胃肠道间质肿瘤组织发生的探讨

目的探讨胃肠道间质肿瘤（ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌｓｔｒｏｍａｌｔｕｍｏｒ，ＧＩＳＴ）的组织发生。方法对３６例ＧＩＳＴ进行组织学、组织化学及免疫组织化学观察。结果胃和大肠间质肿瘤呈间叶细胞表型，但光镜下观察到在１５例发生于小肠的梭形细胞肿瘤中，瘤细胞之间存在着嗜酸性小体即丝团样纤维（ｓｋｅｉｎｏｉｄｆｉｂｅｒ，ＳＦ），Ｍａｓｓｏｎ三色染色呈蓝色，ＰＡＳ呈强阳性；免疫组化染色显示Ｓ－１００蛋白阳性率为４４．４４％，ｄｅｓｍｉｎ阳性率为８．３３％，瘤细胞的免疫表达与其分化程度无关。结论胃和大肠的间质肿瘤免疫表型复杂，提示其起源与原始间叶细胞有关，而小肠间质肿瘤大多数为神经源性肿瘤。可能起源于肠壁内在神经丛的神经膜细胞或来自小肠的自律神经。     

Biomechanics of the connective tissue

The authors discuss the collagen biomechanical properties. Firstly they recall the technical devices used in biomechanics and the mechanical data usually explored. Next, they review the mechanical properties of the various collagens found in tendons, joints, bone, vascular walls, skin and pulmonary alveoli.     

Adenomatoid tumors. Immunohistochemical study and histogenesis

Four testicular adenomatoid tumors were studied by immunohistochemistry, using the following antibodies to cytokeratin, epithelial membrane antigen, carcinoembryonic antigen, and factor VIII-related antigen. Cytokeratin and epithelial membrane antigen demonstrated a different pattern of positive immunostaining while carcinoembryonic antigen and factor VIII-related antigen proved constantly negative. Our findings support a mesothelial origin for adenomatoid tumors.     

Changes in rat connective tissue associated with the development of tumors caused by implantation of cellophane

Summary Small pieces of cellophane and whole cellophane films were introduced subcutaneously in rats. Not a single tumor appeared in rats in which ground cellophane was introduced. In rats in whom whole cellophane films (1×3 cm, 2×3 cm and 7×2.5 cm in size) were implanted the tumors appeared correspondingly in 3.2, 16.6, and 16.6% of the animals.Presented by Active Member of the Akad. Med. Nauk SSSR A. D. Timofeevskii Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 52, No. 12, pp. 79–84, December, 1961     

Morphology and histogenesis of yolk sac tumors in the testis

The differentiation of yolk sac tumor cells was similar to the processes of development of embryonic and extraembryonic endoderm during the first 7 wk after cleavage. Two ways of yolk sac tumor histogenesis are discussed: differentiation of embryonal carcinoma cells, and redifferentiation of the polypotent undifferentiated anaplastic seminoma cells. Histogenesis features described may be responsible for aggressive nature and high malignancy of yolk sac tumors.