毛母质瘤一例

正临床资料患者,男,24岁。主因颈后肿物2年余,于2015年3月6日就诊。2年前,患者颈后中部皮下出现一小指大肿物,无不适,缓慢生长,未诊治。既往体健;否认局部有外伤史;无此类疾病家族史。体格检查:各系统无异常。皮肤科情况:颈后中部可见一皮肤稍隆起区域,表皮正常,皮下可扪及一直径约3cm的深在结节,质地较硬,稍有弹性,可移动,无波动感,表面皮肤触觉、痛温觉正常。实验室检查:     

毛母质瘤

毛母质瘤临床表现多样,无特征性,极易误诊,但其组织病理学改变具有特征性。现报告1例。     

毛母质瘤1例

1临床资料患者,女,43岁,左侧颧部淡黄色结节伴瘙痒半年,于2007年9月13日就诊。半年前无明显诱因左侧颧部出现一米粒大丘疹伴轻度瘙痒,未予治疗,后     

毛母质瘤1例

患者女．70岁。困左面颊出现紫红色结节伴瘙痒、破溃4个月余,于2006年3月27日来我中心门诊就诊。4个月前无明显诱冈患者左面颊部出现一绿豆大红色丘疹,无明显瘙痒及疼痛,曾自行使用细绳结扎皮损,结果皮损迅速增大至鸽蛋大,质地稍硬,自觉瘙痒不适,搔抓后皮损中心破溃、出血、结痂。发病前无外伤史．家族中无类似疾病患者。[第一段]     

多发性毛母质瘤

报告1例多发性毛母质瘤。患者女,14岁,背部3个皮下结节伴触痛1年。3处皮损均切除并行组织病理检查:(背中部皮损)真皮内可见由嗜碱性粒细胞、影细胞、过渡细胞构成的肿瘤团块;(背上部、下部皮损)真皮内见影细胞、吞噬含铁血黄素的异物巨细胞及钙沉积。诊断:多发性毛母质瘤。     

耳后毛母质瘤1例

患者男,51岁.左耳后淡红色结节半年于2009年5月15日就诊.患者半年前发现左耳后绿豆大皮下结节,渐进增大,且顶部出现囊性物,无瘙痒及疼痛等不适,皮损未溃破.发病前无虫咬、外伤史,无其他器官肿瘤病史,家族中未见类似疾病患者.     

水疱型毛母质瘤一例

正临床资料患儿,女,13岁。因右侧肩部结节5个月,出现水疱样外观1个月,于2015年7月29日就诊。5个月前,患儿右侧肩部出现一蚕豆大小淡红色质硬结节,缓慢增大;1个月前结节表面出现水疱样外观,无自觉症状。自起病以来,患儿无发热、肌无力、肌肉酸痛及肌肉萎缩等全身症状。患儿既往体键,无传染病及遗传病史,家族成员中无类似疾病患者。皮损局部无外伤史或蚊虫叮咬史。体格检查:一般情况可,     

毛母质瘤26例临床分析

目的　总结毛母质瘤的临床和病理特征。方法　分析 2 6例毛母质瘤的临床资料和组织病理检查结果。结果　皮损多为单发结节 ,病理特征是以嗜碱性细胞和影细胞组成的不规则条索或团块。结论　本病较理想的治疗是切开刮除瘤体 ,并完全摘除包膜。     

面部巨大毛母质瘤1例

患儿女,14个月.半年前患儿家长发现其左侧面颊有一黄豆大的皮下结节,表面呈青色,无疼痛等不适感,家长未予重视.随患儿年龄增长,肿块亦逐渐增大,增大至约鹅蛋大.入院前半个月,肿块表面破溃,渗出少量淡黄色清亮液体,于2011年2月19日来我科就诊. 体格检查:系统检查无异常.皮肤科检查:左侧面部可见一肿块,大小约7 cm×8 cm,质中,张力稍高.表面皮肤呈红蓝相间(图1A),无明显红肿,表面与皮肤粘连,基底可略活动.双眼不等大,左侧眼睑下垂.辅助检查:B超提示血管瘤,增强CT提示脉管瘤.     

水疱样毛母质瘤一例

报告1 例水疱状毛母质瘤。患儿女, 16 岁。左肩部出现一渐增大水疱6月。皮肤科检查：左肩部见约2x1x1cm大小的皮色半球形、半透明的水疱状新生物,表面光滑,质韧,未见破溃。经皮损组织病理检查诊断为毛母质瘤。     

Two cases of multiple giant pilomatricoma

Pilomatricoma is a skin appendage tumor manifestating as a firm, solitary lesion of the face and upper extremity. It generally measures 0.5 to 3.0 cm in diameter and is typically found in young people. We report a 29-year-old male and a 13-year-old girl who developed three and two protruding masses, respectively. The size of each tumor was larger than 5 cm. The histologic appearance showed sharply demarcated tumor lobules composed of eosinophilic shadow cells and basaloid cells. We describe two unusual cases of multiple giant pilomatricomas and review the literature, emphasizing the number and size.     

毛母质瘤40例临床病理分析

目的：探讨毛母质瘤的临床和病理特点。方法：对40例毛母质瘤进行了临床资料和组织病理回顾性分析。结果：男女发病比例为1：1，平均发病年龄21．2岁，平均病程2．3年，10岁以内发病者20％，20岁以内者加％，30～40岁35％，除1例多发外，均为单发的质地较硬的皮下结节，有压痛者7例（17．5％），病理上均可见到影细胞。发现3例特殊类型，1例表现为穿通型，其中2例为与表皮囊肿相关的毛母质瘤。临床正确诊断率15％。结论：毛母质瘤少见，临床表现多样，影细胞是确诊的重要依据和必要条件。病理上可以出现特殊类型。     

穿通性毛母质瘤1例

报告1例穿通性毛母质瘤。患者女,60岁。因背部结节4个月就诊。皮肤科检查示背部有一突出皮面的紫红色结节,直径0.9cm结节中心有破溃。予以手术切除。组织病理检查示穿通性毛母质瘤。     

Perforating pilomatricoma: transepithelial elimination or not

We present a 56-year-old woman with a perforating pilomatricoma in the left eyebrow region. Histologically, the tumor consisted mainly of basophilic cells and shadow cells, and the tumor components were being eliminated through an ulcer with damage to the epithelial structures. In past reports of perforating pilomatricoma, this elimination pattern has often been described as transepithelial elimination. In many patients with perforating pilomatricoma, elimination is accompanied by ulceration and epithelial damage. Mehregan recently stated that elimination accompanied by epidermal necrosis and superficial ulceration constituted one form of transepithelial elimination. Epidermal necrosis and ulceration generally constitute severe damage. However, when Mehregan first proposed the concept of transepithelial elimination, it was defined as a phenomenon with relatively little or no damage to the epithelial structures, differentiating it from other types of elimination. This original definition makes transepithelial elimination a unique and interesting phenomenon, and its most important feature is that there is relatively little or no damage to the epithelial structures. Therefore, the terms "epidermal necrosis" and "ulceration" should not be used in association with transepithelial elimination. Hence, in patients with perforating pilomatricoma, the elimination of tumor components from ulcers with damage to the epithelial structures, as seen in the present case, should not be described as transepithelial elimination.     

水疱型毛母质瘤一例

患者,女,23岁。1年前蚊虫叮咬后右上臂出现两处皮下结节伴疼痛,3个月前两处皮损均增大为红色囊性肿物。病理特征符合水疱型毛母质瘤。MRI提示：脂肪层见椭圆形乳头状长T1短T2信号,凸向皮肤表面,外缘长T2信号。手术完整切除,创面愈合良好。目前随访未复发。     

水疱型毛母质瘤一例

患者,女,11岁.左上臂水疱样肿物1年.组织病理示真皮内见镜影细胞、过渡细胞及嗜碱性细胞构成界清团块,胶原纤维稀疏,周围可见淋巴细胞和多核巨细胞浸润.诊断:水疱型毛母质瘤.治疗:手术切除.伤口愈合良好.     

Immunohistochemical expression of bone morphogenetic protein-2 in pilomatricoma

BACKGROUND: The mechanism of occurrence of calcification and ossification in pilomatricoma remains unclear. OBJECTIVES: To elucidate the pathogenesis of calcification and ossification in pilomatricoma we examined the role of bone morphogenetic protein (BMP)-2, which plays important parts in inducing ectopic bone formation both in vivo and in vitro. METHODS: Twenty cases of pilomatricoma were studied immunohistochemically using anti-BMP-2 monoclonal antibody. RESULTS: In normal skin, including hair follicles, there was no BMP-2 expression. In all pilomatricomas, BMP-2 was found exclusively in the cytoplasm of shadow cells but not in basophilic cells. In two cases of bone formation seen in pilomatricoma, osteoblasts in the periosteal area showed a strong positive reaction, while bone trabeculum (bone matrix) showed no reaction. CONCLUSIONS: Our findings indicate that shadow cells positive for BMP-2 may play an important part in generating bone formation in pilomatricoma.     

Proliferating pilomatricoma in a 9-year-old girl

Proliferating pilomatricoma is a rare, benign tumor of hair matrix origin that rarely occurs in children. We report the case of a 9-year-old girl with a rapidly growing, proliferating pilomatricoma located on the glabella. The lesion was embolized and surgically excised, with histopathological examination of the tissue confirming the diagnosis of proliferating pilomatricoma.     

β-Catenin expression in the transitional cell zone of pilomatricoma

BACKGROUND: beta-Catenin, a participant in the Wnt pathway, has been shown to play an important role in the morphogenesis of hair follicles and the formation of hair follicle-related tumours, including pilomatricomas. It has been observed that at least 75% of human pilomatricomas possess activating mutations in beta-catenin. These findings suggested that beta-catenin plays an important role in the tumorigenesis of pilomatricomas. However, the pattern of beta-catenin expression in pilomatricoma tissues is still unclear. Objectives To examine the expression of beta-catenin in human pilomatricomas by immunohistochemical staining. METHODS: Twenty-six formalin-fixed and paraffin-embedded samples of pilomatricoma tissue were studied. RESULTS: Most transitional cells of pilomatricoma expressed beta-catenin strongly, but the basophilic cells and shadow cells did not. beta-Catenin showed a prominent membranous immunoreactivity and a small amount of condensed cytoplasmic staining, but there was definitely no evidence of nuclear positivity. CONCLUSIONS: These findings imply that beta-catenin is primarily involved in cell-cell adhesion rather than cellular proliferation during pilomatricoma pathogenesis, and suggest that if beta-catenin is involved in pilomatricoma tumorigenesis and tumour growth, it plays an indirect role.