Seasonal dynamics of serotonin in the duodenum of hibernating animals

A correlation is shown between the duodenal content of serotonin in the red-cheeked souslik and the period of hibernation. The serotonin concentration in the tissue is maximal at the beginning of the hypothermia period and minimal at the end of this period. During spontaneous awakening (winter normothermia) the necessary amount of amine is produced. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 11, pp. 511–513, November, 1994 Presented by Yu. P. Borodin, Member of the Russian Academy of Medical Sciences     

Reaction of mouse ovary to opioid receptor block during early postnatal ontogenesis

Prolonged administration of naloxone (5 mg/kg body weight) during the juvenile period stimulated ovarian folliculogenesis and pubescence in mice; the effect was absent in animals of other ages, when a single injection was given, or when the dose of preparation was decreased. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 3, pp. 341–344, March, 1996 Presented by O. V. Volkova, Member of the Russian Academy of Medical Sciences     

Correlation of prolactin concentration with levels of other hormones and with ultrastructural morphometric parameters of the testes in the human fetus

Consideration is given to the correlations between variations of the prolactin concentration and other hormonal parameters in the human embryonic period. The interrelation between the prolactin concentration and ultrastructural parameters of the testes is also traced. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 6, pp. 654–656, June, 1995 Presented by O. V. Volkova, Member of the Russian Academy of Medical Sciences     

Seasonal patterns of epithelium mitotic activity in the duodenum of two representatives of the sciuridae with different ecological specialization

A marked seasonal dynamics of the mitotic activity of duodenal epithelium is shown in hibernating red-cheek sousliks (Citellus erythrogenys). These seasonal variations are absent inSciurus carolinensis, a closely related nonhibernating species. During hibernation, the mitotic index of souslik epitheliocytes is lower than during the summer period; however, during periodic spontaneous awakenings, a considerable rise of this index takes place, due to the activation of proliferative processes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 6, pp. 642–643, June, 1995 Presented by V. A. Trufakin, Member of the Russian Academy of Medical Sciences     

The mechanism of pulmonary hypertension in rats with high-altitude hypoxia

Morphofunctional examinations of the lungs of rats exposed to high-altitude conditions for 3 to 300 days revealed that systolic pulmonary hypertension observed during the entire period of study is caused by a total increase of the elastic resistance of pulmonary arteries. Adequate bloodflow in such a case is provided by intensive work of the right-ventricular myocardium against this resistance. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 3, pp. 324–327, March, 1996 Presented by V. A. Trufakin, Member of the Russian Academy of Medical Sciences     

Implication of the hippocampus in the development of a pain syndrome in rats following sciatic nerve damage

Local destruction or electrostimulation of the hippocampus did not affect pain sensitivity thresholds in rats with intact sciatic nerve. In rats with transected sciatic nerve, local hippocampal damage accelerated the development of a pain syndrome considerably, while hippocampal electrostimulation delayed it so that 80% of the test rats did not appear to have been experiencing pain throughout the 45-day observation period. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 8, pp. 120–122, August, 1994     

Development of aseptic inflammation during the adaptation of the organism to high altitude hypoxia

The dynamics of lipid peroxidation and of the aseptic inflammatory process is studied in rats adapted to high altitude hypoxia. A greater activity and shorter duration of the acute period of inflammation are found in these animals, while in the reparative period stimulation of the proliferative processes and slowed formation of the fibroblast capsule are noted. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 9, pp. 243–246, September, 1994 Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences     

Effects of some DSIP peptide analogs on rat sleep for intraventricular infusion

Peptide [D-AIa²]DSIP markedly increases the representation of NREM and REM sleep delayed by several hours from the onset of infusion and lasting after the infusion till the end of the 12-hour night period in a chamber. Peptide [D-Tyr¹]DSIP increases NREM sleep during hours IV and XI of recordings. Analogs of these peptides have no noticeable effects. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 1, pp. 56–58, January, 1994 Presented by I. P. Asnmarin. Member of the Russian Academy of Medical Sciences     

Functional activity of blood mononuclear cells during regeneration of bone tissue

It is established that, during elongation of a segment of the extremity, normal regeneration of the bone tissue is attended by a slight decrease in monocyte adherence during the postoperative period and by an increase of the functional activity of lymphocytes during subsequent activation of osteogenesis. Suppression of the lymphoid apparatus is observed in the case of disturbed osteogenesis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 1117, N ^o 1, pp. 104–105, January, 1994     

Ion transport and its adrenergic regulation in erythrocyte membranes of the breamabramis brama injected with a mixture of polychlorinated biphenyls

In the first 10 days after the injection of Sovol-54 (a mixture of chlorinated biphenyls) into the breamAbramis brama, considerable alterations in the hormonal regulation of cotranport were observed for erythrocytes of this fish, along with an increase in the passive permeability of their membranes. No significant changes were recorded in Na⁺, K⁺-ATPase activity or its adrenergic regulation. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 10, pp. 379–381, October, 1995 Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences     

Transplantation of human fetal tissue in hematology

Intravenous transplantation of human fetal tissue, notably of the liver and thymus, is used in emergency hematological states: aplastic anemia and acute leukemia. The strong manifestation of “graft-versus-host” disease proved unexpected. Fetal donor hepatic cells stimulate hemopoiesis in the recipient. In some cases true cellular chimerism has been observed, specifically when a transplant of human fetal tissue (THFT) to a fetus with prenatal pathology was performedin utero. In gene therapy attempts have been made to infuse hemopoietic stem cells intravenously or to introduce the adenosine aminase gene into leukocytes of patients with a deficiency of this enzyme. Treatment using transplantation of human fetal tissue will help solve the problem of HLA-histocompatibility and will make gene therapy more widely applicable. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 4, pp. 375–377, April, 1994     

Transplantation of fetal and xenogeneic nervous tissue in Parkinson's disease

A mixture of fetal human brain tissue and of neural primordia of NotchDrosophila melanogaster is transplanted to the ventrolateral thalamic nucleus of patients with Parkinson's disease in stage 3–4. Two kinds of operation are performed. In the first case cryodestruction of the zone of tissue implantation is performed before transplant, and in the second case this procedure is not performed. A stable effect manifested in the disappearance of tremor and rigidity is achieved for both kinds of operation. When a transplant is performed without cryodestruction, the effect does not manifest itself until 2 months postoperation. The patients are followed up for 7–12 months postoperation. No side effects or relapses of Parkinson's disease are observed in this period. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 4, pp. 369–372, April, 1994 Presented by N. K. Permyakov, Member of the Russian Academy of Medical Sciences     

Immuno- and phagocytosis-modulating properties of low doses of B1-aflatoxin and benzene

Benzene or benzene-dissolved B₁-aflatoxin in low doses promotes an increase of the Thy-1⁺ cell count in the bone marrow of mice and an enhancement of the thymusdependent immune response.In vitro aflatoxin and benzene are unable to induce the expression of Thy-1-antigen in bone marrow T-precursors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 2, pp. 158–160, February, 1994 Presented by S. A. Neifakh, Member of the Russian Academy of Medical Sciences     

Endogenous phosphorylation of lysosomal proteins of rat heart and liver in the early postreanimation period

The lysosomal fraction isolated in a Percoll gradient from rat liver and heart after 30 min of the postreanimation period following a 5-min heart arrest stimulated incorporation of³²P in total lysosomal protein. Addition of cAMP and protein inhibitor of cAMP-dependent protein kinase changed the rate of phosphorylation. Endogenous phosphorylation of total lysosomal protein in the postreanimation period was reduced in the heart and increased in the liver. This may be due to a change in the intracellular level of cAMP, which fell in the heart and rose in the liver. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 7, pp. 51–53, July, 1995 Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences     

Involvement of opioid receptors in the production of nonspecific protective responses

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 10, pp. 381–384, October, 1993     

Morphological characteristics of the brain in 20–21-day-old rat embryos and in 1–5-day-old rats

Translated fromByulleten' Experimental'noi Biologii i Meditsiny, Vol. 116, N ^o 12, pp. 641–642, December, 1993     

Antioxidant and immunomodulating effects of ceruloplasmin in experimental influenza infection

Exogenous ceruloplasmin is shown to increase the resistance of mice to influenza virus, reduce the immunodepressive effect of the virus, and improve the biochemical parameters in the acute period of experimental infection. A possible positive effect of ceruloplasmin on delayed complications of influenza is discussed. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 9, pp. 285–287, September, 1994 Presented by T. T. Berezov, Member of the Russian Academy of Medical Sciences     

Experimental model of depletion of the blood kallikrein-kinin systems

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 10, pp. 343–344, October, 1993     

Effect of 3-orthocresylphosphate on the toxicity of GABA-lytics for mice

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 10, pp. 396–397, October, 1993     

Relationships between catecholamine levels in the salivary glands,oral mucosa,and saliva of rats with experimental staphylococcal sialadenitis

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 7, pp. 38–40, July, 1993.