中青年男性冠心病患者PCI前后性生活质量的变化

Objective To investigate the effect of percutaneous coronary intervention (PCI) on the sexual quality of life among young and middle-aged male patients with coronary heart disease (CHD) by using Sexual Life Quality Questionnaire(SLQQ).Mothods 78 patients cured by PCI were kept in operation group and the drug therapy group contained 80 patients.The sexual quality of life one day before hospitalization and six months after discharge was surveyed with a retrospective questionnaire in both two groups.Results The sexual quality of life in 6 months after discharge in both groups was better than before hospitalization (P＜0.01);the operation group improved more obviously compared to the drug group (P＜0.01).Conclusions PCI can significantly improve the sexual quality of life among young and middle-aged male patients with CHD.     

冠心病患者介入治疗前后焦虑抑郁障碍的心理干预与评价

Objective To discuss the effect of psychological intervention of depression in coronary heart disease after percutaneous coronary intervention (PCI). Methods The depression of 105 cases of coronary heart disease after PCI treatment was investigated. One hundred and five patients were randomly divided into intervention group and control group. The patientsin intervention group were treated with psychological intervention before and after PCI. The patients in control group were treated with normal treatment. Results There was not significant difference of incidence of depression an self-rating depression scale score between two groups. The depression in intervention group was less severe than that in control group ( P ＜ 0.01 ). Multivariate analysis showed: education level, the recent negative life events, household income, length of stay and sequelae of catheter intervention had significantly correlated with depression in coronary heart disease. Conclusion Psychological intervention can reduce the ratio of depression in coronary heart disease after PCI.     

冠心病患者介入治疗前后焦虑抑郁障碍的心理干预与评价

Objective To discuss the effect of psychological intervention of depression in coronary heart disease after percutaneous coronary intervention (PCI). Methods The depression of 105 cases of coronary heart disease after PCI treatment was investigated. One hundred and five patients were randomly divided into intervention group and control group. The patientsin intervention group were treated with psychological intervention before and after PCI. The patients in control group were treated with normal treatment. Results There was not significant difference of incidence of depression an self-rating depression scale score between two groups. The depression in intervention group was less severe than that in control group ( P ＜ 0.01 ). Multivariate analysis showed: education level, the recent negative life events, household income, length of stay and sequelae of catheter intervention had significantly correlated with depression in coronary heart disease. Conclusion Psychological intervention can reduce the ratio of depression in coronary heart disease after PCI.     

急性冠状动脉综合征与高敏C反应蛋白相关性研究

Objective To investigate the relation among triglyce ride (TG), low density lipoprotein cholesterol(LD-C) and high sensitivity C reactive protein(hs-CRP) in acute coronary syndrome(ACS). Methods A total of 132 coronary heart disease patients which were divided as ACS and stable coronary heart dis-ease(SCHD)groups and 65 cases of the health physical exam inees were enrolled as the controls. The levels of hs-CRP, TG,HDL-C and LDL-C among the three groups were analyzed. Results The levels of hs-CRP of patients in ACS and SCHD groups were significantly higher than those in controls group(P ＜0.05). The level of hs-CRP in ACS group was obviously higher than that in SCHD group( P ＜0.01 ). There was a significant correlation between the concentration of hsCRP and TG( r = 0.62 ,P ＜ 0.01 ); there was a significant correlation between hs-CRPand LDL-C ( r =0.41, P ＜ 0.01 ); however there was a significantly negative correlation between hs-CRP and HDL-C ( r = -0.54, P ＜0.01 ). Conclusions The hs-CRP level in patients with acute coronary syndrome is obviously increased. hs-CRP is positively correlated with acute coronary syndrome, hs-CRP is the unstable sign of atheromatous plaque.     

急性冠状动脉综合征与高敏C反应蛋白相关性研究

Objective To investigate the relation among triglyce ride (TG), low density lipoprotein cholesterol(LD-C) and high sensitivity C reactive protein(hs-CRP) in acute coronary syndrome(ACS). Methods A total of 132 coronary heart disease patients which were divided as ACS and stable coronary heart dis-ease(SCHD)groups and 65 cases of the health physical exam inees were enrolled as the controls. The levels of hs-CRP, TG,HDL-C and LDL-C among the three groups were analyzed. Results The levels of hs-CRP of patients in ACS and SCHD groups were significantly higher than those in controls group(P ＜0.05). The level of hs-CRP in ACS group was obviously higher than that in SCHD group( P ＜0.01 ). There was a significant correlation between the concentration of hsCRP and TG( r = 0.62 ,P ＜ 0.01 ); there was a significant correlation between hs-CRPand LDL-C ( r =0.41, P ＜ 0.01 ); however there was a significantly negative correlation between hs-CRP and HDL-C ( r = -0.54, P ＜0.01 ). Conclusions The hs-CRP level in patients with acute coronary syndrome is obviously increased. hs-CRP is positively correlated with acute coronary syndrome, hs-CRP is the unstable sign of atheromatous plaque.     

冠心病心绞痛患者体内纤溶系统的变化及临床意义

目的 探讨冠心病心绞痛患者体内纤溶系统的变化并分析其临床意义.方法 对110例冠心病心绞痛患者体内的纤溶酶原激活物抑制剂-1(PAI-1)、组织型纤溶酶原激活剂(t-PA)、纤维蛋白原(FIB)水平进行检测,并与20例正常对照者进行对照.结果 冠心病组PAI-1、FIB水平分别为(400±90)AU/L,(4.80±1.1)g/L,明显高于对照组[分别为(260±80)AU/L,(3.6±1.0)g/L,均P＜0.05];冠心病组t-PA水平为(240±70)IU/L,明显低于对照组[(290±90)IU/L,P＜0.01)].不稳定型心绞痛患者(70例)PAI-1、FIB水平明显高于稳定型心绞痛患者(40例,均P＜0.05);不稳定型心绞痛患者t-PA水平明显低于稳定型心绞痛患者(P＜0.01).心绞痛发作者(64例)PAI-1、FIB明显高于无心绞痛发作者(46例,均P＜0.05);而t-PA水平明显低于无心绞痛发作者(P＜0.01).结论 冠心病心绞痛患者体内存在纤溶系统功能异常,尤其是在不稳定型心绞痛患者或心绞痛发作者体内更加明显,纤溶系统功能异常可能在冠心病心绞痛发病过程中起重要的作用.

Abstract：

Objective To observe the changes and the clinical significance of fibrinolysis in coronary heart disease(CHD) patients with angina pactoris (AP). Methods Levels of plasmin plasminogen activator inhibitor-1(PAI-1), tissue-type plasminogen activator( t-PA), fibrinogen (FIB)in 110 CHD patients with AP and 20 normal cases as control group were analyzed. Results Levels of PAI-1, FIB in CHD patients with AP[(260 ± 8 ) AU/L,(3.6 ± 1.0) g/L] were significantly higher than those in control cases [(260 ± 8 ) AU/L, (3.6 ± 1.0 ) g/L], and those of t-PA were significantly lower than those in control cases. Level of t-PA in patients with coronary heart disease [(240 ± 7) IU/L] was significantly lower than that in the control group[(290 ± 9) IU/L,P ＜ 0. 01]. Levels of PAI-1 ,FIB in unstable angina(UA) patients with UA heart events were significantly higher than those in patients with stable angina (SA). Level of t-PA in patients with UA was significantly lower than that in patients with SA (P ＜0. 01 ). Levels of PAI-1, FIB in patients with AP events were significantly higher than those in patients without AP events. Levels of t-PA in patients with AP were significantly lower than those in patients without AP events.Conclusions There is abnormal fibrinolysis function in CHD patients with AP, specially in patients with UA or with AP events, which might be play an important rule in coronary heart disease (CHD) patients with angina pactoris.     

冠心病患者介入治疗前后焦虑抑郁障碍的心理干预与评价

目的 研究冠状动脉粥样硬化性心脏病(冠心病)患者介入治疗前后焦虑抑郁障碍情况以及心理干预的效果.方法 采用Zung抑郁自评量表(SDS)对105例拟接受冠状动脉介入治疗的冠心病患者进行焦虑抑郁障碍调查评分.将105例患者完全随机分为干预组57例和对照组48例,干预组在手术前1～2 d和手术后7～10 d、3、6、12、24个月进行焦虑抑郁评定及心理干预,对照组常规治疗并于同时间进行焦虑抑郁评定.同时将影响因素与SDS评分之间进行多因素相关分析.结果 术前2组患者抑郁发生率、SDS评分差异无统计学意义.心理干预后干预组的抑郁障碍较对照组有明显改善[SDS评分:(37±4)分比(46±6)分,P＜0.01],对照组手术前后抑郁发生率无明显变化,而干预组术后抑郁发生率明显低于对照组,差异有统计学意义[15.8%(9例)比35.4%(17例),P＜0.05].多因素分析显示:教育程度、近期负性生活事件、家庭收入、住院时间、导管介入治疗后遗症与冠心病抑郁之间存在明显相关性(P＜0.01).结论 积极的手术前后心理干预可以有效减轻抑郁障碍情况.

Abstract：

Objective To discuss the effect of psychological intervention of depression in coronary heart disease after percutaneous coronary intervention (PCI). Methods The depression of 105 cases of coronary heart disease after PCI treatment was investigated. One hundred and five patients were randomly divided into intervention group and control group. The patientsin intervention group were treated with psychological intervention before and after PCI. The patients in control group were treated with normal treatment. Results There was not significant difference of incidence of depression an self-rating depression scale score between two groups. The depression in intervention group was less severe than that in control group ( P ＜ 0.01 ). Multivariate analysis showed: education level, the recent negative life events, household income, length of stay and sequelae of catheter intervention had significantly correlated with depression in coronary heart disease. Conclusion Psychological intervention can reduce the ratio of depression in coronary heart disease after PCI.     

阿托伐他汀干预对急性冠状动脉综合征患者PCI术后粘附分子水平的影响

Objective To explore the impact of different dose atorvastatin on the adhesion molecules level in the acute coronary syndrome (ACS) patients who had received percutaneous coronary intervention (PCI). Methods Eighty-eight ACS patients were divided into three groups, group A (normal treatment group), group B (normal treatment plus atorvastatin 10mg per day) and group C (normal treatment plus atorvastatin 80mg per day). The patients in group B received atorvastatin 10 mg per day orally before PCI and after PCI subsequently, and the patients in group C received atorvastatin 80 mg per day orally before PCI and after PCI subsequently for three days, then the dose of atorvastatin was decrease to 10 mg per day. The concentrations of soluble intercellular adhesionmolecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were detected before PCI and at the 3rd, 7th 14th day after PCI. Results At the 7th day, the concentrations of sICAM-1 and sVCAM-1 in group C were significantly lower than those in group B, which showed sICAM-1 (68.35±23.80) μg/L vs (131.45±29.12) μg/L and sVCAM-1 (251. 65±36.61)μg/L vs (334.87±32.98) μg/L, respectively. Compared to group A, the adhesion molecule level in group B and group C were significantly decreased (P<0.05) and had no obviously affect on blood fat level. Conclusion The treatment of atorvastatin could significantly decrease the adhesion molecules' level after PCI, which may play an important role in lowing inflammation and coronary artery restenosis after PCI.     

阿托伐他汀干预对急性冠状动脉综合征患者PCI术后粘附分子水平的影响

Objective To explore the impact of different dose atorvastatin on the adhesion molecules level in the acute coronary syndrome (ACS) patients who had received percutaneous coronary intervention (PCI). Methods Eighty-eight ACS patients were divided into three groups, group A (normal treatment group), group B (normal treatment plus atorvastatin 10mg per day) and group C (normal treatment plus atorvastatin 80mg per day). The patients in group B received atorvastatin 10 mg per day orally before PCI and after PCI subsequently, and the patients in group C received atorvastatin 80 mg per day orally before PCI and after PCI subsequently for three days, then the dose of atorvastatin was decrease to 10 mg per day. The concentrations of soluble intercellular adhesionmolecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were detected before PCI and at the 3rd, 7th 14th day after PCI. Results At the 7th day, the concentrations of sICAM-1 and sVCAM-1 in group C were significantly lower than those in group B, which showed sICAM-1 (68.35±23.80) μg/L vs (131.45±29.12) μg/L and sVCAM-1 (251. 65±36.61)μg/L vs (334.87±32.98) μg/L, respectively. Compared to group A, the adhesion molecule level in group B and group C were significantly decreased (P<0.05) and had no obviously affect on blood fat level. Conclusion The treatment of atorvastatin could significantly decrease the adhesion molecules' level after PCI, which may play an important role in lowing inflammation and coronary artery restenosis after PCI.     

老年人支气管哮喘危险因素和临床特点分析

Objective To explore the risk factors and clinical features of elderly asthma.Methods Clinical data of 221 patients with adult asthma were retrospectively analyzed.According to age,the patients were divided into the young group(15 ～59 years) and elderly group( ≥ 60 years).All indices were compared between the two groups to identify risk factors and clinical features.Results In 221 patients with asthma,the elderly patients was 64 patients (28.96% ) ,and their mean age was 73.4 years, of which 39 males(60.93% ) and 25 females (39.06% ).The number of smokers in the elderly group was significantly higher than the young group (x2 = 4.753, P < 0.05) , and infection and climate change was risk factors for asthma in the elderly(x2 =6.352,9.376,all P<0.05) ;The seasonal aspects of old age group was prone to winter and spring, and the young group was prone to winter and summer;The complications and underlying diseases in elderly patients was significantly higher than those in the young group( x2 = 126.270,P <0.01).Conclusion In elderly patients with asthma, male was more than female, and smoking rate was high.The infection and climate change was the main risk factors,which was prone in winter and spring and had more complications and underlying diseases.     

高龄急性冠状动脉综合征患者临床特征及介入治疗预后分析

目的 研究分析≥75岁的急性冠状动脉综合征(acute coronary syndrome,ACS)患者临床特征及介入治疗的预后情况.方法 选取2012年1月-2015年5月收治的100例≥75岁ACS患者作为观察组,另选同期100例＜75岁ACS患者作为对照组.两组患者均行经皮冠状动脉介入治疗(PCI),回顾性分析比较两组患者的临床特点及介入手术的预后情况.结果 观察组患者体重指数低于对照组(P＜0.01).观察组收缩压、空腹血糖和肌酐水平均明显高于对照组(P＜0.05).观察组3支病变、前降支、右冠状动脉和左主干病变明显多于对照组(P ＜0.05,P＜0.01).随访12个月后观察组总体不良心血管事件发生率明显高于对照组(P＜0.05).结论 尽管PCI术治疗高龄ACS患者会产生较多的不良心血管事件,但临床疗效较好,仍可作为治疗高龄ACS的有效手段.     

脑功能电磁治疗仪辅助治疗神经症的对照研究

目的观察采用脑功能电磁治疗仪辅助治疗神经症的临床疗效。方法100洌各类神经症患者随机分为观察组和对照组各50例,对照组采用单纯药物治疗,观察组采用脑功能电磁治疗仪配合药物治疗,两组分别于治疗前及治疗第30天采用症状自评量表（SCL-90）与匹茨堡睡眠质量指数量表（PSQI）进行疗效评定。结果治疗后观察组SCL－90量表的躯体化、人际关系、焦虑、抑郁、敌对、恐怖、强迫、偏执与精神病性等因子分均较治疗前降低（均P〈0．05）;与对照组相比,躯体化和焦虑因子分显著降低（均P〈0．05）。治疗后观察组PSQI量表总得分及睡眠潜伏期、睡眠持续性、睡眠效率、使用睡眠药物及睡眠紊乱等因子分均较治疗前降低（均P〈0．01）;与对照组相比,观察组治疗后PSQI量表各因子分降低更明显（均P〈0．05）。结论采用脑功能电磁治疗仪治疗神经症患者的睡眠改善、缓解焦虑与减轻躯体化症状方面有显著疗效。     

青年慢性前列腺炎患者焦虑抑郁情绪状况与个性特征分析

目的 通过观察分析青年慢性前列腺炎(CP)患者焦虑抑郁情绪状况与个性特征,为临床心理干预提供依据.方法 2014年1月至2015年9月,对80例青年CP患者(观察组)和同期随机选择的50名健康男青年(对照组),分别采用焦虑自评量表(SAS)和抑郁自评量表(SDS)及艾森克成人量表(EPQ)进行测评,比较两组焦虑抑郁状态与个性特征的差异.结果 观察组SAS分值及SDS分值均显著高于对照组(t=8.135、6.861,P＜0.01),EPQ内外向维度显著低于对照组(t=3.579,P＜0.01),神经质维度显著高于对照组(t=4.990,P＜0.01);两组精神质维度及可靠性维度差异无统计学意义(t=0.976、1.018,P＞0.05).结论 青年慢性前列腺炎患者存在焦虑抑郁状态,其个性内向也不稳定,临床治疗时应重视心理干预,以提高临床疗效.     

冠心病合并2型糖尿病患者的脂代谢和冠状动脉造影分析

目的探讨冠状动脉粥样硬化性心脏病（冠心病）合并2型糖尿病患者的脂代谢和冠状动脉造影特点。方法选择经冠状动脉造影证实的冠心病患者310例,其中合并糖尿病患者106例,不合并糖尿病患者204例。比较2类患者的临床和冠状动脉造影资料。结果合并糖尿病的冠心病患者的TG、LDL—C水平较不合并糖尿病者明显升高,HDL—C水平明显下降[合并糖尿病者TG、LDL-C、HDL-C水平分别为（2．86±0．61）mmol／L、（3．42±0．53）mmol／L、（1．05±0．12）mmol／L;不合并者分别为（1．80±0．41）mmol／L、（2．74±0．21）mmol／L、（1．75±0．13）mmol／L],差异有统计学意义（P〈0．05）。合并糖尿病的患者中,血脂异常者冠状动脉主要分支病变均增多。结论冠心病合并2型糖尿病患者的脂代谢明显紊乱,冠状动脉病变较为复杂。     

轻型颅脑外伤患者焦虑的应对方式、社会支持相关因素的研究

目的探讨轻型颅脑外伤焦虑患者的社会支持、应对方式。分析焦虑与社会支持、应对方式之间的相互关系。方法选择150例轻型颅脑外伤患者应用汉密顿焦虑量表（HAMA）展开调查患者焦虑的出现状况;随机平均分为研究组和对照组,每组75例,对照组患者给予普通护理结合单纯的药物治疗,研究组在对照组基础上加心理干预内容。比较患者的社会支持和应对方式。观察两者的变化。问卷调查患者的应对方式、应用社会支持评定量表（SSRS）调查患者的社会支持水平。结果经心理治疗后研究组严重焦虑率明显下降,与对照组比较,差异有显著性（P〈0．05）。研究组与对照组两组间社会支持各因子均分的比较差异有显著性（P〈0．05）。两组解决问题倾向性、求助的倾向性、解决问题的有效性、求助的有效性的均分比较差异有显著性（P〈0．05）。结论轻型颅脑外伤患者焦虑的发生率较高,家庭与社会能够给予轻型颅脑外伤患者一定的社会支持,且患者采取积极的应对方式可减少焦虑。     

急性冠状动脉综合征与高敏C反应蛋白相关性研究

目的 观察不同类型急性冠状动脉综合征（ACS）患者血清TG、HDL-C、LDL-C水平变化及其与高敏C反应蛋白（hs-CRP）的关系,探讨临床识别和预测ACS的指标.方法 将132例冠状动脉粥样硬化性心脏病（冠心病）患者分为ACS组和稳定型冠心病组（SCHD组）,同时选择66例健康体检者作对照组,分别测定、比较3组的血清TG、HDL-C、LDL-C、hs-CRP水平.结果 ACS组和SCHD组患者血清hs-CRP水平[分别（9.26±10.98）mmol/L和（4.65±7.56）mmol/L]显著高于对照组[（1.21±1.32）mmol/L],差异有统计学意义（P＜0.05）.ACS组血清hs-CRP水平显著高于和SCHD组,差异有统计学意义（P＜0.01）.血清hs-CRP水平与TG含量呈显著正相关（r=0.62,P＜0.01）,与LDL-C含量亦呈明显正相关（r=0.41,P＜0.01）,与HDL-C含量呈显著负相关（r=-0.54,P＜0.01）.结论 ACS患者血清hs-CRP水平显著增高 hs-CRP水平与ACS的严重程度呈正相关,是动脉粥样硬化斑块不稳定的标志.     

焦点解决护理干预对血液透析患者焦虑抑郁情绪及生活质量的影响

目的 探究与分析焦点解决护理干预对血液透析患者焦虑抑郁情绪及生活质量的影响.方法 选取本院自2013年9月至2015年9月收治的90例血液透析患者,采取随机数字表法分为对照组与观察组,每组45例;对照组仅给予常规护理,观察组加用焦点解决护理干预,对比两组患者行护理干预后并发症发生率、行护理干预后SCL-90评分情况及KDQOL-SFTM透析患者生存治疗评分情况.结果 两组患者行不同护理干预后,观察组并发症发生率为13.33％,对照组并发症发生率为31.11％,对照组并发症发生率明显高于观察组,差异具有统计学意义(P＜0.05).观察组患者较对照组相比,其护理后SCL-90各项评分情况均明显改善(P＜0.05).两组患者行护理干预前,KDQOL-SF量表各项评分均无明显差异(P＞0.05).干预后,两组患者症状、肾病影响、肾病负担、工作状态、认知功能、社交质量、性功能、睡眠、社会支持、医护鼓励、患者满意度等11个维度评分均较干预前改善,且观察组患者较对照组相比,维度评分明显偏高差异具有统计学意义(P＜0.05).结论 焦点护理干预相比于常规护理可有效消除血液透析患者不良心理状态,降低并发症发生,提高生活质量.     

眠安宁颗粒联合氟哌噻吨美利曲辛片治疗神经衰弱失眠的临床价值评估

目的 观察眠安宁颗粒联合氟哌噻吨美利曲辛片治疗神经衰弱失眠患者的临床效果.方法 取神经衰弱失眠患者60例,随机分为对照组(n=30)和观察组(n=30).对照组口服氟哌噻吨美利曲辛片治疗,观察组在对照组基础上联合眠安宁颗粒治疗,比较两组临床疗效及睡眠质量情况和药物安全性.结果 观察组治疗后睡眠时间、入眠时间、睡眠效率、睡眠质量、睡眠障碍评分低于对照组(均P＜0.05);两组治疗前抑郁量表及焦虑量表评分差异无统计学意义(均P＞ 0.05);观察组治疗后抑郁量表及焦虑量表评分低于对照组(均P＜ 0.05);观察组治疗后药物不良反应发生率为6.67％,对照组不良反应发生率为10.00％,两组不良反应发生率比较差异无统计学意义(P＞0.05).结论 氟哌噻吨美利曲辛片联合眠安宁颗粒治疗神经衰弱患者效果理想,值得推广应用.     

普拉克索联合高压氧舱治疗帕金森病伴睡眠障碍患者的疗效观察

目的 探讨普拉克索联合高压氧舱治疗帕金森病合并睡眠障碍的临床疗效.方法 选取80例合并睡眠障碍的帕金森病患者,根据治疗方法的不同分为3组.普拉克索组25例,给予口服盐酸普拉克索治疗;高压氧组25例,给予高压氧舱吸氧治疗;联合组30例,给予口服盐酸普拉克索联合高压氧舱吸氧治疗.3组患者均接受为期2个月的治疗,观察并记录患者治疗前后睡眠质量水平及焦虑抑郁程度的差异.结果 治疗后,联合组患者PQSI评分、ESS评分分别为(4.36±1.22)、(2.19±3.52),均明显低于普拉克索组[(6.88±1.83)、(5.62±4.33)]和高压氧组[(6.54±1.66)、(5.16±3.96)],组间比较差异有统计学意义(P＜0.05);联合组患者UPDRS-Ⅲ评分、H-Y分级评分低于普拉克索组和高压氧组,但组间比较差异无统计学意义(P＞0.05);联合组卧床时间、总睡眠时间、睡眠效率明显高于普拉克索组和高压氧舱组(P＜0.05),睡眠潜伏期和睡眠觉醒次数明显低于普拉克索组和高压氧舱组(P＜ 0.05).3组患者临床不良反应发生率比较差异无统计学意义(P＞0.05).结论 普拉克索联合高压氧舱治疗帕金森病伴睡眠障碍患者临床疗效显著,能够有效提高睡眠效率,改善睡眠质量,值得临床推广.     

急性冠状动脉综合征患者脑钠肽水平变化的临床观察

目的 探讨急性冠状动脉综合征(ACS)患者经保守或介入治疗后血浆脑钠肽水平的变化.方法 ACS患者95例,介入治疗37例为介入组,保守治疗58例为保守组,健康体检者41例为对照组.酶联免疫吸附法(ELISA)测定入院即刻、第3天、第5天、第10天4个时间点的血浆脑钠肽水平.结果 保守组的血浆脑钠肽水平在入院即刻、第3天、第5天均高于对照组(P＜0.05),但3个时点动态变化不大(P=0.427);介入组在入院即刻、第3天、第5天的血浆脑钠肽水平也均高于对照组(P＜0.05),但3个时点动态变化不大(P=0.544).在第10天保守组和介入组的血浆脑钠肽水平都显著回降,但仍高于对照组且有统计学意义(P=0.025,P=0.012).入院即刻、第3天、第5天及第10天介入组和保守组血浆脑钠肽水平比较无统计学意义.结论 急性冠状动脉综合征患者血浆脑钠肽水平第1周内保持较高水平,第10天显著回降,但仍高于正常水平.急性冠状动脉综合征患者经保守或介入治疗后10 d内血浆脑钠肽水平的变化情况相近.