Primary alveolar cleft bone grafting in unilateral cleft lip and palate: craniofacial form at age 8.

Counterpart analysis can be advantageous for the clinician interested in the underlying determinants of the craniofacial form for any given person. This analysis was performed for a group of patients who underwent primary alveolar cleft bone grafting (N = 18) and a group of patients who did not undergo grafting (N = 19) who were 8 years of age (+/- 6 months). The primary grafting group more frequently noted maxillary retrusion, but of a nonsignificant magnitude. Also, the primary grafting group had greater mean magnitudes of mandibular opening as a compensatory adjustment in some patients, but this could not be generalized to all patients who had underdone primary grafting. The mean magnitude of craniofacial vertical shortening was also greater for some patients who had undergone primary grafting, but it, too, did not exhibit a generalized pattern for all patients who had undergone primary alveolar cleft bone grafting procedures. This study emphasizes the great diversity of craniofacial skeletal adjustments made within each group of patients with unilateral cleft lip and palate and cautions the clinician against generalizations concerning a particular treatment protocol.     

Early versus late alveolar bone grafting in unilateral cleft lip and palate: Dental arch relationships in pre-adolescent patients

Objective

To evaluate the dental arch relationship in preadolescent children with complete unilateral cleft lip and palate after early secondary alveolar bone grafting (E-ABG) by comparing to late bone grafting (L-ABG).

Dental arch dimensions in patients with unilateral cleft lip and palate

In this investigation, dental arch dimensions during different ages were studied in 72 children with unilateral cleft of the lip, alveolar process, and palate and were compared with those of normal children. All the children with clefts were treated surgically by surgeons of the Lancaster Cleft Palate Clinic. The dental arch dimensions were studied with the use of dental casts during the time of full deciduous dentition (3 to 4 years of age), mixed dentition (8 to 9 years of age), and permanent dentition (12 years of age). The major findings were: (1) all maxillary interdental widths and lengths were significantly smaller than the normal dimensions at all ages, except for intermolar width at age 12 years; and (2) the mandibular arch dimensions seemed to be related to changes in the maxillary arch; however, the influence of surgical procedures in the maxillary arch is not reflected severely in mandibular arch dental position.     

Secondary alveolar bone grafting in cleft lip and palate patients

The case records of 72 patients in Northern Ireland who had secondary bone grafting of 94 alveolar clefts between 1987 and 1997 were examined. Details were recorded of age, sex, laterality of cleft, preoperative orthodontic treatment, whether grafting was combined with soft tissue revision, method of harvesting the graft, complications, eruption of canines, and the success of grafting as established by bone levels around the erupted canine.Bone levels were assessed on a four-point scale. Of 64 canines fully erupted in 94 clefts, 91% achieved bone levels of Type I or II and only two grafts failed. The outcome was more favourable when the canine was unerupted preoperatively.     

Effect of alveolar bone grafting on maxillary growth in unilateral cleft lip and palate patients

This cephalometric study reports the extent to which maxillary growth may be impaired by grafting of alveolar bone during the period of mixed dentition. The analysis is confined to subjects with unilateral cleft lip and palate (UCLP). The craniofacial dimensions of a group of 28 children who underwent grafting before the age of 12 years were compared by t-test to those of a nongrafted group (N = 30) at 9 and 16 years of age. In addition, two multiple-regression analyses were performed, the second on a group of 70 subjects with UCLP who received a bone graft between the ages of 8 and 15 years. The principal finding was that bone grafting, even when performed on those as young as 8 or 9 years, had no adverse effect on anteroposterior or vertical maxillary growth. This may be attributable to postponement of grafting until most anteroposterior and transverse growth of the anterior maxilla had ceased and to the grafted tissue's ability to participate in the vertical development of the alveolar process.     

Stability of maxillary surgical movement in unilateral cleft lip and palate with preceding alveolar bone grafting.

OBJECTIVE: To evaluate the long-term three-dimensional stability of Le Fort I maxillary osteotomy in patients with unilateral cleft lip and palate (CLP) who had preceding alveolar bone grafting. DESIGN: Analysis of prospectively collected data. Setting: University teaching hospital and postgraduate training center. SUBJECTS: Thirty consecutive patients with unilateral cleft lip and palate, who underwent the procedure between 1990 and 1999, satisfied the inclusion criteria and had complete records. There were 9 males and 21 females, with an age range of 14 to 28 years (mean, 18 years), and follow-up range of 12 to 66 months (mean, 62 months). METHODS: Cephalometric and study cast analyses using pre- and postoperative records (3, 6, 12, 24, and 36 months). Evaluation of surgical movement and postsurgical change at all above time intervals was carried out to determine stability of surgical maxillary movement in the horizontal and vertical planes and to identify rotational and transverse relapse. RESULTS: Total relapse of surgical movement was 31% in the horizontal plane and 52% in the vertical plane, as well as 30% rotational. Relapse correlated with extent of surgical movement, and most relapse occurred in the first 6 months after surgery. No significant transverse relapse was documented. CONCLUSION: Alveolar bone grafting prior to osteotomy stabilizes the transverse dimension of the dental arch, but does not improve horizontal, vertical, or rotational relapse, which remains significant. Correlation of relapse with extent of surgical movement does suggest that planned over-correction is a reasonable option.     

The influence of bone grafting age on dental abnormalities and alveolar bone height in patients with unilateral cleft lip and palate

Individuals with total unilateral cleft lip, alveolus and palate, (UCLAP), bone grafted at three different ages were compared with regard to dental abnormalities and alveolar bone height in the cleft area. The primary groups, bone grafted prior to one year of age had fewer supernumerary teeth in the cleft area and a lower frequency of missing and severely malformed central incisors than the other groups. The early secondary group, bone grafted after eruption of the permanent incisors, showed the highest frequency of normal lateral incisors and the most favourable alveolar bone height in the cleft area. The secondary group, bone grafted after eruption of the canines, showed the highest frequency of missing teeth outside the cleft area. Early secondary bone grafting, after eruption of the permanent incisors and before eruption of the canines, seems to be preferable.     

Prediction of outcomes of secondary alveolar bone grafting in children born with unilateral cleft lip and palate

The aim of this cross-sectional clinical outcome study using retrospective data capture of treatment histories was to examine the characteristics of children born with unilateral cleft lip and palate (UCLP) in the United Kingdom (UK) who were not grafted at the appropriate age or who had an unsuccessful secondary alveolar bone graft. The subjects were born with complete non-syndromic UCLP between 1.4.82 and 31.3.84 and were aged between 12.0 years and 14.7 years at the time of data collection under the care of 48 cleft teams. The success of secondary alveolar bone grafting was assessed using a modification of the Bergland index. There were no independent predictors for unmet bone grafting need. The outcome of secondary alveolar bone grafting was assessed for 164 subjects; 90 (55%) had a successful first graft. Non-Caucasian (P = 0.037) and increasing age at grafting (P = 0.007) were risk factors for poor outcome. After adjustment for other risk factors, increased age at grafting was independently associated with having a seriously deficient or failed graft (OR = 1.03; 95% CI 1.01-1.06 P = 0.036). All the non-Caucasians in this sample had an unsatisfactory graft. Increasing age in months at grafting and ethnicity are predictors for poor outcome of secondary alveolar bone grafting in children born with UCLP in the UK.     

Factors influencing changes in maxillary arch dimensions in unilateral cleft lip and palate patients until six months of age.

OBJECTIVE: The objectives of the present study were (1) to investigate whether growth increments until 6 months of age are influenced by particular factors, (2) to analyze whether anterior cleft reduction is dependent on the extent of the cleft width at birth, and (3) to examine the correlation between maxillary measurements at birth and the anterior cleft width at 6 months of age. DESIGN: The study design was prospective and longitudinal. SETTING: Heidelberg University Hospital Interdisciplinary Cleft/Craniofacial Center. PATIENTS AND METHOD: The longitudinal records of 34 patients (24 male and 10 female) with complete unilateral cleft lip, alveolar ridge, and hard and soft palate were included in this study. All patients were treated with the same protocol. All participants were assessed at 0 and 6 months of age. Maxillary plaster casts of the patients were analyzed using a computer-controlled three-dimensional digitizing system. MAIN OUTCOME MEASURE: Maxillary models were measured and compared to putative factors influencing growth. RESULTS: No statistically significant differences were found between maxillary growth changes and increases in weight and length. Similarly, there was no significant interaction between the extent of the alveolar cleft width at birth and its reduction prior to lip closure. In contrast, significant differences of maxillary growth increments could be found between male and female patients. Stepwise regression analysis demonstrated a correlation between maxillary measurements at birth and growth increments. CONCLUSION: The results of the study indicate that gender plays a certain role in growth changes within the first 6 months of age.     

Evaluation of secondary alveolar bone grafting outcomes performed after canine eruption in complete unilateral cleft lip and palate

Clinical Oral Investigations - Evaluate the results of secondary alveolar bone grafting (SABG) in patients with complete unilateral cleft lip and palate (UCLP), operated after permanent canine...     

Maxillofacial morphology in post-pubertal patients with unilateral cleft lip and palate following early vs. late secondary alveolar bone grafting

The study aimed at comparing maxillofacial morphology and burden of surgical treatment in post-pubertal patients with unilateral cleft lip and palate (UCLP) following early vs. late secondary alveolar bone grafting (SABG).In this retrospective study maxillofacial morphology was assessed on lateral cephalograms of skeletally matured patients with UCLP operated on consecutively in one center by the same method of one-stage primary cleft repair followed by SABG. Cephalometric analysis comprised 8 angular and 7 linear measurements. Maxillary growth restriction was evaluated by measuring SNA angle and Co-A and PNS-A distances. Five linear regression models with SNA, SNB, ANB, Co-A, and MP/SN as dependent variables and age at primary cleft repair, age at SABG, age at taking cephalogram, surgeon, and total number of surgical interventions as independent variables were also created.135 patients were included in the study - 70 patients (47 males and 23 females) had early SABG (E-SABG group) and 65 patients (40 males and 25 females) had late SABG (L-SABG group). Mean age at bone grafting procedure was 2.7 years (range 1.5–5.9, SD 1.1) and 10.3 years (range 6.1–18.8, SD 3.2) in E-SABG and LSABG group respectively. The variables describing the degree of maxillary growth restriction – SNA, Co-A, and PNS-A – were comparable in both groups (p = 0.707, 0.116, and 0.932, respectively). Regression models demonstrated that independent variables were not associated with the values of SNA angle, SNB angle, ANB angle, MP/SN angle, and Co-A distance (p = 0.761, 0.088, 0.249, 0.380, and 0.363, respectively). The percentages of oronasal fistula repair, VPI repair, repeated SABG, upper lip correction, rhinoplasty, orthognathic surgery were 22.9, 7.1, 15.7, 24.3, 42.9, 2.9 in E-SABG group and 27.7, 7.7, 9.2, 36.9, 47.7, 3.1 in L-SABG group respectively. Mean number of all surgical interventions was 3.2 in E-SABG and 3.4 in L-SABG group, respectively (p = 0.271).Considering the comparable maxillofacial morphology and burden of surgical care in matured patients after early and late SABG, the choice of timing of bone grafting surgery could be left to the discretion of the surgeon.     

Outcome of bone grafting in relation to cleft width in unilateral cleft lip and palate patients

OBJECTIVE: The purpose of this study was to determine the relationship between cleft width and the residual amount of bone after bone grafting in 53 unilateral cleft lip and palate patients. STUDY DESIGN: The fate of the bone graft was determined by the residual amount of bone calculated from computed tomography scans taken immediately after surgery and 1 year postoperatively. Initial cleft width was measured on the computed tomography scans taken immediately after bone grafting. RESULTS: An average cleft width of 6.4 mm (range 3.0-12.2 mm) was found. The average amount of residual bone in the cleft area after 1 year was 64% of the initial bone graft. Linear regression analysis showed that a significant correlation (r = -0.29, P =.04) was found for cleft width in relation to the percentage of residual bone after 1 year. CONCLUSION: The regression analysis indicates that a relation between cleft width and the fate of the bone graft exists. Bone grafts in wider clefts are more prone to resorption than those in more narrow ones.     

牙槽突裂植骨术后鼻外形的改变

目的：通过比较单侧牙槽突裂植骨手术前后鼻外形的变化,评价牙槽突裂植骨术在鼻畸形矫治中的作用。方法：通过人体学测量25例单侧牙槽突裂患者术前、术后即刻及随访6个月的外鼻形态,主要测量指标为健、患侧鼻孔宽度和高度,鼻翼基底宽度及两侧鼻翼基底连线与内眦连线的夹角,应用SPSS18.0软件包,对测得的数据进行配对t检验。结果：25例患者行牙槽突裂植骨手术后患侧鼻孔宽度为（11.61±2.18）mm,大于术前的（10.28±1.83）mm;高度为（4.52±1.19）mm,小于术前的（5.81±1.18）mm;患侧鼻翼基底均高于术前,与术前相比有显著差异（P〈0.01）。随访6个月后,虽形态有向术前回复的倾向,与术前相比仍有显著差异（P〈0.01）。结论：牙槽突裂植骨术后鼻翼基底的变化是植骨成功与否的一个重要指标,适量的超充填可弥补术后骨质吸收,为以后的鼻畸形整复提供一个对称的基底。牙槽突裂植骨后,鼻孔宽度和高度均有变化,故不主张在牙槽突裂植骨同期或之前行鼻畸形整复术。     

Transpalatal distraction osteogenesis prior to alveolar bone grafting in cleft lip and palate patients

Alveolar bone grafting is a standard method for treating alveolar cleft. To ensure the best outcome, improving the arch form as well as soft tissue quality in the area around the cleft is recommended. In this study, 11 patients who presented with alveolar cleft and collapsed maxillary arch were treated in the following sequence: transpalatal distraction osteogenesis followed by soft tissue surgery in some cases and by cancellous bone graft. In all cases, transpalatal distraction osteogenesis successfully corrected the transverse maxillary deficiency. One case showed a complete loss of the bone graft. Other minor complications were reported but they did not affect the final outcome.     

Early assessment of dental arch development in repaired unilateral cleft lip and unilateral cleft lip and palate versus controls.

OBJECTIVE: To evaluate dental arch relationships and dimensions, relative to an age matched noncleft sample, in Caucasian 3-year-old children with repaired unilateral cleft lip (UCL) or unilateral cleft lip and palate (UCLP). DESIGN: Prospective, cross-sectional, case-control study performed in Scotland, U.K. PARTICIPANTS: Eleven children with repaired unilateral cleft lip, 16 children with repaired unilateral cleft lip and palate, and 78 children as controls. MAIN OUTCOME MEASURES: Dental arch relationships and linear arch dimensions. RESULTS: Prevalence of Class III incisor relationship was 31.3% in children with unilateral cleft lip and palate compared with 9.1% in children with unilateral cleft lip. A buccal crossbite was present in 36% of children with unilateral cleft lip, compared with 75.6% of children with unilateral cleft lip and palate.Mean linear maxillary arch dimensions did not differ significantly between children with unilateral cleft lip and the controls. Except for second intermolar width, statistically significant differences existed in mean linear maxillary arch dimensions between the unilateral cleft lip and the unilateral cleft lip and palate groups; the mean linear maxillary arch dimensions were significantly greater in the control group than in the unilateral cleft lip and palate group. The mean cleft-affected anterior quadrant length appeared to be the arch dimension with the greatest power of discrimination among the three groups. There were no significant differences in mean linear mandibular arch dimensions among the three groups. CONCLUSIONS: Anterior crossbite was almost three times more common in the unilateral cleft lip and palate group than in the unilateral cleft lip group. Mean linear maxillary arch dimensions differed significantly between the unilateral cleft lip and palate group and the control group. There were no significant differences in mean linear maxillary arch dimensions between unilateral cleft lip and controls or between mean linear mandibular arch dimensions for unilateral cleft lip, unilateral cleft lip and palate, and controls.     

双侧完全性唇腭裂患者的同期腭裂修复与齿槽嵴裂植骨

目的　分析 8岁以上双侧完全性腭裂患者同期行腭裂修复与齿槽嵴裂植骨的可行性及植骨效果。方法　对 15例同期行腭裂修复与齿槽嵴裂植骨的双侧完全性唇腭裂患者作回顾性研究。分析手术时间、术中出血、术后恢复和创口愈合情况。对术后随访的X线片进行植骨效果的客观评价。结果　所有手术均顺利完成 ,平均手术时间延长 5 2分钟 ,没有明显增加术中出血量 ,患者术后恢复好 ,无创口感染和植入骨暴露 ,植骨的临床成功率为 83.3% ,其中以 8～ 11岁组的成功率最高 (93.8% )。结论　双侧完全性腭裂患者的同期腭裂修复和齿槽嵴裂植骨是安全和可行的 ;对于 8岁以上的腭裂未修复的双侧完全性唇腭裂患者 ,均应同期完成腭裂修复与齿槽嵴裂植骨 ;双侧齿槽嵴裂同期植骨的最佳手术时间与二期植骨相同 ,为尖牙萌出前 ,年龄在 8～ 11岁之间。     

单侧唇裂结合单纯牙槽突裂二期牙槽植骨与正畸治疗

目的评价单侧唇裂合并单纯牙槽突裂二期牙槽突植骨的长期疗效.方法40例单侧唇裂合并单纯牙槽突裂患者(19男,21女),手术进行时患者的平均年龄为13.8岁,年龄范围8至33岁.根据牙槽植骨手术时裂隙尖牙萌出与否将患者分为尖牙萌出组和尖牙未萌出组尖牙萌出组24例;尖牙未萌出组16例.骨瓣材料采用髂骨松质骨.术前及术后拍摄上颌前部咬合片,术后观察期为1至8年,平均2.4年.以Bergland标准评价裂隙部位的牙槽骨高度.结果尖牙萌出组牙槽突植骨的临床成功率为96%;尖牙未萌出组牙槽突植骨的临床成功率为94%.两组成功率没有显著性差异.结论单侧唇裂合并单纯牙槽突裂患者二期牙槽植骨的疗效很好,尖牙萌出与否不是影响单侧唇裂合并单纯牙槽突裂患者牙槽突植骨临床成功率的主要因素.