成人水痘38例临床分析

目的：成人水痘较为少见，近年我科接诊154例水痘患者中，成人38例(24．7％)，成人患者比例明显增多。38例中学生33例(86．8％)。其特点为起病较急，前驱症状明显，发热、畏寒、头痛、咽痛、四肢酸痛等中毒症状明显，皮疹密布全身，病程比儿童长，严重并发症少，预后良好。提示应注意成人水痘的鉴别诊断，应用阿昔洛韦治疗取得较好疗效。     

大中学生水痘48例临床分析

目的探讨大中学生水痘临床特点。方法对48例大中学生水痘患者进行回顾分析,并与40例儿童水痘患者的临床资料进行对比。结果大中学生水痘患者比儿童水痘患者的临床症状重,并发症多,病程长。结论大中学生水痘传染性强,发病人数有逐年上升趋势,预防接种水痘疫苗已成为控制水痘爆发流行的关键。     

35例成人水痘临床分析

目的分析成人水痘临床表现的特点,为预防和治疗成人水痘提供有效的经验。方法对我院皮肤科在2006年1月—2011年1月收治的35例成人水痘患者进行回顾性分析。结果成人水痘的临床表现与儿童患者相比病程长、全身症状重伴高热。结论成人水痘起病急、高热、皮损重、全身症状明显,应注意成人水痘的鉴别诊断;在高发季节,对高发人群应做好预防工作。     

成人水痘20例临床及流行病学分析

目的：分析成人水痘的临床及流行病学特点，总结治疗及预防经验。方法：回顾性分析2006年12月-2007年1月间某部20例成人水痘患者的临床资料，并对其暴发流行进行流行病学调查。结果：20例成人水痘，服用盐酸吗啉胍、板蓝根颗粒，外用龙胆紫溶液，感染患者加用抗生素治疗，体温增高予对症处理。全部痊愈出院，1例出现局部细菌感染。发病人群、地点、发病时间较为集中，对接触人群注射水痘疫苗后疫情得到控制。结论：成人水痘较小儿水痘前驱症状明显，病程长，并发症少，运用盐酸吗啉胍抗病毒及对症处理效果良好。     

成人水痘58例临床分析

目的:探讨成人水痘发病情况,临床表现及其特点.方法:对58例成人水痘进行回顾性分析,并与65例儿童水痘患者的临床资料进行对比.结果:58例成人水痘好发于18岁～30岁,其特点为起病急,前驱症状明显,高热、全身症状、皮疹表现及瘙痒症状较儿童更为严重,心肌酶谱升高以及肺部X线检查异常明显高于儿童水痘患者.密集接触者易感染,成人发病多与精神紧张,抵抗力下降等因素有关.结论::成人水痘起病较急,全身症状明显,病程比儿童患者长,提示应注意成人水痘的鉴别诊断,应用阿昔洛韦治疗取得较好疗效.     

丽珠威治疗水痘35例疗效观察

我科自1998年6月～1999年1月,使用丽珠威治疗水痘,获得满意疗效,现报告如下。1资料和方法1.1病例选择 年龄<14岁;无严重全身症状及并发症者;确诊为水痘普通型者。1.2一般资料 丽珠威组病例35例,其中男17例,女18例,年龄2～12岁,平均4.9岁;病程1～     

静注人丙种球蛋白在重型药疹抢救治疗中的初步应用

静注人丙种球蛋白在重型药疹抢救治疗中的初步应用韩建德，佟菊贞中山医科大学附属第一医院皮肤科（邮政编码５１００８０）我们试用静注人两种球蛋白（ＩＶＩＧ）治疗重型药疹收到较满意效果。现将我们收治的２例报告如下。例１男，６１岁。患者因腰椎间盘脱出症，服用卡...     

成人水痘被误诊8例

水痘是由水痘一带状疱疹病毒引起的急性具有高度传染性的发疹性疾病。本病起病急，前驱期表现为发热、头痛、咽痛、四肢酸痛、恶心、呕吐、腹痛等非特异性症状，一般持续1～2天，长者3～4天。而成人水痘前驱期症状明显，因此在前驱期易造成误疹、漏诊，作者收集了我院2001年至2002年收治的曾误诊为其他疾病的成人水痘8例，占同期水痘的0．9％，占成人水痘的20％。现将结果报告如下：     

成人水痘77例临床分析

近几年成人水痘的发病率不断上升。与儿童水痘相比,成人水痘皮损泛发,全身症状严重,往往伴有高热。现将我院皮肤科2009年1～12月门诊77例成人水痘患者进行临床分析。临床资料77例成人水痘患者诊断明确,其中男42例,女35例;年龄18—35岁,平均22．5岁;病程1～5天,平均2．8天;77例水痘患者中有30例发生在11～12月（38．96％）;有明确水痘接触史者52例,带状疱疹接触者8例;就诊水痘患者中工人包括民工39例（50．65％）,学生27例（35．06％）,全部是住校生,其他职业11例（14．29％）。     

人流术后水痘的中药治疗与体会

水痘（ varicella）是由水痘－带状疱疹病毒（ VZV）引起的一种原发感染性出疹性传染病。也可见于成人,且成人水痘的症状及持续时间多较儿童严重,出现并发症几率亦高于儿童。近年来有关成人水痘的文献报道已不胜枚举,但对某些特殊情况下的成人水痘的探讨尚属少见。笔者近年采用中西医结合方法治疗成年女性无痛人流术后合并水痘,取得满意疗效。现报道如下。     

Systemic varicella zoster virus reinfection in a case of angioimmunoblastic T-cell lymphoma

Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of peripheral T-cell lymphoma that causes immunological disorders such as immunosuppression, autoimmune disease-like symptoms and allergy. We report a case of a 67-year-old man with AITL who had a serious varicella zoster virus (VZV) reinfection that appeared clinically to be varicella. Forty percent of cases of AITL are associated with skin rash. A variety of cutaneous manifestations have been reported; however, the majority are macropapular eruptions that are often diagnosed as drug associated. Our study emphasizes the need to correctly diagnose opportunistic infections, such as the varicella that is documented in our patient, at early stages in AITL.     

Severe Febrile Mucha-Habermann''s Disease in Children: Case Report and Review of the Literature

Mucha-Habermann disease, or pityriasis lichenoides et varioliformis acuta, is usually a benign, papulosquamous, cutaneous disorder. It has also been reported in a severe form with fever and systemic symptoms both in children and adults. We report a 12-year-old boy with the febrile, ulceronecrotic type. A review of similar cases in the literature shows a 16% frequency of acute necrotic lesions, as well as rare complications such as fever, superinfected lesions, bacteremia (most often with Staphylococcus aureus), and rheumatologic manifestations such as arthritis and scleroderma. There is no definitive treatment, but tetracycline, erythromycin, methotrexate, and ultraviolet light are used most frequently. The most common histologic feature is mononuclear perivascular infiltrates. Mucha-Habermann disease can mimic other common entities such as varicella and insect bites.     

Results of virostatic treatment of varicella with various severity]

Chickenpox is the result of primary infection with the varicella zoster virus (VZV), which--like other herpes-viruses--has the ability to remain latent within the nervous system; reactivation then sometimes causes shingles many decades later. While chickenpox is benign in normal children, infection in the immunocompromised patient is characterized by a period of prolonged viral replication, delayed healing and a high frequency of extracutaneous manifestations, such as pneumonitis and involvement of the nervous system. Therefore, current therapeutic research efforts have focused on both the prevention of VZV infections through the development of a live, attenuated vaccine and improved therapeutic modalities. The existing antiviral drug acyclovir has been shown to be effective in reducing severe complications in risk groups. It has been generally accepted that the varicella vaccine is useful in immunocompromised children with acute leukaemia or solid malignant tumours. Healthy seronegative siblings will also benefit from the varicella vaccine. In addition, zoster hyperimmunoglobulin has also been shown to provide protection against primary VCV infection in the incubation period. Preventive and therapeutic efforts should mean that varicella will soon no larger be a medical problem even for immunocompromised patients.     

Prolonged herpes zoster in a patient infected with the human immunodeficiency virus.

In 1983, varicella zoster virus (VZV) disease was first recognized in the context of infection with the human immunodeficiency virus (HIV). Since that time, there have been many reports discussing the occurrence and clinical manifestations of hepes zoster in HIV-infected patients. We describe the development of prolonged herpes zoster in a patient with acquired immunodeficiency syndrome (AIDS) over the course of 104 days. Viral isolates at the three different clinical stages of the skin lesions were sensitive in vitro to acyclovir, and supposed to be a same strain by polymerase chain reaction (PCR) analysis. We also discuss an effective treatment for prolonged cases of zoster.     

Onychomadesis with Lichen Planus: An Under-Recognized Manifestation

Onychomadesis or proximal separation of the nail pate usually results from severe, generalized dermatoses like bullous diseases, hand foot and mouth disease, varicella or severe cutaneous drug reactions. Although lichen planus (LP) produces varied nail manifestations (longitudinal onychorrhexis, onychoschizia, nail pigmentation, pterygium etc.), to the best of our knowledge, onychomadesis as a manifestation of nail LP is not recorded. This report presents two children with onychomadesis arising with generalized eruptive LP.     

Varicella outbreak in Indian students in Magdeburg with detection of the African‐Indian VZV clade 5

Varicella has the highest contagiosity index of all viral diseases. We report an endemic outbreak of varicella among 4 Indian students in Magdeburg in November and December 2008. An initially severe course was observed in three of these patients with a negative vaccination status. Large vesicular skin lesions with a diameter of up to 8 mm were found in all patients. Molecular genetic tests revealed African/Indian clade 5 in 2 patients, although the European clades (i.e., clade 1 and 3) are the most common in Germany, accounting for 85 %. All patients recovered without any complications after administration of intravenous aciclovir at a dosage of 10 mg per kg body weight. Although isolated cases of varicella are not notifiable according to the German Protection against Infection Act, endemic outbreaks must be reported to the appropriate health surveillance authorities.     

成人重症水痘合并多器官衰竭二例并文献复习

水痘是由水痘-带状疱疹病毒引起的发热和皮疹的传染性疾病,多见于儿童,少数可发生于成人.成人水痘往往比儿童水痘症状重,更容易出现并发症,本文将对我院收治的2例成人重症水痘合并多器官衰竭进行报道并对相关文献复习.     

Post-varicella anetoderma. 3 cases

We report three cases of typical macular atrophy which appeared during, or was noticed shortly after varicella. The three patients were children. These cases were particular in that anetoderma lesions occurred independently of the scarring varicella lesions and followed a prolonged course of their own afterwards. We were unable to classify these cases in the primary or secondary type of macular atrophy. The various dermatoses associated with macular atrophy and the numerous physiopathological hypotheses put forward concerning this entity are enumerated.     

Bullöser systemischer Lupus erythematodes

Bullous systemic lupus erythematosus is a rare disease associated with subepidermal blistering and, in most cases, severe systemic manifestations. We describe a 19-year-old man with systemic lupus erythematosus who developed a bullous eruption along with a flare-up of systemic manifestations during the course of his disease and discuss the different forms of bullous lesions in patients with lupus erythematosus.     

静脉注射丙种球蛋白治疗重症带状疱疹4例

4例用常规治疗无效的重症带状疱疹，试用静脉注射丙种球蛋白（IVIg)临床症状迅速缓解，病程明显缩短，IvIg是治疗重症带疹的有效药物。