皮肤型Rosai-Dorfman病一例

患者男,55岁。因颜面多发红色丘疹、结节及斑块4月余,于2006年7月6日来我院就诊4个月余前无明显诱因于右颊部出现一个绿豆大小红色丘疹．似蚊虫叮咬．无明显自觉症状,丘疹逐渐增大,约2个月后长至一元硬币大小,并在鼻根部出现新发皮疹,自行外用食盐和土草药,皮损未见好转且进一步扩大,于右颊部呈融合斑块状,     

皮肤型Rosai-Dorfman病1例

患者女,36岁。双上肢丘疹、斑块、结节1年。皮损组织病理检查示:真皮层内密集的组织细胞浸润,伴有散在的淋巴细胞、中性粒细胞、浆细胞,可见组织细胞吞噬淋巴细胞。免疫组织化学:S-100(+),CD68(+),CD1a(-)。诊断:皮肤型窦性组织细胞增生症。     

丘疹结节型皮肤Rosai-Dorfman病一例

本文报道一例丘疹结节型皮肤Rosai-Dorfman病。患者左下腹、左乳房下方散在大小不等的暗红色斑片,其上散在分布绿豆至黄豆大暗红色丘疹、结节,部分融合成片。经病理学和免疫组化检查诊断为皮肤Rosai-Dorfman病。     

皮肤Rosai-Dorfman病一例并文献回顾性分析

目的:皮肤Rosai-Dorfman病(cutaneous Rosai-Dorfman disease,CRDD)是一种罕见的组织细胞增生性疾病,本文对1例患者资料进行报道,并对既往文献进行回顾性临床病理分析.方法:通过PubMed查询公开发表的英文文献,对该病的人口统计学信息、临床表现、病理特点及治疗等情况进行分析总...     

皮肤Rosai-Dorfman病一例

患者男，43岁,因右大腿斑块14个月入院。14个月前，无明显诱因右大腿内侧出现一蚕豆大红斑，渐大，无发热及不适感，皮损组织病理检查见真皮内有大量浆细胞，考虑为反应性浆细胞增样增生、予以青霉素、泼尼松等治疗，皮疹仍渐大．既往史、家族史无特殊。体检：体温37℃，全身浅表淋巴结未触及，各系统检查无异常。     

皮肤Rosai-Dorfman病1例

皮肤Rosai-Doffman病(cutaneous Rosai-Dorfmandisease,CRDD),即单纯发生于皮肤的窦组织细胞增生症,临床较为罕见,现报告1例. 1 病例资料 患者男,49岁.因背部丘疹、结节、肿块6年余而于2011年5月来我院就诊,患者诉6年前无明显诱因突然于背部出现米粒至玉米大小的暗红色丘疹、结节、斑块,高出皮肤,散在分布,无明显自觉症状.以后皮疹逐渐增多,部分皮疹扩大或融合成不规则暗红色结节、肿块,无破溃.     

皮肤Rosai-Dorfman病1例

1病历摘要患者男,41岁。患者半年前无明显诱因出现面部丘疹、结节,皮损不伴疼痛、瘙痒等症状。后皮损开始融合、增多,逐渐发展至腹部及双下肢。患者既往体健。皮肤科检查:双面颊可见直径0.5 cm~1 cm大小不等的红色的丘疹、结节,部分融合成斑块,表面光滑有光泽(图1A),压之不褪色。下腹部及双下肢可见散在分布的直径约0.5 cm大的类圆形结节。全身未扪及增大的浅表淋巴结。常规实验室检查及腹部B超结果无明显异常。     

皮肤Rosai-Dorfman病1例

1 病历摘要 患者女,32岁.因右面部红斑、结节及脓疱3个月,于2011年8月9日就诊.患者3个月前无明显诱因右面颊出现一小指甲大不规则红斑,无瘙痒及疼痛,后红斑上及其周围出现暗红色结节,逐渐扩大融合成片,并出现脓疱.发病以来无发热、周身乏力、体重减轻、关节疼痛等不适.     

皮肤Rosai-Dorfman病1例

患者男,28岁。左小腿内侧暗红色结节4月。皮损组织病理示:示真皮全层及皮下组织中有大量组织细胞浸润,其间有淋巴细胞及浆细胞,并可见组织细胞内吞噬淋巴细胞及浆细胞。免疫组化结果示淡染的组织细胞S-100蛋白阳性、CD68阳性。诊断:皮肤Rosai-Dorfman病。     

皮肤Rosai-Dorfman病1例

患者,男,57岁。右侧面部无痛性暗红色结节4个月余。皮损组织病理和免疫组化符合皮肤Rosai-Dorfman病的诊断。     

Cutaneous Rosai-Dorfman disease: a case report

Rosai-Dorfman disease, otherwise known as sinus histiocytosis with massive lymphadenopathy, is a non-Langerhans cell histiocytosis with a benign course and unknown etiology. It was described in 1969 as a painless cervical lymph node enlargement in association with fever, weight loss and sweating. Extranodal disease has been reported in 43% of cases, with involvement of multiple organs. Purely extranodal Rosai-Dorfman disease has been already reported, including forms restricted to the skin. This paper reports a case of purely cutaneous Rosai-Dorfman disease, which is of interest in view of the rarity of this condition.     

皮肤窦性组织细胞增生症一例并文献复习

报道1例皮肤窦性组织细胞增生症并对文献进行复习。患者,女,56岁,右上肢暗红色结节、斑块2年余,无系统受累。组织病理：真皮内大量组织细胞、淋巴细胞,可见组织细胞伸入现象。免疫组化：S-100（+）、CD68（+）、CD1a（-）。外用卤米松等治疗后皮损范围已明显缩小。     

沙利度胺成功治疗皮肤Rosai-Dorfman病一例

患者,女,53岁。面部暗红色和淡黄色丘疹、结节1年。组织病理示：表皮正常,真皮全层可见致密的组织细胞浸润,伴散在淋巴细胞、浆细胞及中性粒细胞浸润,可见伸入运动。免疫组化染色：S-100(++)、CD68(-)、CD1a(-)。综上诊断为皮肤Rosai-Dorfman病。予沙利度胺治疗,6个月后皮疹基本消退。     

皮肤Rosai-Dorfman病1例

报告1例皮肤Rosai-Dorfman病。患者男,61岁,胸腹部散在丘疹、斑块结节9个月,不痒不痛。皮肤专科检查:胸部左侧见约2 cm×3 cm、右侧见约5 cm×7 cm大小红斑,散在丘疹、黄豆大结节,腹部脐右侧见15 cm×5 cm大小红褐色斑块、鳞屑、黄豆至鸽子蛋大的结节。外院曾诊断为B淋巴瘤、麻风病。复查病理显示:表皮萎缩,组织细胞、淋巴细胞、浆细胞浸润,见深染区与淡染区,有吞噬现象,抗酸(-)。免疫组化:S-100、CD3、CD20、CD68、CD163均阳性,CD1a(-)。组织液抗酸试验:眉弓(-),下颌(-),耳垂(-),胸部皮疹(-),腹部皮疹(-)。诊断:皮肤窦性组织细胞增生症(Rosai-Dorfman病)。予复方甘草酸苷及沙利度胺口服,卤米松软膏外用,治疗一个月效果不明显,手术切除,随访一年未见复发。     

皮肤Rosai-Dorfman病

<正>患者,女,43岁。主诉:左侧面颊部红斑丘疹7月余。现病史:患者7月前无自觉症状发现左侧面颊部红色丘疹、红斑,无瘙痒、疼痛等不适,日晒后发红明显。无畏寒、发热等不适,皮疹逐渐扩大,曾在外院按"环状肉芽肿?湿疹?"行2次冷冻治疗,皮疹无明显消退。于2016年7月至我院就诊。个人史:否认乙肝、结核等传染病史及密切接触     

Cutaneous Rosai-Dorfman disease

Presented is a case of a 31-year-old woman with cutaneous Rosai-Dorfman disease, which is a rare, benign, generally self-limited histiocytic proliferative disorder that is characterized by painless lymphadenopathy, fever, neutrophilia, an elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. It primarily involves lymph nodes but can affect extranodal sites such as the skin, where it typically appears as indistinct erythematous papules and nodules. On histopathologic examination, emperipolesis is a consistent finding. The etiology is unknown, and treatment is based on clinical manifestations.     

Cutaneous Rosai-Dorfman disease

患者男,52岁.主诉:面部皮疹8个月,于2006年3月就诊.现病史:患者自2005年7月面部出现淡红色丘疹,无痛痒.丘疹最先出现于双侧面颊以及额部,逐渐向面中部扩展.曾于外院多次就诊,均未给予明确诊断,曾经多种抗生素以及中药(具体药物不详)内服及外用,均未见疗效.皮损逐渐增多增大并逐渐融合.为明确诊断遂来我院就诊.皮损处皮肤感觉无异常,无眉毛及毳毛脱落.     

Cutaneous Rosai-Dorfman disease

Sinus histiocytosis with massive lymphadenopathy, or Rosai-Dorfman disease, is a benign idiopathic histiocytic proliferative disorder that commonly involves the lymph nodes but secondarily may involve the skin. However, purely cutaneous disease without lymphadenopathy or internal organ involvement rarely may occur. We present case reports of three patients who presented with asymptomatic nonspecific enlarging skin nodules without evidence of lymphadenopathy or internal disease. Histopathologic examination of skin lesions in all patients showed proliferation of large histiocytes with phagocytosed inflammatory cells characteristic of Rosai-Dorfman disease. However, the diagnoses of dermatofibroma, other spindle cell neoplasm, infectious granulomatous process, and other xanthohistiocytic proliferations were also considered due to the presence of storiform spindle cells and foamy cells in the first case. One patient experienced regression during a course of oral steroids, while another patient cleared spontaneously. In the absence of massive lymphadenopathy characteristic of Rosai-Dorfman disease, the diagnosis of purely cutaneous Rosai-Dorfman disease may be complicated by the rarity, non-specific clinical appearance of skin lesions, and broad histopathological differential diagnosis of this disorder. A high index of suspicion of the clinician and pathologist is often required.     

皮肤巨淋巴结病性窦组织细胞增生症

皮肤和皮下巨淋巴结病性窦组织细胞增生症(Rosai—Dorfman病)多见于青少年,临床上表现为双侧颈部淋巴结增大．皮肤出现丘疹、结节,伴发热和白细胞升高。组织病理改变有一定特征性。该病的病因可能与病毒感染有关。