伊曲康唑联合1％盐酸布替萘芬乳膏治疗念珠菌性包皮龟头炎的临床观察

目的探讨伊曲康唑联合1％盐酸布替萘芬乳膏治疗念珠茵性包皮龟头炎的疗效。方法口服伊曲康唑胶囊，外用1％盐酸布替萘芬乳膏治疗78例念珠茵性包皮龟头炎，1周后判定疗效，1个月后复查判定复发率。结果痊愈50例（64．10％），显效22例（28．21％），有效率92．31％；1个月后仅1例复发，复发率1．39％。且未见明显不良反应。结论伊曲康唑联合1％盐酸布替萘芬乳膏治疗念珠菌性包皮龟头炎安全、有效，值得临床推广应用。     

伊曲康唑胶囊联合盐酸阿莫罗芬乳膏治疗马拉色菌毛囊炎临床疗效观察

目的观察伊曲康唑胶囊联合盐酸阿莫罗芬乳膏治疗马拉色菌毛囊炎的疗效,并评价其安全性。方法 114例马拉色菌毛囊炎患者随机分为研究组61例和对照组53例。研究组采用伊曲康唑胶囊口服联合盐酸阿莫罗芬乳膏;对照组给予盐酸阿莫罗芬乳膏。观察临床疗效。结果治疗组显效率、治愈率、总有效率分别为32.8%、59.0%、91.9%,对照组显效率、治愈率、总有效率分别为22.6%、39.6%、62.3%。结论伊曲康唑胶囊口服联合盐酸阿莫罗芬乳膏外用治疗马拉色菌毛囊炎比单纯外用盐酸阿莫罗芬乳膏疗效好。由于短期内小剂量口服伊曲康唑胶囊,临床上也未见明显不良反应出现。     

特比萘芬与伊曲康唑治疗念珠菌性阴道炎疗效比较

目的：比较特比萘芬与伊曲康唑治疗念珠菌性阴道炎的疗效。方法：134例患分为两组，治疗组作真菌镜检及培养，A组口服特比萘芬0．25g，1次／d，连服7d，B组口服伊曲康唑0．2g，1次／d，连服7d；停药时、停药2周后复诊、作真菌镜检，判定疗效。结果：A组停药时及2周后有效率分别为79．4％，85．3％；B组停经时及2周后有效率分别为81．8％，83．3％，两组比较有效率无显性差异(P＞0．05)。结论：特比萘芬与伊曲康唑均对念珠菌性阴道炎有较好的疗效。     

伊曲康唑和特比萘芬序贯法治疗甲真菌病疗效观察

目的观察伊曲康唑和特比萘芬序贯疗法治疗甲真菌病的临床疗效及安全性。方法对照组采用伊曲康唑冲击治疗(每日中晚餐各口服伊曲康唑200mg,连用1周,停用3周为一个疗程),指甲真菌病治疗2个疗程,趾甲真菌病治疗3个疗程。观察组指甲真菌病先用伊曲康唑冲击治疗1个疗程,随后应用盐酸特比萘芬冲击疗法(每日中晚餐各口服特比萘芬250mg,连用1周,停药3周),趾甲真菌病还需再重复伊曲康唑冲击治疗1个疗程。两组治疗结束后3、6月时各复诊一次,观察不良反应发生情况。结果观察组治疗3个月后的有效率显著高于对照组(P0.05),经6个月治疗后,2组有效率与治疗3个月后有效率相比均略有提高,但差异无统计学意义(P0.05),观察组有效率高于对照组,但无显著性差异(P0.05)。复发率观察显著低于对照组(P0.05)。结论伊曲康唑和特比萘芬序贯疗法治疗甲真菌病疗效确切,复发率与不良反应较少,值得临床推广应用。     

环切包皮过长并用伊曲康唑治疗反复发作念珠菌性龟头炎疗效分析

目的 探讨包皮环切术并伊曲康唑治疗反复发作念球菌性龟头炎疗效。方法 用电刀环切包皮过长并加服伊曲康唑治疗反复发作念珠菌性龟头炎患者。术前曾多次正规地用过多种抗真菌药物，治疗后仍经常反复发作者，用包皮环切疗法，并口服伊曲康唑(西安杨森公司生产)。结果 术后随访6个月，包皮过长伴反复发作念珠菌性龟头炎的治愈率为98％。结论 伊曲康唑治疗念珠菌效果显著，环切包皮术方法简便实用，值得推广。     

伊曲康唑联合特比萘芬凝胶治疗马拉色菌毛囊炎疗效分析

目的观察伊曲康唑胶囊口服联合特比萘芬凝胶外用治疗马拉色菌毛囊炎的效果;方法治疗组采用伊曲康唑胶囊,200mg/d,一次口服,2周为1个疗程,连用2个疗程;同时皮损处外涂特比萘芬凝胶,早晚各1次。对照组单纯外涂特比萘芬凝胶,方法和疗程同治疗组。结果治疗组治愈率、有效率分别为63.3%、88.3%,与对照组治愈率38.3%、有效率60.0%相比较,差异均有统计学意义(χ2=7.50,P﹤0.01;χ2=12.57,P0.01)。结论伊曲康唑胶囊口服联合特比萘芬凝胶外用治疗马拉色菌毛囊炎,见效快,费用低,疗效确切,复发率低,安全性高,耐受性好,值得临床参考应用。     

特比奈芬治疗念珠菌性阴道炎疗效观察

目的观察特比萘芬治疗念珠菌性阴道炎的疗效。方法选择本所STD门诊念珠菌性阴道炎患者160例,随机分为治疗组(口服特比萘芬)和对照组(口服伊曲康唑),每组80例,两组患者均连用14天。结果治疗组和对照组有效率分别为87.5%和93.75%,两组差异无显著性意义意义(χ2=1.839,P>0.05);两组不良反应发生率差异亦无显著性意义(P>0.05)。结论口服特比萘芬治疗念珠菌性阴道炎疗效较好,安全性高。     

特比萘芬治疗念珠菌性外阴阴道炎疗效和安全性评价

目的观察特比萘芬治疗念珠菌性外阴阴道炎的疗效及安全性。方法选择本院念珠菌性外阴阴道炎患者,随机分为治疗组34例,口服特比萘芬250mg,1次/d;对照组31例,口服伊曲康唑200mg,1次/d。两组均连用10天。结果治疗组和对照组有效率分别为67.65%和87.10%,真菌清除率分别为82.35%和83.87%,两组有效率和真菌清除率比较差异均无显著性意义(P均>0.05)。结论口服特比萘芬治疗念珠菌性外阴阴道炎疗效肯定,安全性高。     

依巴斯丁氟康唑联合特比萘芬治疗念珠菌性龟头炎临床观察

目的观察依巴斯丁氟康唑联合特比萘芬外用治疗念珠菌性龟头炎疗效。方法 44例分为两组,治疗组22例口服依巴斯丁10mg,1次/d,氟康唑150mg,1次/w,同时外用特比萘芬乳膏,1次/d;对照组22例仅外用特比特萘芬乳膏,1次/d。疗程2周。结果治疗组和对照组的痊愈率分别为81.81%和45.45%,两组差异有显著性意义(χ2=6.29,P0.05);两组有效率分别为95.45%和59.09%,差异具有显著性意义(χ2=8.28,P0.01)。结论依巴斯丁氟康唑联合特比萘芬乳膏外用治疗念珠菌性龟头炎疗效显著。     

1%盐酸布替萘芬软膏治疗浅部真菌病随机单盲对照多中心临床试验

采用1%盐酸布替萘芬软膏与1%联苯苄唑乳膏治疗219例浅部真菌病,治疗结果表明,二类新药1%盐酸布替萘芬软膏对手足癣和体股癣临床疗效、真菌学疗效、不良反应发生率与对照药1%联苯苄唑乳膏相似。虽然停药后1周试验组手足癣和体股癣治愈率均高于对照组(P<0.05),但两组的有效率均差异无统计学意义(P=1.000)。     

特比萘芬联合黄蒲洁夫洗剂治疗念珠菌性龟头炎疗效观察

目的:观察特比萘芬联合黄蒲洁夫洗剂治疗念珠茵性龟头炎的疗效.方法:选择100例念珠茵性龟头炎患者随机分成两组,治疗组50例,采用特比萘芬250mg/次,1次/d,联合黄蒲洁夫洗剂外洗,2次/d;对照组50例单纯使用特比萘芬250mg/次,次/d,2周后根据临床症状、体征及真茵学镜检判定治疗.结果:治疗组临床疗效、真菌学疗效明显优于对照组,差异有显著性(P＜0.05).治疗组复发率明显低于对照组.结论:特比萘芬联合黄蒲洁夫洗剂治疗念珠茵性龟头炎疗效明显,复发率低,副作用小,为临床治疗念珠茵性龟头炎提供一种治疗手段.     

Comparison of the efficacy and safety of oral fluconazole and topical clotrimazole in patients with candida balanitis.

One hundred fifty seven men with candidal balanitis were entered in a randomised, open-label parallel-group multicentre study comparing efficacy and safety of a single oral 150-mg fluconazole-dose with clotrimazole applied topically twice daily for 7 days. Of 64 fluconazole and 68 clotrimazole treated patients who were evaluable at short term follow up, 92% and 91% respectively were clinically cured or improved. Candida albicans was eradicated in 78% and 83% of patients respectively. Median time to relief of erythema was 6 days for fluconazole and 7 days for clotrimazole. Twelve of 15 patients who had received previous topical therapy for balanitis said they preferred oral therapy. At the one month follow up visit, 24/36 and 29/33 patients in the two groups were clinically cured or improved. Nine in the fluconazole group experienced a relapse; 6 of these 9 patients reported previous episodes of this infection during the past year. Two patients in the clotrimazole group had a relapse; neither had a history of previous episodes. Mycological eradication was noted in 26/36 and 25/33 patients in the two groups. Both treatment regimens were well tolerated. Thus a single 150 mg dose of fluconazole was comparable in efficacy and safety to clotrimazole cream applied topically for 7 days when administered to patients with balanitis.     

Clotrimazole (Canesten) in the treatment of candidal balanitis in men. With incidental observations on diabetic candidal balanoposthitis

Clotrimazole 1% (Canesten) cream was used in a trial comprising 138 men with candidal balanitis. Eighty-six (91%) out of 94 men were asymptomatic after seven days and 57 (98%) of 58 men were asymptomatic after three weeks' treatment. After seven days, Candida albicans could no longer be cultured from 86 (90%) of 96 men, nor from 55 (95%) of 58 men three weeks after treatment. Microscopical examination gave varying results. Fifteen (10.9%) of 138 men were found to have diabetes mellitus; this group was significantly older than the non-diabetics. It is concluded that treatment with clotrimazole for seven days is effective in the treatment of candidal balanitis.     

Clotrimazole (Canesten) in the treatment of candidal balanitis in men. With incidental observations on diabetic candidal balanoposthitis.

Clotrimazole 1% (Canesten) cream was used in a trial comprising 138 men with candidal balanitis. Eighty-six (91%) out of 94 men were asymptomatic after seven days and 57 (98%) of 58 men were asymptomatic after three weeks' treatment. After seven days, Candida albicans could no longer be cultured from 86 (90%) of 96 men, nor from 55 (95%) of 58 men three weeks after treatment. Microscopical examination gave varying results. Fifteen (10.9%) of 138 men were found to have diabetes mellitus; this group was significantly older than the non-diabetics. It is concluded that treatment with clotrimazole for seven days is effective in the treatment of candidal balanitis.     

伊曲康唑治疗浅表念珠菌感染临床经验回顾

目的：评价适宜国人的伊曲康唑治疗浅表念珠菌感染的治疗方案。方法：复习10年来在我国皮肤科中文核心期刊上发表的有关伊曲康唑治疗浅表念珠菌感染的文献。结果：伊曲康唑治疗皮肤念珠菌感染的有效剂量为200mg／d，连续应用3d；治疗念珠菌性包皮龟头炎的有效剂量为200mg／d，连续应用5d；治疗初发性念珠菌性阴道炎的有效剂量为400mg／d，连续应用2d；治疗复发性念珠菌性阴道炎的有效剂量为400mg／d，以后在每月月经期加用伊曲康唑200mg／d，应用3～5d，连续3～6个月。结论：伊曲康唑治疗国人浅表念珠菌感染安全有效，不良反应发生率较低。     

秋水仙碱联合小剂量强的松治疗结节性痒疹的疗效观察

目的：研究秋水仙碱联合小剂量强的松治疗结节性痒疹的疗效。方法：结节性痒疹患分成两组，每组30例；治疗组患服用秋水仙碱片0．5mg隔tid，强的松片15mg qa，艾洛松霜外用；对照组患服用强的松片15mg qa，艾洛松霜外用；两组疗程均为4周；每周随访记录每例患皮损变化情况、瘙痒减轻情况及不良反应，疗程结束后记录疗效。结果：治疗组总有效率为80％，而对照组为53．3％(P＜0．05)；治疗组和对照组的瘙痒减轻平均时间为6天和9天(P＜0．01)；两组结节开始消退平均时间为14天和20天(P＜0．01)。结论：秋水仙碱联合小剂量强的松治疗结节性痒疹具有起效快、有效率高、使用安全等特点，是一种较理想的治疗结节性痒疹的方法。     

外喷中药制剂联合曲安奈德益康唑乳膏治疗念球菌性龟头炎效果的临床观察

目的：观察中药汤剂改颗粒剂外喷联合曲安奈德益康唑乳膏治疗念球菌性龟头炎的临床疗效。方法：135例患者随机分为治疗组和对照A组和对照B组,每组45例。治疗组给予中药基本方取颗粒剂兑成中药汤液,装入专用容器外喷,2次/d,联合曲安奈德益康唑乳膏外涂,2次/d。对照A组,基本方水煎外洗,2次/d,联合曲安奈德益康唑乳膏外涂,2次/d。对照B组,单独使用曲安奈德益康唑乳膏,2次/d,连用14d。结果：联合用药组治疗念珠菌性包皮龟头炎的方法无论在治疗1周与2周时临床有效率（痊愈＋显效）均高于单独使用曲安奈德益康唑乳膏组,两组真菌学疗效无差异。而中药外喷组与中药外洗组在疗效上无明显差异。结论：中药汤剂外洗改颗粒剂外喷联合曲安奈德益康唑乳膏外涂治疗念球菌性龟头炎安全有效,可行。     

盐酸布替萘芬软膏治疗浅部真菌病疗效观察

目的探讨盐酸布替萘芬软膏治疗浅部真菌病的临床疗效。方法使用1%盐酸布替萘芬软膏,早、晚各1次薄薄涂于患处,1～4周判断疗效;并以克霉唑软膏作对照。结果盐酸布替萘芬软膏治疗体股癣痊愈率59.01%,有效率和真菌清除率均95.45%;治疗手足癣痊愈率为44.44%,有效率为92.60%,真菌清除率为88.89%;治疗花斑癣痊愈率为56.25%,有效率为93.75%,真菌清除率93.75%。各病种治疗组与对照组治愈率、有效率及真菌清除率分别比较,差异均有统计学意义(P均<0.05)。结论盐酸布替萘芬软膏治疗浅部真菌病安全、有效。     

综合疗法治疗复发性念珠菌性包皮龟头炎

目的探讨口服氟康唑胶囊、外用曲安奈德益康唑乳膏联合包皮环切术防治复发性念珠菌包皮龟头炎的疗效。方法采用随机分组法,治疗组(46例)给予氟康唑胶囊200mg,1次/d,连服3d,外用曲安奈德益康唑乳膏,早、晚各1次,2周为1个疗程,炎症控制后行包皮环切术。对照组(40例)给予氟康唑胶囊连服6d,曲安奈德益康唑乳膏外用2周。治疗后2周及2,4和6个月时随访。结果 2周后,两组痊愈率分别为89.13%和85.00%,差异无统计学意义(P>0.05)。两组有效率分别为100.00%和95.00%,差异无统计学意义(P>0.05)。2,4,6个月治疗组复发率分别为4.88%,9.76%和9.76%,对照组复发率分别为23.53%,38.24%和50.00%,两组比较差异均有统计学意义(P均<0.05)。结论综合疗法治疗复发性念珠菌包皮龟头炎安全有效,并能有效减少复发。     

润燥止痒胶囊联合复方甘草酸苷治疗血虚风燥型湿疹30例临床观察

目的观察润燥止痒胶囊联合复方甘草酸苷治疗血虚风燥型湿疹的疗效和安全性。方法将60例血虚风燥型湿疹的患者随机分为治疗组和对照组,各30例。治疗组口服润燥止痒胶囊4粒,复方甘草酸苷片75mg,均3次/d,外用卤米松乳膏2次/d;对照组30例口服复方甘草酸苷片75mg,3次/d,外用卤米松乳膏2次/d;连续治疗4周判定疗效。结果治疗组有效率为86.67%,对照组为58.62%,二者差异有统计学意义(P<0.05);治疗组不良反应发生率为6.66%,对照组为20.68%,差异无统计学意义(P>0.05)。结论润燥止痒胶囊联合复方甘草酸苷片治疗血虚风燥型湿疹是安全有效的。