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Identification of promoter elements responsible for regulation of gene expression has been hampered by the AT richness of
P. falciparum intergenic regions. Nested deletions of histidine-rich protein 3 (hrp3) promoter suggested the presence of a multipartite ring-specific element. Linker scanning (LS) of this ring-specific promoter
showed that the alteration of several promoter regions decreased the luciferase activity compared to the wild-type configuration,
indicating that these regions played a role in gene expression. No homology was observed by comparison of putative regulatory
elements of other genes identified by bioinformatic analysis with the hrp3 enhancer, implying a different mechanism of gene regulation by the hrp3 promoter. LS and deletion analysis of the 5′ untranslated region (UTR) of the hrp3 suggested that this region contains elements which interact with promoter elements to regulate gene expression. Analysis
of the intron in the UTR region suggested that this region does not play a role in stage specificity in the hrp3 promoter. Together, our results indicate the presence of multiple mechanisms of gene regulation in the parasite. 相似文献
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The Potential Roles of Endogenous Retroviruses in Autoimmunity 总被引:7,自引:0,他引:7
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rs2294008T,a risk allele for gastric and gallbladder cancers,suppresses the PSCA promoter by recruiting the transcription factor YY1
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Norihisa Saeki Hiroe Ono Kazuyoshi Yanagihara Kazuhiko Aoyagi Hiroki Sasaki Hiromi Sakamoto Teruhiko Yoshida 《Genes to cells : devoted to molecular & cellular mechanisms》2015,20(5):382-391