翠绿宝石激光治疗太田痣96例

目的：观察翠绿宝石激光治疗太田痣的效果，找出治疗太田痣合适的能量值。方法：应用Photo GenicaT10 Q-开关翠绿宝石激光器(波长752nm，脉宽45～75ns)对96例太田痣患者进行治疗。结果：采用该疗法可安全去除太田痣，且创伤小，操作简便，无瘢痕等并发症发生，总有效率达96％。结论：Q-开关翠绿宝石激光治疗太田痣具有很好的效果，选择合适的能量值及做好围术期处理是成功治疗太田痣的关键。     

调Q-开关Nd：YAG激光治疗色素增多性皮肤病临床探索（附427例报告）

目的 探索调Q-开关Nd：YAG激光治疗内源性与外源性色素增多性皮肤病的临床效果。方法 对内源性及外源性色素增多性皮肤病427例，选择不同的技术参数进行治疗。结果 经过1～7次治疗，总有效率达100％，均无瘢痕形成。结论 调Q-开关Nd：YAG激光对多种色素增多性皮肤病有较好的疗效，明显优于其他方法。     

Q开关Nd:YAG激光治疗色素增加性皮肤病128例临床疗效分析

目的：观察Q开关Nd：YAG激光治疗色素增加性皮肤病临床疗效与美容效果以及治疗次数。方法：Q开关Nd：YAG激光(1064nm、532nm波长)治疗128例色素增多性皮肤病，观察并分析其疗效和美容效果。结果：Q开关Nd：YAG激光治疗色素增多性皮肤病的治疗有效。其中对文眉、雀斑、脂溢性角化、色素痣等总有效率为96％以上，治疗次数为1-4次。结论：Q开关Nd：YAG激光治疗色素增加性皮肤病特别是错误文眉治疗效果好。     

长脉冲翠绿宝石激光治疗微静脉畸形的临床分析

目的：探讨长脉冲翠绿宝石激光治疗微静脉畸形的临床疗效及并发症发生情况,并与长脉冲染料激光进行比较。方法：应用长脉冲翠绿宝石激光和长脉冲染料激光治疗微静脉畸形11例,其中一半皮损用长脉冲翠绿宝石激光治疗,另一半皮损用长脉冲染料激光进行治疗,观察皮损红斑消退及并发症发生情况。结果：长脉冲翠绿宝石激光可有效地治疗微静脉畸形,治疗后3例发生色素沉着,1例发生色素脱失;而长脉冲染料激光治疗后2例发生色素沉着。两者治疗后均无瘢痕形成。结论：应用长脉冲翠绿宝石激光治疗微静脉畸形疗效显著,主要适用于隆起性、暗紫色的皮损,而长脉冲染料激光适用于扁平的淡红色皮损。     

两种激光治疗咖啡斑的疗效比较

目的:对Q-开关倍频Nd:YAG激光与Q-开关翠绿宝石激光治疗咖啡斑进行临床评价.方法:106例面部咖啡斑患者,随机分为两组,在局部麻醉下分别用Q-开关倍频Nd:YAG激光(波长532nm)和Q-开关翠绿宝石激光(波长755nm)逐个对面部色素损害进行扫描;治疗参数:波长532nm,激光能量密度2.2～26J/cm2,光斑直径2～3mm,频率2.5～5Hz;波长755nm,激光能量密度5.0-60J/cm2,光斑直径2～3mm,频率2.5～5Hz.疗效评定在术后3个月以上进行.结果:106例咖啡斑患者有41例(38.7%)进行了2次治疗.波长532m治疗咖啡斑的痊愈率及显效率为87.6%;波长755m激光治疗咖啡斑的痊愈率及显效率为85.1%两组间差异无显著意义(P＞005).两种激光治疗的总有效率均为100%;共有19例(17.9%)发生色煮沉着反应,两组间的发生率也无明显差异,所有患者均无皮肤瘢痕发生.结论:开关波长532nm和755nm激光治疗咖啡斑有较高的安垒性及有效性,两种激光的疗效及副反应差异无显著意义.     

Q—开关翠绿宝石激光治疗雀斑及雀斑样痣

目的;观察翠绿宝石激光治疗雀斑及雀斑样痣的疗效及并发症。方法：用Q－开关翠绿宝石激光不同剂量治疗不同部位雀斑及雀斑样痣。结果：共治疗125例,有效率100％。结论：Q－开关翠绿宝石激光治疗雀斑及雀斑样痣疗效良好,皮肤不留疤痕。     

Q开关Nd:YAG激光治疗面部色素增加性病变疗效分析

目的:观察Q开关Nd:YAG激光治疗面部色素增加性皮肤病的临床疗效及副反应。方法:使用Q开关Nd:YAG激光治疗145例色素增加性皮肤病患者。雀斑、咖啡斑和脂溢性角化病采用波长532nm,太田痣和文身采用波长l 064nm。结果:145例患者经治疗后,色素性病变逐渐消退,其中文身、雀斑、脂溢性角化病疗效较为显著。结论:Q开关Nd:YAG激光治疗色素增加性皮肤病疗效好,安全有效,是一种无创的治疗方法。     

rhEGF联合Q开关翠绿宝石激光治疗色素增加性皮肤病疗效及对皮肤屏障功能的影响

目的：观察rhEGF联合Q开关翠绿宝石激光治疗色素增加性皮肤病的疗效,及其对患者皮肤屏障功能的影响。方法：选取2018年10月-2019年12月于笔者医院诊疗的色素增加性皮肤病患者268例,按照随机数字表法分为对照组和观察组,每组134例。对照组给予波长为755 nm的Q开关翠绿宝石激光治疗,观察组在对照组治疗基础上给予外敷rhEGF凝胶。两组患者均治疗3次,每次间隔3～6个月。比较两组患者疗效,两组治疗前后皮肤屏障功能[皮肤经皮水分丢失(TEWL)、角质层的含水量、pH值、乳酸刺激评分、a值及粘脱蛋白质含量],色素沉着评分及色素沉着面积,比较两组不良反应发生率。结果：观察组及对照组有效率分别为92.54%和81.34%,观察组有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者a值、pH值、TEWL、角质层含水量、粘脱蛋白质含量及乳酸刺激评分差异无统计学意义(P>0.05);治疗后,观察组a值、TEWL、粘脱蛋白质含量及乳酸刺激评分低于对照组,差异有统计学意义(P<0.05),角质层含水量高于对照组,差异有统计学意义(P<0.05)。治疗后,两...     

Q开关755nm翠绿宝石激光与CO_2点阵激光治疗脂溢性角化病疗效对比

目的:比较Q开关755nm翠绿宝石激光与CO_2点阵激光治疗脂溢性角化病的疗效。方法:将127例脂溢性角化病患者随机分成两组,观察组用Q开关755nm翠绿宝石激光治疗;对照组用CO2点阵激光治疗,比较两组疗效。结果:两组总有效率均为100%,观察组治愈率96.67%,对照组83.4%,两组疗效比较有显著性差异(P0.05);色素沉着率观察组1.7%,对照组11.9%;色素减退率观察组1.7%,对照组14.9%。结论:Q开关755nm翠绿宝石激光治疗脂溢性角化病明显优于CO_2点阵激光,更安全有效。     

第一讲色素性皮肤病的概述与分类

色素增加性皮肤病是一类常见的有碍美容的色素障碍性疾病，可由遗传、环境等因素引起，常影响患者的自信心、外在形象及社交等，多数求治心切。因其存在普遍性，应广大读者要求，我刊特邀广州军区总医院皮肤科杨慧兰主任等专家撰文进行专题讲座，就色素增加性皮肤病的病因、发病机理和临床经验及目前的治疗进展等进行深入讨论，欢迎广大读者来信来函交流。相关章节具体如下： 第一讲：色素性皮肤病的概述与分类；第二讲：黄褐斑的治疗；第三讲：雀斑的治疗；第四讲：色素细胞性肿瘤；第五讲：色素性皮肤病的鉴别诊断；第六讲：色素性皮肤病的治疗及进展；第七讲：激光在色素性皮肤病中的应用；第八讲：常见色素增加性皮肤病的中医诊治；第九讲：色素增加性皮肤病激光治疗后的护理。[编者按]     

Successful Removal of Freckles in Asian Skin with a Q-Switched Alexandrite Laser

BACKGROUND.: Although freckles are light-brown macules most frequently observed in individuals with red or blond hair and blue or gray eyes, freckles are common to Asian people, including Koreans. Treatment may be requested on cosmetic grounds. OBJECTIVE.: The objective of this study was to determine the effectiveness of the Q-switched alexandrite laser (wavelength 755 nm; pulse width 100 nsec) in treating the 197 cases of Asian skin with freckles and to observe any side effects such as pigmentary changes or scarring. METHODS.: One hundred ninety-seven patients with freckles were treated with the Q-switched alexandrite laser at 8-week intervals and clinically analyzed. RESULTS.: More than 76% removal of freckles required an average of 1.5 treatment sessions with 7.0 J/cm2. No scarring, long-standing pigmentary changes, or textural changes were seen in laser-irradiated skin. CONCLUSION.: The Q-switched alexandrite laser is a safe and highly effective modality for removing freckles without scarring or permanent pigmentary changes in Asian skin.     

Q开关紫翠宝石激光治疗P-J综合征面部黑子15例

目的：探讨Q开关紫翠宝石激光治疗p-J综合征患者面部黑子的有效性和安全性。方法：15例P—J综合征患者,均采用Q开关紫翠宝石激光治疗,脉宽75ns,波长755nm,光斑直径2．4mm。结果：经1～3次治疗后,15例患者均取得了满意疗效,没有发生严重的并发症。结论：Q开关紫翠宝石激光是治疗p-J综合征患者面部黑子的一种安全、有效的方法。     

Pigmentary Changes After Alexandrite Laser Hair Removal

BACKGROUND: Postinflammatory pigmentary changes are a frequently encountered problem with numerous dermatologic procedures. Limited literature is available that documents this complication with laser hair removal. OBJECTIVE: It is important for all physicians performing laser hair removal to be aware of this potential complication. We present our experience with postinflammatory pigmentary change and discuss some potential etiologic factors. METHODS: Seven patients who experienced postinflammatory complications after alexandrite laser hair removal are presented. These are all the patients who developed this complication in our office over the past 2.5 years. RESULTS: The patients who we describe in this article all developed a similar pattern of initial hyperpigmented rings, later developing into a thin wafer-like crust followed by hypopigmentation with gradual return to their normal skin color. CONCLUSION: In general, the alexandrite laser is both safe and effective for hair removal in patients of varying skin types. Complication rates will increase as skin pigment increases and as the power used increases. However, even in light-skinned individuals without recent pretreatment or posttreatment sun exposure, with proper treatment parameters, complications, and side effects can arise. We have found this to be especially true when treating areas other than the face.     

Q开关紫翠宝石激光治疗Peutz-Jeghers综合征色素沉着的疗效分析

目的:观察Q开关紫翠宝石激光治疗Peutz-Jeghers综合征色素沉着的临床疗效及不良反应。方法:采用Q开关紫翠宝石激光对18例Peutz-Jeghers综合征患者的色素沉着进行治疗,治疗次数1～3次,每次治疗间隔3～6个月,根据治疗前后的照片对比判定疗效。结果:18例患者,11例痊愈(占61.1%),6例显效(占33.3%),1例有效(占5.6%),总有效率达94.4%,无瘢痕等严重不良反应。结论:Q开关紫翠宝石激光治疗Peutz-Jeghers综合征临床疗效佳,不良反应少。     

Analysis of 602 Chinese Cases of Nevus of Ota and the Treatment Results Treated by Q-Switched Alexandrite Laser

BACKGROUND: Nevus of Ota is a congenital or acquired pigmentary disorder of the skin and mucous membranes, which are areas innervated by the first and second branches of the trigeminal nerve. Nevus of Ota is very common in Asia. Nevus of Ota was effectively treated with Q-switched alexandrite (755 nm) laser, but no detailed report existed on many Chinese cases treated with Q-switched alexandrite laser. OBJECTIVE: The objective was to gauge clinical and treatment data and material statistics for 602 cases of nevus of Ota and analyze its pathogenic mechanism and therapeutic results. METHODS: A total of 602 cases of clinical data on nevus of Ota were collected by means of clinical registration, photo verification, and telephone inquiry or correspondence. CONCLUSIONS: There are some differences in sex, age, and local regions in nevus of Ota. Nevus of Ota can combine with other diseases. The treatment of Nevus of Ota by a Q-switched alexandrite laser is safe and effective. Additional treatment will achieve good results. The results correlate to the eyelids and Tanino's classification.     

Evaluation comparing multiple treatments with a 2-msec and 10-msec alexandrite laser for hair removal.

BACKGROUND AND OBJECTIVES: There are a variety of different laser hair removal systems currently available. There are also systems with identical emitted wavelengths; yet their emitted pulse durations vary. There are few data comparing these systems in an objective manner. STUDY DESIGN/MATERIALS AND METHODS: Fourteen subjects received three treatments with two different pulse duration 755-nm alexandrite lasers. Paired anatomic sites were treated three times with both a 2-msec and a 10-msec system. Subjects were evaluated prior to laser treatment and 6 months after the three treatments with manual hair counts and incidence of complications. RESULTS: The average percentage of hair reduction was 33.1% for the 2-msec-pulse duration and 33.9% for the 10-msec-pulse duration alexandrite laser. No cutaneous pigmentary changes or scarring was noted 6 months after the final treatment. CONCLUSION: The alexandrite laser is effective in removing unwanted hair. There was no difference in response between a 2-msec and a 10-msec alexandrite laser.     

Laser-Assisted Hair Removal in Asian Skin: Efficacy, Complications, and the Effect of Single Versus Multiple Treatments

BACKGROUND: Alexandrite laser hair removal can be quite successful in lighter skin types. Effective hair removal in Asians can be difficult, and multiple treatments are usually required for effective treatment. OBJECTIVE: To evaluate the safety and efficacy of alexandrite laser hair removal in Asian skin, to determine the benefit of multiple treatments, and to evaluate the value of test patches before laser treatment. METHODS: One hundred forty-four Asian subjects with Fitzpatrick skin types III to V were treated with a cooled 40-ms alexandrite laser with fluences of 16 to 24 J/cm2. Initially, all treated subjects underwent test patch application. After test patch application, 35 subjects with 66 anatomic sites received three treatments. Thirty-five subjects with 66 anatomic sites received two treatments, and 74 subjects with 124 anatomic received a single treatment. All subjects were followed for 9 months after their final treatment. RESULTS: In subjects that were treated three times, a 55% hair reduction was noted at 9 months after the third treatment. In subjects treated two times, a 44% hair reduction was noted at 9 months after the second treatment. In subjects treated only one time, a 32% hair reduction was noted at 9 months after the single treatment. No subjects had scarring or long-term pigmentary changes. There appeared to be no correlation between test patch acute complications and those seen after actual treatments. CONCLUSION: Although Asian skin can be effectively treated with a cooled, long-pulsed alexandrite laser, complications do occur. Laser hair removal efficacy was increased with multiple treatments. There does not appear to be an exact correlation in Asian skin between complications occurring after test patch treatment and those seen with subsequent treatments.     

Treatment of Exogenous Ochronosis With a Q-Switched Alexandrite (755 nm) Laser

Background. Exogenous ochronosis is a cutaneous disorder characterized by blue-black or slate-gray hyperpigmentation resulting from the prolonged use of certain topical agents, most commonly hydroquinones. It is notoriously difficult to treat.
Objective. To report the effectiveness of a quality-switched (QS) 755-nm alexandrite laser in treating hydroquinone-induced exogenous ochronosis.
Methods. Hydroquinone-induced exogenous ochronosis in two patients was treated with a QS alexandrite laser. The first patient received six treatments (average fluence=7.8 J/cm²) at 2-month intervals. The second patient received four treatments (average fluence=6.9 J/cm²) at 4-month intervals. Biopsies of lesional skin were obtained before and after laser treatment for histologic evaluation.
Results. Significant lightening of the pigmented skin areas was achieved in both patients without scarring or textural changes. Decreased dermal pigmentation was observed on histologic examination of treated skin specimens.
Conclusion. The QS alexandrite laser can effectively treat exogenous ochronosis without untoward side effects.     

Q开关激光治疗双侧面部获得性太田痣样斑287例疗效分析

目的：比较Q开关紫翠宝石755nm激光、Nd：YAG1064nm激光和倍频Nd：YAG532nm激光对双侧获得性太田痣样斑的治疗效果和副作用。方法：运用Q开关紫翠宝石755nm激光、Nd：YAG1064nm激光和倍频Nd：YAG532nm激光分别对287例患者进行治疗。结果：经过1～13次治疗后,痊愈140例,显效66例,有效59例,无效22例,总有效率71.8%,总治愈率48.8%。倍频Nd：YAG532nm激光治疗起效快而副反应明显,Q开关紫翠宝石755nm激光和Nd：YAG1064nm激光起效慢但副反应轻微。结论：三种Q开关激光均能有效治疗双侧获得性太田痣样斑,长程低能量的Q开关紫翠宝石755nm激光和Nd：YAG1064nm激光因副反应轻微更适合美容患者的需要。