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臧载阳 《南京中医药大学学报》1990,6(1):57-59
羚羊角入药始载于《神农本草经》。具有平肝息风,清热解毒,镇痉明目等功能。用于眩晕、头痛、热病、痉搐,目医内障等症,功效卓著,为历代医家所赏用。在古代方书中,使用羚羊角的方剂很多,说明羚羊角在古代是常用药物。但近代羚角药源很少,价格昂贵,已成为比较稀有的名贵药材,因而临床处方,受到了一定限制。笔者根据有关史料以及历代诸家本草的记载,认为这种情况是由于羚羊角的来源古今有异所致。现代所用的羚羊角,色黄白如蜡,长约25~40cm,中下部有10~20个棱节。其原动物 相似文献
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YU Xiao-hong GIAO Fei CHENG Li-hui CHEN Gang LONG Xiao-ying WANG Xin-ran LI Xiao-li LIANG Run-cheng YANG Fan 《广东药学院学报》2012,(4):374
Objective This study engaged in investigation of optimal formulation,characteristics analysis of Brucea javanica oil microemulsion(BJOM) in order to address safety concerns and make recommendations for improvements in BJOM safety during clinical use in vivo.Methods Pseudo-ternary phase diagram techniques were used to determine the appropriate ratio of surfactant,cosurfactant,and oil phases.Subsequent stability testing of BJOM was performed by dilution,centrifugation,and accelerated stability testing.The results were expounded through additional assessment utilizing the classical thermostat method to establish the shelf life of the material.These results were utilized to evaluate the safety of BJOM by haemolytic,irritative and allergic testing in vitro.In addition,the cytotoxicity of BJOM was examined using the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide(MTT),with particular emphasis given to potential uses in cancer treatment.Results The most suitable method of preparation for BJOM was found to be a one to one ratio(Km 1∶ 1) of Solutol HS15 surfactant matched with sorbitol cosurfactant in the ratio.The microemulsion droplets of BJOM possessed a spherical shape,uniform size,and average diameter of 23.8nm.The expiration date of BJOM was found to be 568d.The safety study demonstrated no haemolysis activity at the experimental BJOM concentrations;however,mild haemolysis was observed at higher concentrations of Brucea javanica oil emulsion(BJOE),a common commercially available product.Irritation observed upon BIOM treatment can be primarily attributed to Brucea javanica oil(BJO) with little influence of BJOM excipients.In addition,BJOM caused no observed hypersensitivity or other visible allergic reactions in guinea pigs.The anticancer activity curves of BJOM and BJOE demonstrate that both BJOM and BJOE inhibit Hela cells,with BIOM demonstrating significantly more dramatic anticancer activity.Conclusion An optimal formulation of BJOM superior to commercially available products and safe for medical application such as intravenous injection has been outlined along with its anticancer activity rating. 相似文献
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三维适形放疗联合鸦胆子油乳介入治疗原发性肝癌临床研究 总被引:2,自引:0,他引:2
目的 探讨三维适形放射治疗联合介入化疗治疗肝癌的临床效果.方法 选取本院2007年9月至2009年3月收治的78例无法手术切除的肝癌患者,随机分为单纯介入治疗组38例(鸦胆子油乳10 mg/m2,5-Fu 500 mg/m2,顺铂40 mg/m2,表阿霉素40 mg/m2);介入治疗(同前)加三维适形放射治疗组40例,放射治疗肿瘤的平均剂量为56 Gy(50~60 Gy),观察两组患者1年无进展生存率、1.5年总体生存率与毒性反应情况.结果 平均生存时间,单纯介入化疗组为(9.2±2.1)个月,介入化疗加放射治疗组为(13.5±1.9)个月,两组比较差异有统计学意义(P<0.05);单纯介入化 相似文献
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目的:研究鸦胆子油乳对胶质瘤U251细胞血管内皮生长因子(VEGF)表达水平的抑制情况.方法:体外培养人脑胶质瘤U251细胞,设置对照组和3个药物组(鸦胆子油乳终质量浓度分别为5 g/L、25 g/L和1.25 g/L),利用酶联免疫吸附法测定培养细胞上清液中VEGF含量;应用免疫细胞化学法检测胶质瘤U251细胞中VEGF的变化.结果:酶联免疫吸附法测定培养细胞上清中VEGF含量显示,随着药物浓度的增加U251细胞分泌的VEGF均较对照组明显减少(P<0.01).免疫组织化学显示,随着鸦胆子油乳注射液作用剂量的增加,VEGF蛋白的表达逐渐减少.结论:鸦胆子油乳注射液能抑制胶质瘤细胞中VEGF的表达. 相似文献
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中药复方药代动力学研究新进展 总被引:6,自引:0,他引:6
近年来,中药复方药代动力学研究取得了较大的进展,一些新理论、新方法不断涌现,如药动一药效的相关分析、中西药药动学相互作用研究、肠道菌群代谢研究等,但这些方法也存在一定的缺陷,有待进一步完善。 相似文献
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中药复方治疗抑郁症实验研究进展 总被引:1,自引:0,他引:1
文章分析了近10年来中药复方治疗抑郁症的实验研究进展。发现多集中在疏肝的逍遥散类、祛痰的温胆汤类以及安神之酸枣仁汤类的经典中药复方及其加减方,显示了中医药在抗抑郁方面良好的发展前景。但也分析了存在的许多不足,指出了今后的研究方向。 相似文献