女性闭经后萎缩性尿道炎患者血清FSH、LH、PRL检验的临床意义分析

目的:分析并探讨女性闭经后萎缩性尿道炎患者血清卵泡刺激素(FSH)、促黄体生成素(LH)、泌乳素(PRL)检验指标的意义。方法:选取2012年1月至2016年1月我院收治的女性闭经后萎缩性尿道炎患者80例为观察组,选取同期体检健康女性80例为对照组,检测两组FSH、LH、PRL水平。结果:观察组FSH水平为(11.73±6.31)mU/mL,LH水平为(12.31±7.34)mU/mL,PRL水平为(38.13±12.14)ng/mL。对照组FSH水平为(6.57±2.45)mU/mL,LH水平为(4.49±3.12)mU/mL,PRL水平为(15.24±5.35)ng/mL。观察组FSH、LH以及PRL水平明显高于对照组(P0.05)。观察组雌二醇(E_2)水平为(41.24±16.53)pg/mL,孕酮(P)水平为(0.51±0.34)pg/mL,睾酮(T)水平为(0.33±0.14)ng/mL。对照组E_2水平为(51.42±9.43)pg/mL,P水平为(0.52±0.32)pg/mL,T水平为(0.34±0.15)ng/mL。观察组E_2水平明显低于对照组(P0.05),两组P、T检测无显著差异(P0.05)。结论:女性闭经后萎缩性尿道炎患者血清FSH、LH、PRL明显升高,临床上可作为闭经后萎缩性尿道炎诊断进行参考,提前做好防治措施。     

女性闭经后萎缩性尿道炎患者血清FSH、LH、PRL检验的临床意义研究

目的:探讨女性闭经后萎缩性尿道炎患者血清促卵泡素(FSH)、黄体生成素(LH)、垂体泌乳素(PRL)等性激素检验的临床方法及规律,为女性闭经后萎缩性尿道炎身心保健提供了理论支持。方法:选取40例闭经患者作为观察组,并选同期健康体检月经正常女性40例作为对照组。对象选取时间为2012年1月至2013年12月。采用放射免疫法分别对两组对象进行血清FSH、LH、PRL、E2、P、T水平检验,进行对照研究。结果:观察组对象血清FSH、LH、PRL检验结果水平均明显高于对照组(P0.05),E2检测水平低于对照组(P0.05),P、T检测水平两组无差异(P0.05)。结论:性激素水平检测可以有效反映女性闭经后萎缩性尿道炎的身体状况,有助于预防相关疾病,可作为临床诊治参考。     

AMH联合E_2、FSH/LH检测对不孕症患者卵巢储备功能及反应性的评估作用

目的探讨抗苗勒管激素(AMH)联合雌二醇(E_2)、促卵泡激素(FSH)/黄体生成素(LH)检测对不孕症患者卵巢储备功能及反应性的评估作用。方法选取2016年3月至2018年12月湖北省襄阳市第一人民医院诊治的193例不孕症患者作为研究对象。均于月经期第2d～第3d检测血清AMH、E_2和FSH/LH水平,另记录获取卵子数目。根据获卵数将患者分为卵巢反应正常组(n=149)、卵巢低反应组(n=25)、卵巢高反应组(n=19),比较三组患者血清AMH、基础E_2和FSH/LH水平,并绘制基于血清AMH、基础E_2和FSH/LH水平单项及联合预测卵巢储备功能及反应性的工作曲线(ROC),分析其灵敏度、特异度及曲线下面积(AUC)。结果 193例不孕症患者血清AMH为(1.82±0.41)ng/mL,基础E_2水平为(30.45±2.37)pg/mL,基础FSH/LH为(1.64±0.35);193例不孕症患者中卵巢低反应25例(12.95%),卵巢正常反应149例(77.20%),卵巢高反应19例(9.84%);卵巢反应正常组、卵巢高反应组的血清AMH水平均明显高于卵巢低反应组,差异具有统计学意义(P0.05),卵巢高反应组的AMH水平高于卵巢反应正常组,差异具有统计学意义(P0.05);卵巢反应正常组、卵巢高反应组的基础E_2、FSH/LH水平均明显低于卵巢低反应组,差异具有统计学意义P0.05),卵巢高反应组的基础E_2、FSH/LH水平均明显低于卵巢反应正常组,差异具有统计学意义(P0.05);血清AMH、基础E_2、FSH/LH及联合预测不孕症患者卵巢低反应的AUC分别为0.824、0.652、0.765、0.911,灵敏度分别为72.00%、60.00%、64.00%、84.00%,特异度分别为82.55%、83.22%、79.87%、88.59%;血清AMH、基础E_2、FSH/LH及联合预测不孕症患者卵巢高反应的AUC分别为0.714、0.791、0.691、0.936,灵敏度分别为73.68%、68.42%、73.68%、84.21%,特异度分别为82.55%、83.89%、74.50%、88.59%。结论不孕症患者血清AMH水平在卵巢高反应性、卵巢正常反应性、卵巢低反应性中呈逐渐降低趋势,而基础E_2、FSH/LH则逐渐升高,血清AMH、基础E_2、基础FSH/LH均对卵巢反应性具有一定的预测价值,但此3项指标联合预测的价值优于各指标单独预测。     

色素障碍性皮肤病

982265 黄褐斑患者血清性激素水平的研究/万苗坚（空军总医院）…//中华皮肤科杂志.-1997,30（6）.-403 检测50例黄褐斑患者血清卵泡刺激素（FSH）、孕酮（P）、雌三醇（E_3）、黄体生成激素（LH）及催乳激素（PRL）的水平,以探讨内分泌改变与黄褐斑发病之间的关系。对照组50例。结果发现,25例男性患者血清FSH、PRL、E_3、P、LH水平与男性健康人对照组比较无显著性差异。25例女性患者血清FSH、PRL、LH、E_3、P     

PRL水平变化与内分泌失调性不孕症相关性研究

目的:探讨泌乳素(PRL)水平变化与内分泌失调性不孕症的相关性。方法:选取我院120例不孕症患者作为观察组,其中根据月经周期紊乱与否分为月经紊乱组(82例)和月经正常组(38例),另选取同期健康体检者120例作为对照组,测定观察组和对照组的PRL、雌二醇(E_2)、卵泡刺激素(FSH)、睾酮(T)和促黄体激素(LH)水平。结果:观察组患者的PRL、FSH及LH水平明显高于对照组,差异比较均有统计学意义(P0.05);观察组的T和E_2水平明显低于对照组,差异比较均有统计学意义(P0.05);月经紊乱组的PRL、FSH及LH明显高于月经正常组,差异比较均有统计学意义(P0.05),但T及E_2与月经正常组相比无显著性差异(P0.05);观察组患者的PRL与LH呈正相关(r=0.528,P=0.000),与FSH存在明显正相关(r=0.529,P=0.000),与E_2负相关(r=-0.548,P=0.000),与T无相关性(r=0.052,P=0.081)。结论:内分泌失调性不孕症患者的PRL水平明显高于正常人群,其与E_2、FSH、LH存在明显相关性,PRL的水平检测对内分泌失调性不孕症的临床诊断具有重要意义。     

巨噬细胞炎症蛋白-1α水平与多囊卵巢综合征病情的相关性研究

目的研究多囊卵巢综合征患者巨噬细胞炎症蛋白(MIP)-1α水平与病情的相关性。方法随机选取2017年1月至2019年1月恩施土家族苗族自治州中心医院收治的30例多囊卵巢综合征患者作为研究对象。将这30例患者设为研究组,另选取同期健康体检的10例女性健康志愿者作设对照组。检测两组研究对象血清MIP-1α水平、激素水平,分析MIP-1α与疾病分型的关系及多囊卵巢综合征患者血清MIP-1α水平升高相关因素。结果研究组患者血清中MIP-1α、LH、LH/FSH、T、E_2水平均显著高于对照组,差异均具有统计学意义(均P0.05)。两组研究对象血清FSH、PRL水平比较,差异无统计学意义(P0.05)。研究组患者随着多囊卵巢综合征分型的升高,血清MIP-1α水平显著升高,各分型间的差异均具有统计学意义(均P0.05)。研究组患者血清MIP-1α水平升高与LH、T、E_2以及疾病类型为呈正相关(P0.05);与FSH、PRL无相关性,差异无统计学意义(P0.05)。结论多囊卵巢综合征患者血清MIP-1α水平升高与LH、T、E_2以及疾病类型为呈正相关,参与疾病的发展,且随着疾病的加重MIP-1α表达加剧。     

糖皮质激素联合氯米芬治疗多囊卵巢综合征对患者血清孕酮、雌二醇的影响分析

目的:分析糖皮质激素与氯米芬合用治疗多囊卵巢综合征对患者血清孕酮、雌二醇的影响。方法:选取2015年1月至2016年3月在我院生殖科诊断为多囊卵巢综合征的患者共120例,随机均分为两组,每组60例。对照组仅给予氯米芬治疗,观察组加服糖皮质激素治疗。比较两组治疗效果;检测两组患者成熟卵泡数、子宫内膜厚度、注射HCG日血清E_2值,对宫颈粘液进行评分;检测两组患者治疗前后的生殖内分泌指标水平,包括卵泡刺激素(FSH)、黄体生成素(LH)、孕酮(P)、雌二醇(E_2)、睾酮(T)、泌乳素(PRL)、性激素结合蛋白(SHBG)。结果:观察组总有效率96.67%,显著大于对照组的81.67%(P0.05);观察组HCG日血清E_2水平、子宫内膜厚度、成熟卵泡数、宫颈粘液评分均显著优于对照组(P0.05);观察组FSH、LH、E_2、T、PRL水平明显降低(P0.05),P、SHBG水平明显升高;两组比较有统计学差异(P0.05)。结论:糖皮质激素与氯米芬合用治疗多囊卵巢综合征可有效改善患者激素水平。     

青春期后女性痤疮患者卵泡期性激素水平的检测

目的观察青春期后女性痤疮患者(25~40岁)性激素水平的改变情况。方法对入选的60例青春期后女性痤疮患者(肝经郁热型42例,阴虚火旺型18例)分别于月经周期第2~3天时采集空腹静脉血以检测其血清性激素水平,包括血清睾酮(T)、雌二醇(E2)、孕酮(P)、催乳素(PRL)、促卵泡激素(FSH)、黄体生成素(LH)、性激素结合蛋白(SHBG)、硫酸脱氢表雄酮(DHEAS),另选择30例同期在本院进行健康体检的女性志愿者或职工作为对照组。结果青春期后女性痤疮患者组DHEAS显著高于志愿者组,SHBG显著低于志愿者组(P均0.01);肝经郁热型患者FSH低于阴虚火旺型,而LH、LH/FSH及PRL均高于阴虚火旺型(P均0.05)。结论 DHEAS和SHBG异常改变与青春期后女性痤疮的发病可能有关。肝经郁热型青春期后女性痤疮患者性激素水平改变主要为LH,FSH及PRL异常。     

性激素水平与痤疮中医分型的关系研究

目的探讨性激素水平与痤疮中医分型的关系。方法采用放射免疫双抗法进行血清LH,FSH,E2,T,PRL水平的检测。结果女性肝郁气滞型痤疮患者血清性激素水平与女性湿热内蕴型痤疮患者血清性激素水平比较,LH差异无显著性(P>0.05);FSH,E2,T,PRL,LH/FSH差异均有显著性(P<0.01);男性肝郁气滞型痤疮患者血清性激素水平与男性湿热内蕴型痤疮患者血清性激素水平进行比较,血清T,PRL差异有显著性(P<0.05)。结论性激素水平与痤疮中医分型有关。PRL,LH/FSH是肝郁气滞型痤疮患者中医分型的微观物质基础,而T是湿热内蕴型痤疮患者中医分型的微观物质基础。     

男性寻常型银屑病患者血清性激素测定及意义

目的:测定男性寻常型银屑病的性激素水平。方法:采用化学发光法测定34例男性寻常型银屑病患者和13名健康男性血清FSH、E_2、PRI、LH、Pg、T。结果:寻常型银屑病组血清FSH、PRL PRL/E_2和FSH/E_2升高(P<0.05或<0.01),E_2降低(P<0.01),T、LH和Pg与对照组无显著性差异(P>0.05)。结论:某些性激素可能与男性寻常型银屑病的发病相关。     

Immunoreactivity of corticotropin-releasing hormone, adrenocorticotropic hormone and alpha-melanocyte-stimulating hormone in alopecia areata

Psychological factors are believed to play a role in the pathogenesis of alopecia areata (AA), a frequently encountered hair disorder. In our study, statistically significant elevation of psychological stress was felt by AA patients prior hair loss compared with control, which was strongly believed contributory to hair loss (t-test, P < 0.01). The corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) mRNA have been identified in the basal layer of the epidermis and pilosebaceous units of the normal scalp. And with the recent discovery of melanocytes and dermal fibroblasts capable of corticosterone production, the presence of a local stress response system resembling the hypothalamic-pituitary-adrenal (HPA) axis has been suggested. The local stress response system is involved in regulation of the normal hair cycle, but its precise role in AA is unknown. The influence of a local HPA axis or rather, CRH-POMC axis in AA was investigated by analysing immunohistochemically the expression levels of CRH and POMC peptides, including the adrenocorticotropic hormone (ACTH) and alpha-melanocyte-stimulating hormone (alpha-MSH), in a number of AA lesions and normal scalp (as control). The epidermis and pilosebaceous units of normal scalp stained weakly with CRH, ACTH and alpha-MSH, whereas those from the affected sites of the AA group showed intense expression of the peptides (chi-square test, P < 0.01). The meaning of this enhanced expression and their role in the pathogenesis of AA should be further evaluated in future.     

Hypoplastic thyroid,growth hormone deficiency,corneal opacities,cataract and hyperkeratotic skin disease: a possible new ichthyosis syndrome associated with endocrinopathies

A 56 year old man presented with ichthyosis vulgaris since early childhood, clinically characterised by fine scaling of the trunk and hyperkeratotic scales on the exterior surfaces of the upper and lower extremities. The patient also showed hypothyroidism due to hypoplastic thyroid, cataract, hypercholesterinemia with concommitant arcus cornealis and biliary concrements. Renal lithiasis caused by calcio-oxalate was additionally present. Endocrinological screening revealed growth hormone deficiency in the 1.55 m tall man—(secondary) osteoporosis was observed. The clinical symptomatology indicates that this case cannot be considered as a subtype of the inherited ichthyosis group, but suggests a new syndrome as a separate nosologic entity.     

癫痫、抗癫痫药与男性病人性激素的相互关系

Objective To explore the relationship between antiepileptic drugs(AED)and hormones of male epilep-tics.Methods:Comparison of 13 male epileptics before and after taking AED.Radioimmunoassay was taken totest total testosterone(TT),follicli-stimulation hormone(FSH),luteinising hormone(LH),prolactin(PRL),percentage of free testosterone(FT%),free testosterone(FTpmol/1),sex hormone binding globulin(SHBG).Result:After the treatment,TT,FT(pmol/1 were increased significantly,PRL was decreased definitely.LH、FSH、FT%、SHBG were of no significant differences.Conclusion:AED had some effects on the hormones of thepatients and epilepsy had no direct relationship with the sex hormones of the patients.     

Early serial Q-switched ruby laser therapy for medium-sized to giant congenital melanocytic naevi

Background  The sebaceous gland exhibits an independent peripheral endocrine function and expresses receptors for neuropeptides. Previous reports have confirmed the presence of a complete corticotropin-releasing hormone (CRH) system in human sebocytes in vitro . The capability of hypothalamic CRH to induce lipid synthesis, induce steroidogenesis and interact with testosterone and growth hormone implicates a possibility of its involvement in the clinical development of acne.
Objectives  The purpose of the study was to detect expression changes of CRH/CRH binding protein (CRHBP)/CRH receptors (CRHRs) in acne-involved skin, especially in the sebaceous glands.
Methods  Expression of CRH/CRHBP/CRHRs was analysed by immunohistochemistry in biopsies from facial skin of 33 patients with acne, noninvolved thigh skin of the same patients and normal skin of eight age-matched healthy volunteers.
Results  Very strong positive reaction for CRH was observed in acne-involved skin in all types of sebaceous gland cells, irrespective of their differentiation stage, whereas in noninvolved and normal skin sebaceous glands exhibited a weaker CRH staining depending upon the differentiation stage of sebocytes. The strongest reaction for CRHBP in acne-involved sebaceous glands was in differentiating sebocytes. CRHR-1 and CRHR-2 exhibited the strongest expression in sweat glands and sebaceous glands, respectively.
Conclusions  Expression of the complete CRH system is abundant in acne-involved skin, especially in the sebaceous glands, possibly activating pathways which affect immune and inflammatory processes leading to the development and stress-induced exacerbation of acne.     

雌、孕激素及促性腺激素水平测定对于绝经后妇女子宫内膜异常病变筛查的临床研究

目的探讨性激素水平测定对于筛查绝经后妇女子宫内膜病变的意义.方法选取我院门诊有充分手术指征的绝经后流血的患者,空腹时采肘静脉血3ml采用放射免疫RIA法测定性激素水平,并行分段诊刮,任何程度的子宫内膜增殖或增生均视为异常子宫内膜.结果绝经后妇女子宫内膜异常病变患者的雌激素水平明显高于正常绝经妇女(P＜0.05),尤其子宫内膜癌患者及子宫内膜不典型增生患者体内雌激素水平较正常绝经妇女显著增高,P＜0.01,且前两者之间亦有明显差异(P＜0.05).结论绝经后妇女阴道流血不能作为子宫内膜异常病变筛查的单一指标,对绝经后妇女常规进行性激素检测可作为子宫内膜异常病变的筛查方法之一.     

少弱精子症、死精子症、无精子症患者染色体及性激素检测分析

目的：了解少弱精子症、死精子症、无精子症发生率与染色体及性激素之间的关系。方法：对2005-2009年门诊765例少弱精子症、死精子症、无精子症患者,进行染色体以及血清中性激素检测,并对结果进行比较分析。结果：染色体异常总数占182例,异常发生率达23．8％。性染色体异常155例,占异常总数的85．2％,常染色体异常刀例,占异常总数14．8％。性激素检测,无论染色体核型正常与否,血清中睾酮（T）值均较低,而卵泡刺激素（FSH）、黄体生成素（LH）值均升高。性染色体核型异常者,T值降低更明显,FSH、LH值升高也更明显。泌乳素（PRL）、雌二醇（E）则没有明显改变。结论：精子质量与染色体异常程度呈正相关：少弱精子症染色体异常率6．5％,且多表现为常染色体异常;死精子症染色体异常率20．8％,无精子症染色体异常率30．3％,且多表现为性染色体异常。精子质量与性激素FSH、LH、T密切相关,与PRL、E2无明显差异：少弱精子症FSH、LH升高T下降;死精子症、无精子症FSH、LH明显升高T明显下降,尤其是性染色体异常者改变更显著。染色体异常与性激素的改变表现为：性染色体异常与性激素FSH、LH呈正相关,与T呈负相关;常染色体异常则不尽然。提示：男性不育少弱精子症、死精子症、无精子症患者常规做染色体检查和性激素检测是必要的,对确定其是否有治疗价值及是否应用内分泌治疗提供重要依据。     

Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model

In a murine model of epidermal hyperplasia reproducing some of the abnormalities of several common skin disorders, we previously demonstrated the antiproliferative and pro-differentiating effects of peroxisome proliferator-activated receptor (PPAR)alpha, PPARbeta/delta, and liver X receptor activators. Unlike other subgroups of PPAR activators, thiazolidinediones (TZDs), a family of PPARgamma ligands, did not inhibit keratinocyte proliferation in normal murine skin. Here, we studied the effects of two TZDs, namely ciglitazone (10 mM) and troglitazone (1 mM), in the same murine model where epidermal hyperproliferation was reproduced by repeated barrier abrogation with tape stripping. Topical treatment with ciglitazone and troglitazone resulted in a marked and significant decrease in epidermal thickness. Furthermore, in all TZD-treated groups, we observed a significant decrease in keratinocyte proliferation using proliferating cell nuclear antigen, 5-bromo-2'-deoxyuridine, and tritiated thymidine incorporation. However, using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, we found no difference in apoptosis between different treatments, emphasizing that it is the antiproliferative role of these activators that accounts for the decrease of epidermal thickness. Finally, using immunohistochemical methods, we determined the effects of ciglitazone on keratinocyte differentiation in this hyperproliferative model. We observed an increased expression of involucrin and filaggrin following ciglitazone treatment, suggesting a pro-differentiating action of TZDs in this model. In summary, topical TZDs significantly reduce epidermal keratinocyte proliferation while promoting differentiation in a murine model of hyperproliferative epidermis. Together, these results suggest that in addition to their metabolic effects currently in use in the treatment of type 2 diabetes, topical TZDs could be considered as potential alternative therapeutic agents in hyperproliferative skin diseases such as psoriasis.     

人黑素浓集素受体1抗原表位肽的表达、纯化及其在白癜风患者中的检测

目的 表达及纯化人黑素浓集素受体1抗原表位肽,探讨其在白癜风患者自身抗体检测中的应用。方法 人黑素浓集素受体1抗原表位肽编码基因合成后克隆至原核表达载体pGEX-4T-2,转化大肠杆菌BL21菌株,异丙基-β-D-硫代半乳糖苷（IPTG）诱导蛋白表达,通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳（SDS-PAGE）分析和Western印迹鉴定目的蛋白表达。以提取的黑素细胞膜蛋白作为阻断抗原,进行阻断ELISA分析。以目的蛋白为抗原,检测100例进展期白癜风患者和30例正常人血清IgG抗体情况。结果 成功构建重组表达载体,重组蛋白成功表达并纯化,上样量低于0.0625 μg时纯化率达100％。目的蛋白与白癜风患者血清IgG抗体间的结合能被天然黑素细胞膜抗原抑制。100例进展期白癜风患者血清中有36例与目的蛋白结合反应呈阳性。结论 成功表达并纯化了人黑素浓集素受体1抗原表位肽,该目的蛋白能够结合白癜风患者血清中IgG抗体,可以用于抗人黑素浓集素受体1抗体的检测。     

Investigation of the corticotropin-releasing hormone-proopiomelanocortin axis in various skin tumours

BACKGROUND: Various types of external stress cause the skin and central neuroendocrine system to express corticotropin-releasing hormone (CRH)-proopiomelanocortin (POMC) axis-related hormones. However, the precise role of the CRH-POMC axis-related hormones in various skin tumours is unclear. OBJECTIVES: This study examined expression patterns of the CRH-POMC axis-related hormones in skin tumours. METHODS: The production of CRH, adrenocorticotropic hormone (ACTH) and alpha-melanocyte-stimulating hormone (alpha-MSH) in various tumour cell lines including HaCaT and primary keratinocytes was examined using an enzyme-linked immunosorbent assay. Immunohistochemical analysis of the skin tumours was also performed. RESULTS: CRH, ACTH and alpha-MSH were strongly expressed in malignant skin tumour cell lines such as G-361 and DX-3 (both malignant melanoma, MM). However, normal and haematological malignancy cell lines did not express the CRH-POMC axis-related hormones. Immunohistochemical analysis of the skin tumours showed that MM (80%), squamous cell carcinoma (SCC, 70%) and basal cell carcinoma (BCC, 10%) had strong immunoreactivity (++/+++) for CRH. Strong ACTH and alpha-MSH expression was observed in MM (70% and 50%, respectively), SCC (80% and 60%, respectively) and BCC (70% and 50%, respectively). CONCLUSIONS: We report that an increase in the level of the CRH-POMC axis-related hormones is associated with malignant skin tumours such as MM. These results highlight the importance of the CRH-POMC axis-related hormones in the malignant tendency of skin tumours.     

青春期延迟56例临床分析

目的:探讨青春期延迟的分型诊断和治疗方法。方法:采用化学发光法测定促卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、雌二醇(E2)、泌乳素(PRL),同时进行绒毛膜促性腺素(HCG)兴奋试验。并进行外周血染色体检查和B超检查睾丸、附睾、精索、前列腺、精囊腺。根据检查结果进行分型诊断和病因学诊断,治疗以缺什么补什么为原则。结果:本组病例共56例,其中高促性腺激素型6例(占10.71%),低促性腺激素型50例(占89.29%)。通过激素的补充治疗,第二性征和阴茎均能得到改善,但睾丸生长缓慢,低促性腺激素型部分患者能恢复生殖功能,本组病例中3例精子密度正常,其中1例妻子已怀孕。结论:青春期延迟通过分型诊断,并进行相应的内分泌补充治疗,第二性征和阴茎发育正常,低促性腺激素型患者尚能恢复生殖功能。