血清肌钙蛋白T测定对不稳定型心绞痛患预后的评估

目的 探讨肌钙蛋白T在不稳定型心绞痛中的诊断和预后判断价值.方法 选择98例不稳定型心绞痛(UAP)患者和100例稳定型心绞痛(SAP)患者,分别在入院后0～4 h及12～24 h检测血清肌钙蛋白T(cTnT)水平,并随访其血清cTnT水平与6个月内急性心脏事件发生之间的关系.结果 不稳定型心绞痛患者血清cTnT阳性率明显高于稳定型心绞痛患者[46.9%(46/98)比2%(2/100)],Braunwald 3级者cTnT阳性率(27例,84.4%)高于2级者(16例,47.1%)和l级者(3例,9.4%),血清cTnT阳性者6个月内急性心脏事件发生率明显高于血清cTnT阴性者[19例比l例].结论 检测血清cTnT水平对于分析不稳定型心绞痛患者的病情严重程度,判断其预后具有重要意义.

Abstract：

Objective To study the diagnostic and prognostic value of troponin T(cTnT) in patients with unstable angina pectoris(UAP). Methods Totally 98 cases of patients with UAP and 100 cases patients with stable angina pectoris(SAP) were selected, their levels of cTnT were measured respectively at 0-4 hours and 12-24 hours after hospitalization, and the relationship between their cTnT levels and the occurrences of acute heart events within 6 months was observed in follow-up. Results Positive rates of the serum of cTnT in patients with UAP were significantly higher than those in patients with SAP, and those of the serum of cTnT in Braunwald grade 3 were also significantly higher than those in grade 2 and grade 1. The rates of acute heart events in patients with positive cTnT were significantly higher than those with negative cTnT. Conclusion There were an important roles in measuring the serum of cTnT at evaluate the pathogenesis of UAP and its prognostic states.     

胶原蛋白贴敷料联合复方甘草酸苷治疗面部激素依赖性皮炎疗效观察

目的 探讨胶原蛋白贴敷料联合复方甘草酸苷治疗面部激素依赖性皮炎的临床疗效.方法 将77例面部激素依赖性皮炎患者完全随机分为2组,治疗组38例静脉滴注复方甘草酸苷,同时面部外敷胶原蛋白贴敷料;对照组39例静脉滴注复方甘草酸苷,同时外搽肝素钠软膏.4周后分别观察2组疗效.结果 治疗组与对照组有效率分别为86.8%(33例)、66.7%(24例),2组比较差异有统计学意义(χ2=4.256,P<0.05).结论 胶原蛋白贴敷料联合复方甘草酸苷治疗面部激素依赖性皮炎疗效肯定,药物不良反应少.

Abstract：

Objective To investigate the efficacy of collagen dressing combined with compound glycyrrhizin for the treatment of hormone dependence dermatitis. Methods Seventy-seven patients were randomly divided into two groups.Treatment group was theated with collagen dressing and compound glycyrrhizin,while control group was treated with heparin sodium cream combined with compound glycyrrhizin. Results The efficacy rate in treatment group wa8 86.8%and 66.7%in control group(χ2=4.256,P<0.05).Conclusion Collagen dressing combined with Compound glycyrrhizin is effective and safe for the treatment of hormone dependence dermatitis.     

腹腔镜下手术治疗老年胆石症临床分析

Objective To explore the clinical effect of laparoscopy in treatment of elderly patients with cholelithiasis. Method The clinical data of 120 elderly patients with cholelithiasis were retrospectively analyzed,which were divided into observation group and control group. Result The operation time, hemorrhage amount of operations,length of stay and recurrence rate after operation of the observation group were lower than that of the control group, and the stone clearance rate in the observation group had significantly higher than that of the control group ,the difference was statistical significance( all P ＜ 0. 05). Conclusion The clinical curative effect of laparoscopy in treatment of elderly patients with cholelithiasis was good.     

低分子量肝素钙治疗不稳定型心绞痛的临床疗效观察

不稳定型心绞痛(unstable angina pectoris,UAP)是介于稳定型心绞痛(stable angina pectoris,SAP)和急性心肌梗死(acute myocardial infarct,AMI)之间的一组综合征,不及时治疗极易发展为AMI和猝死,选择适当的治疗对改善其预后有重要意义.此次我们对比分析了阿司匹林和低分子量肝素钙对UAP患者的临床疗效.     

持续小剂量肝素治疗严重脓毒症的疗效分析

Objective To investigate the therapeutic effects of continuous low-dose heparin on severe sepsis.Mehoda 67 severe septic patients were randomly divided into tow groups:routine treat-ment group(n=36)and heparin treatment group(n=31).The levels of platelet(PET)count,APTr,PT,FIB and AT-Ⅲ were determined before and after treatment in two groups.The days of mechanical ventilation and the incidence nltes of disseminated intravascular coagulopathy(DIC),acute renal failure(ARF),acute respiratory distress syndrome(ARDS),multiple organ dysfunction syndrome(MODS),The 7-day and 28-dav mortalitv were observed.Results There are significant differences for the incidence rate of ARDS,DIC.MODS and 28-day mortality between routine treatment group and heparin treatment group(P＜0.05).And there are no siguificant differences for the levels of PLT count,APTT,PT,FIB,AT-Ⅲ,the days of mechanical ventilation,the incidence rate of ARF,7-day mortality between routine treatment group and heparin treatment group (P>0.05).Conclusion Continuous low-dose heparin on severe sepsis was sale relatively,and it could improve the prognosis and decrease the mortality rate of severe septic patients.     

持续小剂量肝素治疗严重脓毒症的疗效分析

Objective To investigate the therapeutic effects of continuous low-dose heparin on severe sepsis.Mehoda 67 severe septic patients were randomly divided into tow groups:routine treat-ment group(n=36)and heparin treatment group(n=31).The levels of platelet(PET)count,APTr,PT,FIB and AT-Ⅲ were determined before and after treatment in two groups.The days of mechanical ventilation and the incidence nltes of disseminated intravascular coagulopathy(DIC),acute renal failure(ARF),acute respiratory distress syndrome(ARDS),multiple organ dysfunction syndrome(MODS),The 7-day and 28-dav mortalitv were observed.Results There are significant differences for the incidence rate of ARDS,DIC.MODS and 28-day mortality between routine treatment group and heparin treatment group(P＜0.05).And there are no siguificant differences for the levels of PLT count,APTT,PT,FIB,AT-Ⅲ,the days of mechanical ventilation,the incidence rate of ARF,7-day mortality between routine treatment group and heparin treatment group (P>0.05).Conclusion Continuous low-dose heparin on severe sepsis was sale relatively,and it could improve the prognosis and decrease the mortality rate of severe septic patients.     

持续小剂量肝素治疗严重脓毒症的疗效分析

Objective To investigate the therapeutic effects of continuous low-dose heparin on severe sepsis.Mehoda 67 severe septic patients were randomly divided into tow groups:routine treat-ment group(n=36)and heparin treatment group(n=31).The levels of platelet(PET)count,APTr,PT,FIB and AT-Ⅲ were determined before and after treatment in two groups.The days of mechanical ventilation and the incidence nltes of disseminated intravascular coagulopathy(DIC),acute renal failure(ARF),acute respiratory distress syndrome(ARDS),multiple organ dysfunction syndrome(MODS),The 7-day and 28-dav mortalitv were observed.Results There are significant differences for the incidence rate of ARDS,DIC.MODS and 28-day mortality between routine treatment group and heparin treatment group(P＜0.05).And there are no siguificant differences for the levels of PLT count,APTT,PT,FIB,AT-Ⅲ,the days of mechanical ventilation,the incidence rate of ARF,7-day mortality between routine treatment group and heparin treatment group (P>0.05).Conclusion Continuous low-dose heparin on severe sepsis was sale relatively,and it could improve the prognosis and decrease the mortality rate of severe septic patients.     

盐酸氟哌噻吨美西辛辅助治疗肠易激综合征66例疗效分析

Objective To investigate the effect of deanxit in adjuvant treatment of the patients with irritable bowel syndrome and the psychologicalon of the patients. Methods Clinical data of 66 patients with irritable bowel syndrome were retrospectively analyzed. The control group was treated by conventional therapy, and the observation group was given deanxit based on the treatment of the control group. Then the curative effect were observed. Results In 132 patients,98 cases were troubed with anxiety,9 cases with athymia, the incidence rate was 81%. After treatment the SAS and SDS score of the observation group reduced,compared with before treatment,and the difference was significant( P ＜0. 05 ); Before and after treatment the SAS and SDS score of the control group had no significant difference(P ＞0. 05). Compared with the control group,the excellence and total effective rate increased significantly in the observation group(P ＞ 0. 05). Conclusion Adjunctive therapy with deanxit could improve the anxiety and athymia,and elevate clinical curative effect.     

冠心病心绞痛患者体内纤溶系统的变化及临床意义

目的 探讨冠心病心绞痛患者体内纤溶系统的变化并分析其临床意义.方法 对110例冠心病心绞痛患者体内的纤溶酶原激活物抑制剂-1(PAI-1)、组织型纤溶酶原激活剂(t-PA)、纤维蛋白原(FIB)水平进行检测,并与20例正常对照者进行对照.结果 冠心病组PAI-1、FIB水平分别为(400±90)AU/L,(4.80±1.1)g/L,明显高于对照组[分别为(260±80)AU/L,(3.6±1.0)g/L,均P＜0.05];冠心病组t-PA水平为(240±70)IU/L,明显低于对照组[(290±90)IU/L,P＜0.01)].不稳定型心绞痛患者(70例)PAI-1、FIB水平明显高于稳定型心绞痛患者(40例,均P＜0.05);不稳定型心绞痛患者t-PA水平明显低于稳定型心绞痛患者(P＜0.01).心绞痛发作者(64例)PAI-1、FIB明显高于无心绞痛发作者(46例,均P＜0.05);而t-PA水平明显低于无心绞痛发作者(P＜0.01).结论 冠心病心绞痛患者体内存在纤溶系统功能异常,尤其是在不稳定型心绞痛患者或心绞痛发作者体内更加明显,纤溶系统功能异常可能在冠心病心绞痛发病过程中起重要的作用.

Abstract：

Objective To observe the changes and the clinical significance of fibrinolysis in coronary heart disease(CHD) patients with angina pactoris (AP). Methods Levels of plasmin plasminogen activator inhibitor-1(PAI-1), tissue-type plasminogen activator( t-PA), fibrinogen (FIB)in 110 CHD patients with AP and 20 normal cases as control group were analyzed. Results Levels of PAI-1, FIB in CHD patients with AP[(260 ± 8 ) AU/L,(3.6 ± 1.0) g/L] were significantly higher than those in control cases [(260 ± 8 ) AU/L, (3.6 ± 1.0 ) g/L], and those of t-PA were significantly lower than those in control cases. Level of t-PA in patients with coronary heart disease [(240 ± 7) IU/L] was significantly lower than that in the control group[(290 ± 9) IU/L,P ＜ 0. 01]. Levels of PAI-1 ,FIB in unstable angina(UA) patients with UA heart events were significantly higher than those in patients with stable angina (SA). Level of t-PA in patients with UA was significantly lower than that in patients with SA (P ＜0. 01 ). Levels of PAI-1, FIB in patients with AP events were significantly higher than those in patients without AP events. Levels of t-PA in patients with AP were significantly lower than those in patients without AP events.Conclusions There is abnormal fibrinolysis function in CHD patients with AP, specially in patients with UA or with AP events, which might be play an important rule in coronary heart disease (CHD) patients with angina pactoris.     

丹参多酚酸盐对不稳定型心绞痛的临床研究

不稳定型心绞痛(unstable angina pectoris,UAP)是介于稳定型心绞痛与急性心肌梗死(Acute myocardial Infartion,AMI)之间的一种急性心肌局部缺血所致的临床综合征.本文通过对照应用丹参多酚酸盐治疗UAP患者100例,分析如下.作者单位:     

地尔对硫莗不稳定型心绞痛患者血小板聚集功能的影响

不稳定型心绞痛( unstable angina pectoris, UAP)系急性心肌缺血综合征中主要类型之一.研究表明,血小板功能异常参与UAP的发生和发展[1].地尔硫莗已被确认是治疗心绞痛的有效药物[2][3].本研究旨在观察地尔硫莗对UAP患者体内血小板聚集功能的影响.     

布地奈德联合沙丁胺醇治疗小儿支气管哮喘疗效分析

Objective To investigate the effect of Budesonide combined with Salbutamol in treatment of chil-dren with bronchial asthma.Methods 100 cases of children with asthma were randomly divided into conventional therapy group(Group A)50 cases and combined treatment group(Group B)50 cases;Conventional therapy was given to group B and Group A Was givend the conventional therapy puls Budesonide combined with salbutamol treatment,2 times a day.The course of treatment was 10d;The effect of clinical symptom score、clinical recovery and adverse reac-tions in two groups were observed.Results The total efficiency of 47 cases(94.O%) in group A were significantly higher than the B group 36 cases(72.0%)(P<0.05);The index of breathing diffculties、coushing、wheezing、wheezing sustain and sleep satisfaction after treatment were significantly decreased compared with before treatment in two groups(all P<0.01);The time of recovery of breath shortness、cough、asthma、wheezing and therapy hys in group A were less than group B(all P<0.05).Condusion Atomizing inhalation treatment of Bedesonide combined with Sallbutamol was effective to treat children with bronchial asthma.     

布地奈德联合沙丁胺醇治疗小儿支气管哮喘疗效分析

Objective To investigate the effect of Budesonide combined with Salbutamol in treatment of chil-dren with bronchial asthma.Methods 100 cases of children with asthma were randomly divided into conventional therapy group(Group A)50 cases and combined treatment group(Group B)50 cases;Conventional therapy was given to group B and Group A Was givend the conventional therapy puls Budesonide combined with salbutamol treatment,2 times a day.The course of treatment was 10d;The effect of clinical symptom score、clinical recovery and adverse reac-tions in two groups were observed.Results The total efficiency of 47 cases(94.O%) in group A were significantly higher than the B group 36 cases(72.0%)(P<0.05);The index of breathing diffculties、coushing、wheezing、wheezing sustain and sleep satisfaction after treatment were significantly decreased compared with before treatment in two groups(all P<0.01);The time of recovery of breath shortness、cough、asthma、wheezing and therapy hys in group A were less than group B(all P<0.05).Condusion Atomizing inhalation treatment of Bedesonide combined with Sallbutamol was effective to treat children with bronchial asthma.     

无创正压通气在老年慢性阻塞性肺疾病急性加重期患者中的应用效果分析

Objective To study the clinical effect of non-invasive positive pressure ventilation (NPPV) in elderly patients with acute exacerbation of chronic obstructive pulmonary diseases (AECOPD). Methods One hundred and Fourteen elderly patients with AECOPD were divided into two groups. The observed group of 58 patients was given oxygen, anti-inflammatory and other conventional treatment, at the same time NPPV treatment was given, But the control group of 56 cases was only given the conventional treatment. The difference of blood oxygen pressure ( PaO2 ), carbon dioxide partial pressure ( PaCO2 ), pH value, respiratory rate (RR) and heart rate (HR)between two groups were compared after 12 h. To compare two groups endotracheal intubation rate and mortality differences. Results The pH and PaO2 of the observation group were significantly higher than that before treatment , HR, RR and PaCO2 decreased significantly compared with before treatment, and the various indicators were better than the same period in the control group. The observation group endotracheal intubation rate and mortality were less than the control group ( all P ＜ 0. 05). Conclusions NPPV can effectively alleviate breathing difficulties of the elderly patients with AECOPD and correct hypoxia. NPPV can reduce the rate of endotracheal intubation and mortality.     

新生儿病理性黄疸心肌酶和C反应蛋白的观察

Objective To investigate the levels of myocardium enzymes and CRP in the neonatus with pathological jaundice. Methods The myocardium and CRP of observation group(60 patients) were detected before and after treatment. The two indexes were also observed in the control group ( 40 patients ). Result The myocardium enzymes,bilirubins and CRP were normal in the control group. However,they were significantly higher than that of control group( allP ＜ 0. 01 ). After treatment, they decreased significantly in observation group( all P ＜ 0. 05 ) except CRP. Conclusion The myocardium damage could happen in the neonatus with pathological jaundice,and the protection of the myocardium should be emphasized.     

青鹏膏剂治疗肩关节周围炎临床疗效研究

Objective To investigate the clinical efficacy of Qingpeng ointment treating periarthritis.Methods Three hundred patients with periarthritis were randomly divided into two groups. Observed groups( 150 cases ) were given Qingpeng ointment, control group( 150 cases ) were given Guzhining liniment. Shoulder pain scores and shoulder joint function score of both group were compared. Results The total efficiency of observation group ( 85.3% ) was better than that of control group(72.7% ) ( P ＜ 0.05 ). After treatment, both groups activity in patients with shoulder pain score and functional activity score of comparison, the observation group were better than the control group ( P ＜ 0.01 ). Conclusion Clinical treatment of frozen shoulder by Qingpeng paste is better, is worthy of clinical.     

青鹏膏剂治疗肩关节周围炎临床疗效研究

Objective To investigate the clinical efficacy of Qingpeng ointment treating periarthritis.Methods Three hundred patients with periarthritis were randomly divided into two groups. Observed groups( 150 cases ) were given Qingpeng ointment, control group( 150 cases ) were given Guzhining liniment. Shoulder pain scores and shoulder joint function score of both group were compared. Results The total efficiency of observation group ( 85.3% ) was better than that of control group(72.7% ) ( P ＜ 0.05 ). After treatment, both groups activity in patients with shoulder pain score and functional activity score of comparison, the observation group were better than the control group ( P ＜ 0.01 ). Conclusion Clinical treatment of frozen shoulder by Qingpeng paste is better, is worthy of clinical.     

清热化痰中药对老年肺部感染患者抗生素耐药性的影响

目的 探讨清热化痰中药对老年肺部感染患者抗生素耐药性的影响.方法 将200例老年肺部感染患者完全随机分为治疗组和对照组,各100例.对照组常规给予抗生素和化痰药,治疗组在常规治疗的基础上,给患者口服清热化痰方,每日1剂,分早晚2次服用.7 d为1个疗程.1周后,观察患者的临床表现、血常规结果、胸部x线片及痰培养结果.结果 治疗组显效58例(58.0%),有效35例(35.0%),总有效93.0%;对照组显效47例(47.0%),有效34例(34.0%),总有效81.0%,治疗组总有效率高于对照组,差异有统计学意义(P<0.05).结论 清热化痰方可有效降低老年肺部感染患者抗生素耐药性.

Abstract：

Objective To observe the clinical effect of Qingrehuatan traditional Chinese medicine in treating antibiotic resistance after pneumonia.Methods Two hundred patients of pneumonia were randomly divided into 2 groups.The control group with 100 cases were treated with antibiotic and therapy group were treated with Qingrehuatan traditional Chinese medicine and western medicine.The treating course was 7 days.The blood routine examination,pleuragraphy and exfoliative cell examination of sputum were observed.Resuits The relapse rate of cardiac angina in treatment group Was considerably lower than that in control group(93.0% vs 81.0%).Conclusion Qingrehuatan traditional Chinese medicine can reduce drug-resistance of antibiotics in elderly pneumonia patients.     

环孢素联合达那唑对糖皮质激素无效或依赖的特发性血小板减少性紫癜患者疗效分析

目的 探讨环孢素联合达那唑对糖皮质激素无效或依赖的特发性血小板减少性紫癜(ITP)患者的疗效.方法 选择50例对糖皮质激素无效或依赖的ITP患者,其中30例作为治疗组在常规支持治疗的基础上应用环孢素联合达那唑治疗;20例作为对照组用其他免疫抑制剂治疗.对2组的疗效进行对比.结果 对照组治疗1和12个月时的有效率分别为50%和20%;治疗组分别为80%和50%,2组之间1、12个月时的有效率相比,差异均有统计学意义(P＜0.01).结论 环孢素联合达那唑对激素无效或依赖的IPT有较好的治疗效果.

Abstract：

Objective To investigate the effect of cyclosporine combined with danazol on the glucocorticoid invalid or dependent idiopathic thrombocytopenic purpura(ITP). Methods The ITP patients of the glucocorticoid invalid or dependent in 50 cases were randomly divided into cyclosporine combined danazol group in 30 cases, control group in 20 cases. Results The efficacy rates of one month and twelve months: control group were respectively 50.0%, 20.0%; treatment group were 80%, 50% ,showing significant differences ( P ＜ 0.01 ). Conclusion The efficacy of cyclosporine combined with danazol on the glucocorticoid invalid or dependent ITP is excellent.     

无创正压通气在老年慢性阻塞性肺疾病急性加重期患者中的应用效果分析

Objective To study the clinical effect of non-invasive positive pressure ventilation (NPPV) in elderly patients with acute exacerbation of chronic obstructive pulmonary diseases (AECOPD). Methods One hundred and Fourteen elderly patients with AECOPD were divided into two groups. The observed group of 58 patients was given oxygen, anti-inflammatory and other conventional treatment, at the same time NPPV treatment was given, But the control group of 56 cases was only given the conventional treatment. The difference of blood oxygen pressure ( PaO2 ), carbon dioxide partial pressure ( PaCO2 ), pH value, respiratory rate (RR) and heart rate (HR)between two groups were compared after 12 h. To compare two groups endotracheal intubation rate and mortality differences. Results The pH and PaO2 of the observation group were significantly higher than that before treatment , HR, RR and PaCO2 decreased significantly compared with before treatment, and the various indicators were better than the same period in the control group. The observation group endotracheal intubation rate and mortality were less than the control group ( all P ＜ 0. 05). Conclusions NPPV can effectively alleviate breathing difficulties of the elderly patients with AECOPD and correct hypoxia. NPPV can reduce the rate of endotracheal intubation and mortality.