Polycyclic aromatic hydrocarbons bound to outdoor and indoor airborne particles (PM2.5) and their mutagenicity and carcinogenicity in Silesian kindergartens,Poland

Assessment of exposure to polycyclic aromatic hydrocarbons (PAHs) is important due to the widespread presence of PAHs in the environment and their toxicological relevance, especially to susceptible populations such as children and their health. The aim of this study is to compare indoor and outdoor concentrations of particulate matter with a diameter of 2.5 μm or less (PM2.5) and 15 individual PAHs, as well as contribution of the analyzed PAHs to mutagenic and carcinogenic activity. Samples were collected during spring season in two sites in southern Poland (Silesia) representing urban and rural areas. Indoor samples of PM2.5 were sampled in kindergartens. At the same time, in the vicinity of the kindergarten buildings, the collection of the outdoor PM2.5 samples was carried out. Mutagenic (MEQ) and carcinogenic (TEQ) equivalents related to BaP and the percentage share expressed as mutagenic (MP) and carcinogenic (CP) potential of each individual compound to the total mutagenic/carcinogenic potential of the PAH mixture were calculated. The obtained results show that high concentrations of PM2.5 (above 25 μg/m³) and 15 PM2.5-bound PAHs in outdoor and indoor air were similar in the two studied areas. In overall PAHs mutagenic and carcinogenic potential, the percentage share of benzo(a)pyrene (BaP) was dominant and varied from 49.0–54.5% to 62.5–70.0%, respectively. The carried out study indicates the necessity of reducing PAH emission from solid fuel combustion, which is reflected in PM2.5-bound PAHs concentrations and their diagnostic ratios. In the recent years, health effects on children resulting from their activity pattern and air quality in the public places have been a serious problem.     

Porphyrin Pattern and Methemoglobin Levels in <Emphasis Type="Italic">Columba livia</Emphasis> Applied to Assess Toxicological Risk by Air Pollution in Urban Areas

The study has explored two conservative biomarkers, porphyrin pattern in guano and methemoglobin levels in blood of Columba livia, in order to assay their potential use for monitoring toxic effects induced by exposure to urban air pollution. Fieldwork was conducted between October 2003 and June 2005 in the city of Milan, Italy, by sampling the pigeons in different areas almost twice a week. Six air contaminants, CO, PM10, NO₂, O₃, SO₂, and C₆H₆, plus polycyclic aromatic hydrocarbons (PAHs) in fine particles, temperature, and UV index, were considered. Protoporphyrins from pigeon excreta sampled outdoors were always higher than in indoor animals, particularly in winter. A positive correlation (p < 0.001) of protoporphyrin with PAHs was observed. In terms of the values of methemoglobinemia, animals exposed to urban air showed significant differences from season to season but only in summer and autumn did the outdoor pigeons show higher values than indoor animals. In summer, a regression model with a positive correlation between O₃ and benzene was determined (p < 0.01). The use of Columba livia as a sentinel for urban air pollution as well as for detecting complex interactions between contaminants in the urban air pollutant mixture was discussed.     

Size-segregated urban particulate matter: mass closure,chemical composition,and primary and secondary matter content

Forty-nine components of ambient particulate matter (PM) in size-fractionated PM were investigated at an urban background site in Katowice (Silesian Agglomeration in Southern Poland) in the non-heating season of 2012. PM was analyzed for two groups of carbon compounds (organic (OC) and elemental (EC) carbon, Lab OC-EC Aerosol Analyzer), five major water-soluble ions (NH₄ ⁺, Cl^?, SO₄ ^2?, NO₃ ^?, and Na⁺ contents in PM water extracts, ion chromatography), 26 elements (X-ray fluorescence spectrometry), and 16 polycyclic aromatic hydrocarbons (PAHs, gas chromatography). The distributions of the masses of these components among 13 basic PM fractions were determined, and chemical mass closure was checked for each of these fractions separately. The particles having their aerodynamic diameters in the interval 0.03–0.26 μm, the fraction PM_0.03–0.26, contributed about 13 % to the total PM mass. This PM fraction consisted of primary particles predominantly composed of various inorganic compounds, primary organic compounds, and, in lesser amounts, of elemental carbon, secondary ions, and secondary organic compounds. The second particle fraction, PM_0.26–1.6, consisted mainly of secondary matter, and its mass contribution to the total PM mass was about 59 %. The third fraction, PM_1.6–40, was a fraction of coarse particles composed of mineral/soil and organic matter and elemental carbon. It contributed to the PM mass about 28 %. For each of PM_0.03–0.26, PM_0.26–1.6, and PM_1.6–40, the health hazard from its 16 PAH contents was determined by computing toxicity factors. PM_0.26–1.6 posed the greatest health hazard from the mixture of the 16 PAHs that it contained, PM_1.6–40 was the next, and the hazard from the PM_0.03–0.26-bound 16 PAHs was the smallest. The molecular diagnostic ratios computed for these three fractions were specific for coal and wood combustion; some indicated the road traffic effects.     

An assessment of air pollution and its attributable mortality in Ulaanbaatar, Mongolia

Epidemiologic studies have consistently reported associations between outdoor fine particulate matter (PM_2.5) air pollution and adverse health effects. Although Asia bears the majority of the public health burden from air pollution, few epidemiologic studies have been conducted outside of North America and Europe due in part to challenges in population exposure assessment. We assessed the feasibility of two current exposure assessment techniques, land use regression (LUR) modeling and mobile monitoring, and estimated the mortality attributable to air pollution in Ulaanbaatar, Mongolia. We developed LUR models for predicting wintertime spatial patterns of NO₂ and SO₂ based on 2-week passive Ogawa measurements at 37 locations and freely available geographic predictors. The models explained 74% and 78% of the variance in NO₂ and SO₂, respectively. Land cover characteristics derived from satellite images were useful predictors of both pollutants. Mobile PM_2.5 monitoring with an integrating nephelometer also showed promise, capturing substantial spatial variation in PM_2.5 concentrations. The spatial patterns in SO₂ and PM, seasonal and diurnal patterns in PM_2.5, and high wintertime PM_2.5/PM₁₀ ratios were consistent with a major impact from coal and wood combustion in the city’s low-income traditional housing (ger) areas. The annual average concentration of PM_2.5 measured at a centrally located government monitoring site was 75 μg/m³ or more than seven times the World Health Organization’s PM_2.5 air quality guideline, driven by a wintertime average concentration of 148 μg/m³. PM_2.5 concentrations measured in a traditional housing area were higher, with a wintertime mean PM_2.5 concentration of 250 μg/m³. We conservatively estimated that 29% (95% CI, 12–43%) of cardiopulmonary deaths and 40% (95% CI, 17–56%) of lung cancer deaths in the city are attributable to outdoor air pollution. These deaths correspond to nearly 10% of the city’s total mortality, with estimates ranging to more than 13% of mortality under less conservative model assumptions. LUR models and mobile monitoring can be successfully implemented in developing country cities, thus cost-effectively improving exposure assessment for epidemiology and risk assessment. Air pollution represents a major threat to public health in Ulaanbaatar, Mongolia, and reducing home heating emissions in traditional housing areas should be the primary focus of air pollution control efforts.     

Respiratory Disease in Relation to Outdoor Air Pollution in Kanpur,India

ABSTRACT

This paper examines the effect of outdoor air pollution on respiratory disease in Kanpur, India, based on data from 2006. Exposure to air pollution is represented by annual emissions of sulfur dioxide (SO₂), particulate matter (PM), and nitrogen oxides (NO_x) from 11 source categories, established as a geographic information system (GIS)-based emission inventory in 2 km × 2 km grid. Respiratory disease is represented by number of patients who visited specialist pulmonary hospital with symptoms of respiratory disease. The results showed that (1) the main sources of air pollution are industries, domestic fuel burning, and vehicles; (2) the emissions of PM per grid are strongly correlated to the emissions of SO₂ and NO_x; and (3) there is a strong correlation between visits to a hospital due to respiratory disease and emission strength in the area of residence. These results clearly indicate that appropriate health and environmental monitoring, actions to reduce emissions to air, and further studies that would allow assessing the development in health status are necessary.

[Supplementary materials are available for this article. Go to the publisher's online edition of Archives of Environmental & Occupational Health for material on emission of SO₂, PM, NO_x from various sources, and total number of inhabitants, total number of patients in grid squares covering the Kanpur city.]     

Spatial and seasonal variability of the mass concentration and chemical composition of PM2.5 in Poland

The seasonal changes in ambient mass concentrations and chemical composition of fine particulate matter (PM_2.5) were investigated in three locations in Poland. The analyses included PM_2.5-bound hazardous benzo(a)pyrene (BaP), As, Ni, Cd, and Pb. The samples of PM_2.5 were collected daily in Katowice (southern Poland, urban background site), Gdańsk, and Diabla Góra (northern Poland, urban and regional background sites, respectively) during 1-year-long campaign in 2010. Based on monthly ambient concentrations of PM_2.5-bound carbon (organic and elemental), water-soluble ions (Na⁺, NH₄ ⁺, K⁺, Mg²⁺, Ca²⁺, Cl^?, NO₃ ^?, SO₄ ^2?), and elements As, Ni, Cd, Pb, Ti, Al, Fe, the chemical mass closure of PM_2.5 was checked for each of the four seasons of the year and for the heating and non-heating periods at each site. Also, the annual concentrations of PM_2.5 were determined and the annual PM_2.5 mass closure checked. At each measuring point, the PM_2.5 concentrations were high compared to its Polish yearly permissible value, 25 μg/m³, and its concentrations elsewhere in Europe. The highest annual PM_2.5 concentration, 43 μg/m³, occurred in Katowice; it was twice the annual PM_2.5 concentration in Gdańsk, and thrice the one in Diabla Góra. The high annual averages were due to very high monthly concentrations in the heating period, which were highest in the winter. PM_2.5 consisted mainly of carbonaceous matter (elemental carbon (EC) + organic matter (OM), the sum of elemental carbon, EC, and organic matter, OM; its annual mass contributions to PM_2.5 were 43, 31, and 33 % in Katowice, Gdansk, and Diabla Góra, respectively), secondary inorganic aerosol (SIA), the Na_Cl group, and crustal matter (CM)—in the decreasing order of their yearly mass contributions to PM_2.5. OM, EC, SIA, Na_Cl, and CM accounted for almost 81 % of the PM_2.5 mass in Katowice, 74 % in Gdańsk, and 90 % in Diabla Góra. The annual average toxic metal contribution to the PM_2.5 mass was not greater than 0.2 % at each site. In Katowice and Gdańsk, the yearly ambient BaP concentrations were high (15.4 and 3.2 ng/m³, respectively); in rural Diabla Góra, the concentrations of BaP were almost equal to 1 ng/m³, the Polish BaP annual limit. The great seasonal fluctuations of the shares of the component groups in PM_2.5 and of the concentrations of PM_2.5 and its components are due to the seasonal fluctuations of the emissions of PM and its precursors from hard and brown coal combustion for energy production, growing in a heating season, reaching maximum in winter, and decreasing in a non-heating period. In Gdańsk, northern Poland, especially in the spring and autumn, sea spray might have affected the chemical composition of PM_2.5. The greatest hazard from PM_2.5 occurs in Katowice, southern Poland, in winter, when very high concentrations of PM_2.5 and PM_2.5-related carbonaceous matter, including BaP, are maintained by poor natural ventilation in cities, weather conditions, and the highest level of industrialization in Poland. In less industrialized northern Poland, where the aeration in cities is better and rather gaseous than solid fuels are used, the health hazard from ambient PM_2.5 is much lower.     

Indoor air pollutant exposure and determinant factors controlling household air quality for elderly people in Hong Kong

This study investigated the levels and determinant factors of indoor air pollutants including fine particles (PM_2.5), nitrogen dioxide (NO₂), and formaldehyde (HCHO) in 55 households exclusively for the elderly in Hong Kong during summer and winter (Jul.–Sep. 2016 and Nov. 2016–Mar. 2017). The average concentrations of PM_2.5, NO₂, and formaldehyde were 25.3?±?15.0, 40.5?±?16.0, and 26.1?±?22.8 μg/m³ in summer and 34.2?±?19.0, 43.5?±?17.0, and 15.4?±?4.5 μg/m³ in winter, respectively. There were ~?50.3% of households exceeding the World Health Organization indoor air quality standard for PM_2.5 throughout the study, with ~?40.6 and ~61.0% of the households in summer and winter, respectively. The determinant factors for indoor PM_2.5 and NO₂ concentrations were identified as from incense burning and cooking. Cooking with suitable ventilation is an important factor to ease indoor pollutant concentrations. Both of PM_2.5 and NO₂ indoor concentrations showed good correlations with outdoor concentrations. Winter was observed with higher pollutant concentrations than summer except for formaldehyde concentrations. Major factors controlling indoor formaldehyde concentrations are temperature and humidity. The outcome will be useful for the development of future indoor air quality guidelines for Hong Kong.     

Indoor and outdoor air quality analysis for the city of Nablus in Palestine: seasonal trends of PM<Subscript>10</Subscript>, PM<Subscript>5.0</Subscript>, PM<Subscript>2.5</Subscript>, and PM<Subscript>1.0</Subscript> of residential homes

Nablus city is an important urban and industrial center in the West Bank, Palestine. The topography of the city, combined with multiple sources of air pollution, creates a potential air quality problem that might affect human health. The indoor and outdoor particle concentration distributions of PM₁₀, PM_5.0, PM_2.5, and PM_1.0 were measured using a Grimm aerosol spectrometer from December 2014 to November 2015, at four roadsides and four urban homes in Nablus. The results of the annual averages of PM₁₀ and PM_2.5 concentrations were found to be at least three times higher than that of the European Air Quality Standards both in indoors and outdoors. The difference in the results between both the roadside and the urban areas was attributed to human and industrial activities in Nablus. The results revealed that the highest concentrations of the particulate matters are during summer, especially June and July, in the roadside areas due to heavy industrial activities during these months. The same behavior was noticed for urban areas during summer and due to other human activities. The results of indoor/outdoor (I/O) ratios were found to be less than, but very close to, 1 for both roadside and urban areas in summer and winter months. In winter times, areas with poor ventilation indicated the existence of additional sources of PM within the indoor environments, especially when smoking cigarettes and using fuel-based heaters such as fireplaces gas and kerosene heaters.     

Influence of Number of Visitors and Weather Conditions on Airborne Particulate Matter Mass Concentrations at The Plitvice Lakes National Park,Croatia During Summer and Autumn

We investigated the influence of local meteorological conditions and number of visitors on ambient particulate matter (PM) mass concentrations and particle fraction ratios at the Plitvice Lakes National Park between July and October 2018. Outdoor mass concentrations of particles with aerodynamic diameters of less than 1, 2.5, and 10 μm (PM₁, PM_2.5, and PM₁₀, respectively) and indoor PM₁ were measured with two light-scattering laser photometers set up near the largest and most visited Kozjak Lake. Our findings suggest that the particles mainly originated from background sources, although some came from local anthropogenic activities. More specifically, increases in both indoor and outdoor mass concentrations coincided with the increase in the number of visitors. Indoor PM₁ concentrations also increased with increase in outdoor air temperature, while outdoor PMs exhibited U-shaped dependence (i.e., concentrations increased only at higher outdoor air temperatures). This behaviour and the decrease in the PM₁/PM_2.5 ratio with higher temperatures suggests that the production and growth of particles is influenced by photochemical reactions. The obtained spectra also pointed to a daily but not to weekly periodicity of PM levels.Key words: anthropogenic PM sources, bivariate polar plot, light-scattering laser photometry, weighted overlapped segment averaging     

Characteristic and Source of Atmospheric PM<Subscript>10</Subscript>- and PM<Subscript>2.5</Subscript>-bound PAHs in a Typical Metallurgic City Near Yangtze River in China

The characteristics of atmospheric PM₁₀- and PM_2.5-bound polycyclic aromatic hydrocarbons (PAHs) were investigated in Tongling city, China. Results showed that the total concentrations of PM₁₀- and PM_2.5-bound PAHs exhibited distinct seasonal and spatial variability. The metallurgic sites showed the highest PAH concentrations, which is mainly attributed to the metallurgic activities (mainly copper ore smelting) and coal combustion as the smelting fuel. The rural area showed the lowest concentrations, but exhibited significant increase from summer to autumn. This seasonal fluctuation is mainly caused by the biomass burning at the sites in the harvest season. The diagnostic ratio indicated that the main PAHs sources were vehicle exhausts, coal combustion and biomass burning. The total BaP equivalent concentration (BAP-TEQ) was found to be maximum at DGS site in winter, whereas it was minimum at BGC site in summer. Risk assessment indicates that residential exposure to PAHs in the industrial area, especially in the winter season, may pose a greater inhalation cancer risk than people living in living area and rural area.     

Could portable powered respirators help us avoid the exposure to air pollution?

Atmospheric pollution has become a persistent threat to human health. Consequently, the effects of breathing polluted air in large cities are being assessed for given risk groups and different indoor and outdoor activities. This work delves into the study of the possibility to develop individual portable air-purifying respirators to avoid the exposure to atmospheric pollution when carrying out common daily activities at home or outdoors. Samples of known concentrations of the criteria pollutants (except for lead) have been monitored before and after passing through a powered occupational respirator which has been also tested carrying out physical activities mainly under outdoor conditions. The results show that the system is not effective against carbon monoxide but it does provide protection against particulate matter, SO₂, NO_x, O₃, and volatile organic compounds, that is, most of the main pollutants found in outdoor air. Thus, individual powered respirators are technologically viable based on the current occupational devices and by providing them with additional suggested improvements. Being affordable, this kind of systems may become very helpful not only for assistive applications but also for healthy people willing to reduce exposure to air pollution.     

Exposure to fine particles (PM2.5 and PM1) and black smoke in the general population: personal, indoor, and outdoor levels

Personal exposure to PM(2.5) and PM(1), together with indoor and residential outdoor levels, was measured in the general adult population (30 subjects, 23-51 years of age) of Gothenburg, Sweden. Simultaneously, urban background concentrations of PM(2.5) were monitored with an EPA WINS impactor. The 24-h samples were gravimetrically analyzed for mass concentration and black smoke (BS) using a smokestain reflectometer. Median levels of PM(2.5) were 8.4 microg/m(3) (personal), 8.6 microg/m(3) (indoor), 6.4 microg/m(3) (residential outdoor), and 5.6 microg/m(3) (urban background). Personal exposure to PM(1) was 5.4 microg/m(3), while PM(1) indoor and outdoor levels were 6.2 and 5.2 microg/m(3), respectively. In non-smokers, personal exposure to PM(2.5) was significantly higher than were residential outdoor levels. BS absorption coefficients were fairly similar for all microenvironments (0.4-0.5 10(-5) m(-1)). Personal exposure to particulate matter (PM) and BS was well correlated with indoor levels, and there was an acceptable agreement between personal exposure and urban background concentrations for PM(2.5) and BS(2.5) (r(s)=0.61 and 0.65, respectively). PM(1) made up a considerable amount (70-80%) of PM(2.5) in all microenvironments. Levels of BS were higher outdoors than indoors and higher during the fall compared with spring. The correlations between particle mass and BS for both PM(2.5) vs. BS(2.5) and PM(1) versus BS(1) were weak for all microenvironments including personal exposure. The urban background station provided a good estimate of residential outdoor levels of PM(2.5) and BS(2.5) within the city (r(s)=0.90 and 0.77, respectively). Outdoor levels were considerably affected by long-range transported air pollution, which was not found for personal exposure or indoor levels. The within-individual (day-to-day) variability dominated for personal exposure to both PM(2.5) and BS(2.5) in non-smokers.     

The PM<Subscript>10</Subscript> compositions,sources and health risks assessment in mechanically ventilated office buildings in an urban environment

Office buildings can be considered a “second home” for working people and so the contribution of pollutants in this indoor environment to a person’s overall exposure is significant. The aims of this study were to examine the composition of PM₁₀ and the sources influencing the indoor and outdoor office environments. The PM₁₀ sampling was performed using a mini-vol portable sampler at two sampling sites from May to August 2014 for daily 24 h sampling. The concentrations of ionic species (F^?, Cl^?, NO₃ ^?, SO₄ ^2?) were analysed using ion chromatography while the concentration of major elements (Mg, Ca, K, Na) and trace elements (Mn, Ni, Fe, Cu, Zn, Pb, Cr, Cd, Al) were determined by inductively couple plasma-mass spectrometry (ICP-MS). The concentration of NH₄ ⁺ was determined using the indophenol blue method. The results showed that the average concentrations of PM₁₀ were 61.3?±?27.0 μg/m³ (indoor) and 101?±?42.8 μg/m³ (outdoor) with an indoor/outdoor ratio value of <1. The dominant components in PM₁₀ for both the indoor and outdoor environments were NO₃ ^?, SO₄ ^2?, Na, Fe, Al and Zn. Source apportionment analysis of the PM₁₀ composition identified three sources of PM₁₀ in the indoor and outdoor environments. The major source for indoor PM₁₀ was Earth’s crust elements (95 %) followed by oil burning and human activities (4 %) and motor vehicles (1 %). The major source for outdoor PM₁₀ was the Earth’s crust and motor exhaust emissions (80 %) with contributions of other sources such as oil burning and human activities (18 %) and motor vehicles (2 %). The potential health risks for trace elements in PM₁₀, via inhalation exposure to the indoor occupants, show that the total hazard quotient (HQ) value was slightly higher than acceptable limits (1.0). The total excess life time carcinogenic risk (ELCR) value for both sampling stations was higher than the acceptable limit (1.0?×?E?6), suggesting a high exposure to carcinogenic risk. This study suggests there is a high contribution of outdoor sources to the indoor office environment where PM₁₀ can significantly affect the indoor air quality and occupant health.     

Spatial and seasonal variations of gaseous and particulate matter pollutants in 31 provincial capital cities,China

In order to know air pollution situation and their health, environmental, and climate effects, the air quality data with high temporal and spatial resolutions are essential. The spatial and seasonal variations of six criteria pollutants were investigated in 31 provincial capital cities between April 2014 and March 2015 using hourly mean air quality monitoring data, and the cities were classified by cluster analysis based on annual variations of air pollutants. The annual mean concentrations of PM_2.5 (particulate matter with aerodynamic diameter less than 2.5 μm) and PM₁₀ (particulate matter with aerodynamic diameter less than 10 μm) were high for all cities, which exceeded Chinese Ambient Air Quality Standards (CAAQS) Grade I standards. Only Fuzhou, Haikou, Kunming, and Lasa met Grade II standards for PM_2.5 and PM₁₀. Additionally, elevated SO₂ concentration was observed in northern cities, especially in winter. However, the seasonal variation of O₃ was opposite to other pollutants with the lowest concentrations in the winter and the highest in the summer. Winter domestic heating has significant impact on urban air quality, especially SO₂ and PM₁₀.     

Polycyclic aromatic hydrocarbons and their nitro derivatives from indoor biomass-fueled cooking in two rural areas of Thailand: a case study

Household fuel combustion for cooking is a major source of hazardous pollutants, including polycyclic aromatic hydrocarbons (PAHs) and their nitro derivatives (NPAHs). These pollutants impact indoor air quality and human health. In this study of two rural households in Chiang Mai, Thailand, PM_2.5 samples were collected both inside and outside the houses during cooking and noncooking periods. Real-time monitoring of indoor PM_2.5 was also conducted. The concentrations of PAHs, NPAHs, levoglucosan (LG), and carbon fractions in the PM_2.5 fractions were quantified. The most severe contamination was observed inside the house during cooking with mean concentrations of 9980 ng/m³ and 18,700 pg/m³ for PAHs and NPAHs, respectively. The composition profiles of PAHs and NPAHs showed that benz[a]anthracene, benzo[k]fluoranthrene, and benzo[a]pyrene made the greatest contribution to total PAHs, while 9-nitroanthracene made the greatest contribution to total NPAHs. The correlation coefficient (p < 0.01) of PAHs and NPAHs, using LG as a tracer, confirmed that the main source of PAHs and NPAHs was biomass burning. This was further confirmed by the indoor to outdoor ratios and diagnostic ratios using PAHs and NPAHs and carbonaceous fractions. During cooking periods, the carcinogenic risks exceeded the WHO guideline values and would be classified as “definite risks.” This suggest that biomass burning inside houses poses serious health risks through inhalation, which is the main route of exposure and may increase the incidence of cancer. Upgradation of residential environments is needed to improve indoor air quality, especially, in rural areas of Thailand.     

Air pollution and population health: a global challenge

“Air pollution and population health” is one of the most important environmental and public health issues. Economic development, urbanization, energy consumption, transportation/motorization, and rapid population growth are major driving forces of air pollution in large cities, especially in megacities. Air pollution levels in developed countries have been decreasing dramatically in recent decades. However, in developing countries and in countries in transition, air pollution levels are still at relatively high levels, though the levels have been gradually decreasing or have remained stable during rapid economic development. In recent years, several hundred epidemiological studies have emerged showing adverse health effects associated with short-term and long-term exposure to air pollutants. Time-series studies conducted in Asian cities also showed similar health effects on mortality associated with exposure to particulate matter (PM), sulfur dioxide (SO₂), nitrogen dioxide (NO₂) and ozone (O₃) to those explored in Europe and North America. The World Health Organization (WHO) published the “WHO Air Quality Guidelines (AQGs), Global Update” in 2006. These updated AQGs provide much stricter guidelines for PM, NO₂, SO₂ and O₃. Considering that current air pollution levels are much higher than the WHO-recommended AQGs, interim targets for these four air pollutants are also recommended for member states, especially for developing countries in setting their country-specific air quality standards. In conclusion, ambient air pollution is a health hazard. It is more important in Asian developing countries within the context of pollution level and population density. Improving air quality has substantial, measurable and important public health benefits.     

Relationship between indoor and outdoor levels of fine particle mass, particle number concentrations and black smoke under different ventilation conditions

Fine particle mass (PM(2.5)), black smoke (BS) and particle number concentration (NC) were measured simultaneously indoors and outdoors at an urban location in Erfurt, Germany. Measurements were conducted during 2-month periods in summer and winter. Different ventilation modes were applied during each measurement period: windows closed; windows opened widely for 15 min twice per day; windows and door across the room opened widely for 5 min twice per day and windows tilted open all day long. The lowest indoor/outdoor (I/O) ratios for all pollutants were found for closed windows, whereas the ratios for ventilated environments were higher. For closed windows, the I/O ratios for PM(2.5) are larger than the corresponding values for BS and NC (0.63 vs. 0.44 or 0.33, respectively) probably due to lower penetration factors for particles sizes <500 nm and higher deposition rates for ultrafine particles (<100 nm). The largest differences for the I/O ratios between closed and tilted windows were found for NC (0.33 vs. 0.78). The indoor and outdoor levels of PM(2.5) and BS were strongly correlated for all ventilation modes. The linear regression models showed that more than 75% of the daily indoor variation could be explained by the daily outdoor variation for those pollutants. However, the correlation between indoor and outdoor NC for ventilation twice a day was weak. It indicates that rapid changes of the air exchange rates during the day may affect the correlation and regression analysis of NC indoor and outdoor concentrations. This effect was not observed for PM(2.5) or BS. This study shows the importance of the indoor air aerosol measurements for health effects studies and the need for more research on I/O transport mechanisms for NC.     

Urinary polycyclic aromatic hydrocarbons as a biomarker of exposure to PAHs in air: a pilot study among pregnant women

Recent studies have linked increased polycyclic aromatic hydrocarbons (PAHs) in air and adverse fetal health outcomes. Urinary PAH metabolites are of interest for exposure assessment if they can predict PAHs in air. We investigated exposure to PAHs by collecting air and urine samples among pregnant women pre-selected as living in "high" (downtown and close to steel mills, n=9) and "low" (suburban, n=10) exposure areas. We analyzed first-morning urine voids from all 3 trimesters of pregnancy for urinary PAH metabolites and compared these to personal air PAH/PM(2.5)/NO(2)/NO(X) samples collected in the 3rd trimester. We also evaluated activities and home characteristics, geographic indicators and outdoor central site PM(2.5)/NO(2)/NO(X) (all trimesters). Personal air exposures to the lighter molecular weight (MW) PAHs were linked to indoor sources (candles and incense), whereas the heavier PAHs were related to outdoor sources. Geometric means of all personal air measurements were higher in the "high" exposure group. We suggest that centrally monitored heavier MW PAHs could be used to predict personal exposures for heavier PAHs only. Urine metabolites were only directly correlated with their parent air PAHs for phenanthrene (Pearson's r=0.31-0.45) and fluorene (r=0.37-0.58). Predictive models suggest that specific metabolites (3-hydroyxyfluorene and 3-hydroxyphenanthrene) may be related to their parent air PAH exposures. The metabolite 2-hydroxynaphthalene was linked to smoking and the metabolite 1-hydroxypyrene was linked to dietary exposures. For researchers interested in predicting exposure to airborne lighter MW PAHs using urinary PAH metabolites, we propose that hydroxyfluorene and hydroxyphenanthrene metabolites be considered.     

DNA damage in outdoor workers occupationally exposed to environmental air pollutants

Background

Health concerns about the exposure to genotoxic and carcinogenic agents in the air are particularly significant for outdoor workers in less developed countries.

Aims

To investigate the association between personal exposure to a group of air pollutants and severity of DNA damage in outdoor workers from two Mexican cities.

Methods

DNA damage (Comet assay) and personal exposure to volatile organic compounds, PM_2.5, and ozone were investigated in 55 outdoor and indoor workers from México City and Puebla.

Results

In México City, outdoor workers had greater DNA damage, reflected by a longer tail length, than indoor workers (median 46.8 v 30.1 μm), and a greater percentage of highly damaged cells (cells with tail length ⩾41 μm); in Puebla, outdoor and indoor workers had similar DNA damage. There were more alkali labile sites in outdoor than indoor workers. The DNA damage magnitude was positively correlated with PM_2.5 and ozone exposure. Outdoor and indoor workers with ⩾60% of highly damaged cells (highly damaged workers) had significantly higher exposures to PM_2.5, ozone, and some volatile organic compounds. The main factors associated with the highly damaged workers were ozone, PM_2.5, and 1‐ethyl‐2‐methyl benzene exposure.

Conclusions

With this approach, the effects of some air pollutants could be correlated with biological endpoints from the Comet assay. It is suggested that the use of personal exposure assessment and biological endpoints evaluation could be an important tool to generate a more precise assessment of the associated potential health risks.     

Fine particulate air pollution and cardiorespiratory effects in the elderly

BACKGROUND: Past studies of air pollution effects among sensitive subgroups have produced inconsistent results. Our objective was to determine relationships between various measures of air pollution and cardiorespiratory effects in older subjects. METHODS: We conducted a study that included repeated measurements of pulmonary function (arterial oxygen saturation) and cardiac function (heart rate and blood pressure) in a panel of 88 subjects (>57 years of age) in Seattle during the years 1999 to 2001. Subjects were healthy or had lung or heart disease. Each subject participated in sessions of 10 consecutive days of exposure monitoring and collection of health outcomes for up to 2 sessions. Associations between health outcomes and indoor, outdoor, and personal measures of particulate matter 相似文献