浅表肢端纤维黏液瘤1例

患者男,24岁,左手中指指腹肤色结节3年.皮肤科情况:左手中指第二指腹侧可见一0.7 cm×0.6 cm大小肤色结节,质硬,表面光滑,边界清楚,表面无破溃、糜烂.皮损组织病理示:表皮大致正常,真皮内及皮下组织内可见一界限清楚、无包膜的肿瘤.肿瘤由束状、编织状排列的短梭形、卵圆形和星形肿瘤细胞组成,其间有较多分支状的小到...     

浅表性肢端纤维黏液瘤

患儿女,8岁. 主诉:右足趾甲下结节1年. 现病史:患儿1年前发现右足第5趾趾甲远端甲下出现米粒大肤色丘疹,无自觉症状,未予诊治,皮损逐渐增大至黄豆大的结节,局部受压时疼痛,逐来我院就诊. 既往史、家族史:既往体健,家族中无类似疾病患者. 体格检查:系统检查无异常. 皮肤科检查:右足第5趾趾甲末端甲下及甲缘一约0.8 ...     

甲下浅表性肢端纤维粘液瘤1例

报告甲下浅表性肢端纤维粘液瘤1例。患者女,74岁,因右足拇趾甲下肿物2个月就诊。皮肤科检查：右足拇趾甲床部位见一大小约3.0 cm×2.0 cm×1.0 cm的红色肿物,质韧,压痛(+),甲板缺如。体表肿物超声：拇趾探及范围约21 mm×20 mm低回声包块,内回声不均,呈囊实混合性。右足DR:拇趾软组织肿胀,骨质未见明显异常。皮损组织病理示：表皮角化过度、角化不全,部分棘层增厚,真皮浅层水肿,小血管增多,见梭形细胞及星状增生,纤维组织增多,血管周围少量淋巴细胞浸润。阿辛蓝染色(+)。免疫组化：CD34局灶性阳性、Vimentin弥漫性阳性,S-100、Desmin、Actin、CD31、HHV-8均阴性。诊断：甲下浅表性肢端纤维粘液瘤。予手术切除肿物,术后甲床愈合良好,随访未见复发。     

浅表肢端纤维黏液瘤一例

患者男,43岁,左足跟肿块7年余.无明显不适,行走时偶尔有疼痛,逐渐增大.临床表现为左足跟1.5 cm×1.5 cm大小浅红色、质硬、境界清楚的肿块.病理检查可见黏液样基质中较多的梭形或星形细胞增殖呈席纹样或束状排列,其间可见有较多的小血管,梭形或星形细胞未见明显异形.免疫组化显示波形蛋白、纤维结合素、CD34和上皮膜抗原阳性,平滑肌抗体、S-100、神经微丝、结蛋白和CD99均为阴性.诊断为浅表肢端纤维黏液瘤.行足跟部肿块扩大切除术合并游离皮片移植术,术后随访5月余未见复发.     

肢端纤维软骨黏液样肿瘤1例

【摘要】 患者男,44岁,左手小指皮下结节3年。皮肤科检查：左手小指末节背侧一0.4 cm × 0.4 cm皮下结节,触之橡皮样硬度,无压痛,末端指间关节活动不受限。术后组织病理：肿瘤含有丰富的纤维样、软骨样、黏液样间质。肿瘤细胞呈卵圆形至短梭形,核仁不明显,未见有丝分裂。细胞排列杂乱或呈小团簇状。免疫组化：肿瘤细胞表达波形蛋白、CD34、转录因子ERG、SOX9,不表达S100、P63、广谱角蛋白（AE1/AE3）、上皮膜抗原、平滑肌肌动蛋白、结蛋白,Ki67 增殖指数小于1%。诊断：肢端纤维软骨黏液样肿瘤。     

肢端纤维角皮瘤1例

<正>1临床资料患者男,66岁,左掌桡侧肿物25年。患者25年前无诱因,左掌桡侧出现黄豆大小肿物,无痒痛,近5年肿物逐渐增大,皮损从未破溃,患者未曾治疗,为进一步诊治于2015年5月19日就诊我院皮肤科门诊。患者既往体健,否认局部外伤史,家族中无类似疾病患者。体检:未见指关节活动障碍,内科系统检查未见明显异常。皮肤科检查:左掌桡侧可见约0.7 cm×0.7 cm×0.9 cm皮色肿物,呈指状隆起皮肤表面,表面粗糙,轻度角化过度,触之较硬,见图1。皮肤组织     

浅表肢端纤维黏液瘤一例

A case of superficial acral fibromyxoma is reported.A 43-year-old male patient presented with a 7-year-history progressive mass arising on the Ieft heel.There was no evident discomfort but occasional pain during walking.Clinical examination revealed a plum,solid,well-defined mass sized 1.5 cm×1.5 cm on the left heel.Histologically,there was a proliferation of numerous spindle or stellate cells arranged in a storiform or fascicular pattern embedded in a myxoid stroma with many small blood vessels;no evident atypia or mitosis was observed in these cells.Immunohistochemical staining of lesional tissue was positive for vimentin,fibronectin,CD34 and early membrane antigen,but negative for smooth muscle antibodv,S-100,neurofilaments,desmin or CD99.A diagnosis of superficial acral fibromyxoma Was made.The tumor was removed by expanded excision followed by free skin flap transplantation.No recurrence Was observed dunng a 5-mobth follow up.     

浅表性血管黏液瘤

报告1例浅表性血管黏液瘤。患者男,53岁。头皮结节3年,时有疼痛,逐渐增大。皮损组织病理学检查示:肿瘤位于真皮内,周围有胶原纤维包绕。肿瘤由卵圆形较饱满的基质细胞组成,细胞质呈双染性,未见异形及核分裂像。肿瘤基质内有丰富的黏液样物质,散在分布中、小血管,未见大血管。诊断为浅表性血管黏液瘤。     

获得性肢端纤维角皮瘤七例临床分析

回顾性分析2016-2019年间我科确诊为获得性肢端纤维角皮瘤的7例患者,平均发病年龄（30.25±15.17）岁,平均病程（4.15±5.12）年,男女比例4∶3。皮损表现为发生于肢端的无症状的单发丘疹状、柱状或角化斑块状增生物、直径多＜1 cm,呈正常皮色或黄褐色。组织病理学特征性表现为胶原束与表皮垂直。皮肤镜特征因皮损部位、生长模式、胶原及毛细血管形成的不同而表现不同。     

肢端型血管角皮瘤1例

患者,23岁。因双手背暗红色斑点,丘疹7年,于2004年3月16日来我科就诊。患者7年前双手严重冻伤,局部红肿、溃破、糜烂,愈后双后背皮肤遗留较多暗红色斑及捕疹,多数皮损压之退色,部分皮损表面逐渐角化,颜色加深,未曾治疗。现每年冬季手部皮肤仍有冻伤,但程度较轻,皮损不再增加。既往体健,自6-7岁始每年冬季手部均有冻疮。     

Superficial acral fibromyxoma in the heel with new vascular features on dermoscopy

Superficial acral fibromyxoma (SAFM) is an uncommon mesenchymal soft tissue tumor with a predilection for the acral extremites and nail bed involvement. SAFM is diagnosed with clinicopathological and immunohistochemical examination. Awareness of this rare tumor is important because of amounts of benign and malignant neoplasms. We report a case of SAFM in a rare localization in the heel with a new finding on dermoscopy.     

A Case of Recurrent Superficial Acral Fibromyxoma

Superficial acral fibromyxoma (SAFM) is a rare myxoid tumor that was first described in 2001. The presence of a very slow growing solitary tender mass in the subungual area is the typical clinical feature at presentation. Histopathologically, SAFM is composed of stellate cells in a myxocollagenous matrix with a poorly circumscribed margin. This tumor is thought to be benign, but its natural course is not fully understood. We describe a 15-year-old patient with recurrent SAFM and discuss the proper treatment and follow up.     

对称性肢端角化病四例

报道4例对称性肢端角化病患者,其中男3例,女1例。表现为手腕、手背及足背部对称性红褐色角化性斑片,遇水皮损发白,冬季明显缓解。组织病理：角化过度,角化不全,表皮增生,棘层增厚,真皮浅层血管周围可见少许淋巴细胞浸润。符合对称性肢端角化病。     

Superficial acral fibromyxoma: a clinicopathological study of new 41 cases from the U.K.: should myxoma (NOS) and fibroma (NOS) continue as part of 21st‐century reporting?

Background Superficial acral fibromyxoma (SAF) remains poorly recognized by general pathologists and dermatopathologists, partly attributable to its relatively uncommon occurrence and recent documentation. Objectives To examine a series of SAF and document the U.K. experience with this new entity. Methods We reviewed 771 tumours reported between 1970 and 2006 in seven different U.K. hospitals and coded as myxoma, not otherwise specified (NOS), fibroma (NOS) or dermatofibroma (NOS) presenting at acral sites. Forty‐one cases of SAF were studied. Results The patients comprised 27 men and 14 women, age range 19–91 years (mean 50, median 47), presenting with a solitary mass or nodule with a mean size of 1·92 cm. The common clinical sites were the toes (n = 29) and fingers (n = 11) as well as the palm (n = 1), with more than 75% of cases close to or involving the nail bed. All cases presented with a painless mass except for four cases where pain was the presenting complaint. A history of trauma was reported in only two cases. Histologically, all cases presented as proliferation of spindle‐shaped and/or stellate cells with a storiform and fascicular pattern embedded in a fibromyxoid/collagenous stroma with conspicuous mast cells. Multinucleated cells were observed (n = 22), increased number of blood vessels in the stroma and extravasation of red blood cells (n = 4). The characteristic immunophenotype was CD34+, CD99+/?, epithelial membrane antigen+ focally/?, S100?, desmin?, smooth muscle actin?, HMB45? and cytokeratin?. Conclusions We describe a large series of 41 cases of SAF showing that it is a distinct entity with typical clinical, histological and immunohistochemical features. Follow‐up was available only in 12 patients, precluding a firm comment on recurrence. However, complete excision and follow‐up review is recommended.     

Superficial acral fibromyxoma: report of two cases

Superficial acral fibromyxoma (SAFM) is a rare soft tissue tumor that has recently been delineated as a separate entity. We report 2 cases of SAFM and discuss its pathological features and differential diagnosis. Both patients had lesions on the toe. In 1 patient, the tumor was found after nail extraction, which had been performed for the treatment of onychomycosis, whereas in the other patient the tumor itself was the reason for seeking dermatological assistance. Biopsies from both cases demonstrated similar features. There was a moderately circumscribed, non-encapsulated tumor extending through the whole dermis. The neoplasm was composed of spindle and stellate cells with slight nuclear atypia arranged in a loose storiform, partly fascicular growth pattern. In 1 case, strands of cells with rather wavy nuclei were seen at the periphery of the tumor. Mitotic figures were scarce. The neoplastic cells were embedded in a myxoid stroma with increased numbers of small blood vessels and scattered mast cells. Immunohistochemically, the tumor cells showed weak focal positivity for CD34 and stained negatively for S-100 protein and alpha-smooth muscle actin. In 1 case epithelial membrane antigen (EMA) was negative, whereas in the second case focal expression of EMA by neoplastic cells was seen. Alcian blue staining revealed abundant mucinous material within the stroma. In conclusion, SAFM represents a distinct entity in the spectrum of cutaneous myxoid tumors. The differential diagnosis of SAFM includes various myxoid neoplasms and tumors with a predilection for distal parts of the extremities.     

炎症性浅表播散性汗孔角化症一例

患者,男,64岁。全身褐色环形斑块2年,伴瘙痒2个月。组织病理示：表皮角化不全,角化过度,可见角化不全柱,其下方棘层散在角化不良细胞,基底层灶状液化变性,真皮见团块状淋巴细胞为主的炎细胞浸润。诊断：炎症性浅表播散性汗孔角化症。给予阿维A 30 mg/d口服治疗,皮损部分消退,目前随访中。     

局灶性肢端角化过度

报告1例局灶性肢端角化过度.患者女,45岁.双手淡黄色扁平丘疹10余年,无自觉症状.组织病理检查可见表皮明显角化过度,颗粒层及棘层增厚,未见典型空泡细胞.弹性纤维染色示真皮弹性纤维大致正常.