肥大细胞在幽门螺杆菌相关性胃炎中的作用

目的探讨肥大细胞（MC）在幽门螺杆菌（Hp）相关性胃炎中的作用。方法选择200例行胃镜检查的慢性胃炎患者,取胃窦黏膜分别行组织病理学HE染色及Hp检查（快速尿素酶、改良Giemsa染色）、改良甲苯胺兰染色,分别计算黏膜及黏膜下的完整和脱颗粒MC数。结果MC计数在Hp阳性和Hp阴性组间无统计学差异（P〉0．05）。但前者黏膜内MC脱颗粒者明显多于后者（P〈0．01）;MC计数在活动性炎症组显著高于非活动性炎症组（P〈0．01）。结论MC可能在Hp相关性胃炎的发生发展中起重要作用。     

肥大细胞在幽门螺杆菌相关性胃炎中的作用

幽门螺杆菌(Hp)在慢性胃炎,特别是在慢性活动性胃炎中的作用已经得到公认.但Hp的致病机制仍未明确,有些学者认为肥大细胞(MC)可能参与了Hp的致病过程.本文通过对慢性胃炎黏膜MC的观察,探讨MC在Hp相关性胃炎中的作用.     

幽门螺杆菌感染与胃炎癌变相关性研究

我院地处秦巴山区之间，从胃镜开诊以来十五年的统计资料显示，除单纯性浅表性胃炎以外．胃镜检出阳性率仍在37％-51％之间。我们选择胃癌、慢性萎缩性胃炎、上消化道溃疡病例进行Hp试纸测定，以探讨Hp感染与以上三种疾病的关系。     

幽门螺杆菌感染相关胃炎

幽门螺杆菌感染相关胃炎陈希陶幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，Ｈｐ）感染人体胃粘膜后，引起胃及十二指肠粘膜炎症。Ｈｐ感染引起的胃炎是发病率最高的消化道疾病，在世界某些地区及发展中国家的人群中发病率尤高。西方某些发达国家的５０岁以上人群...     

中医治疗幽门螺杆菌相关性胃炎的临床研究

[目的]讨论分析中医综合方法预防和治疗幽门螺杆菌相关性胃炎的临床效果.[方法]将2012年10月～2014年3月于我院就诊的100例幽门螺杆菌相关性胃炎患者随机均分成对照组和治疗组.对照组患者服用奥美拉唑钠肠溶胶囊、阿奠西林胶囊和克拉霉素分散片治疗;治疗组采用中医综合方法,包括：健康宣教、情志疏导、体质辨识和辨证论治相结合,服用中药汤剂予以预防和治疗,比较2组患者的临床疗效.[结果]治疗组50例患者治疗后出现胃脘痛、灼热、泛酸、饱胀及嗳气的比率显著低于对照组,差异有统计学意义（P＜0.05）;治疗组的总显效率76％,显著高于对照组的总显效率40％,差异有统计学意义（P＜0.05）.[结论]中医可有效预防幽门螺杆菌胃炎的发生,明显改善患者各临床症状,治疗幽门螺杆菌相关性胃炎效果显著.     

肥大细胞脱颗粒在幽门螺杆菌致病中的作用

目的 研究肥大细胞（MC）在幽门螺杆菌（H pylori)发病中的作用。方法 选胃镜检查者87例，其中诊断十二指肠溃疡（DU）33例，浅表性胃炎45例，糜烂性胃炎9例。取胃窦、体部活检分别作组织病理学（HE染色）及H pylori检查（快速尿素酶、培养及Warthin-Starry银染），免疫组织化学染色（ABC法）后分别计算粘膜及粘膜下的完整和脱颗粒MC数。结果 MC计数在H pylori阳性和H pylori阴性组间无明显差别（P＞0．05），但前者粘膜内MC脱颗粒者明显多于后者（分别为43％和23％，P＜0．01）。MC计数与粘膜炎症程度无明显关系，但在活动性炎症时显著高于非活动性炎症组（P＜0．05）。各病变组间MC计数也无显著差异。结论 MC可能在粘膜H pylori相关炎症的发生发展中起着重要作用。     

幽门螺杆菌与胃炎

幽门螺杆菌与胃炎潘占荣贵州省凯里市黔东南州人民医院内科５５６０００ＳｕｂｊｅｃｔｈｅａｄｉｎｇｓＧａｓｔｒｉｔｉｓ／ｍｉｃｒｏｂｉｏｌｏｇｙＨｅｌｉｃｏｂａｃｔｅｒｉｎｆｅｃｔｉｏｎｓ／ｃｏｍｐｌｉｃａｔｉｏｎｓＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒ...     

胃液氨含量与幽门螺杆菌相关性胃炎炎症程度的关系

为了探讨胃液氨含量与幽门螺杆菌（Ｈｐ）相关性胃炎炎症程度的关系，对３９例Ｈｐ（＋）及２３例Ｈｐ（－）慢性胃炎患者胃液氨含量进行测定，同时对其胃窦粘膜的炎症程度用中性粒细胞（ＰＭＮ）及单个核细胞（ＭＮ）计数方法予以评价，研究发现，Ｈｐ（＋）胃炎组胃液氨含量（８４．１０±３３．０７ｍｇ／Ｌ）显著高于Ｈｐ（－）胃炎组（２２．５９±１３．１２ｍｇ／Ｌ）（Ｐ〈０．０１），ＰＭＮ及ＭＮ计数在Ｈｐ（＋）胃炎组显     

海尔曼螺杆菌与幽门螺杆菌相关性胃炎的临床病理特征

目的:分析海尔曼螺杆菌(Helicobacter heilmannii,H.heilmannii)相关性胃炎与幽门螺杆菌(Helicobacter pylori,H.pylori)相关性胃炎的胃镜及组织病理学差异.方法:回顾性分析2003-01/2010-01于北京大学第三医院行胃镜及病理检查的53559例病例的相关资料.对H.heilmannii相关性胃炎与H.pylori相关性胃炎在内镜所见、炎症浸润、癌前病变的等方面进行对比分析.结果:H.heilmannii感染病例的检出率为0.1%(46/53559);与H.pylori相关性胃炎相比,H.heilmannii相关性胃炎病例中螺旋杆菌定植量较少(P<0.001),胃黏膜急、慢性炎症程度轻(P<0.001),内镜下溃疡性病变更为少见(P=0.021).此外,两组病例中胃黏膜萎缩、肠上皮化生及上皮内瘤变的检出率及病变程度均无显著性差异.相关分析显示H.heilmannii相关性胃炎病例中细菌定植量仅与胃黏膜急性炎症细胞浸润程度相关(P=0.02).报道1例伴发H.heilmannii感染的胃印戒细胞癌病例.结论:H.heilmannii相关性胃炎非常少见且其炎症反应较轻,但是其癌前病变的检出率及病变程度与H.pylori相关性胃炎相比未见显著性差异,表明H.heilmannii在胃恶性相关性病变的发生过程中可能发挥与H.pylori相似的作用.     

幽门螺杆菌相关性胃炎的病理特征

萎缩性胃炎则一般被认为是胃癌发生的最危险因素之一，为了进一步了解Hp与不同类型的胃炎之间的关系，我们对1165例Hp阳性及1403例Hp阴性慢性胃炎患从胃粘膜病理方面进行系统的分析。     

ENDOSCOPIC IDENTIFICATION OF HELICOBACTER PYLORI GASTRITIS IN CHILDREN

Aim: The role of endoscopic findings in deciding whether to biopsy the gastric mucosa of children remains unclear. The present study attempted, for the first time, to identify the value of endoscopic features for diagnosis of Helicobacter pylori (Hp) infection in children. Methods: Hp status of consecutive children receiving esophagogastroduodenoscopy (EGD) was established by combinations of histology, ¹³C‐urea breath test, and serum Hp immunoglobulin (Ig)G antibody. After routine EGD using a conventional endoscope, the presence of RAC (regular arrangement of collecting venules) was scored by close observation, which was carried out at two sites of lower corpus lesser curvature and upper corpus greater curvature. RAC‐positive was defined as the presence of minute red points in a regular pattern. Antral nodularity was also scored as present/absent. Results: Eighty‐seven consecutive children (38 boys, median age 13 years, range 9–15 years) were evaluated; 25 (29%) were Hp positive. Antral nodularity was seen in 21 (84%) all of whom were Hp positive. The RAC‐negative pattern based on examination of the upper and lower corpus yielded a sensitivity, specificity, positive predictive value and negative predictive value for the presence of Hp infection of 100%, 90%, 81%, and 100%. Magnifying endoscopy confirmed that the RAC pattern corresponded to collecting venules in the gastric corpus. Conclusions: The absence of RAC pattern suggests that gastric mucosa biopsies should be taken despite otherwise normal‐appearing gastric mucosa for the diagnosis of Hp infection in children.     

幽门螺杆菌相关性胃炎中的非典型增生

本文分析６１５例幽门螺杆菌相关性胃炎及３８５例幽门螺杆菌非相关性胃炎。结果表明两者在非典型增生、肠上皮化生以及相关病变之间具有显著性差异（Ｐ＜０．０１）。据此结果，作者认为幽门螺杆菌的感染是胃粘膜非典型增生及肠上皮化生的危险因素之一。     

用支气管镜诊断免疫缺陷合并肺感染性疾病进展

用支气管镜诊断免疫缺陷合并肺感染性疾病进展任少华综述　胡华成审校免疫缺陷患者极易发生各种肺部感染，积极防治这些肺部并发症能够提高患者的生存期。纤维支气管镜（ＦＯＢ）是检查各种肺部感染性疾病的重要工具之一。本文就ＦＯＢ在诊断免疫缺陷患者肺部感染方面的应...     

ISOLATED GRANULOMATOUS GASTRITIS SHOWING DISCOLORATION OF LESIONS AFTER HELICOBACTER PYLORI ERADICATION

We report a case of isolated granulomatous gastritis (IGG) with a submucosal tumor and multiple ulcer scars which showed discoloration after Helicobacter pylori (Hp) eradication. Furthermore, other discolored areas were newly observed after Hp eradication in the present case. Although IGG is extremely rare, the relation between IGG and Hp infection has attracted recent attention, and some case reports of IGG with Hp eradication have appeared in the literature. Discoloration after Hp eradication, however, has never been noted in any case reports and, therefore, this feature made the present case clinically interesting.     

口腔牙菌斑中的幽门螺杆菌

报道用快速尿素酶法、免疫荧光染色和细菌培养法及电镜观察检测４０例消化性溃疡、慢性胃炎和胃癌患者牙菌斑中的幽门螺杆菌（Ｈｐ），同时从胃粘膜活检做嗜银染色（ＷＳ）和尿素酶试验检测Ｈｐ。结果发现，多数患者的牙菌斑中可能有大量Ｈｐ存在，牙菌斑中的Ｈｐ形态、生化特性和免疫学特性、培养条件均与胃粘膜Ｈｐ相似，说明牙菌斑中很可能有Ｈｐ寄生，它与胃粘膜Ｈｐ可能相同。     

幽门螺杆菌相关性胃炎内镜随访研究

为了解Ｈｐ长期感染是否促进胃粘膜萎缩、肠上皮化生和异型增生的形成与发展，对首次胃镜检查诊断为慢性胃炎而不伴有肠化生和异型增生的１２０例Ｈｐ阳性患者和８７例Ｈｐ阴性患者进行内镜随访。随访时间３～８年，平均４．８年，随访次数２－１０次，活检组织进行Ｈｐ检查、病理学检查和ＡｇＮＯＲｓ，银染及ＰＣＮＡ免疫组化染色。结果Ｈｐ阳性患者其慢性萎缩性胃炎、肠化生、Ⅲ型肠化生和异型增生的发生率显著高于Ｈｐ阴性患者，Ｈｐ阳性胃粘膜ＰＣＨＡ标记指教和ＡｇＮＯＲｓ数也显著高于Ｈｐ阴性胃粘膜。表明Ｈｐ感染可能通过刺激胃粘膜细胞的过度增殖、更新加快，促进萎缩性胃炎和肠化生的形成与发展，从而增加患胃癌的危险性。     

幽门螺杆菌相关性胃炎内镜随访研究

为了解Ｈｐ长期感染是否促进胃粘膜萎缩、肠上皮化生和异型增生的形成与发展，对首次胃镜检查诊断为慢性胃炎而不伴有肠化生和异型增生的１２０例Ｈｐ阳性患者和８７例Ｈｐ阴性患者进行内镜随访。随访时间３～８年，平均４．８年，随访次数２～１０次，活检组织进行Ｈｐ检查、病理学检查和ＡｇＮＯＲｓ，银染及ＰＣＮＡ免疫组化染色。结果Ｈｐ阳性患者其慢性萎缩性胃炎、肠化生、Ⅲ型肠化生和异型增生的发生率显著高于Ｈｐ阴性患者，Ｈｐ阳性胃粘膜ＰＣＮＡ标记指数和ＡｇＮＯＲｓ数也显著高于Ｈｐ阴性胃粘膜。表明Ｈｐ感染可能通过刺激胃粘膜细胞的过度增殖、更新加快，促进萎缩性胃炎和肠化生的形成与发展，从而增加患胃癌的危险性。     

儿童幽门螺杆菌感染与上胃肠道疾病

我们对153例因胃肠道症状接受胃镜检查的连续患儿进行前瞻性活检组织学、尿素酶试验及血清学检查,探讨幽门螺杆菌(HP)感染和上胃肠道疾病关系,并和成人及健康儿童对照。结果显示,消化性溃疡患儿HP感染率15/22(68％),明显高于功能性消化不良29/130(22％),而后者和健康儿童62/181(34％)无显著差异,提示HP和消化性溃疡相关,但与症状无关。儿童HP相关性胃炎内镜无特异性征象,组织学多集中在胃窦部,炎症细胞浸润和活动较明显。     

NODULAR GASTRITIS WITH HELICOBACTER PYLORI INFECTION IS STRONGLY ASSOCIATED WITH DIFFUSE‐TYPE GASTRIC CANCER IN YOUNG PATIENTS

Background: Nodular gastritis (NG), a particular type of gastritis, is now defined as antral nodularity. Recent studies have shown that NG is strongly associated with Helicobacter pylori infection, and we recently showed that it may be associated with diffuse‐type gastric cancer of the corpus. We retrospectively investigated the relation between NG and gastric cancer in patients aged 29 years or less. Patients and Methods: The study group comprised 150 patients (48 males, 102 females; mean age, 27.7 years) who were endoscopically diagnosed with NG and were less than 29 years of age; 3939 sex‐ and age‐matched patients without NG who were H. pylori‐positive served as the control group (1184 males, 2755 females; mean age, 27.5 years). We estimated the risk of gastric cancer development in patients with NG relative to that of patients without NG. Results: The prevalence of gastric cancer was significantly higher in patients with NG than in the control patients (7/150; 4.7% vs 3/3939; 0.08%, P < 0.001). The odds ratio for the risk of gastric cancer in patients with NG was found to be 64.2 (95% confidence interval; 16.4–250.9). The seven cases of gastric cancer with NG showed the same characteristics: all were diagnosed histologically as the diffuse type and were located in the corpus with H. pylori infection. Conclusion: NG with H. pylori infection is strongly associated with diffuse‐type gastric cancer of the corpus in young patients.