床疑有下肢动脉硬化闭塞症的患者行16排CT容积扫描及血管三维重建,扫描范围1100~1200mm,层厚5mm,螺距1.375mm,重建层厚1.2mm,造影剂量120~150ml,注射速率3.5~4ml/s,智能跟踪自动触发扫描,扫描时间20~35s,对全部图像行最大密度投影,容积再现及表面阴影显示重建。结果32例共608节段,血管重度狭窄120节段,闭塞102节段。结论作为一项高度准确的成像技术和非侵袭性检查方法,16排CT管成像诊断下肢动脉闭塞性疾病有较高的敏感性、特异性和准确性。 相似文献
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牙颌模型测量精度的正确界定 总被引:8,自引:0,他引:8
牙颌模型测量和分析是正畸治疗的重要根据,通过实验及统计分析指出牙颌模型测量误差的大小及其产生原因,为新型测量仪开发提供精度标准,并为规范牙颌模型测量数据的记录提供依据. 相似文献
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深化改革持续探索积极创建为部队服务新模式 总被引:4,自引:3,他引:1
向月应 《解放军医院管理杂志》2007,14(9):660-662
本文分析了军队医院建立为部队服务新模式的依据,介绍了为部队全程全方位服务新模式的特点和做法,即服务体制一体化,服务功能综合化,服务保障全程化,资源配置合理化和管理调控制度化,以及在医院推行新模式所取得的成效。 相似文献
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Jen Nickelson PhD RD Carol A. Bryant PhD Robert J. McDermott PhD FASHA Eric R. Buhi MPH PhD CHES Rita D. DeBate PhD MPH CHES 《The Journal of school health》2012,82(12):560-571
BACKGROUND: The prevalence of obesity among high school students has risen in recent decades. Many high school students report trying to lose weight and some engage in disordered eating to do so. The obesity proneness model suggests that parents may influence their offspring's development of disordered eating. This study examined the viability of a modified obesity proneness model in a high school population. METHODS: Cross‐sectional survey data from a random cluster sample of 1533 students in grades 9–12 from a Florida school district were analyzed using structural equation modeling. Variables included adolescents' weight concerns; inability to self‐regulate eating; and perceptions about maternal comments about adolescents' weight, restrictive feeding practices, and maternal weight‐related concern and values. RESULTS: All the model's originally proposed relationships were statistically significant, for example perceived maternal weight comments were associated with adolescents' weight concerns (β = 0.64; p < .0001), and perceived maternal restrictive feeding practices were associated with adolescents' inability to self‐regulate eating (β = 0.22; p < .001). CONCLUSION: Some points of intervention should be subjected to empirical study. These interventions should give mothers guidance about appropriate feeding practices and discourage mothers from making weight‐related comments to their offspring. Together, as 1 component of a multilevel intervention, these behaviors may help prevent disordered eating and obesity. 相似文献
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Harry J. Smolen MS David J. Cohen MD MSc Gregory P. Samsa PhD James F. Toole MD Robert W. Klein MS Nicolas M. Furiak MS Beverly H. Lorell MD 《Value in health》2007,10(6):489-497
ObjectiveTo develop a model to predict stroke-free survival and mortality over a multiyear time frame for a trial-excluded population of medically managed asymptomatic patients with significant carotid artery stenosis.MethodsWe calibrated, validated, and applied a Monte Carlo microsimulation model. For calibration we adjusted general-population mortality and stroke risks to capture these risks specific to asymptomatic carotid stenosis patients. For validation, we compared model-predicted and actual stroke-free survival curves and stroke counts from a population of comparable patients. For application, the validated model predicted stroke-free survival for a hypothetical medically managed arm of a recent single-arm carotid revascularization trial.ResultsFor each month in the 60-month time frame, the model-predicted and actual calibration trial stroke-free survival curves were not statistically different (P > 0.62). In validation, the calibrated model's stroke-free survival curvematched the actual curve from an independent population; beyond 24 months, the model-predicted and actual curves were not statistically different (P > 0.32). We also compared model-predicted and actual number of strokes from the independent trial. The model predicted 187.25 strokes (95% confidence interval 161.49–213.01), while the actual number was 171.6, within 1.22 standard deviations of the simulated mean.ConclusionsGiven the absence of medically managed populations in recent carotid stenosis trials, our model can estimate stroke-free survival and mortality data for these patients. The model may also estimate the effectiveness of novel medical and procedural therapies for stroke prevention. These effectiveness estimates can inform the development of policies, guidelines, or cost-effectiveness analyses when only single-arm trial data exist. 相似文献