腹腔镜卵巢囊肿剥除术创面不同止血法对残留卵巢储备功能的影响

目的探讨腹腔镜卵巢囊肿剥除术创面不同止血法对残留卵巢储备功能的影响。方法随机将96例卵巢囊肿患者分为2组,对照组用双极电凝止血,观察组用缝合止血,比较2组治疗效果。结果囊肿位于卵巢门之外,对照组卵巢储备功能优于观察组;囊肿在卵巢门处者,观察组卵巢储备功能则优于对照组。2组差异有统计学意义(P0.05)。结论腹腔镜下卵巢囊肿剥除术后,若囊肿在卵巢门之外,采用双极电凝止血简单易行,不会对残留卵巢功能造成影响;若囊肿在卵巢门处,应尽量行缝合止血方法,确保残留卵巢的储备功能。     

腹腔镜下卵巢囊肿剥除术中不同止血方法对卵巢功能的影响

目的探讨腹腔镜下卵巢囊肿剥除术中电凝与缝合两种止血方法对卵巢功能的影响。方法将63例接受腹腔镜下卵巢囊肿剥除术患者,随机分为电凝组和缝合组,各33例。电凝组采用电凝方式止血,缝合组采用缝合的方式止血。比较两组术中、术后各指标的变化情况。结果两组患者手术时间、术中出血量及住院时间比较,差异无统计学意义(P0.05),缝合组患者术后12个月后出现月经量少、稀发或月经周期延长者2例(6.06%),对照组8例(26.67%),差异有统计学意义(P0.05)。两组术前卵泡期性激素E2、FSH、LH差异无统计学意义(P0.05),术后缝合组变化幅度小于对照组,差异有统计学意义(P0.05)。结论腹腔镜下卵巢囊肿剥除术中应用缝合方式止血比电凝止血方式对卵巢功能损害小,能够更好保护卵巢功能。     

两种止血方式对腹腔镜卵巢囊肿剥除术患者卵巢功能的影响

目的探讨不同止血方式对腹腔镜卵巢囊肿剥除术(LOCR)患者卵巢功能的影响。方法将60例行LOCR治疗的患者随机分为2组,分别实施电凝止血法和缝合止血法。观察2组术后卵巢功能指标(E2、FSH和LH水平)恢复情况。结果 2组术前卵巢功能指标水平差异无统计学意义(P0.05)。2组患者术后1个月及对照组6个月的卵巢功能指标均受到显著影响,与术前比较,差异均有统计学意义(P0.05)。但观察组术后6个月时的上述指标已基本恢复,与术前比较,差异无统计学意义(P0.05)。术后6个月内观察组患者月经异常率低于对照组,差异有统计学意义(P0.05)。结论与电凝止血比较,腹腔镜卵巢囊肿剥除术中实施缝合止血,有利于保护卵巢功能和术后卵巢功能的恢复。     

腹腔镜手术治疗卵巢囊肿386例

目的总结腹腔镜下卵巢囊肿手术的经验. 方法回顾分析1999年7月～2004年12月我院386例囊腹腔镜卵巢囊肿手术的临床资料. 结果 384例腹腔镜手术成功,2例因既往有手术史或盆腔粘连中转开腹.术中出血平均20.6 ml(10～60 ml).手术时间平均55 min(20～140 min ).术后住院平均3 d(2～5 d).194例随访1～60个月,平均24个月,盆腔检查和B超均正常. 结论腹腔镜下卵巢囊肿手术安全有效,具有创伤小、术后恢复快、住院时间短等特点.     

腹腔镜手术治疗巨大卵巢囊肿

目的探讨腹腔镜下巨大卵巢囊肿手术的安全性及可行性。方法对46例巨大卵巢囊肿（直径12～267cm，平均18cm）在脐上2～3cm处做直径1cm横切口，囊肿直径〉20cm者采用纵行开放1．5cm切口，然后置入trocar再缝合作为置镜的第一穿刺点，在腹腔镜直视下吸出囊液，行囊肿剥除或附件切除，然后标本袋取出标本。结果除1例因术中堡萼病理证实为交界性肿瘤中转开腹外，余45例均在腹腔镜下完成手术，术中未发生严重并发症。术中出血量70～130ml，手术     

卵巢囊肿蒂扭转保留卵巢腹腔镜手术62例报告

目的：探讨卵巢囊肿蒂扭转保留卵巢腹腔镜手术的价值。方法2007年1月～2012年6月我院收治卵巢囊肿蒂扭转62例,其中合并妊娠12例,腹腔镜下先高位结扎卵巢动、静脉,再将扭转的卵巢复位,剔除卵巢囊肿。结果62例均成功保留患侧卵巢。蒂扭转180°～1080°,其中＜360°19例,360°～720°21例,＞720°22例;颜色紫黑色26例,紫色或正常36例。手术时间（57±23）min;术中出血量5～130 ml,平均50．6 ml;术后肛门排气时间（24±13）h。无血栓形成、感染等,妊娠患者无流产等发生。术后1～3个月性激素水平恢复正常,6～24个月43例患侧卵巢有排卵。结论腹腔镜下高位结扎卵巢动静脉,剔除卵巢囊肿,既避免血栓脱落的可能,又能保留卵巢,是一种较好的手术方法,但对医师腹腔镜手术操作技能的要求较高。     

腹腔镜卵巢巧克力囊肿剔除联合缝合止血术对卵巢储备功能的影响

目的探讨腹腔镜卵巢巧克力囊肿剔除联合缝合止血术对卵巢储备功能的影响。方法回顾性分析2012年1月至2013年12月在我院妇科住院行腹腔镜卵巢巧克力囊肿剔除联合缝合止血术的卵巢巧克力囊肿患者(80例)的临床资料,根据囊肿发生部位不同分为单侧囊肿组(36例)和双侧囊肿组(32例),于术前及术后6个月、12个月月经来潮的第1~3天进行B超检查及实验室检测,比较两组患者手术前后的基础窦卵泡数(AFC)、抗苗勒管激素(AMH)、卵泡刺激素(FSH)、黄体生成素(LH)及雌二醇(E2)水平。结果 (1)组内比较,双侧囊肿组患者术后6个月和12个月的血清AMH水平显著低于术前(P0.05);单侧囊肿组患者术后6个月和12个月血清AMH水平虽有所下降,但与术前比较无显著性差异(P0.05)。双侧囊肿组患者血清FSH水平术后12个月显著高于术前(P0.05);其余各项指标组内比较无显著性差异(P0.05)。(2)组间比较,双侧囊肿组术后6个月及12个月AMH水平显著低于单侧囊肿组(P0.05);双侧囊肿组术后12个月血清FSH水平显著高于单侧囊肿组(P0.05);其余各项指标组间比较无显著性差异(P0.05)。结论腹腔镜卵巢巧克力囊肿剔除联合缝合止血术对卵巢储备功能仍然存在一定程度的损伤,尤其是双侧囊肿剔除术后,卵巢储备功能下降的风险增大。     

腹腔镜卵巢囊肿剥除术中电凝次数与卵巢储备功能的相关研究

目的:分析腹腔镜卵巢囊肿剥除术中电凝次数与患者卵巢储备功能的相关程度。方法:回顾分析65例接受腹腔镜卵巢囊肿剥除术患者的临床资料,根据术中电凝次数将患者分为两组,其中36例多于5次(多次组),29例不大于5次(少量组)。两组患者均于术前、术后第3个月检测血清性激素(FSH、LH、E2、T及P)浓度,并应用阴道彩超检测卵巢截面积、卵巢间质动脉血流的收缩期峰值(PSV),窦卵泡数(F0),并进行对比分析。应用Logistic回归分析电凝次数与上述各指标的相关性。结果:两组患者术前血清性激素(FSH、LH、E2、T及P)浓度及卵巢截面积、PSV与F0差异均无统计学意义(P>0.05)。与少量组相比,治疗后3个月,多次组FSH、LH浓度较高,E2浓度及卵巢截面积、PSV与F0则较低(P<0.05);而T、P两组相比差异无统计学意义(P>0.05)。Logistic回归分析显示,电凝次数与E2血清浓度呈负相关(OR=0.634,P=0.037),而与F0呈正相关(OR=2.527,P=0.022)。结论:腹腔镜卵巢囊肿剥除术中增加电凝次数可降低卵巢储备功能,应尽量减少使用次数。     

腹腔镜手术治疗良性卵巢囊肿临床体会

目的总结腹腔镜手术治疗良性卵巢囊肿的临床体会。方法将180例良性卵巢囊肿患者按照不同手术方式分为对照组和观察组,各90例。对照组行常规开腹手术,观察组行腹腔镜手术,比较两组手术时间、术中出血量、术后并发症等指标。结果两组患者手术时间比较,差异无统计学意义(P0.05)。腹腔镜组术中出血量少于传统传统开腹组。腹腔镜组住院时间、术后下床活动时间及术后并发症发生率均低于传统开腹组,两组比较,差异均有统计学意义(P0.05)。结论腹腔镜手术治疗良性卵巢囊肿创伤小,术中出血量小,术后恢复时间短,术后并发症低,值得临床应用。     

腹腔镜下卵巢巧克力囊肿剔除术中缝合止血法对卵巢功能的影响

目的探讨腹腔镜下卵巢巧克力囊肿剔除术中创面采用缝合法止血对术后卵巢储备功能的影响。方法2001年6月~2006年8月,对36例卵巢巧克力囊肿在腹腔镜下剔除囊肿后,术中创面采用缝合法止血。术前、术后第2次月经第2~3天及术后6个月第1次月经第2~3天分别抽血检测卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)及阴道B超探测窦状卵泡数(Fo),以判断卵巢储备功能。结果①FSH、LH、E2在术前、术后及术后6个月比较差异均无显著性(P>0.05)。②术后第2次月经和术后6个月第1次月经Fo分别为(5.0±1.5)个及(5.2±1.5)个,较术前(6.1±1.2)个明显减少(q=4.690、3.838,P<0.05)。③术后2个时点基础FSH≥12IU/L的例数(5例和3例)均多于术前(0例),但无统计学意义(χ2=3.439,P=0.064;χ2=1.391,P=0.238)。未发现FSH≥40IU/L的患者。结论腹腔镜下卵巢巧克力囊肿剔除术中缝合止血法未见影响卵巢储备功能。     

Continuous Infusion of Intraperitoneal Bupivacaine after Laparoscopic Surgery: A Randomized Controlled Trial

Background  A standard approach for postoperative analgesia in laparoscopic surgery is to infiltrate the incisions with local anesthetic in combination with systemic opioids. The intraperitoneal introduction of local anesthetic in this setting has the potential to provide appropriate analgesia without the side effects of systemic opioids. We performed a randomized clinical trial of the On-Q pump delivery system to determine the safety and efficacy of this device for this novel purpose. Methods  Thirty patients undergoing laparoscopic adjustable gastric banding were randomly assigned to one of two groups. The treatment group received On-Q pump systems filled with 0.375% bupivacaine, while the control group received pumps filled with 0.9% normal saline. The pump’s catheter was introduced intraperitoneally, and bupivacaine or saline was then delivered for the first 48 h after surgery. Patient’s subjective pain scores were evaluated at preset intervals. In addition, shoulder pain, morphine requirements, and anti-emetic requirements were tabulated. Results  A statistically significant decrease in patient’s subjective reports of pain by visual analog score was noted in the On-Q group 1.8 ± 1.93 vs. control 3.5 ± 2.4, p < 0.046 and remained significant until the end of the study (48 h). No statistical difference was noted in shoulder pain, morphine requirements, or anti-emetic requirements at any time point. Conclusion  Our trial was able to provide evidence of significant reduction in postoperative pain as measured by subjective pain scores with the use of continuous intraperitoneal bupivacaine using the On-Q pain pump system. Further investigation is warranted to evaluate the cost effectiveness of this technique.     

快速康复外科理论在高龄患者腹腔镜胆囊切除术中的应用——前瞻性随机对照研究

目的探讨快速康复外科(fast track surgery,FTS)理论在高龄患者腹腔镜胆囊切除术(laparoscopiccholecystectomy,LC)中的应用价值。方法 2008年3月～2011年3月30例80岁以上择期3孔法LC,随机分为FTS组及对照组,FTS组接受FTS方案治疗,对照组接受传统方法治疗。比较2组术后肠道排气时间、住院时间、术后并发症和住院总费用等。结果 FTS组术后排气时间(22.9±5.5)h显著短于对照组(36.1±8.1)h(t=-5.280,P=0.000),FTS组术后住院时间(2.8±2.1)d显著短于对照组(5.6±2.0)d(t=-3.725,P=0.000),FTS组术后住院总费用(9.9±1.8)千元显著少于对照组(12.2±2.1)千元(t=-3.231,P=0.000);2组并发症发生率无统计学差异(P=0.586)。结论对80岁以上患者择期LC应用FTS能缩短患者的住院时间,加速康复。     

AirSeal智能气腹系统在腹腔镜直肠癌根治手术中的应用价值:前瞻性随机对照研究

目的探讨AirSeal智能气腹系统在腹腔镜直肠癌根治手术中的应用价值。方法将2017年7月~2019年6月80例腹腔镜直肠癌根治手术,随机分为AirSeal组和对照组各40例,AirSeal组应用AirSeal智能气腹系统,对照组应用常规气腹机,比较2组术中擦镜次数、盆腔自主神经显示情况、手术时间、术中出血量、淋巴结清扫个数、术中动脉血气变化、肛门排气时间、腹腔引流量和并发症。结果均成功完成手术,无严重并发症和死亡。术中擦镜次数AirSeal组更少[(8.3±2.5)次vs.(12.8±3.7)次,t=-7.686,P=0.000],盆神经丛显示例数AirSeal组更多(25例vs.14例,χ^2=6.054,P=0.014),低位直肠癌手术时间AirSeal组更短[Dixon:(105.4±17.4)min vs.(136.8±25.6)min,t=-4.536,P=0.000;Miles:(145.2±17.6)min vs.(186.3±31.5)min,t=-2.829,P=0.016],术中动脉血气指标pH值、PaCO2、PaO2、BE和HCO-32组差异无显著性(P>0.05)。2组术中出血量、淋巴结清扫个数、肛门排气时间、术后腹腔引流量和术后并发症均无显著差异(P>0.05)。结论AirSeal智能气腹系统在腹腔镜直肠癌根治手术中能及时排出术中烟雾,减少术中擦镜次数,保持镜头清晰,缩短低位直肠癌腹腔镜手术时间,有一定的临床应用价值。     

A Randomized, Controlled Study Comparing Two Standardized Closure Methods of Laparoscopic Port Sites

Objectives:

To compare octyl-cyanoacrylate tissue adhesive (OCT) with the standard suture technique for the closure of laparoscopic port sites.

Methods:

This was a randomized clinical trial of 40 patients. All participants had 2 lower abdominal ports, with one port closed using OCT while the opposite port was closed with 4-0 monocryl suture. An evaluation of the wound was performed 2 weeks to 4 weeks after surgery. The Hollander Wound Evaluation Scale (HWES, including step-off of borders, contour irregularities, margin separation, edge inversion, excessive distortion, and overall appearance) was used for cosmetic evaluation. Complications, such as erythema, warmth, tenderness, drainage, and wound infection, were evaluated. Analysis of complications was performed using the chi-square test, and cosmetic evaluation including individual components of the HWES was compared with the t test, P<0.05 considered significant.

Results:

Eighty wounds were evaluated in 40 patients. The number of patients with complications including erythema (1/40 vs. 16/40), tenderness (1/40 vs. 19/40), and drainage (1/40 vs. 9/40) was lower with OCT than with sutures, respectively (all P<0.001). The ports closed with OCT had higher overall HWES, ie, better cosmetic score (5.92±0.05 vs 5.50±0.13) and lower margin separation (1/40 vs. 10/40) but had higher contour irregularity (6/40 vs. 1/40) (all P<0.05). However, skin contour irregularity was significantly better when OCT was applied using fine tissue forceps (P=0.002).

Conclusion:

Laparoscopic ports closed with OCT had fewer early complications, such as wound erythema, tenderness, and drainage. Ports closed with OCT had a better cosmetic appearance.     

Oncologic Results of Laparoscopic Versus Conventional Open Surgery for Stage II or III Left-Sided Colon Cancers: A Randomized Controlled Trial

Introduction Minimal invasive surgical approach can achieve quick functional recovery. However, the oncologic outcome for cancer is still a concern. This study aims to compare the oncologic outcome between laparoscopic and open methods in the curative resection of Stage II or III left-sided colon cancers. Methods In consideration of statistical power up to 90%, 286 eligible patients with curable left-sided colon cancer (Tumor-Node-Metastasis Stage II and Stage III disease) requiring the takedown of colonic splenic flexure to facilitate a curative left hemicolectomy were recruited randomly and equally allocated to the laparoscopic and open group. The primary endpoint was time-to-recurrence of tumor. Data was analyzed according to intention-to-treat principle. Results Postrandomization exclusion occurred because of metastatic disease detected intraoperatively occurred in 13 patients and because of patient withdrawal from trial in 4. Therefore, 135 and 134 patients actually comprised the laparoscopic and open group, respectively. The median follow-up of patient was 40 months (range: 18–72 months). The oncologic results were similar (P = 0.362, one-sided log-rank test) in laparoscopic and open group of patients, with the estimated cumulative recurrence rate of 13.2% (9/68) versus 17.2% (11/64) in Stage II disease and 20.9% (14/67) versus 25.7% (18/70) in Stage III disease, respectively. The recurrence patterns were similar between the two groups. Both open and laparoscopic groups were comparable in the number of dissected lymph node (15.6 ± 3.0 vs. 16.0 ± 6.0, P = 0.489), various demographic and clinicopathologic parameters. Conclusions The estimated cumulative recurrence rate for the surgery of Stage II or III left-sided colon cancers was the same between laparoscopic and open methods.     

Comparison of 5-, 10-, and 15-Point Laparoscopic Ovarian Electrocauterization in Patients With Polycystic Ovarian Disease: a Prospective, Randomized Study

Objective:

We compared 12-month pregnancy and live birth rates in patients with polycystic ovarian disease undergoing 5-, 10-, and 15-point laparoscopic ovarian electrocauterization.

Methods:

This was a prospective, randomized study performed at the Dabirashrafi Fertility and Endoscopy Research Center, Tehran, Iran. The study included 187 patients with polycystic ovarian disease who were randomly assigned to 3 groups. Group I comprised 67 patients whose ovaries received 5-point electrocauterization. Group II comprised 57 patients whose ovaries received 10-point electrocauterization. Group III comprised 63 patients whose ovaries received 15-point electocauterization.Laparoscopic ovarian electrocauterization with a unipolar current was used. The main outcome measures were 12-month pregnancy and live birth rates.

Results:

Patients were homogeneous for age, body mass index, and type and duration of infertility. Twenty pregnancies resulted in Group I, with a pregnancy rate of 29.9% (20/67) and a live birth rate of 20.9% (14/57). Eighteen pregnancies resulted in Group II, with a pregnancy rate of 31.6% (18/57), and a live birth rate of 28.1% (16/57).Thirty-three pregnancies resulted in group III, with a pregnancy rate of 52.4% (33/63), and a live birth rate of 47.6% (30/63). Comparison of Group III with Groups I and II revealed a statistically significant increase in pregnancies (P=0.016) and live birth rates (P=0.004).

Conclusion:

We recommend 15-point electrocauterization of ovaries in patients with polycystic ovarian disease.     

腹腔镜手术治疗盆腔包裹性积液99例分析

目的探讨腹腔镜手术治疗盆腔包裹性积液的的可行性和安全性。方法2009年1月~2018年4月我科99例术前盆腔肿物性质不明,术后病理诊断为盆腔包裹性积液。年龄<40岁、有生育需求者行腹腔镜患侧附件囊肿剥除术;绝经期、年龄>45岁且无生育需求者行腹腔镜患侧附件切除术;年龄40~45岁,根据既往手术史、有无生育需求并结合患者个人意愿决定行腹腔镜患侧附件囊肿剥除术或患侧附件切除。结果98例完成腹腔镜手术,1例因粘连严重中转开腹。术中见99例均存在粘连,其中重度粘连(mAFS评分5~6分)76例。行患侧囊肿剥除术69例,患侧附件切除术30例,同时行粘连松解术。手术时间19~285 min,中位数88 min。术中出血量5~200 ml,中位数25 ml。截止2019年3月,随访78例,其中30例随访不足1年,48例随访1~10年(中位随访时间3.5年),6例(12.5%)超声检查示再发盆腔包块(复发时间术后2个月~5年,中位数20个月),其中2例出现下腹痛等症状,其余均为无症状复发。结论腹腔镜手术治疗盆腔包裹性积液安全、可行。     

腹腔镜卵巢内膜异位症囊肿剥除术中不同止血方法对卵巢储备功能的影响及术后疗效分析

[摘要]目的探讨腹腔镜卵巢子宫内膜异位症囊肿剥除术中使用不同止血方法对卵巢储备功能的影响。方法选择2010年1月至2011年12月在湖南省人民医院妇产科住院,初步诊断为卵巢子宫内膜异位症囊肿的120例患者。人院前病人在月经第3d早晨抽取空腹静脉血,查内分泌全套,包括促卵泡激素（follicle．stimulatinghormone,FSH）。同时行阴道彩色超声检查,测量双侧卵巢基础窦卵泡计数（antralfolliclecount,AFC）。根据止血方法的不同将患者分为3组,行常规腹腔镜卵巢内异症囊肿剥除术,术中分别在剥除囊肿后采用缝合法（缝合组,60例）、双极电凝法（双极电凝组,30例）和超声刀法（超声刀组,30例）止血。术后第1、3、6、12次月经周期第3d,复查FSH水平及AFC,比较腹腔镜术中不同止血方法对卵巢储备功能的影响。结果各组患者年龄、卵巢子宫内膜异位症囊肿大小、术前FSH水平和AFC水平比较,差异均无统计学意义（P〉0．05）。术后卵巢储备功能变化：①FSH：术后1、3、6、12个月时,双极电凝和超声刀组均明显高于缝合组,差异均有统计学意义（P〈0．05）。②AFC：手术后1个月和3个月时,各组患者的AFC比较,差异无统计学意义（P〉0．05）;但术后6、12个月时,缝合组的AFC明显高于双极电凝组和超声刀组,差异均有统计学意义（P〈0．05）。③术后自然妊娠率：术后18月内,缝合组术后妊娠率均高于双极电凝组及超声刀组,但差异无统计学意义（P〉0．05）。结论腹腔镜卵巢子宫内膜异位症囊肿剥除术中,应用双极电凝或超声刀止血会导致卵巢储备功能下降,应该慎用电凝烧灼方式止血。     

硬膜外麻醉下不同二氧化碳气腹压在腹腔镜胆囊切除手术中应用的前瞻性随机对照研究

目的通过评价硬膜外麻醉下腹腔镜胆囊切除术（laparoscopic cholecystectomy，LC）中不同二氧化碳（CO2）气腹压对患者生命体征、血气指标及术后恢复的影响，探讨LC术更经济、安全、微创的治疗条件。方法采用前瞻性随机对照研究方法，60例择期LC术分为低、中、高气腹压三组，气腹压力A组8mmHg，B组11mmHg，C组14mmHg。对比术前术中生命体征、血气指标及术后恢复等指标。结果60例LC术在硬膜外麻醉下均顺利完成。气腹后3组血压（BP）均明显下降（P〈0．001），C组明显低于A、B组（P〈0．05）。气腹后3组心率（HR）均减慢（P〈0．001），3组间差异无显著性（P〉0．05）。气腹后3组呼吸频率（RF）均显著增快（P〈0．001），C组增加较A、B组明显（P〈0．05）。气腹后3组动脉血CO2分压（PaCO2）均明显增高（P〈0．05），B、C组明显高于A组（P〈0．05）。气腹后3组pH值均明显降低（P〈0．01），C组明显低于A组（P〈0．05）。气腹后3组血浆CO2含量（TCO2）、碳酸氢根（HCO3^-）明显增高（P〈0．05），3组间差异无显著性（P〉0．05）。3组手术时间、术中CO2消耗量、术后肩痛和恶心呕吐发生率差异无显著性（P〉0．05）。结论硬膜外麻醉、低气腹压（8mmHg）完全能够满足绝大部分LC手术需要，而且可以达到更安全、经济、微创的目的。