Renal scintigraphy in children with urinary tract infections

BACKGROUND/AIM: To determine the incidence of abnormal Technetium Tc 99m Dimercaptosuccinic Acid (Tc99m DMSA) renal scintigraphy findings in the children with urinary tract infection (UTI), and to evaluate the difference between the children with UTI and vesico-ureteral reflux (VUR), and the children with UTI without VUR. METHODS: Tc99m DMSA renal scintigraphy was performed in 170 children with UTI, mean age 7.07 years (1 month to 14 years, 137 were girls and 33 were boys). In 88 of the children, VUR was proved by micturating cystouretherography (MCU), while in 82 VUR could not be detected by MCU. VUR was graded in accordance with MCU recommended by the intemational study of VUR. In 13 of the children the grade of VUR was grade I, in 30 was grade II, in 23 grade III, in 17 grade IV, while the grade V was in 5 of the children. Findings of Tc99m DMSA renal scintigraphy were classified as: 1--normal, 2--probably normal, 3--equivocal, 4--probably abnormal, and 5--abnormal. The degree of the significance of the difference of the findings was estimated using chi2, taking p < 0.01 as the limit of statistical significance. RESULTS: Of the total number of 170 studied children, the abnormal findings were detected in 30% (51/170), normal findings in 62% (106/170), and equivocal in 8% (13/170). In the children with UTI and VUR, the incidence of abnormal findings was 49% (43/88), of normal 43% (38/88), and of equivocal findings 8% (7/88). All the children with VUR grade V had the abnormal findings (the incidence of the abnormal findings was 100%). In the children with VUR grade IV, the abnormal findings were 71%. In the children with VUR grade I, 77% of the findings were normal, in the children with VUR grade II 53% of the findings were normal and in the children with VUR grade III, 30% otfthe findings of renal scintigraphy were normal. In the children with UTI without VUR, the incidence of abnormal findings was 10% (8/82), of normal findings 83% (68/82), and of equivocal findings 7% (6/82). The incidence of abnormal findings was significantly higher in the children with UTI and VUR than in those with UTI without VUR (p < 0.01). Also, the incidence of the abnormal findings was higher in the children with VUR grades IV and V than in the children with VUR grade I (p < 0.01). CONCLUSION: DMSA renal scintigraphy in the children with ITU revealed the abnormal findings in 30% of the cases. The incidence of the abnormallfindings was signficantly higher when VUR was present, as well as if the grade of VUR was higher. Our results confirmed that Tc99m DMSA renal scintigraphy was a very important technique in the evaluation of the children with ITU.     

Recurrent urinary tract infections in infants and children.

Urinary tract infection is the most common abnormality found in the urinary tract of children, and it is as dangerous as it is common. The infections usually commence in infancy, especially in neonates. Of special interest to the radiologist is the fact that radiologic examination is the only way to assess damage to the kidneys and to determine the long term risk to the child.     

Technetium-99m-dimercaptosuccinic acid renal scintigraphy in children with urinary tract infections

The aim of this study was to determine the incidence of abnormal dimercaptosuccinic acid-Tc-99m ((99m)Tc-DMSA) renal scintigraphy findings in children with culture proved urinary tract infection (UTI) with or without vesicoureteral reflux (VUR). (99m)Tc-DMSA renal scintigraphy was performed in 343 children with culture documented UTI (247 girls and 96 boys) aged from three months to 14 years (middle age of 4.82 years). The children studied were all those submitted for renal scintiscan to the Institute of Nuclear Medicine, Military Medical Academy, Belgrade during a five-year period (2000-2004). Micturating cystoureterography (MCU) performed in all patients before (99m)Tc-DMSA scan, revealed VUR in 213 children, while in 130 children VUR was not detected by MCU. In 15 of the 213 children the grade of VUR was I, in 88 was II, in 57 was III, in 33 was IV and 20 children had grade V of VUR. Findings of (99m)Tc-DMSA renal scintigraphy were classified as: normal, equivocal and abnormal. Statistical analysis was performed using c(2)test. In all patients abnormal findings were detected in 38% (131/343), normal in 51% (174/343) and equivocal findings in 11% (38/343). In children with UTI and VUR the incidence of abnormal findings was 53% (112/213), of normal 37% (80/213) and of equivocal findings 10% (21/213). In children with UTI without VUR the incidence of abnormal findings was 15% (19/130), of normal findings 72% (94/130), and of equivocal findings 13% (17/130). The incidence of abnormal findings was significantly higher in children with UTI and VUR than in those with UTI without VUR (P<0.001). In children with VUR grades I, II, III, IV and V abnormal findings were 33%, 32%, 60%, 79% and 95% respectively. The incidence of abnormal findings was higher in children with VUR grades IV and V, than in grade I and II (P<0.001). Our results suggest that (99m)Tc-DMSA renal scintigraphy in children can discriminate between grade I-II and IV-V of VUR and also that in children with UTI and VUR abnormal findings in the scintiscan were more than three times higher than in children with UTI alone.     

Artificial urinary sphincters. Radiographic evaluation

A small selected group of patients with urinary incontinence can be treated effectively with an artificial urinary sphincter. Since the fluid in the hydraulic system of this device is radiopaque, radiography is useful in its evaluation. An immediate postoperative radiogram should be performed to control the position and integrity of the system. It also serves as a useful baseline study in case of later complications. It should include radiograms both in the deactivated and activated state. A few cases of tube kinking may be overlooked when exposures in only one projection are used. Experience with 110 implanted sphincters is presented.     

Urinary tract infections in children: renal ultrasound evaluation

Ultrasound may replace urography in screening pediatric patients with uncomplicated urinary tract infections but without vesicoureteral reflux. A child undergoing a first radiographic evaluation for urinary tract infection is initially examined by voiding cystourethrography. If reflux is present, urography is performed. If no reflux is present, the kidneys are evaluated by real-time ultrasound; urography may also be performed if the ultrasound examination is abnormal, equivocal, or inadequate. A total of 192 patients was evaluated with this protocol; 146 (76%) had no reflux and therefore were examined with ultrasound. One patient was found to have hydronephrosis and underwent surgical correction. This group of patients was compared with a similar group of 223 patients without reflux who were evaluated by urography prior to the institution of the ultrasound protocol; there was no significant difference between the two groups in upper urinary tract findings that influenced patient management.     

Radiographic manifestations of congenital anomalies of the lower urinary tract

The evaluation of anomalies of the lower urinary tract (ureter, bladder, and urethra) requires high quality ultrasonography, voiding cystourethrography, and, occasionally, intravenous urography and contrast sinography. Infants with these anomalies present because of abnormal intrauterine ultrasonographic examinations, urinary tract infections, or obvious external malformations. With a solid embryologic knowledge of the development of the lower urinary tract the radiologist can tailor the imaging procedures to demonstrate almost all aspects of the anomaly and the presence or absence of frequently associated malformations.     

Traumatic lesions of the urinary tract. Radiographic aspects]

Techniques of radiology of use in the study of traumatic lesions of the urinary apparatus are discussed and 14 cases are reported in detail.     

Radiographic evaluation of children and adolescents with a spinal deformity

Accurate and reproducible measurement of radiographs of children and adolescents with spinal deformities by radiologists is important. It provides useful information for treating physicians. Standing posteroanterior (PA) and lateral radiographs of the entire spine are the preferred views. Common radiographic measurements include the Cobb angle for curve magnitude, the center sacral line for trunk shift, and the Risser sign for maturity. A vocabulary of standard spinal deformity terminology is presented to be utilized on radiographic reports to improve communication. Correctly measuring spinal deformity and determining skeletal maturity enables the treating physician to evaluate the status of their patients' deformity, determine if treatment is necessary, and assess the stability of the spine during orthotic treatment and after surgery.     

Resistance of catheter-associated urinary tract infections to antibacterials

INTRODUCTION: Catheter-associated urinary tract infections (CAUTI) are the most common nosocomial infections. The worldwide data show the increasing resistance to conventional antibiotics among urinary tract pathogens. AIM: To evaluate the adequacy of initial antimicrobial therapy in relation to the antimicrobial resistance of pathogens responsible for CAUTI in Clinical Center of Banja Luka. METHODS: A retrospective study on major causes of CAUTI, antibiotic resistance and treatment principles was conducted at four departments of the Clinical Center of Banja Luka from January 1st, 2000 to April 1st, 2003. RESULTS: The results showed that 265 patients had developed CAUTI. The seven most commonly isolated microorganisms were, in descending order: E. coil (31.0%), Pseudomonas aeruginosa (13.8%), Proteus mirabilis (12.9%), Gr. Klebsiella-Enterobacter (12.3%), Enterococcus spp. (5.2%), Pseudomonas spp. (4.3%), Serratia spp. (4.0%). The most common pathogens were highly resistant to ampicillin (64-100%), gentamycin (63-100%), and trimethoprim-sulfamethoxazole (68-100%), while some bacterias, like Pseudomonas aeruginosa and Serratia spp. showed rates of ciprofloxacin resistance as high as 42.8% and 72.7%, respectively. In 55.5% of the cases, the initial antibiotic therapy was inadequate, and was corrected latter on. There were no standard therapeutic protocols for this type of nosocomial infections. CONCLUSION: The results of this study emphasized an urgency of the prevention and introduction of clinical protocols for better management of CAUTI. Treatment principles should better correspond to the antibiotic sensitivity of uropathogens.     

The dilated urinary tract in children

Dilatation of the urinary tract is detected in a number of settings throughout childhood. Children may be asymptomatic or present with urinary tract infection, hematuria, or voiding symptoms. Evaluation of the affected urinary tract may require standard radiographic techniques (VCUG, EU) complemented by ultrasound and nuclear medicine studies. The goal of imaging is to differentiate hydronephrosis (HN) from hydroureteronephrosis (HUN) and to provide the correct diagnosis so that appropriate treatment can be given. This article reviews and demonstrates the findings in some common and uncommon causes of HN and HUN.     

Influence of vesicoureteral reflux and urinary tract infection on renal growth in children with upper urinary tract duplication

The growth of the renal parenchyma was examined in children with duplicated outflow systems, vesicoureteral reflux (VUR), urinary tract infection (UTI) and no sign of obstruction. Ten patients with reflux occurring only in the caudal system (group A) and 4 patients with reflux both to the caudal and the apical system (group B) were studied shortly after their first UTI (study 1) and then 1.5 to 9 years later (study 2). The frequency of UTI was relatively high during the follow-up period. At urography, renal length and renal area were normal in group A in studies 1 and 2. Parenchymal thickness of the apical pole (APT/L) did not differ from normal values in any of the studies. Parenchymal thickness of the caudal pole (CPT/L) was significantly smaller than normal in both studies. There was also a significant decrease in CPT/L between study 1 and 2. UTI during the first year of life was associated with a greater reduction in CPT/L. The determination of renal length and renal area in children with a duplicated ureter, VUR and UTI, does not identify subjects at risk of developing renal growth retardation while serial determinations of parenchymal thickness appear to be an appropriate method.