同时性多中心骨肉瘤一例报道并文献复习

目的 总结并探讨同时性多中心骨肉瘤(synchronous multifocal osteosarcoma,SMOS)的临床特征,探讨其发病机制及治疗与预后.方法 报告我院诊治的1例伴有肺转移的SMOS病例;计算机检索2001年至2021年,PubMed、中国知网、万方数据库、维普数据库等公开发表的文献,阅读全文进行二...     

A large parosteal osteosarcoma with transformation to high-grade osteosarcoma: a case report.

This case of a large (31 cm) parosteal osteosarcoma had x-ray documentation 4 1/2 years before treatment. When the tumor began enlarging rapidly, treatment was sought. The tumor histologically showed typical parosteal osteosarcoma as well as malignant cartilage, osteoid, and undifferentiated sarcoma. The case shows one course a parosteal osteosarcoma can take over a 7-year untreated period. The significance of high-grade sarcoma and intramedullary involvement is discussed. When unequivocal high-grade osteosarcoma is present, it should be treated with radical resection and adjuvant multi-drug chemotherapy.     

Synchronous primary cancer of the rectum and lung: a case report

Multiple primary cancers refer to the condition where more than two cancers occur independently in an individual. The incidence of lung cancer in cases of colorectal cancer is rare and synchronous rectal cancer and lung cancer is even rare. A 61-year-old man was referred to our hospital with a 2-month history of blood in his stool, tenesmus, and mucous discharge in July 2010. Colonoscopy showed an irregular ulcerated rectal mass and histological examination of biopsy material showed a poorly differentiated adenocarcinoma. Computed tomography (CT) scan of the chest and abdomen showed a mass in the posterior segment of the right upper lobe of the lung and a mass in the right rectal wall of upper rectum. The rectal tumor was diagnosed as primary cancer based on the findings of immunohistochemical stain. An anterior resection (AR) and video assisted thoracoscopic (VAT) wedge resection were performed and histological findings of resected rectal and lung tumor specimen showed synchronous primary rectal cancer and lung cancer. A combination chemotherapy regimen with docetaxel and lobaplatin was used and the patient was successfully discharged from hospital in August 2010. Although the incidence of synchronous multiple primary cancers is very low, we need to remain suspicious, when faced with two or even multiple organ lesions, and employ the necessary examination methods to confirm the diagnosis. For synchronous multiple primary cancers, if conditions allow, surgical resection for all the cancers can be performed in a single operation.     

Multifocal osteosarcoma: a case report with review of the literature.

Multifocal osteosarcoma with unique patho-biological features in a 23-year old white male is reported. The natural history and classification of multiple osteosarcomas are reviewed. A proposal is presented for evaluation of the multicentric origin in future cases.     

A case of primary unknown carcinoma with lymphatic spread

A 51-year-old female was referred to our hospital for a furtherevaluation and treatment of a left inguinal tumor. An excisionalbiopsy of the left     

Primary osteosarcoma of the lung: a case report and review of the literature

Primary osteosarcoma of the lung is exceedingly rare. A 72-year-old man was admitted to our hospital; a primary osteosarcoma of the lung was diagnosed following computed tomography-guided needle biopsy. He died of rapidly progressing respiratory insufficiency without effective treatment seven months after the onset of symptoms. Macroscopic findings at autopsy showed typical histologic features of osteosarcoma without any bony lesion. Here we present a rare case and review the clinicopathological features of 20 previously reported cases.     

Synchronous multifocal osteosarcoma: Results in twelve patients treated with neoadjuvant chemotherapy and simultaneous resection of all involved bones

BACKGROUND:: Multifocal osteosarcoma is a rare type of tumor which is alwaysexcluded from therapy trials and is therefore rarely investigatedfor prognosis and treatment. PATIENTS AND METHODS:: Twelve patients with synchronous multifocal osteosarcoma underwentneoadjuvant chemotherapy and, when feasible, simultaneous resectionof involved bones. RESULTS:: Four patients were unsuitable for resection and died 5–13months (average 9 months) later. In eight patients all lesionswere resected simultaneously. Four patients are disease freeat 15, 20, 24, and 60 months (average 29 months), and four relapsedand died at 12, 24, 30 and 36 months (average 30.5 months). CONCLUSIONS:: Chemotherapy associated with aggressive surgery may be useful.The histological response of different lesions in the same patientare strongly correlated, confirming that synchronous multifocalosteosarcorna is not originally multicentric but unicentricwith bone metastases. bone sarcomas, chemotherapy, metastasis, multicentric, osteosarcoma, surgery     

Pseudomalignant osteoblastoma versus arrested osteosarcoma: a case report.

A case is presented which is interpreted as a histologically pseudomalignant osteoblastoma. This diagnosis is supported by the clinical and radiologic findings. Arguments are presented in support of this diagnosis as against an osteogenic sarcoma with an arrest in growth, although this latter diagnosis cannot be completely excluded.     

Primary intracerebral osteosarcoma: A case report

Primary intracerebral sarcomas are rare tumors. Malignantfibrous histiocytoma and fibrosarcoma are the predominant histologies. A 3 year old girl with a primary, intraparenchymalcerebral osteosarcoma, the second case reported in the literature,is described. Partial surgical resection, systemic chemotherapy and radiosurgery has provided tumor control at 18 months. Treatment issues are discussed.     

Long-term control of multiple lung metastases from osteosarcoma obtained by conventional radiotherapy: a case report.

An osteosarcoma patient whose lung metastases were successfully treated with radiotherapy is reported. The patient developed multiple lung metastases repeatedly after successful treatment of the primary lesion in his femur. Resection of the lung metastases was performed 5 times during 4 years (12 metastatic nodules in total). One of the specimens was evaluated using the micronucleus test, which suggested moderate radiosensitivity of the tumor. He further developed 2 metastases 19 months after the last operation, and these tumors were treated with conventional radiation with 60 and 64 Gy, respectively. The tumors regressed slowly after radiation and disappeared later. Although he developed another lung metastasis 2 years later, the lesion was also treated with radiation with 66 Gy and all of the 3 irradiated tumors are now under control at 43 months after the first radiotherapy and 15 months after the second one. Our experience would suggest that some (at least) metastatic osteosarcomas have reasonable radiosensitivity, and radiation therapy including radiosurgery may be a good alternative to surgery in patients for whom operation is not indicated.     

Mesenteric extraskeletal osteosarcoma with telangiectatic features: a case report

Background  

Extraskeletal osteosarcoma is a rare malignant mesenchymal tumor, with a predominant occurrence in the extremities. Only two cases of mesenteric extraskeletal osteosarcoma have been documented. We describe an unusual case of extraskeletal osteosarcoma with telangiectatic features occurring in the mesentery.     

Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: A case report of Fanconi anemia

We report the case of a 32-year-old woman who presented with multiple squamous cell neoplasms synchronously arising in the cervix, vulva, oral cavity and oropharynx. During the period when the patient was treated by radiotherapy, she developed severe radiation mucositis and pancytopenia. Immunofluorescence staining for foci of the monoubiquitinated form of FANCD2 revealed a complete absence of such foci in all cancer tissues that were examined.     

Primary intracerebral small-cell osteosarcoma in an adolescent girl: report of a case

A young patient surviving four years after treatment for primary intracerebral small-cell osteosarcoma is reported.This 16-year-old girl presented with headaches, visual disturbance, and papilledema and was found to have a large,heavily calcified mass in the left parietal lobe. A gross total resection of the tumor was performed and pathologic analysis revealed a small-cell osteosarcoma. Thoracic computerized tomography (CT) scans and a complete bone scan showed no other lesions.The patient received adjuvant chemotherapy and radiotherapy.She continues to do wellwith no evidence of metastases or local recurrence 4 years afterher initial presentation. The clinical, radiographic, surgical, pathologic, and immunohistochemical features of this case, alongwith therapeutic interventions and outcome, are presented.     

乳腺原发性骨肉瘤1例报告

乳腺原发的骨肉瘤是骨外骨肉瘤,属恶性间叶性肿瘤,由肿瘤性骨母细胞产生骨样、骨基质或软骨样物质,位于软组织而与骨无关。乳腺骨肉瘤极为罕见。现将本院治疗的1例患者报告如下。     

Neoadjuvant chemotherapy for patients with synchronous multifocal osteosarcoma: results in eleven cases.

Between January 1995 and December 1999, 11 patients with synchronous multifocal osteosarcoma (SMO) received neoadjuvant treatment with high-dose methotrexate, cisplatinum, Adriamycin, and ifosfamide. After primary chemotherapy in 4 patients who had only two bone localizations, it was possible to treat all tumor foci locally. The remaining patients, with more than three bones involved, were treated surgically only in 3 cases at the primary site, while secondary lesions did not receive any treatment. The final results of our study were disappointing. All patients died of the tumor 6 to 24 months after the beginning of treatment (mean 11.9 months). Nevertheless, the survival time of the 4 patients with locally treated lesions was significantly longer than the one of 7 patients in whom the secondary lesions were not locally treated (18.2 vs 9.1 months; P<0.008). It should be noted that those patients simultaneously operated on two sites, the response to chemotherapy of "primary" and "secondary" lesions was always similar. This homogeneity supports the thesis that in synchronous multifocal osteosarcoma the tumors are not multicentric in origin but represent bone-to-bone metastases from a monocentric tumor.     

同时性卵巢癌合并非小细胞肺癌1例并文献复习

目的:探讨多原发癌的临床诊断、治疗和预后,提高对多原发癌的认识,从而延长患者生存期,改善预后。方法:报道1例卵巢癌同期并非小细胞肺癌的多原发癌病例,并通过文献复习,阐述其发病率、发病机制、临床诊治方法及预后。结果:1名54岁女性以卵巢癌收住入院,行胸部CT及病理穿刺活检诊断同时合并肺腺癌,遂采用紫杉醇联合卡铂3周方案化疗,并肺部病灶射频消融。6周期化疗后,持续口服埃克替尼靶向治疗近13个月,肺部病灶较前明显缩小,卵巢癌无复发及转移征象。结论:临床需提高多原发癌的诊断意识,掌握多原发癌发病特点、诊疗方法,以提高治疗水平。     

Extraskeletal osteosarcoma of penis: A case report

Extraskeletal osteosarcoma (EOS) is rare and commonly arises in the retroperitoneum, limbs, head and neck. There is no significant difference between EOS and other malignant tumors in soft tissue. Localized pain and swelling are the common presenting symptoms. Clinical diagnosis of EOS is difficult, imaging techniques may be helpful and careful, and the histopathological analysis is necessary. The common histological variants of EOS include: osteoblastoma, chondroblastoma, and fibroblastoma, and other unusual subtypes were reported occasionally. It should be distinguished with myositis ossificans, malignant mesenchymoma, giant cell tumor and parosteal osteosarcoma. We present an EOS arising in the penis. The primary site and histological category of the tumor were extremely rare. We hope the case will be helpful to the recognition of clinical signs, iconography and histopathology of EOS.