《中国行为医学科学》核心竞争力测评:基于载文被引的分析与研究

目的 从文献引证的角度了解《中国行为医学科学》(简称CJBMS)的学术水平和期刊质量.方法 依据《中国全文数据库》、《中国期刊引文数据库》,采用文献计量学方法对CJBMS载文被《中国期刊引文数据库》来源期刊引用的情况进行统计、分析及评价.主要文献计量学统计指标为各年度发文被引比例、单篇论文平均被引次数、论文被引的区间分布、作者发文被引篇数、高被引论文的地区分布、高被引作者机构等.结果 CJBMS2001 至2005年发表论文2176 篇, 被《中国引文数据库》来源期刊引用了1419 篇4881 次(截至到本文数据统计时),被引率分别为68.44%、70.19%、69.05%、60.95%和60.20%,平均被引率为65.21%,单篇论文被引次数分别为4.04,4.00,3.57,3.13和2.67 次,平均被引次数为3.44 次.被引作者群的地域分布国内31个省市自治区直辖市和美国,山东、广东、北京和湖南居于前列.结论 CJBMS学术水平和期刊质量高,已形成具有自己风格与特色且相对稳定的研究体系,是医学研究领域的重要信息源之一,是我国行为医学研究领域的权威期刊.     

《中国行为医学科学》核心竞争力测评：基于载文被引的分析与研究

目的从文献引证的角度了解《中国行为医学科学》（简称CJBMS）的学术水平和期刊质量。方法依据《中国全文数据库》、《中国期刊引文数据库》,采用文献计量学方法对CJBMS载文被《中国期刊引文数据库》来源期刊引用的情况进行统计、分析及评价。主要文献计量学统计指标为各年度发文被引比例、单篇论文平均被引次数、论文被引的区间分布、作者发文被引篇数、高被引论文的地区分布、高被引作者机构等。结果CJBMS2001至2005年发表论文2176篇,被《中国引文数据库》来源期刊引用了1419篇4881次（截至到本文数据统计时）,被引率分别为68.44%、70.19%、69.05%、60.95%和60.20%,平均被引率为65.21%,单篇论文被引次数分别为4.04,4.00,3.57,3.13和2.67次,平均被引次数为3.44次。被引作者群的地域分布国内31个省市自治区直辖市和美国,山东、广东、北京和湖南居于前列。结论CJBMS学术水平和期刊质量高,已形成具有自己风格与特色且相对稳定的研究体系,是医学研究领域的重要信息源之一,是我国行为医学研究领域的权威期刊。     

2001-2004年军事医学科学院在SCI收录期刊上发表论文的计量研究

利用美国科学情报研究所（ISI）的《科学引文索引》数据库（SCI），对军事医学科学院2001—2004年间在SCI收录期刊上发表论文情况进行了统计，并计量统计分析了各所发文数量、参考文献、载文期刊、发文作者、被引频次和影响因子等指标，旨在揭示该院在SCI收录期刊上发表论文的现状、科研能力、科技产出力和学术交流能力。     

中国高影响力医学科技论文与核心期刊的相互关系

利用《中国生物医学期刊引文数据库》(CMCI)的数据,计量分析了1994-2004年来国内医学领域高影响力的科研论文期刊分布情况;对照《中文核心期刊要目总览》(第4版)和《中国科技期刊引证报告》(2005年版)收录的核心期刊进行比较分析研究。发现高影响力医学论文多刊登在国家最权威的核心期刊上,但有不少核心期刊没有一篇高影响力论文,而个别非核心期刊的高影响力论文多达数十篇。所以不能简单地以高影响力论文或核心期刊论文来评价论文和期刊的质量。     

《南京医科大学学报(自然科学版)》引文分析及评价

目的:通过评价《南京医科大学学报(自然科学版)》引文情况,旨在揭示我国医学院校学报领域引文的一般资料,了解和分析医学领域著者吸收利用科技文献的实际情况。方法:对《南京医科大学学报(自然科学版)》2000￣2004年间30期论著引文作引文量的时间分布、引文的语种分布,计算引文普赖斯指数及引文半衰期,并采用布拉德福文献规律找出引文核心区域期刊。结果:①30期发表的全部论著共引用6 141条引文,平均每篇论著引文7.53条;②引文以英文为主,占68.80%,其次为中文占30.99%;③引文普赖斯指数为47%,半衰期为5.43年;④根据布拉德福定律得出,核心区域期刊中文19种,外文为40种。结论:《南京医科大学学报(自然科学版)》引文涉猎范围广,引文类型以期刊为主,语种以英文为主。语种结构较为单一。学报作者引用文献较新,刊载的论文在新颖性方面能紧跟各学科发展水平。《南京医科大学学报(自然科学版)》为我国综合医学领域最重要的信息源之一。     

《上海铁道大学学报(医学辑)》用文及引文计量分析

目的分析<上海铁道大学学报(医学辑)>(以下简称<学报(医)>)的用文及引文情况,为图书馆收藏及有效配置文献资源、提高学报文献质量提供参考依据.方法运用文献计量学方法和引文分析法对<学报(医)>1996～1997年用文、引文的平均值、引文类型等进行了统计分析.结果论文中论著、经验交流分别占总引文的18.70%、34.29%,论文平均引文量为4.49条,期刊占总引量的83.70%,被引文献峰值是在发表后的第2～4年,文献半衰期为5.28年. 结论论文用文以论著、经验交流为主,期刊尤其是英文期刊是<学报(医)>的主要引文源,20年以上的文献可视为老化文献,可适当剔除或转入二线库存.     

《中国行为医学科学》核心竞争力测评:基于引文的分析

目的 测评<中国行为医学科学>的核心竞争力.方法 以<中国行为医学科学>杂志2002～2006年刊载的论文作为研究对象,对引文数量、引文率、引文语种、引文年代、自引率、被引高频期刊、普赖斯指数进行分析.结果 5 年共载文2323篇,其中有引文的文章有2238篇,引文率为96.34%,引文总量17292条,篇均引文为7.44条,引文语种以中文为主,共8888条(51.40%),其次为英文,共8389条(48.51%) ,日文15条(0.09%),自引率为12.47%.中文文献在出版后第2年被引频次最高,出版后1～2年被引频次占全部中文引文的29.73%.英文文献在出版后第2年被引频次最高,出版后1～2年被引频次占全部英文引文的17.74%.引用的744种中文期刊中,频次最高前41种期刊被引频次达4596次,占期刊引文总数的51.71%.引用的1686种英文期刊中,频次最高前42种期刊被引频次达2952次,占期刊引文总数的35.19%.结论 该刊在引文量、篇均引文率、自引率以及普赖斯指数方面正逐年增加,引用文献的实效性比较强,说明本刊能反映该学科最新成果和前沿动态,是该专业最具代表性的期刊.     

《中国病案》杂志被引分析研究

目的从文献引证的角度分析《中国病案》的文献计量指标,了解该刊的学术质量和水平。方法利用中国知识资源总库（CNKI）的＂中国引文数据库＂,对《中国病案》2000年-2008年被引文献进行计量分析和评价。结果各年总被引频次、即年指标和被引半衰期均呈上升趋势;影响因子领先于医学期刊;被引论文地区分布十分广泛,但主要集中在广东、北京、福建、江苏、河北等地区,被引论文作者多来自国家重点医药院校的附属医院和特大型医院;高影响力论文占被引用的论文较大,载文质量普遍较好。结论《中国病案》所载论文质量较高,能全面反映我国病案学领域的研究成果和最新研究进展,对相关专业具有较强的影响力,是代表我国病案学研究领域最高学术水平的核心期刊,是我国病案管理及相关学科最重要的信息源之一。     

2000-2009年SCI收录期刊刊载的我国中医药高校论文的情况分析

目的:通过对2000-2009年国内12所较有影响的中医药高等院校科研人员在SCI收录期刊上发表论文和论文被引情况的分析,了解国内中医药院校的科研方向、科研实力和科技影响力。方法:从发文数量、学科分布、发表期刊和被引情况4方面对12所中医药高等院校近10年在SCI收录期刊发表的论文进行分析。结果:发文数量以上海中医药大学为最高,中药学论文最多,并以中药化学、中药药理学论文最多。2006年以后各院校发文呈快速增长趋势。发文期刊多为中国出版的SCI收录期刊,论文的篇均被引次数为3.04。在高影响因子期刊上发表的论文较少。1篇发表在Lancet上,影响因子最高,为30.758。结论:国内中医药院校在SCI收录期刊发表论文虽呈上升态势,但明显比西医院校低。应加大中医药院校优势学科的培育力度,加强研究生和教师外语阅读和写作能力的培养,同时了解SCI的特点、定位、投稿方法和技巧。     

SCI收录7所中医药院校科技论文的计量分析

以SCI-EXPAND为数据源统计上海、北京、广州、南京、成都、山东及黑龙江7所中医药大学在2003-2010年间被SCI收录的文献,从文献量、年代、来源出版物、影响因子、引文情况等几方面进行统计分析。结果显示,7所高校被SCI收录论文数逐年增加,尤其从2005年开始增加显著;但各校发表SCI论文期刊的影响因子多数相对较低、篇均被引频次不高,今后有待在论文的质量和数量上有所突破。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.