鼻渊冲剂治疗慢性鼻窦炎132例

观察鼻渊冲剂治疗慢性鼻窦炎的临床疗效。采用随机分组对照法：治疗组132例应用鼻渊冲剂，对照组60例应用阿莫西林胶囊。鼻渊冲剂对鼻塞、流脓涕、头痛等症状的疗效明显优于对照组。鼻渊冲剂组总有效率达88．9％，对照总有效率为60％。两组有显差异（P＜0．01）。结论：鼻渊冲剂治疗慢性鼻窦炎有较好的疗效。     

中西医结合治疗儿童慢性鼻窦炎疗效观察

目的观察中西医结合治疗儿童慢性鼻窦炎的疗效。方法112例儿童慢性鼻窦炎患者随机分成两组，治疗组：口服阿莫西林／克拉维酸钾，呋麻液滴鼻每日三次，上颌窦积脓者每周冲洗一次，口服清鼻汤；对照组：口服阿莫西林／克拉维酸钾，呋麻液滴鼻每日三次。比较两组疗效。结果治愈率：治疗组为60．71％，对照组32．14％。显效率：治疗组87．5％，对照组62．5％。两组疗效差异有显著性意义（P〈0．01）。结论中西医结合治疗儿童慢性鼻窦炎具有较好疗效。     

鼻内镜手术治疗儿童慢性鼻窦炎78例临床分析

本文回顾性分析了78例儿童慢性鼻窦炎鼻内镜手术治疗的临床资料。其中治愈32例（41．0％），好转39例（50．0％），无效7例（9．0％），总有效率为91．0％，提示鼻内镜鼻窦手术是治疗儿童慢性鼻窦炎的有效方法。     

79例儿童及青少年鼻内镜手术临床分析

目的：探讨鼻内镜手术治疗儿童及青少年人慢性鼻窦炎的临床疗效。方法：对79例进行鼻内镜手术治疗慢性鼻窦炎的儿童及青少年患者随访6个月～2年。结果：79例儿童及青少年患者中,鼻塞、脓涕、头痛等症状消失者64例（81.0%）,鼻部症状明显减轻或改善者12例（15.2%）,无效3例（3.8%）,总有效率96.2%。结论：儿童及青少年慢性鼻窦炎经保守治疗无效时行鼻内镜手术疗效满意。     

儿童慢性鼻窦炎的诊治

目的探讨儿童慢性鼻窦炎的有效治疗方法。方法33例59侧儿童慢性鼻窦炎Ⅰ型患者采取保守治疗，其中5例患者行腺样体刮除；21例38侧儿童慢性鼻窦炎Ⅱ型患者在保守治疗基础上采取全麻下鼻内镜手术治疗。结果所有患者均随访1年以上。Ⅰ型：Ⅰ期4例（100．0％）均治愈；Ⅱ期7例（33．3％）治愈，13例（61．9％）好转，1例（4．8％）无效；Ⅲ期2例（25．0％）治愈，3例（37．5％）好转，3例（37，5％）无效。Ⅱ型：Ⅰ期2例（100．0％）均治愈；Ⅱ期5例（38．5％）治愈，7例（53．8％）好转，1例（7．7％）无效；Ⅲ期1例（16．7％）治愈；3例（so．0％）好转；2例（33．3％）无效。结论儿童慢性鼻窦炎Ⅰ型患者应积极保守治疗，特别是对Ⅰ、Ⅱ期患者，对伴有腺样体肥大治疗效果不佳者应刮除肥大的腺样体；对儿童慢性鼻窦炎Ⅱ型患者采取鼻内镜下手术加药物治疗。     

仙璐贝联合鼻渊舒治疗儿童慢性鼻窦炎的疗效

目的探讨仙璐贝联合鼻渊舒12＇服液治疗儿童慢性鼻一鼻窦炎的t临床疗效。方法将52例慢性鼻一鼻窦炎患儿随机分为两组,对照组予以抗生素治疗4周,治疗组在对照组的基础上加用仙璐贝和鼻渊舒口服液治疗4周。结果治疗组I临床痊愈16例,占57．1％,显效5例,占17．9％,有效5例,占17．9％,无效2例,占7．1％,总有效率92．9％。对照组临床痊愈5例,占20．8％,显效7例,占29．2％,有效6例,占25％,无效6例,占25％,总有效率75％。两组比较差异有统计学意义（P〈0．01）。结论儿童慢性鼻一鼻窦炎在抗生素治疗的基础上加用仙璐贝、鼻渊舒口服液,可有效提高治疗效果,值得临床推广应用。     

苍耳子合剂灌注治疗鼻窦炎临床观察

目的 探讨苍耳子合剂浓缩液治疗鼻窦炎的效果。方法：苍耳液负压置换疗法灌注或（和）口服治疗鼻窦炎，设对照组，并轻鼻窦内窥镜观察用药前后鼻及鼻窦粘膜的病理改变情况。结果：第1组苍耳子合剂负压灌注治疗患者69例，有效率达97．1％；其中头痛缓解显效率达94．2％，流涕显效率达65．2％，鼻塞缓解49．3％；第2组负压灌注加口服，共治疗患者96例，有效率达100％；显效率：头痛缓解达97．9％，流涕达85．4％，鼻塞达67．7％；第3组为对照组，共治疗患者33例，有效率为42．4％。经统计学处理：X^2检验，P＜0．005，有极显著性意义。用区间图筛选法显示第3组疗效最差，第2组最好，第1组居中。结论：本疗法治疗鼻窦炎疗效显著，尤其可快速缓解鼻源性头痛。     

腺样体切除术治疗儿童慢性鼻-鼻窦炎的研究

目的探讨鼻内镜下腺样体切除术治疗儿童慢性鼻-鼻窦炎的临床疗效。方法选择2011年9月—2013年6月该院收治的50例慢性鼻-鼻窦炎患儿,随机将其分为观察组与对照组,各25例。观察组行鼻内镜下腺样体切除术,对照组单纯应用药物治疗,再综合比较两组疗效。结果观察组总有效率为92.0%,对照组总有效率为80.0%。两组差异有统计学意义（P〈0.05）;两组患儿在嗅觉减退改善上,差异无统计学意义（P〉0.05）,在流涕、鼻塞、头痛的改善方面,差异有统计学意义（P〈0.05）,在流涕、鼻塞、嗅觉减退、头痛四方面VSA评分上,观察组症状平均分为（3.12±1.42）,对照组症状平均分为（4.32±1.63）,差异有统计学意义（P〈0.05）;观察组患儿在围手术期与随访期间均未出现并发症。结论经鼻内镜下行腺样体切除术可有效治疗儿童慢性鼻-鼻窦炎,疗效确切,值得在临床上推广应用。     

鼻内窥镜手术650例临床疗效分析

目的 探讨影响功能性鼻内窥镜手术（FESS）治疗慢性鼻一鼻窦炎（CRS）疗效的相关因素。方法 对完成随访的650例内窥镜鼻窦手术进行临床疗效分析，其中Ⅰ型182例（28．0％）、Ⅱ型367例（56、5％）、Ⅲ型101例（15．4％）。术后随访6～36个月，平均12个月。结果 总治愈率82、9％，好转率14、9％，无效2．4％。其中，治愈率Ⅰ型94．5％，Ⅱ型83．0％，Ⅲ型54．3％，三型之间治愈率差异有统计学意义（P〈0.01）哮喘明显改善。术中并发症发生率2.4％（16／650），术后2-4年内行修正手术3．2％（21／650）。结论 鼻窦内窥镜手术是目前治疗慢性鼻炎、鼻窦炎最有效的方法，疗效与临床分型，手术技巧及术后随访处理关系密切。     

氦-氖激光结合超短波治疗慢性鼻窦炎98例

0 引言 慢性鼻窦炎常见,其人群发病率15％;可有脓涕、鼻塞、头痛、嗅觉减退或消失等．我科2005—12／2007-02治疗慢性鼻窦炎98例,取得满意效果．     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.