Kinesiophobia in chronic low back pain patients—does the startle paradigm support the hypothesis?

Pain research has shown that fear-avoidance beliefs determine disability from back pain to a significant degree. It is assumed that anxiety regarding certain movements or activities motivates avoidance behavior. It has not yet been established whether chronic low back pain (CLBP) patients actually experience fear of movement when confronted with back pain-related movements. Startle response measures reliably differentiate the affective quality of a stimulus. This study investigates whether CLBP patients show a startle response typical for aversive stimuli when confronted with pictures of back pain-related movements. In 36 patients with CLBP, 18 headache patients and 18 healthy controls, the startle response was examined in the presence of pictures of back pain-related movements (e.g., bending) and pleasant movements (e.g., taking a relaxed position). Back pain patients did not show the predicted startle potentiation when viewing back pain-related pictures, although they rated these pictures as more aversive than did the other two groups. Results may indicate that it is not fear of pain that motivates avoidance behavior and determines disability, but rather an individual’s beliefs and attitudes concerning back stressing movements.     

Walking with chronic non-specific low back pain – A failed strategy: What can we learn from sports?

The present theoretical consideration is focused on the different behaviours of patients with chronic non-specific low back pain and healthy people when walking. The ground reaction force pattern and its direct influence on the success of the applied strategy are of special interest. This consideration does not clarify whether or not and to what limit the indicated pattern is the main cause or compensatory effect of chronic non-specific low back pain. It is known that pain patients exhibit divergent walking patterns. In addition to a shorter stride, the relationship between swing-to-stance phase shifts in the direction of stance. This strategy should contribute to an improvement in the control. Simultaneously, the impact and the forces should be reduced. Recent studies refer to different activation behaviours of the bi-articular Musculus biceps femoris. According to our analysis, this muscle owns a key function concerning force transmission. The type of force transmission immediately influences system loading. The strategy exhibited by patients with chronic non-specific back pain fails due to false activations, in particular false activations of the M. biceps femoris. The essential objective of the strategy for reducing the maxima of the applied forces, as well as to distribute the force over a longer period of time, was implemented; however, it could be shown that the increase in the maximum force is clearly reached early. Such a fast development in force is equivalent to higher loadings to the human system. This concerns visco-elastic structures in particular. Due to the fast increasing forces, these structures possess low or insufficient damping properties. If our hypothesis of the failed strategy holds true, it might be the basis for new therapeutic approaches, as well as diagnostics involving non-specific low back pain.     

Is chronic non-specific low back pain chronic? Definitions of a problem and problems of a definition.

BACKGROUND: Chronic low back pain (LBP) accounts for the majority of the disability and costs for LBP. However, the definition of chronicity is unclear. AIM: To elicit practitioners' definitions of chronic LBP patients, both in general and in the patients they were treating; to assess the most common characteristics of these practitioners' chronic LBP patients; and to assess the stability of chronicity in a sample of the general population. METHOD: Semi-structured interviews were conducted with 33 practitioners working in private practice, 71 LBP patients and their therapists, and 252 employees of a chain store who were assessed yearly in a prospective study. RESULTS: The therapists' definitions of chronic LBP patients generally included psychosocial aspects. Only physical symptoms and signs were stressed in the patients they were treating. These patients displayed common characteristics with reference to pain, functional problems, and contact with health care services. Duration of symptoms was not sufficient to define chronicity. In the employee population, chronicity defined according to pain duration was unstable. However, the same was true when chronicity was measured according to the criteria defined in the patient population. CONCLUSION: There is a discrepancy between theory and practice regarding the definition of chronic LBP. This discrepancy concerns not only the literature but also clinical practice itself. The term 'chronic' LBP as currently used is therefore equivocal.     

Evolution of medical treatment for endometriosis: back to the roots?

Experimental evidence is accumulating to suggest that medicinal botanicals have anti-inflammatory and pain-alleviating properties and hold promise for treatment of endometriosis. Herein, we present a systematic review of clinical and experimental data on the use of medicinal herbs in the treatment of endometriosis. Although there is a general lack of evidence from clinical studies on the potential efficacy of medicinal herbs for the treatment of endometriosis-associated symptoms, our review highlights the anti-inflammatory and pain-alleviating mechanisms of action of herbal remedies. Medicinal herbs and their active components exhibit cytokine-suppressive, COX-2-inhibiting, antioxidant, sedative and pain-alleviating properties. Each of these mechanisms of action would be predicted to have salutary effects in endometriosis. Better understanding of the mechanisms of action, toxicity and herb-herb and herb-drug interactions permits the optimization of design and execution of complementary alternative medicine trials for endometriosis-associated pain. A potential benefit of herbal therapy is the likelihood of synergistic interactions within individual or combinations of plants. In this sense, phytotherapies may be analogous to nutraceuticals or whole food nutrition. We encourage the development of herbal analogues and establishment of special, simplified registration procedures for certain medicinal products, particularly herbal derivates with a long tradition of safe use.     

What are people willing to pay for whole-genome sequencing information,and who decides what they receive?

PurposeWhole-genome sequencing (WGS) can be used as a powerful diagnostic tool as well as for screening, but it may lead to anxiety, unnecessary testing, and overtreatment. Current guidelines suggest reporting clinically actionable secondary findings when diagnostic testing is performed. We examined preferences for receiving WGS results.MethodsA US nationally representative survey (n = 410 adults) was used to rank preferences for who decides (an expert panel, your doctor, you) which WGS results are reported. We estimated the value of information about variants with varying levels of clinical usefulness by using willingness to pay contingent valuation questions.ResultsThe results were as follows: 43% preferred to decide themselves what information is included in the WGS report. 38% (95% confidence interval (CI): 33–43%) would not pay for actionable variants, and 3% (95% CI: 1–5%) would pay more than $1,000. 55% (95% CI: 50–60%) would not pay for variants for which medical treatment is currently unclear, and 7% (95% CI: 5–9%) would pay more than $400.ConclusionMost people prefer to decide what WGS results are reported. Despite valuing actionable information more, some respondents perceive that genetic information could negatively impact them. Preference heterogeneity for WGS information should be considered in the development of policies, particularly to integrate patient preferences with personalized medicine and shared decision making.Genet Med 18 12, 1295–1302.     

Low back muscle fatigue during Sørensen endurance test in patients with chronic low back pain: relationship between electromyographic spectral compression and anthropometric characteristics

This study assessed low back muscle fatigue during S?rensen back endurance test in chronic low back pain (CLBP) patients and healthy controls, and investigated relationship between the erector spinae muscle fatigability and subject's anthropometric characteristics. Four groups (n = 10 per group) of middle-aged (47-52-year-old) subjects participated: 1) female CLBP patients, 2) healthy female subjects, 3) male CLBP patients and 4) healthy male subjects. Subjects performed S?rensen back endurance test until exhaustion, while electromyographic (EMG) power spectrum median frequency compression over time (MF slope) as indicator of the erector spinae muscle fatigability, and endurance time were recorded. The endurance time was shorter (p < 0.05) in male CLBP patients compared to the healthy male and female subjects. No significant gender differences in endurance time were found in CLBP patients and in healthy subjects. EMG power spectrum MF slope did not differ significantly in CLBP patients and in healthy subjects. However, MF slope was higher (p < 0.05) in healthy male than in female subjects. Body mass and BMI correlated moderately positively with MF slope (r = 0.40-0.67) in all measured groups. We conclude that male CLBP patients had lower back extensor muscle isometric endurance compared to the healthy subjects of both genders, whereas no gender differences in isometric endurance were found in CLBP patients and in healthy subjects. Healthy male subjects had greater lumbar erector spinae muscle fatigability compared to the healthy female subjects. Subjects with higher body mass and body mass index fatigued faster during S?rensen back endurance test.     

Test�Cretest reliability of the nociceptive withdrawal reflex and electrical pain thresholds after single and repeated stimulation in patients with chronic low back pain

Recent studies have shown that the nociceptive withdrawal reflex threshold (NWR-T) and the electrical pain threshold (EP-T) are reliable measures in pain-free populations. However, it is necessary to investigate the reliability of these measures in patients with chronic pain in order to translate these techniques from laboratory to clinic. The aims of this study were to determine the test?Cretest reliability of the NWR-T and EP-T after single and repeated (temporal summation) electrical stimulation in a group of patients with chronic low back pain, and to investigate the association between the NWR-T and the EP-T. To this end, 25 patients with chronic pain participated in three identical sessions, separated by 1?week in average, in which the NWR-T and the EP-T to single and repeated stimulation were measured. Test?Cretest reliability was assessed using intra-class correlation coefficient (ICC), coefficient of variation (CV), and Bland?CAltman analysis. The association between the thresholds was assessed using the coefficient of determination (r ²). The results showed good-to-excellent reliability for both NWR-T and EP-T in all cases, with average ICC values ranging 0.76?C0.90 and average CV values ranging 12.0?C17.7%. The association between thresholds was better after repeated stimulation than after single stimulation, with average r ² values of 0.83 and 0.56, respectively. In conclusion, the NWR-T and the EP-T are reliable assessment tools for assessing the sensitivity of spinal nociceptive pathways in patients with chronic pain.     

Assessing pain and pain-related fear in acute low back pain: what is the smallest detectable change?

Background: The Tampa Scale for Kinesiophobia (TSK) and the Fear-Avoidance Beliefs Questionnaire (FABQ) are frequently used questionnaires for pain-related fear, and the visual analogue scale (VAS) is for pain. Purpose: This study aims to determine the smallest detectable change (SDC) of these questionnaires in patients with acute low back pain (LBP), as well as ceiling and/or floor effects. Results: The SDC for the TSK (scoring range: 17–68) was 9.2 (95% CI: 8.4; 10.3). The estimated SDC was 9.4 (95% CI: 8.5; 10.6) and 12.7 (95% CI: 11.5; 14.1) for the FABQphysical activity subscale (scoring range: 0–24) and/or work subscale (scoring range: 0–42), respectively. For the VAS for pain (0–100 mm), the SDC turned out to be 36.2 mm (95% CI: 32.4; 41.0). The FABQ physical activity subscale and pain (VAS) seem to have considerable problems in detecting improvement and deterioration. The TSK appears to be able to detect improvement as well as deterioration. Conclusion: The SDCs of the (subscales of) questionnaires range from 18% to 40%. Floor and/or ceiling effects were detected for most scales, except the TSK total and the TSK activity avoidance subscale. These results should be considered when using these questionnaires as measures of therapeutic change in acute LBP.     

Making knowledge clips with patients: What learning mechanisms are triggered in medical students?

ObjectiveTo prepare medical students for a rapidly changing healthcare landscape, where new means of communication emerge, innovative teaching methods are needed. We developed a project-based learning course in which medical students design audiovisual patient information in collaboration with patients and with students in Communication and Information Sciences (CIS). We studied what learning mechanisms are triggered in medical students by elements of a project-based-learning course.MethodsIn this qualitative study, twelve sixth year medical students that participated in the course were individually interviewed. Data were analyzed according to the principles of qualitative template analysis.ResultsWe identified four learning mechanisms: Challenging assumptions about patients’ information needs; Becoming aware of the origin of patients’ information needs; Taking a patient’s perspective; Analyzing language to adapt to patients’ needs. These learning mechanisms were activated by making a knowledge clip, collaborating with patients, and collaborating with CIS students.ConclusionCollaborating with patients helped students to recognize and understand patients’ perspectives. Working on a tangible product in partnership with patients and CIS students, triggered students to apply their understanding in conveying information back to patients.Practice implicationBased on our findings we encourage educators to involve patients as collaborators in authentic assignments for students so they can apply what they learned from taking patients’ perspectives.     

The patient–physician relationship in patients with chronic low back pain as a predictor of outcomes after rehabilitation

For patients with chronic diseases, especially those with chronic low back pain, the patient–physician relationship is significant for treatment adherence. In a sample of N = 688 low back pain patients, we examined the hypothesis that aspects of the patient–physician relationship (e.g. satisfaction with care, trust in the physician, patient participation) have a significant association with outcomes (pain, disability, quality of life, pain-related psychological impairment) after a multimodal treatment program (rehabilitation) after adjusting for a number of sociodemographic, medical, and psychological factors. Results show that the patient–physician relationship is significantly associated with the outcome. In the medium term (6 months after rehabilitation), the effect of the patient–physician relationship is clearer than in the short term (end of rehabilitation). In addition, risk factors for less improvement are female gender, higher age, low income, comorbidity, low treatment motivation, fear avoidance beliefs, and external locus of control. Future studies should examine the causal paths between the relationship variables and the outcome variables.     

How should alternative medicine be taught to medical students and physicians?

Advocates of alternative medicine are critical of current medical curricula, and have proposed fundamental changes, including the introduction of "integrative medicine" programs to teach alternative medicine. Medical educators have not replied to these criticisms, and have not developed basic curricula in alternative medicine. The author analyzes the alleged deficiencies in medical education, which are based on misrepresentations of medicine and medical training. (For example, critics state that physicians ignore mind-body interactions; in response, several examples are given to show that training physicians to consider the whole person and to identify and address emotional and social problems-the biopsycho-social model-are central tenets of medical education.) The author also examines fundamental differences between traditional and alternative medicine (e.g., their different attitudes toward the importance of evidence; the vitalistic versus the biomedical models of health and disease) that are central to the issue of how alternative medicine should be taught. He concludes that physicians need additional education in order to provide guidance to patients, but teaching about alternative medicine should be evidence-based, not merely the transmission of unproven practices.     

Occupational and nonoccupational risk indicators for incident and chronic low back pain in a sample of the swedish general population during a 4-year period: An influence of depression?

The objectives of this study were to examine the relation between occupational and nonoccupational conditions and both incident (IBLP) and chronic low back pain (CLBP), aswellasdepression, among women and men. Data from a4-year follow-up of a study group consisting of 420 participants of both genders from the general Swedish population were analysed. Occupational risk indicators were predictors for both ILBP and CLBP. Depression was not found to be a predictor for either IBLP or CLBP among women, but was a predictor for CLBP among men. Among women, depression had some risk indicators in common with ILBP and appeared to be a concurrent outcome rather than a risk indicator. Low back pain in 1993 was not a predictor for depression in 1997 in either women or men. Occupational conditions are of relevance in relation to both incident and CLBP. Nonoccupational conditions were stronger predictors for CLBP than for ILBP but had some predictive value also for ILBP.