Distraction epiphyseolysis. An experimental study for bone lengthening. Part II (author's transl)]

Histological findings of rabbit's tibia after distraction epiphyseolysis within the first days and weeks shown severe disturbances of growth. There is a transformation zone between epiphyseal bone plate and resting cells with early ossification. Furthermore there was a lasting interruption of the perichondral ring, especially with growth disturbance in longitudinal direction of the epiphyseal plate. Comparison to the traumatic epiphyseolysis in children and adolescents are discussed, also the reaction of lasting tension power on epiphyseal plates.     

Distraction epiphyseolysis. An experimental study for bone lengthening. Part I (author's transl)]

Distraction epiphyseolysis is an operation for bone lengthening in children and adolescent which is often performed in Russia. Our experimental examination in rabbits has shown a lot of problems with this method. With distraction epiphyseolysis it is possible to get a primary lengthening of bone and a soon consolidation of the distraction-cleft. During further growth this primary lengthening is going lost. After the end of growth there was no significant difference between operated and non operated bone. The cause of the growth-disturbance is discussed in a further publication guided by histological findings.     

Coagulation problems associated with massive blood transfusions. An experimental study (author's transl)]

During storage banked blood show changes as far as function and concentration of their corpuscular and plasmatic ingredients are concerned. Antihaemophilic globulin (factor VIII) and pro-accelerin (factor V) in particular lose their activities so quickly that only very few activities still remain after a storage period of 3-5 days. In connection with existing primary diseases but also in trauma and shock a dilution-coagulopathy caused by insufficient supply of factors VIII and V can develop during massive transfusion, and this especially with banked blood already stored over a longer period of time. Therapy of this disturbance of coagulation consists of substituting the missing coagulation factors under heparin protection.     

The effects of extreme cold on major blood vessels. An experimental study (author's transl)]

In 10 beagles cryogenic experiments were performed to study the effects of freezing the iliac artery and vein. The histological tissue reaction after cold exposure in major pelvic vessels was early inflammation and followed by a rapidly progressing reparative process. Long-term microscopic changes were proliferations of the vessel intima and focal splitting on the elastic membrane. No evidence of thrombosis, aneurysm fomation and rupture of the vessel was found. Vascular function as a blood conduit was undisturbed.     

Present state of lung transplantation (author's transl)]

Lung allotransplantation is still an experimental method. Immunologic rejection makes it highly lethal in experimental animals as well as in man. Its present state can in no way be compared with renal transplantation in man.