地塞米松及葡萄糖酸钙联合米索前列醇预防产后出血的临床观察

Objective To explore the clinical effect of a combined treatment of postpartum haemorrhage with misoprostol and calcium gluconale. Methods Two hundred and fourty normal part urients who were pregnancy at term, normal delivery without pregnancy complications or use of prostaglandin inhibition They were randomized into groups: misoprostol with calcium gluconate group and oxytocin group respectively oral misoprostol and calcium gluconate with intraranous injection. Oxytocin with intramuscular injection in the early third stage of labour, then the time of the third stage of labour was calculated. Also the mount of bleeding at the time of placental expulsion. with in 2 h and 24 h after delivery were measured. At the same time, blood pressure, pusle, the frequency of respiration. Saturation of blood oxygen, sideeffect were observed in misoprostol with calcium gluconate group before and after a drministration. Results Time of the third stage of labour, the mount of bleeding with in 2 h and morthan 500 ml with in 24 h in the misoprostol calcum gluconate group were less than that of oxytocin group (P ＜ 0.05 ).Conclusions Misoprostol and intravenous drip of calcium gluconate can strenghen and increase womb systole frequncy and stop postpartum haemorrhage. It is a simple, safe, convenient, cainical valuable to treat postpartum haemorrhage.     

地塞米松及葡萄糖酸钙联合米索前列醇预防产后出血的临床观察

Objective To explore the clinical effect of a combined treatment of postpartum haemorrhage with misoprostol and calcium gluconale. Methods Two hundred and fourty normal part urients who were pregnancy at term, normal delivery without pregnancy complications or use of prostaglandin inhibition They were randomized into groups: misoprostol with calcium gluconate group and oxytocin group respectively oral misoprostol and calcium gluconate with intraranous injection. Oxytocin with intramuscular injection in the early third stage of labour, then the time of the third stage of labour was calculated. Also the mount of bleeding at the time of placental expulsion. with in 2 h and 24 h after delivery were measured. At the same time, blood pressure, pusle, the frequency of respiration. Saturation of blood oxygen, sideeffect were observed in misoprostol with calcium gluconate group before and after a drministration. Results Time of the third stage of labour, the mount of bleeding with in 2 h and morthan 500 ml with in 24 h in the misoprostol calcum gluconate group were less than that of oxytocin group (P ＜ 0.05 ).Conclusions Misoprostol and intravenous drip of calcium gluconate can strenghen and increase womb systole frequncy and stop postpartum haemorrhage. It is a simple, safe, convenient, cainical valuable to treat postpartum haemorrhage.     

复方米非司酮配伍米索前列醇终止早孕的临床观察

Objective To observe the curative effect and safety of compound mifepristone combined with misoprostol on the termination of early pregnancy.Methods 151 women who ask for termination dearly pregnancy were randomly divided into two groups, observation group taking compound Mifepristone combined with Misoprostol, while control group taking Mifepristone combined with Misoprostol.Results The complete abortion rate in the observation group were higher than that of the control group(96.0% vs 89. 5%),and the failure, rate in the observation group were lower than that of the control group(1.3% vs 3.9%), the time of gestational sac diseharge in the observation group were shorter than in the control group[(3.7± 1.2)h vs (4.1 ±1.5)h], but there were no obvious difference between these two groups(P > 0.05).The time of bleeding post-abortion in the observation group were significantly shorter than in the control greup[(12.3±3. 6)h vs (17.1 ±4.7)h](P< 0.01). There were no significant difference on the rate of side effects between these two groups(P> 0.05).Conclusions Compound Mifepristone combined with Misoprostol is effective on the termination of early pregnancy with small bleeding post-abertion.     

Gastric ulcer healing effect of wild honey and its combination with Turmeric（Curcuma domestica Val.） Rhizome on male Wistar rats

Gastric ulcer is a common disorder in human at any ages. In this research, the antiulcer activity of wild honey produced by Apis dorsata, alone or in combination with Turmeric Rhizome, was evaluated in healing acute gastric ulcer. Male Wistar albino rats（150-250 g） were induced ulcers with aspirin at 405 mg/kg BW and ethanol. Antiulcer evaluation was done based on the gastric acidity, numbers and diameter of ulcers, ulcer index, healing ratio, histological examinations, and body weight. The results showed that the groups given honey alone, turmeric alone, and combination of turmeric-honey displayed significant ulcer healing compared to the control group. Ulcers in the group administered with combination of turmeric-wild honey was different significantly from the turmeric alone and wild honey alone groups with increased body weight in that group. The result showed that wild honey（2125 mg/kg BW） had the greatest activity in healing ulcers among other groups. The combination of turmeric-wild honey had a good activity in healing ulcers and increased the body weight of the group.     

瘢痕子宫产妇剖宫产术出血量分析

Objective To explore the clinic value of blood loss during and after cesarean section in women with scarred uterus. Methods From July 2007 to December 2008, thirty-six women with scarred uterus received weighing methods to evaluate the actual blood loss during and after cesarean section in Yuhuangding hospital, while 98 cases without pregnant complications were chosen as control. Results In women with scarred uterus, the blood loss during operation Was (372.4 ± 180.0) ml, and the total amount after 2 hours and 24 hours were (444.7± 228.2) ml and (527.4 ±251.6) ml respectively, which were higher than corresponding values in control group (P < 0. 05). The incidence of postpartum hemorrhage in scarred uterus was 47.2%, higher than that in control group (P < 0. 05). There were no significant differences between two groups in the tests of hemoglobin and coagulation functions (P > 0. 05). Conclusions Scarred uterus may be one of the important reasons which lead to postpartum hemorrhage. The clinical treatment of pregnant women with scarred uterus should focus on the prevention of blood loss during the cesarean section.     

康妇特栓联合波姆治疗宫颈柱状上皮异位的临床效果观察

Objective To 0bserve the clinical efficacy of KFTS in combination with POME infra-red in the treatment of columnar ectopy.Methods A case control prospective clinical Observe was carried out to explore the effect of KFTS in combination with POME infra-red 75 cases with columnar ectopy as 0bserve group, and interferon in combination with POME infra-red on 75 as control group. Then 0bserve the join of columnar ectopy, the lasting time of the vagina liquor drainage, the percentage of bleeding and adverse reactions after exposure of POME infra-red. Results The heal of the columnar ectopy of the two groups Two months after the operation, the cure rate of the KFTS and POME infra-red group and the control group were respectively 90% (68) and 77.3% (58) while the efficiency were 100% and 90.7%. Obvious significant differences in treat efficiency between agents were observable (P＜0.05). The result after three months: the cure rate of the KFIS and POME infra-red group and the control group were respectively 96% (72) and 84% (63) while the efficiency were 100% and 93.3%. Also there are obvious significant differences in treat efficiency (P＜0.05). The duration of vagina letting of the KFTS and POME infra-red group is shorter than that of the control group and obvious significant differences in treat efficiency between agents were observable (P＜0.05). Also the frequency of bleeding after the operation of the KFTS and POME infra-red group is lower than the control group and obvious significant differences in treat efficiency between agents were observable (P＜0.05).Neither group showed any ill reaction while experiments.Conclusion As the pretreatment medicine in the POME infra-red treatment of columnar ectopy, KRTS can accelerate the heal of the erosion, shorten the duration of vagina letting and debase the frequency of bleeding. Its efficiency shows it is worth promoting.     

The protective effect of genistein postconditioning on hypoxia/ reoxygenation-induced injury in human gastric epithelial cells

Aim： The aim of this study was to investigate the protective effect of genistein postconditioning on hypoxia/reoxygenation- induced injury in human gastric epithelial cells and to begin a tentative discussion on the mechanism behind this protection. Methods： A model of hypoxia/reoxygenation-induced injury was established in the human gastric epithelial cell line （GES-1）. All cells in our present study were randomly divided into five groups： a normal control group （N）, a hypoxia/ reoxygenation group （H/R）, a genistein postconditioning group （GP）, a capsazepine＋genistein postconditioning group （C＋GP） and a DMSO vehicle postconditioning group （DM）. The methods used included MTT assays to test cell viability, flow cytometric analyses to quantify the percentage of cell apoptosis, Western blot analyses to measure the protein expression of calcitonin gene-related peptide （CGRP）, Bcl-2, and Bax, and immunocytochemistry assays to detect the expression of CGRP in each group. Results： The MTT assays indicated that the cell viabilities of the groups were 100.0%±0%, 51.4%±4.1%, 66.7%±2.0%, 56.1%±2.8%, and 50.7%±2.4%, respectively. Compared with the H/R group, the viability of the GP group was significantly increased （P〈0.01）. Flow cytometric analysis showed that the cell apoptosis percentage of each group was 2.28%±0.44%, 12.17%±2.15%, 5.40%±1.22%, 10.43%±1.37%, and 11.02%±2.19%, respectively. Western blot analysis demonstrated that CGRP, Bcl-2, and Bax were expressed in normal human gastric epithelial cells. Compared with the H/R group, the GP group exhibited increased expression of CGRP and Bcl-2 and decreased expression of Bax. Immunocytochemistry assays indicated that the number of CGRP-positive cells in the GP group was significantly increased. Conclusion： Genistein postconditioning has a protective effect on hypoxia/reoxygenation-induced injury in human gastric epithelial ceils. The mechanism by which genistein exerts this protection may be via activation of cell     

Effect of total flavonoids of dracocephalum heterophyllum benth on norepinephrine-induced cardiomyocyte hypertrophy in rats北大核心CSCD

OBJECTIVE: To study the effect of total flavonoids of Dracocephalum heterophyllum (TFDH), a Uygur medicine, on cardiomyocyte hypertrophy induced by norepinephrine (NE), and to provide insights into the mechanism. METHODS: Cardiomyocytes of primarily cultured neonatal rats were used as models. Myocardial hypertrophy was induced by NE 2 umol · L-1. The cells were divided into cell control group, NE 2 umol-L-1 model group, and TFDH 10, 25 and 50 umol-L-1+NE 2 umol-L-1 groups. CCK-8 method was used to observe the activity of myocardial cells, while RT-PCR technique was used to detect the expression of mRNA of cardiac hypertrophy gene atrial natriuretic peptide (ANP) and β-myosin heavy chain (β-MHC). The internal factors were glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Confocal laser scanning was used to detect the surface area of myocardial cells and [Ca2+]. The activity of Ca2+-ATP was measured with enzymatic reaction of fragmentation cells. The concentration of NO and the activity of NOS were determined with colorimetry. RESULTS: Compared with the cell control group, cardiomyocytes were stimulated at 48 h by NE 2 umol · L-1 which could decrease the survival rate of cardiomyocytes from (95±1)% to (78+5)%, surface area increased from (178±29) μm2 to (274±38) μ2 (P<0.05), the expression of mRNA of ANP and β-MHC increased from (1.00±0.01) and (1.00±0.02) to (2.76±0.55) and (2.69±0.31), respectively (P<0.05). The concentration of [Ca2+], increased from 1.00±0.12 to (1.52 ± 0.41) umol-L-1, while the activity of Ca2+-ATP decreased from 1.01±0.14 to (0.41±0.06) umol-L-1 (P<0.05). The concentration of NO decreased from 1.50±0.14 to (1.12±0.05) umol-L-1, and the activity of NOS decreased from 0.86±0.06 to (0.52±0.10) μmol-L-1 (P<0.05). TFDH 10, 25 and 50 μmol · L-1 could inhibit the decline of the survival rate, increase of the surface area and the increased expressions of mRNA of ANP and β-MHC that were induced by NE (P<0.05). At the same time, it also could inhibit the increase of the concentration of [Ca2+], the decreased of activity of Ca2+-ATP, and the decline of the concentration of NO and the activity of NOS (P<0.05). CONCLUSION: TFDH can improve the activity of cardiomyocyte hypertrophy induced by NE, down-regutate mRNA expressions of proto oncogene ANP and β-MHC, and reduce the surface area of cardiomyocytes induced by NE. The mechanism may be related to promoting the release of NO and regulating the concentration of [Ca2+], and the activity of Ca2+-ATP. © 2017 Chinese Journal of Pharmacology and Toxicology. All rights reserved.     

米索前列醇用于足月妊娠促宫颈成熟和引产的疗效观察

目的 探讨米索前列醇用于足月妊娠促宫颈成熟和引产的有效性及安全性.方法 选择2007年7月至2009年7月在我院住院的初产妇67例作为试验组,选择同期相同条件的足月孕妇51例作为对照组,试验组用米索前列醇引产,对照组用催产素静脉滴注引产.比较2组产妇宫颈成熟度评分、临产时间、破膜时间、分娩时间、总产程时间、分娩情况和结局以及新生儿评分.结果 试验组用于足月妊娠促宫颈成熟和引产效果明显优于对照组(有效率为92.5%比80.4%,P＜0.01),用药至临产时间明显短于对照组[(41.31±17.25)min比(57.14±14.72)min,P＜0.01],对母婴影响无明显差别.试验组患者最终经阴道顺娩48例,阴道助娩4例,剖宫产15例,对照组阴道顺娩32例,阴道助娩3例,剖宫产16例.结论 米索前列醇是一种安全有效方便实惠的引产药物,对母婴没有明显不良影响,可在临床上应用.

Abstract：

Objective To investigate the efficacy and safety of misoprostol in term pregnancy for cervical ripening and induction of labor. Methods Sixty-seven term primipara were treated from July 2007 to July 2009 (test group) ,and 51 term primipara with same conditions were conducted in the control group during the same period. Misoprostol was used in the test group and oxytoxin was used in the control group. The differences of bishop cervical score, time of labor, total stage of labor, condition and results in deliveryin and baby apgar score were observed. Results Misoprostol used in the test group showed a shorter time of labor than oxytoxin used in the control group( P ＜ 0.01 ). The mission success rate in the test group was higher than that in the control group. Conclusions Misoprostol is a safe and effective new drug used for cervical ripening and induction of labor.     

氧化亚氮吸入联合术前舌下含化米索前列醇与异丙酚静脉麻醉用于人工流产的比较

目的:比较氧化亚氮吸入联合术前舌下含化米索前列醇与异丙酚静脉麻醉用于人工流产的镇痛效果及相关副作用。方法:将240例要求终止妊娠的早孕妇女随机分成3组:氧化亚氮吸入联合术前舌下含化米索前列醇组(A组)、异丙酚静脉麻醉组(B组)、不用药组(C组),观察各组的宫颈扩张情况、疼痛情况、人工流产综合征发生率及其他副作用。结果:B组无痛率100%,与A组比较无显著性差异(P>0·05);A、B组宫口松弛、人流综合征发生率无显著性差异(P>0·05);B组有呼吸抑制、术后定向障碍等不良反应,自行离手术床时间长于A、C组(P<0·05)。结论:氧化亚氮吸入联合术前舌下含化米索前列醇用于人流镇痛效果确切,方法简便、安全、经济,值得推广应用。     

米索前列醇联合氧化亚氮用于无痛人工流产的临床效果

目的探讨米索前列醇联合氧化亚氮(笑气)用于无痛人工流产的临床效果。方法对200例要求无痛人工流产的孕妇,给予米索前列醇联合氧化亚氮,以实施无痛人工流产术为观察组。另随机选择200例不用任何药物要求人工流产术的孕妇为对照组。分别观察镇痛效果、宫颈扩张情况、人工流产综合征发生率、术前后血压、脉搏、呼吸、术中出血情况。结果镇痛效果、人工流产综合征发生率、宫颈扩张情况,观察组和对照组相比有非常显著性差异(P<0.01)。术中出血、术前后血压、脉搏、呼吸两组相比无显著性差异。结论米索前列醇和氧化亚氮联合用于人工流产,既可实现无痛人工流产又可达到良好的宫颈扩张效果,减少或减轻人工流产综合征的发生,值得推广应用。     

氧化亚氮人工流产镇痛的安全性

目的 :探讨氧化亚氮 (N2 O)人工流产镇痛的安全性。方法 :回顾性分析自 2 0 0 1年 10月～ 2 0 0 3年 9月的 12 90 0例人工流产 (观察组 :术前 6 0min口服米索前列醇 0 .4mg ,术中采用氧化亚氮吸入镇痛 )的镇痛效果、手术并发症和氧化亚氮不良反应 ,并与 2 0 0 0年 10月～ 2 0 0 1年 9月的 4 16 0例人工流产 (对照组 :术前 6 0min口服米索前列醇 0 .4mg)进行比较。 结果 :观察组的镇痛效果优于对照组 (P <0 .0 1) ;观察组无一例人流综合反应发生 ,与对照组比较 ,差异非常显著 (P <0 .0 1) ,而术中子宫出血、子宫穿孔、宫颈裂伤、漏吸、人工流产不全、术后感染、术后宫腔积血等并发症的发生率在两组间无差异 (P >0 .0 5 ) ;观察组未出现与氧化亚氮有关的严重不良反应。结论 :氧化亚氮吸入应用于人工流产镇痛效果理想、安全 ,不增加手术并发症 ,没有与氧化亚氮有关的严重不良反应发生。     

米索前列醇氧化亚氮用于人工流产术临床研究

目的　探讨米索前列醇、氧化亚氮用于人工流产的临床效果。方法　将行人工流产的妇女 180例随机分米索前列醇组、氧化亚氮组、米索前列醇氧化亚氮组 ,每组 6 0例。分别观察镇痛效果、宫颈扩张情况、手术时间、术中出血及不良反应。结果　镇痛效果 :氧化亚氮组、米索前列醇氧化亚氮组与单用米索前列醇组相比差异有非常显著意义 (P <0 0 1)。宫颈扩张情况 :米索前列醇组、米索前列醇氧化亚氮组与单用氧化亚氮组相比差异有非常显著意义 (P <0 0 1)。术中出血、手术时间三组相比差异无显著意义。结论　米索前列醇和氧化亚氮联合用于人工流产 ,既可实现无痛人流又可达到良好的宫颈扩张效果 ,值得推广应用。     

米索前列醇联合复方萘普生栓用于绝经后妇女宫腔镜检查治疗的疗效

目的观察绝经后妇女宫腔镜检查治疗中应用复方萘普生栓联合米索前列醇的临床效果。方法将行宫腔镜检查治疗的144例绝经后妇女随机分为对照组、米索前列醇组、复方萘普生栓组及联合用药组,比较各组术中宫颈扩张度、镇痛效果、人流综合征发生情况及术中出血量。结果联合用药组术中的宫颈扩张度、人流综合征发生与其他3组相比,差异有统计学意义（P〈0.05）,镇痛效果除与复方萘普生组无明显差异外,与其余各组相比,差异有统计学意义（P〈0.05）;各组出血量相比,差异无统计学意义（P〉0.05）。结论米索前列醇与复方萘普生栓联合用于绝经后宫腔镜检查治疗,可使宫颈扩张至理想状态、减轻术中疼痛,降低人流综合征的发生,且不增加术中出血量,值得临床推广。     

米索联合吸引套管用于剖宫产术后无痛人流120例的观察

目的探讨米索前列醇联合一次性宫腔吸引管用于剖宫产术后患者无痛人流的临床效果及并发症发生情况。方法选择门诊自愿要求实施无痛人流术的剖宫产术后患者360例,将其随机均分为3组。观察组120例患者术前2h口服米索前列醇600μg,使用一次性宫腔吸引套管进行无痛人流术;同等条件选择120例剖宫产术后患者作为对照组1,对照组1术前不予米索前列醇,采用常规金属吸头施行手术;另随机选择120例剖宫产术后患者作为对照组2,对照组2术前予以米索前列醇600μg口服,手术器械同对照组1。观察3组患者宫颈口扩张情况、镇痛效果及手术并发症情况。结果观察组、对照组2宫颈扩张程度、镇痛效果等指标结果均明显优于对照组1（P〈0.01）。在手术并发症方面,观察组、对照组2宫颈（宫腔）粘连、子宫穿孔、月经失调的发生明显少于对照组1（P〈0.01）,漏吸的发生3组无明显差异（P〉0.05）。观察组子宫穿孔发生明显少于对照组2（P〈0.05）;两组宫腔（宫颈）粘连、月经改变发生情况无明显差异（P〉0.05）。结论无痛人工流产术前2h口服米索前列醇600μg、术中联合采用一次性宫腔吸引管能有效扩张宫颈,增强麻醉效果,降低手术并发症,是一种比较理想的终止剖宫产术后患者早孕的方法。     

复方米非司酮终止10～14周瘢痕子宫妊娠的临床观察

目的探讨复方米非司酮配伍米索前列醇终止10-14周瘢痕子宫妊娠的效果。方法53例剖宫产后10～14周妊娠要求流产妇女为观察组,孕周相同的同期非瘢痕子宫流产妇女51例作为对照组。两组均给于复方米非司酮配伍米索前列醇,比较临床效果。结果两组流产成功率、胎儿排出时间、阴道流血时问及转经天数比较差异无显著性（P〉0．05）;观察组产时及术后24h阴道出血量略高于对照组（P〈0．05）。观察组和对照组出现恶心率分别为32．1％和31．4％,呕吐率分别为13．2％和11．8％,腹泄率分别为9．4％和7．8％,腹痛率分别为50．9％和49．0％,两者比较差异无显著性（P〉0．05）。结论复方米非司酮配伍米索前列醇对瘢痕子宫妊娠流产与非瘢痕子宫妊娠流产均具有很好的临床疗效。     

瘢痕子宫孕妇中期妊娠引产术的临床观察与护理

目的 探讨瘢痕子宫孕妇孕中期引产的安全性、效果及并发症的情况.方法 将60例瘢痕子宫孕中期孕妇分为利凡诺组(32例)和米索前列醇组(28例),分别按照相应的用药方案引产和护理干预,观察孕妇宫缩情况,记录自服药至出现宫缩的时间、用药至分娩的时间、引产后的出血量、胎盘残留情况、引产成功率及子宫破裂的发生情况.结果 两组孕妇在引产成功率和产后出血量方面比较差异无统计学意义(P＞0.05).利凡诺组孕妇口服药物后至出现宫缩的时间和分娩的时间要长于米索前列醇组孕妇,两组比较差异有统计学意义(P＜0.05).米索前列醇组的孕妇有25例在服药24 h内分娩,分娩率达到89.3％;利凡诺组孕妇仅有5例在服药24 h内分娩,分娩率为15.6％,24例孕妇在服药48 h后才开始分娩.米索前列醇组的孕妇出现胎盘残留需要清宫治疗者仅有6例,胎盘残留率为21.4％,而利凡诺组孕妇有14例出现胎盘残留,胎盘残留率为43.8％,两组比较差异有统计学意义(P＜0.05).结论 对瘢痕子宫孕中期引产的孕妇要提高关注、严密观察引产过程,及时发现、处理问题,瘢痕子宫孕中期引产的效果是相对可靠的.     

米非司酮配伍米索前列醇及利凡诺用于中期妊娠引产的疗效观察

目的探讨米非司酮配伍米索前列醇及利凡诺用于中期妊娠引产的临床意义.方法对80例利凡诺引产的中期妊娠妇女应用米非司酮配伍米索前列醇促宫颈成熟(观察组),并与同期80例单纯用利凡诺引产的中期妊娠妇女(对照组)进行比较.结果观察组80例宫颈Bishop评分均有升高,显效率为86.25%,总有效率为100%;流产时间缩短;与对照组比较差异有显著性.结论米非司酮配伍米索及利凡诺用于中期妊娠引产,宫颈成熟效果好,副反应轻微,完全流产率高,减少了清宫率,减少感染机会,同时引产时间显著缩短.     

丙泊酚配伍米索前列醇用于无痛人流术80例临床疗效观察

目的 观察丙泊酚配伍米索前列醇用于无痛人流术的临床疗效.方法 将2005年1～12月来我院要求人流术的早孕妇女160例随机分为2组,采用丙泊酚静脉麻醉作人流术的早孕妇女于术前加用米索前列醇为手术组(A组);单用丙泊酚静脉麻醉作人流术的早孕妇女为对照组(B组).观察术中扩宫的难易程度、手术时间、术中出血量及手术并发症.结果 A组术中无阻力扩宫的例数明显多于对照组(P＜0.01),手术时间亦明显缩短(P＜0.05),麻醉药物用量减少,术中副反应下降,但术中出血量差异无显著性(P＞0.05).结论 丙泊酚配伍米索前列醇用于无痛人流术,具有扩张宫颈,便于手术操作,缩短手术时间,减少丙泊酚用量优点,并能减轻人流术所造成的孕妇身心负担.