足月胎膜早破先露衔接对剖宫产指征的影响

Objective To explore the cesarean section indications of fetal presentation unengagement in primipara with full-term premature rupture of membrane. Methods Five hundreds and ten primipara with premature rupture of membrane at term were divided into 2 groups: the fetal head was not engaged in the birthing process ( study group 218 cases) and engaged in the birthing process( control group 292 cases). The delivery course and the incidence of complication of the mother and infant were compared between 2 groups. The main outcome measure was the rate of caesarean section, indications of cesarean section, the cervical maturity(by Bishop scoring), the rate of fetal distress and newborn asphyxia, et al. Results The rate of cesarean section was higher in study group (64.7%) than that in control group( 17.5% ) ( P ＜0.01 ), so were the rate of fetal distress, stagnant labor and of failure of induction( P ＜0.05 ). In the cases of study group, the cervical condition of easy delivery ones was better than that of caesarean section ones. Average neonatal weight of easy delivery ones is lighter than caesarean section ones. Conclusions When the fetal head is not engaged in the birthing process in primipara with premature rupture of membrane at term, the labor induction is difficult. The labor complications are common, and the rate of caesarean section is high because of the loss of amniotic fluid and the poor cervical condition. Primipara at term whose presentation is not engaged in the birthing process should try to avoid premature rupture of membrane. Cervical ripening and induction should be done as soon as possible after membrane rupture.     

足月胎膜早破先露衔接对剖宫产指征的影响

Objective To explore the cesarean section indications of fetal presentation unengagement in primipara with full-term premature rupture of membrane. Methods Five hundreds and ten primipara with premature rupture of membrane at term were divided into 2 groups: the fetal head was not engaged in the birthing process ( study group 218 cases) and engaged in the birthing process( control group 292 cases). The delivery course and the incidence of complication of the mother and infant were compared between 2 groups. The main outcome measure was the rate of caesarean section, indications of cesarean section, the cervical maturity(by Bishop scoring), the rate of fetal distress and newborn asphyxia, et al. Results The rate of cesarean section was higher in study group (64.7%) than that in control group( 17.5% ) ( P ＜0.01 ), so were the rate of fetal distress, stagnant labor and of failure of induction( P ＜0.05 ). In the cases of study group, the cervical condition of easy delivery ones was better than that of caesarean section ones. Average neonatal weight of easy delivery ones is lighter than caesarean section ones. Conclusions When the fetal head is not engaged in the birthing process in primipara with premature rupture of membrane at term, the labor induction is difficult. The labor complications are common, and the rate of caesarean section is high because of the loss of amniotic fluid and the poor cervical condition. Primipara at term whose presentation is not engaged in the birthing process should try to avoid premature rupture of membrane. Cervical ripening and induction should be done as soon as possible after membrane rupture.     

足月胎膜早破先露衔接对剖宫产指征的影响

目的 探讨胎膜早破患者的胎先露衔接情况对剖宫产指征的影响.方法 选择我院2008年4月至2009年4月足月妊娠(孕37～41+6周)分娩的510例胎膜早破初产妇.根据先露衔接与否分为未衔接组(218例)和衔接组(292例).对2组分娩方式、剖宫产指征、宫颈Bishop评分、新生儿结局进行分析.结果 不衔接组剖宫产率为64.7%(141/218),衔接组剖宫产率为17.5%(51/292),2组比较差异有统计学意义(P＜0.01).不衔接组的胎儿窘迫、胎方位异常、活跃期停滞、引产失败率均高于衔接组(18.9%比8.9%,12.8%比3.4%,12.4%比1.0%,15.6%比2.4%,P＜0.05).不衔接组顺产孕妇的宫颈Bishop评分高于剖宫产孕妇的宫颈Bishop评分[(4.2±1.3)分比(3.5±1.7)分,P＜0.01],顺产孕妇新生儿平均体重低于剖宫产孕妇的新生儿平均体重[(3.1±0.3)kg比(3.3±0.5)kg,P＜0.05].结论 胎膜早破胎先露不衔接者由于破膜后羊水流失难以控制、宫颈条件差,导致引产难度大、分娩并发症多、剖宫产率高,故足月后先露部尚未衔接者应尽可能避免胎膜早破,胎膜早破后应尽快促宫颈成熟、终止妊娠.

Abstract：

Objective To explore the cesarean section indications of fetal presentation unengagement in primipara with full-term premature rupture of membrane. Methods Five hundreds and ten primipara with premature rupture of membrane at term were divided into 2 groups: the fetal head was not engaged in the birthing process ( study group 218 cases) and engaged in the birthing process( control group 292 cases). The delivery course and the incidence of complication of the mother and infant were compared between 2 groups. The main outcome measure was the rate of caesarean section, indications of cesarean section, the cervical maturity(by Bishop scoring), the rate of fetal distress and newborn asphyxia, et al. Results The rate of cesarean section was higher in study group (64.7%) than that in control group( 17.5% ) ( P ＜0.01 ), so were the rate of fetal distress, stagnant labor and of failure of induction( P ＜0.05 ). In the cases of study group, the cervical condition of easy delivery ones was better than that of caesarean section ones. Average neonatal weight of easy delivery ones is lighter than caesarean section ones. Conclusions When the fetal head is not engaged in the birthing process in primipara with premature rupture of membrane at term, the labor induction is difficult. The labor complications are common, and the rate of caesarean section is high because of the loss of amniotic fluid and the poor cervical condition. Primipara at term whose presentation is not engaged in the birthing process should try to avoid premature rupture of membrane. Cervical ripening and induction should be done as soon as possible after membrane rupture.     

白细胞介素-6及C反应蛋白检测对预测胎膜早破合并绒毛膜羊膜炎的意义

Objective To investigate significance of interleukin-6 and C-reactive protein as a predictor of chorioamnionitis in patients with premature rupture of the membranes. Methods Maternal serum was collected for detection of IL-6 and CRP, and placenta and membranes sample for pathology examination. Results ( 1 ) The level of maternal serum CRP and IL-6 raised signficantly in patients with premature rupture of membranes complicated by chorioamnionitis(P ＜0.01). (2)The levels of maternal serum CRP and IL-6 also raised signficantly with the time prolongation of premature rupture of themembranes( P ＜ 0. 0l ). ( 3 ) The positive rate of the predict diagnosis of PROM with early CMA was promoted by the standard of CRP≥10 mg/L and IL-6≥11 ng/L. Conclusion The maternal serum CRP and IL-6 determination could be used for the prediction of early CMA.     

孕妇血清一氧化氮水平与胎膜早破和绒毛膜羊膜炎的关系

目的 探讨血清NO水平与胎膜早破(PROM)及绒毛膜羊膜炎的关系.方法 将78例胎膜早破孕妇按照实际情况分为早产合并胎膜早破(pPROM)组33例和足月胎膜早破(tPROM)组45例,50例临产前剖宫产的胎膜完好孕妇为正常对照组,分析比较3组血清NO水平,观察3组发生绒毛膜羊膜炎的情况及绒毛膜羊膜炎患者血清NO水平.结果 pPROM组和tPROM组血清NO水平相近,均高于正常对照组,差异有统计学意义[(85±26)μmol/L、(83±21)μmoL/L比(60±16)μmoL/L,P＜0.05];pPROM组和tPROM组绒毛膜羊膜炎发生率高于正常对照组,差异有统计学意义[33.3%(11/33)、31.1%(14/45)比4.0%(2/50)];绒毛膜羊膜炎患者血清NO水平明显高于非绒毛膜羊膜炎患者,差异有统计学意义[(109±39)μmol/L比(73±33)μmol/L,P＜0.05].结论 血清NO水平的增高可能预示绒毛膜羊膜炎及胎膜早破的存在.

Abstract：

Objective To study the relationship between the level of nitric oxide(NO) in blood and premature rupture of membranes (PROM) and chorioamnionitis. Methods The 78 cases of premature rupture of membranes were divided into two groups according to the actual situation. The group of preterm premature rupture of membranes (pPROM) included 33 patients and the full-term premature rupture of membranes (tPROM) group had 45 patients. Fifty intact membranes' pregnant women who chose cesarean section before labor were selected as the normal control group. The levels of serum NO and the occurrence of chorioamnionitis were analyzed and compared among the three groups. Results The blood serum NO level was similar in PROM group and tPROM group but higher than that of the normal control group[(85 ±26)μmol/L, (83±21)μmol/L vs (60 ±16)μmol/L, P＜0.05]. The incidence of chorioamnionitis in PROM group and tPROM group was higher than that of the normal control group. The blood serum NO level of chorioamnionitis group was higher than that of the non-chorioamnionitis group [(109 ± 39)μmol/L vs (73 ± 33) μmol/L, P＜0. 05]. Couclusion The level of blood serum NO may predict PROM and chorioamnionitis.     

地诺前列酮用于促宫颈成熟及引产的观察和护理

目的 探讨地诺前列酮用于延期和过期妊娠促宫颈成熟及引产的效果和安全性.方法 将60例孕周超过41周,单胎头位无严重合并症的初产妇,分为地诺前列酮组和缩宫素组各30例.地诺前列酮组采用地诺前列酮1枚放置于阴道后穹窿引产,缩宫素组常规缩宫素静脉微量泵泵入引产,比较两组产妇的宫颈Bishop评分和分娩情况,剖宫产率,新生儿窒息率和羊水污染发生率.结果 地诺前列酮组用药后6 h宫颈评分为(7.44±0.38)分,高于缩宫素组(5.55±1.23)分,地诺前列酮组引产时间明显短于缩宫素组(P＜0.01),地诺前列酮组的剖宫产率(11.1%)低于缩宫素组(40%)(P＜0.01);两组新生儿窒息率和羊水污染发生率差异元统计学意义.结论 地诺前列酮是一种安全、省时、方便、有效的促宫颈成熟和引产药物,对母儿无明显不良影响.     

卡前列素氨丁三醇预防前置胎盘产后出血临床观察

目的 探讨卡前列素氨丁三醇预防前置胎盘产后出血疗效.方法 2007年12月至2011年11月因前置胎盘行剖宫产手术患者192例完全随机分为研究组与对照组,各96例.剖宫产术中,胎儿娩出后吸尽残余羊水.2组均予5%葡萄糖注射液500 ml加缩宫素20 u静脉滴注.研究组于子宫体注射卡前列素氨丁三醇250μg;对照组于子宫体部注射缩宫素20 U,口服米索前列醇400μg.胎盘剥离后的出血经负压吸引器吸引到有刻度的吸引瓶内,以计算出血量.经以上处理后仍有活动性出血者,采用官腔填塞纱条及可吸收线"8"字缝合创面.观察产后2、24 h出血量、产后出血发生率及药物不良反应发生情况.结果 研究组产后2、24 h平均出血量分别为(255.7±63.2)和(358.9±67.4)ml,对照组产后2、24 h平均出血量分别为(388.2±85.1)和(556.7±73.4)ml.研究组产后2、24 h平均出血量明显少于对照组,差异均有统计学意义(P<0.05).研究组96例中,17例发生产后出血,产后出血发生率为17.7%;其中2例因大部分胎盘植入而切除子宫.对照组96例中产后出血72例,产后出血发生率75.0%,其中4例因大部分胎盘植入而切除子宫.2组产后出血发生率比较,差异有统计学意义(P<0.05).2组均未见明显药物不良反应发生.结论 卡前列素氨丁三醇是预防前置胎盘产后出血的有效药物.

Abstract：

Objective To investigate the prophylactic treatment effect of carbopmst tromethamine(Hemabate)on postpartum hemorrhage in patients with placenta praevia.Methods Totally 192 patients who underwent cesarean gection for placenta praevia from December 2007 througe November 2010 were retrospectively analyzed.The patients were divided into hemabate group(n=96)and control group(n=96).In hemabate group,the body of utems was injected with carboprost tromethamine.Ahernatively,the body of uterus was injected with oxytocin.Misoprostol was taken orally in control group.Oxytocin was used in both groups.The loss volume of blood was observed.Postpartum hemorrhage rates were analyzed.Results The mean loss volume of blood at postpartum 2 hour and 24 hour in hemabate group were much lower than that in control group(P<0.05).The postpartum hemorrhage rate was significantly decreased in hemabate group than that in control group(17.7%versus 75.0%.P<0.05).Condusion The study suggests that hemabate can decrease the postpartum hemorrhage volume and reduce the incidence of postpartum hemorrhage over oxytocin and misoprostol.     

米索前列醇用于足月妊娠促宫颈成熟和引产的疗效观察

目的 探讨米索前列醇用于足月妊娠促宫颈成熟和引产的有效性及安全性.方法 选择2007年7月至2009年7月在我院住院的初产妇67例作为试验组,选择同期相同条件的足月孕妇51例作为对照组,试验组用米索前列醇引产,对照组用催产素静脉滴注引产.比较2组产妇宫颈成熟度评分、临产时间、破膜时间、分娩时间、总产程时间、分娩情况和结局以及新生儿评分.结果 试验组用于足月妊娠促宫颈成熟和引产效果明显优于对照组(有效率为92.5%比80.4%,P＜0.01),用药至临产时间明显短于对照组[(41.31±17.25)min比(57.14±14.72)min,P＜0.01],对母婴影响无明显差别.试验组患者最终经阴道顺娩48例,阴道助娩4例,剖宫产15例,对照组阴道顺娩32例,阴道助娩3例,剖宫产16例.结论 米索前列醇是一种安全有效方便实惠的引产药物,对母婴没有明显不良影响,可在临床上应用.

Abstract：

Objective To investigate the efficacy and safety of misoprostol in term pregnancy for cervical ripening and induction of labor. Methods Sixty-seven term primipara were treated from July 2007 to July 2009 (test group) ,and 51 term primipara with same conditions were conducted in the control group during the same period. Misoprostol was used in the test group and oxytoxin was used in the control group. The differences of bishop cervical score, time of labor, total stage of labor, condition and results in deliveryin and baby apgar score were observed. Results Misoprostol used in the test group showed a shorter time of labor than oxytoxin used in the control group( P ＜ 0.01 ). The mission success rate in the test group was higher than that in the control group. Conclusions Misoprostol is a safe and effective new drug used for cervical ripening and induction of labor.     

地塞米松及葡萄糖酸钙联合米索前列醇预防产后出血的临床观察

Objective To explore the clinical effect of a combined treatment of postpartum haemorrhage with misoprostol and calcium gluconale. Methods Two hundred and fourty normal part urients who were pregnancy at term, normal delivery without pregnancy complications or use of prostaglandin inhibition They were randomized into groups: misoprostol with calcium gluconate group and oxytocin group respectively oral misoprostol and calcium gluconate with intraranous injection. Oxytocin with intramuscular injection in the early third stage of labour, then the time of the third stage of labour was calculated. Also the mount of bleeding at the time of placental expulsion. with in 2 h and 24 h after delivery were measured. At the same time, blood pressure, pusle, the frequency of respiration. Saturation of blood oxygen, sideeffect were observed in misoprostol with calcium gluconate group before and after a drministration. Results Time of the third stage of labour, the mount of bleeding with in 2 h and morthan 500 ml with in 24 h in the misoprostol calcum gluconate group were less than that of oxytocin group (P ＜ 0.05 ).Conclusions Misoprostol and intravenous drip of calcium gluconate can strenghen and increase womb systole frequncy and stop postpartum haemorrhage. It is a simple, safe, convenient, cainical valuable to treat postpartum haemorrhage.     

地塞米松及葡萄糖酸钙联合米索前列醇预防产后出血的临床观察

Objective To explore the clinical effect of a combined treatment of postpartum haemorrhage with misoprostol and calcium gluconale. Methods Two hundred and fourty normal part urients who were pregnancy at term, normal delivery without pregnancy complications or use of prostaglandin inhibition They were randomized into groups: misoprostol with calcium gluconate group and oxytocin group respectively oral misoprostol and calcium gluconate with intraranous injection. Oxytocin with intramuscular injection in the early third stage of labour, then the time of the third stage of labour was calculated. Also the mount of bleeding at the time of placental expulsion. with in 2 h and 24 h after delivery were measured. At the same time, blood pressure, pusle, the frequency of respiration. Saturation of blood oxygen, sideeffect were observed in misoprostol with calcium gluconate group before and after a drministration. Results Time of the third stage of labour, the mount of bleeding with in 2 h and morthan 500 ml with in 24 h in the misoprostol calcum gluconate group were less than that of oxytocin group (P ＜ 0.05 ).Conclusions Misoprostol and intravenous drip of calcium gluconate can strenghen and increase womb systole frequncy and stop postpartum haemorrhage. It is a simple, safe, convenient, cainical valuable to treat postpartum haemorrhage.     

欣普贝生用于足月胎膜早破病例引产的临床研究

目的 探讨欣普贝生用于足月胎膜早破引产病例的临床疗效及安全性.方法 将80例足月胎膜早破≥12h、Bishop宫颈评分≤6分、无妊娠合并症、无阴道分娩禁忌证、单胎头位的初产妇随机分为两组,分为阴道放置欣普贝生的研究组和小剂量缩宫素静滴的对照组,每组40例.观察比较两组用药12h后宫颈Bishop评分变化、临产情况、分娩方式、产后2h出血量、产程及新生儿的情况.结果 研究组促宫颈成熟评分及引产成功率均高于缩宫素组,差异有统计学意义(P<0.05),用药后至临产的时间两组比较差异有统计学意义(P<0.05),研究组的剖宫产率低于对照组,两组的产后出血量及胎儿窘迫发生率、新生儿窒息率无统计学意义(P>0.05).结论 欣普贝生用于足月胎膜早破安全有效,与缩宫素相比,促子宫颈成熟有效率高,临产时间短,对新生儿不良影响小,可有效降低难产率及剖宫产率.     

地诺前列酮对足月胎膜早破宫颈成熟及母婴结局的影响

目的：观察地诺前列酮对足月胎膜早破宫颈成熟及母婴结局的影响。方法118例足月胎膜早破孕妇按照数字表法随机分为两组,两组各有59例。对照组采用催产素治疗,观察组采用地诺前列酮治疗。观察两组12 h促宫颈成熟程度,剖宫产、产褥感染、产后出血、新生儿肺炎及胎儿窘迫发生情况。结果对照组显效27例,有效23例,无效9例,总有效率为84.7%;观察组分别为32例,24例,3例,总有效率为94.9%。两组比较差异有统计学意义（χ2=4.86, P〈0.05）。对照组剖宫产、产褥感染、产后出血、新生儿肺炎及胎儿窘迫为27例、13例、（492.1±177;38.4）ml、6例、4例;观察组分别为6例、4例、（301.1±177;33.7）ml、2例、1例。观察组均明显少于对照组（χ2=6.94,χ2=5.78, t=3.0692,χ2=4.72,χ2=5.06, P〈0.05）。结论±对足月胎膜早破产妇采用地诺前列酮治疗可以明显提高宫颈成熟程度,减少产后母婴并发症。     

足月胎膜早破至分娩时间对妊娠结局的影响

目的观察孕足月胎膜早破时间至分娩的时间间隔对妊娠结局的影响。方法统计深圳市第六人民医院2010年10月至2011年10月间入院分娩之足月胎膜早破患者638例。按胎膜早破时间至分娩的时间间隔分组。统计各组产妇的剖宫产率、产后出血量、绒毛膜羊膜炎发生率、胎儿窘迫发生率、新生儿出生后Apgar评分以及新生儿收住院率。结果各组间产后出血、胎儿窘迫发生率及新生儿Apgar评分差异无统计学意义(χ2=8.71,P=0.084)。胎膜破裂至分娩时间≥48h组的剖宫产率为46.8%,显著高于破水至分娩时间<24h组,差异有统计学意义(χ2=4.66,P=0.047)。胎膜破裂至分娩时间≥48h组的绒毛膜羊膜炎发生率、剖宫产率及新生儿收住院率均显著高于破水时间<24h组(χ2=3.94,P=0.011)。结论孕足月胎膜早破至分娩时间超过48h绒毛膜羊膜炎、剖宫产率及新生儿并发症的发生率增加。     

地诺前列酮栓用于足月妊娠引产的临床评价

目的评价地诺前列酮阴道栓剂用于足月妊娠引产的有效性和安全性。方法对本院2008年1月至10月间足月妊娠应用地诺前列酮栓引产的320例病例进行回顾性分析,设为观察组;另外随机选择同期足月妊娠自然临产孕妇320例为对照组,比较两组产程、妊娠结局。结果观察组中放置地诺前列酮栓后直接临产者268例(83.75%),需静脉滴注缩宫素临产者33例(10.31%),引产失败者19例(5.94%)。观察组第一、二产程均缩短,(P<0.01,P<0.05)。缩宫素使用率、剖宫产率观察组明显小于对照组(P<0.01)。两组的胎儿窘迫、新生儿窒息、产后出血发生率比较差异无统计学意义(P>0.05)。结论地诺前列酮栓用于足月妊娠引产安全、有效。在使用中应注意放药指征和撤药时机,以保证安全性和成功率。     

欣普贝生应用于足月胎膜早破引产的临床分析

目的 探讨欣普贝生应用于足月胎膜早破的引产效果. 方法 选择我院70例有引产指征的足月胎膜早破孕妇,完全随机分为2组.研究组35例使用欣普贝生引产,对照组35例以缩宫素引产,比较两组的引产效果以及分娩结局. 结果 研究组12 h内促宫颈成熟有效率100%,高于对照组48.39%;研究组用药至临产时间（6.27±6.13）h,短于对照组（9.65±6.79）h,用药至分娩时间（12.15±7.51）h,也短于对照组（19.34±9.22）h;研究组剖宫产率22.86%,低于对照组45.71%（均P＜0.05）;研究组总产程（6.10±2.60）h,短于对照组（10.97±3.37）h（P＜0.05）;两组产后出血、胎儿窘迫及新生儿窒息的发生率差异均无统计学意义（P＞0.05）. 结论 欣普贝生可安全地用于足月胎膜早破的引产,效果优于缩宫素.     

宫颈扩张球囊与地诺前列酮栓在足月妊娠初产妇引产中的效果比较

目的 比较宫颈扩张球囊和地诺前列酮栓在足月妊娠初产妇引产中的效果。方法 选取2017年7月至2019年6月在安徽医科大学第二附属医院妇产科进行治疗的60例足月妊娠引产初产妇为研究对象,根据随机数字表法将患者分为对照组30例和观察组30例,其中对照组采用宫颈扩张球囊术引产,观察组采用地诺前列酮栓引产,比较两组产妇的促宫颈成熟度;临产时间、总产程、出血量;产后不良反应发生率及新生儿情况。结果 两组孕妇引产前宫颈成熟度差异无统计学意义（P>0.05）;观察组Bishop评分干预前后差值低于对照组,但差异无统计学意义（P>0.05）;观察组孕妇的临产时间、总产程较对照组短,差异有统计学意义（P<0.05）,但两组产后出血量差异无统计学意义（P>0.05）;两组孕妇胎膜早破、宫缩过强、宫颈出血等不良反应发生率差异无统计学意义（P>0.05）;两组胎儿发生呼吸窘迫的概率、早产儿体质量情况以及Apgar评分差异无统计学意义（P>0.05）。结论 与宫颈扩张球囊术比较,地诺前列酮可缩短足月妊娠初产妇的临产时间和总产程;两者均可促进宫颈成熟,且术后不良反应发生率相当。     

妊娠期肝内胆汁淤积症妊娠结局的临床研究

目的探讨妊娠肝内胆汁淤积症(ICP)对妊娠结局的影响。方法将2005年1月至2008年12月在本院分娩诊断为ICP110例为观察组,同期在本院分娩3130例为对照组,比较两组产科并发症、分娩方式及新生儿情况。结果两组孕妇年龄、孕产次、初产妇方面无显著性差异(P>0.05);观察组孕周小于对照组(P<0.05);观察组产后出血、胎膜早破、剖宫产、早产、胎儿宫内窘迫、胎粪污染发生、围生儿病死率均高于对照组(P<0.05);观察组新生儿体重低于对照组(P<0.05)。结论ICP是产科严重的并发症之一,它可导致早产、胎儿宫内窘迫、围生儿死亡、新生儿并发症及产后出血,增加难产及剖宫产率,通过有效处理和适时终止妊娠,可能降低胎儿宫内窘迫和死亡的发生并改善围产儿结局。     

地诺前列酮用于足月妊娠促宫颈成熟和引产的临床研究

目的观察地诺前列酮（普贝生）用于足月妊娠促宫颈成熟和引产的临床效果和安全性。方法将486例妊娠足月、有引产指征的初产妇按抽签法分为2组,观察组269例将地诺前列酮栓1枚置于阴道后窟窿深处,对照组217例予缩宫素2．5IU加入5％葡萄糖500ml中静脉微泵泵入。比较2组用药后临产情况、剖宫产率对母婴的影响。结果观察组引产成功212例（78．8％）,剖宫产37例（13．8％）,对照组引产成功127例（58．5％）,剖宫产69例（31．8％）。观察组新生儿窒息、羊水类染,产后出血分别为7例（2．6％）、28例（10．4％）、20例（7．4％）,对照组分别为9例（4．1％）、17例（8．8％）、21例（9．7％）,2组差异无统计学意义（P〉0．05）。观察组有16例（5．95％）产妇发生宫缩过频过强,取出地诺前列酮后好转。结论地诺前列酮能有效地促宫颈成熟及引产,可安全用于临床。     

地诺前列酮栓与缩宫素注射液用于足月妊娠促宫颈成熟的临床观察比较

目的观察比较地诺前列酮栓（普贝生）和缩宫素注射液用于足月妊娠促宫颈成熟的效果,评价其有效性与安全性。方法选择2008年3月至2010年3月成都市锦江区妇幼保健院产科住院的86例孕妇随机分为对照组和普贝生组,每组43例。普贝生组孕妇阴道后穹隆放置普贝生1枚,对照组孕妇给予5%葡萄糖500mL加入1U缩宫素静脉滴注,对2组孕妇的Bishop评分、产后出血、临产情况、用药至临产发作时间、阴道分娩率、剖宫产率及新生儿窒息率进行比较。结果普贝生组总有效率和24 h内阴道分娩率均显著高于对照组（P〈0.01）,普贝生组用药至临产时间显著短于对照组（P〈0.01）,治疗组剖宫产率显著低于对照组（P〈0.01）。普贝生组的新生儿窒息率和产后出血率明具有降低的趋势,但在统计学上无显著差异（P〉0.05）。结论普贝生用于足月妊娠促宫颈成熟引产优于缩宫素注射液,是一种安全、有效并且使用方便的促宫颈成熟引产药物。     

地诺前列酮与缩宫素用于足月妊娠引产效果的临床观察

目的：观察分析地诺前列酮与缩宫素用于足月妊娠引产效果的临床效果和安全性。方法选取108例足月妊娠引产产妇,随机分为观察组和对照组,各54例。分别给予地诺前列酮和缩宫素引产。观察比较两组的引产效果。结果在宫颈Bishop评分、12 h临产率、24 h临产率、总有效率、阴道分娩率方面比较,观察组明显优于对照组,差异有统计学意义。在不良反应、新生儿结局方面比较,差异无统计学意义。结论地诺前列酮用于足月妊娠引产效果的临床效果较好,安全性较高,值得推广。