尖锐湿疣并发乳房外Paget病1例

患者男,64岁.因阴茎下方出现红斑半年,伴疣状赘生物1个月,于2006年11月29 13来我科就诊.     

色素性乳房和乳房外Paget病

报告12例色素性乳房和乳房外Paget病.男女各6例,年龄46～77岁.皮损表现为乳头、乳晕和外生殖器的色素性斑片和斑块,临床上类似于黑素瘤.组织病理表现为表皮内有大的、胞质有空泡化的肿瘤细胞增生.这些肿瘤细胞以单个或数个聚集在一起呈巢状分布.部分肿瘤细胞的胞质内可见黑素颗粒.免疫组化染色示所有患者的肿瘤细胞广谱细胞角...     

乳房外Paget病1例

患者男，72岁。因外阴部红斑、渗出伴瘙痒4年，于2005年5月6日就诊。患者4年前无明显诱因阴茎根部出现红斑伴瘙痒，皮损逐渐向邻近皮肤蔓延，时有渗液及脓性分泌物，曾多次在外院就诊，均诊断为湿疹，给予曲安奈德益康唑乳膏等药物治疗，皮损时好时坏，范围逐渐扩大，病程中无发热、消瘦、乏力等。既往有痛眦病史20年，高血压病史1年余。体格检查：系统俭查未见异常。[第一段]     

乳房外Paget病1例

患者男，6l岁。阴囊左侧皮肤瘙痒性皮疹2年，于2002年8月2日就诊。患者于2年前阴囊部位起小丘疹，伴瘙痒，皮疹逐渐增多、增厚，日寸有渗出，一直不消退。发病后，曾至多家医院就诊，均诊断为“湿疹”，给予抗组胺药及皮质类固醇软膏外用，疗效不明显。患者既往身体健康，否认有糖尿病病史。体格检查：局部淋巴结不肿大，心肺等无异常发现。皮肤科检查。     

乳房外Paget病1例

患者男,58岁。左腹股沟反复起红斑,糜烂伴瘙痒8年,于2004年2月来我院就诊。患者8年前无明显诱因于左侧腹股沟出现红斑伴瘙痒,曾多次就医,以“湿疹”给予糖皮质激素类软膏外用,皮损可减轻,但易反复;随后皮损逐渐扩大,伴糜烂及渗出,俚未出现畏寒,发热等全身症状。     

乳房外Paget病1例

患者男,73岁。阴茎根部、阴囊出现红斑伴瘙痒13年,糜烂、渗出、溃疡、出现肿物伴异味1年。组织病理示局部区域有表皮下浸润,PAS(+),Alcianblue(-),免疫组化CEA(3+),CK(2+),HMB45(-),S-100(-)。诊断:乳房外Paget病。     

乳房外Paget病1例

患者男 ,64岁。阴囊皮疹偶伴渗出、瘙痒 10年。病理检查示 :全层表皮均见Paget细胞 ,有的成巢状 ,个别真皮乳头可见基底突破。诊断为 :乳房外Paget病 ,突破基底膜。     

乳房外Paget病1例

患者女,73岁.外阴及会阴红色斑片、糜烂3年伴疼痛1年,于2011年7月18日就诊.患者3年前无明显诱因外阴和阴唇部出现红斑,无糜烂,无自觉症状,未经治疗.皮损逐渐向会阴部发展,并且小阴唇红斑上出现点状糜烂伴少许渗液.曾在当地妇产科就诊,具体诊断与用药不详,未见好转.近1年患者自觉皮损持续性隐痛,且肛周出现红斑,无尿频、尿痛、无腹痛、腹泻,无发热.自起病以来患者精神、饮食、睡眠较差.2001年8月15日曾在当地医院行直肠腺癌手术治疗.     

乳房外Paget病1例

<正>1病历摘要患者男,79岁。因阴囊及阴茎丘疹和糜烂伴瘙痒10余年,加重1个月,于2016年5月30日来我科就诊。患者10余年不明原因阴囊出现芝麻大淡红色丘疹,自觉轻微瘙痒,未予诊治。皮损逐渐增多,部分融合成片,瘙痒剧烈,搔抓后形成糜烂面伴渗液,曾多次在外院就诊,均诊断为阴囊湿疹,予静脉滴注复方甘草酸苷,肌内注射卡介菌素多糖核酸,口服左西替利嗪,外用卤米松、     

巨大尖锐湿疣

报告1例变性人发生巨大尖锐湿疣.患者23岁,男变女性术后近2年发现肛周和再造阴道周围赘生物近8个月.根据临床表现和皮损组织病理检查诊断为巨大尖锐湿疣.实时定量荧光聚合酶链式反应(RT-PCR)证实为人乳头瘤病毒(HPV)-6、11型感染.先后给予钬激光和液氮冷冻处理后治愈.     

Giant condyloma acuminatum in pregnancy: A case report

The giant condyloma acuminatum (GCA), also known as Buschke–Löwenstein tumor (BLT), is a type of human papilloma virus‐associated sexually transmitted infection. Treatment options for condyloma acuminatum remain controversial, but surgery seems to be the best option. The management of GCA during pregnancy is more complicated since one has to evaluate the condition of both the mother and the fetus. In this report, we presented a GCA case in a pregnant woman with giant masses that covered the perineal and perianal region. Considering the gestational age and the fetal neurological risk from the anticipated lengthy procedure of mass removal surgery for tumor of this size, we decided to resect the tumor 2 weeks after the infant was delivered via C‐section.     

乳房外Paget病伴多脏器转移1例

报道1例乳房外Paget病伴右腹股沟淋巴结、肝、肺、胸腰椎、颅骨及骨髓转移的患者。原发皮损位于右侧阴囊，最后因呼吸循环衰竭而死亡。     

儿童多发性口腔尖锐湿疣

患儿女,9岁。因下唇赘生物2年,手术切除后复发并增多1个月就诊。皮肤科检查:牙龈、下唇、舌体中部可见数枚米粒至黄豆大赘生物、色淡红、表面粗糙。牙龈皮损组织病理检查示角化过度,表皮乳头瘤样增生,表皮颗粒层及棘层上部见多量凹空细胞,真皮浅层少量淋巴细胞浸润。免疫组化染色示棘层中上部的细胞核P16呈阳性。原位杂交:人乳头瘤病毒(HPV)6型阳性,诊断:口腔多发尖锐湿疣。     

下疳样脓皮病伴非淋菌性尿道炎及尖锐湿疣1例

报告1例下疳样脓皮病伴尖锐湿疣及非淋菌性尿道炎。患者男，27岁。临床表现为尿频、尿急、尿痛，全身散在黄豆至蚕豆大梅毒硬下疳样溃疡和阴茎背侧赘生物。既往有非婚性接触史。尿道分泌物衣原体快速检测( )；反复暗视野查梅毒螺旋体及梅毒血清试验均阴性。诊断为下疳样脓皮病伴尖锐湿疣及非淋菌性尿道炎。给予口服米诺环素、左氧氟沙星及盐酸伐昔洛韦片，局部湿敷、尖锐湿疣皮损局部电凝等治疗，效果显著。     

Extramammary Paget disease – clinical appearance,pathogenesis, management

Extramammary Paget disease is a rare malignant neoplasm. With regard to the pathogenesis, two prognostically different forms can be distinguished. The primary form of extramammary Paget disease is an in situ carcinoma of the apocrine gland ducts. In contrast, the secondary form is characterized by an intraepithelial spread due to an underlying carcinoma of the skin or other organ systems. Extramammary Paget disease occurs in older patients. The predilection sites include the entire anogenital skin and less often the axillary region. We present five different patients with this disease, thereby demonstrating its variation in clinical morphology. The lesion usually presents as an erythematous sharply defined spot. The polygonal borders, caused by the centrifugal growth of the tumor, may provide a diagnostic clue. The treatment of choice for extramammary Paget disease remains Mohs’ microscopic surgery. However, radiotherapy or topical applications may be alternative treatment options in selected cases. In patients with the secondary form of extramam‐mary Paget disease, treatment of the primary tumor is the main approach.     

17例儿童尖锐湿疣分析

本文报道17例儿童CA患儿,14例患儿的父母有CA病史,所有女患儿处女膜完整。儿童感染CA可通过非性接触途径。     

五联疗法治疗肛门尖锐湿疣的临床观察

采用外科破坏法。干扰素局部浸润注射、自体疣移植、口服免疫应答调节剂、中药熏洗坐浴等5联疗法治疗肛门尖锐湿疣,对照组采用疣体切除术加干扰素局部注射。结果表明,两组治愈率和复发率分别为100%、0%和82.5%、27.0%,差异有统计学意义(P<0.01)。     

Atypical cells on reflectance confocal microscopy may not represent melanoma: A case of axillary pigmented extramammary Paget disease

Pigmented extramammary Paget disease (PEMPD) is a rare intraepithelial carcinoma which can clinically resemble other pigmented neoplasms. Similarities to melanoma on dermoscopy, histopathology, and reflectance confocal microscopy (RCM) increase the risk of misdiagnosis and, consequently, mismanagement. Here, we describe a case of a 67-year-old African American woman with a large, pigmented axillary patch that exhibited features of melanoma on RCM, guiding the clinician to perform an excisional biopsy. While traditional histopathology resembled melanoma, immunohistochemistry staining was performed and revealed PEMPD. We highlight an uncommon clinical presentation of PEMPD disease and identify morphologic mimickers of melanoma on RCM—as well as differentiating features.     

乳房外Paget病19例临床与随访分析

目的探讨乳房外Paget病的临床、病理特点及影响生存率的因素。方法回顾性分析2000-2010年间本院收治的19例乳房外Paget病患者的临床资料。结果 19例中女4例,男15例,平均年龄(70.26±8.90)岁。确诊时病程1月~6.5年,平均43月。临床表现主要为红斑、糜烂及湿疹、皮炎样皮损。手术治疗13例,其中2例复发;光动力治疗5例;未治疗1例。随访期间死亡7例,5年生存率61.20%。单因素变量分析显示淋巴结转移、肿瘤细胞侵袭至真皮、伴发其他肿瘤或远处转移、CEA水平升高与患者生存率有关。结论乳房外Paget病早期诊断困难,复发率高,淋巴结转移、伴发肿瘤或远处转移者预后差,需长期随访。迁延不愈的"湿疹"患者应尽早行皮肤活检,免疫组化检查可提高早期诊断率并指导早期治疗。