夏季皮炎方治疗夏季皮炎疗效观察

夏季皮炎方治疗夏季皮炎疗效观察倪晓，陆明琳，季凤歧我们于１９９１年７～８月用夏季皮炎方治疗夏季皮炎，并进行了对照观察，现报告如下：临床资料：从门诊选择典型夏季皮炎患者共８０例，其中男２０例，女６０例；年龄１８～８３岁，病程３～３０年，按随机数字表法将...     

派瑞松霜治疗皮炎湿疹的疗效观察

目的观察派瑞松霜治疗皮炎湿疹的疗效、耐受性及不良反应。方法60例患者来自门诊和住院病人,男55例,女5例。年龄14～87岁,平均71.1±15.1岁;病程2天～20年,平均9.5±25.1月。每日2次外用派瑞松霜涂于患处,每周随访1次,共3周。结果治愈33例(55.0％),显效16例(26.7％),好转4例(6.6％),无效7例(11.7％)。总有效率为81.7％,未发现不良反应。结论派瑞松霜是治疗皮炎湿疹类皮肤病的安全、有效药物。     

色素障碍性皮肤病

952236 SOD霜外用配合内治法治疗面部色素增多症90例疗效观察/周翔…//皮肤病与性病。-1995,17(1).-40～41 均为女性,包括雀斑29例、黄褐斑38例、外源性(炎症后色沉、化妆品皮炎等)色沉23例;应用SOD霜(10克基质中含SOD一千单位)早晚各一次,并按摩1～3分钟,连用12周;每日静注硫代硫酸钠0.64克加维生素C1克,连用4周,并口服维生素C、E和施尔康。结果治愈5例(5.6％),显效28例(31.1％),有效     

复方止痒洗剂治疗夏季皮炎100例疗效观察

目前,夏季皮炎尚无特效疗法,既往采用一般药物治疗,效果较差。作者于1988年高温季节采用本院配制的复方止痒洗剂治疗夏季皮炎,取得了满意的效果。100例中:男性52例,女性48例,治疗方法及结果:复方止痒洗剂:(配方:冰片1.0,液化苯酚1.8ml,薄荷脑0.4,50%酒精45ml,氯氟舒松0.01,蒸馏水加趸100ml)外搽患处,每日4～5次,4天为一疗程,以皮肤瘙痒症     

166例面部皮炎患者临床及致病因素分析

对166例面部皮炎患者进行问卷调查,部分患者行皮肤斑贴试验与点刺试验。其中,女性(138例)多于男性(28例),年龄2~89岁,平均(30+12)岁;春季发病率为3.85%,高于夏季(0.56%)、秋季(0.84%)和冬季(3.33%);接触性皮炎与激素依赖性皮炎是面部皮炎最常见的类型,分别占30.7%和21.1%;皮肤斑贴试验和点刺试验的阳性率分别为69.05%、72.22%,是寻找致敏原的有效方法。     

清血糖浆治疗夏季皮炎的疗效观察

目的观察清血糖浆治疗夏季皮炎的疗效及不良反应。方法 148例患者随机分为2组,治疗组78例口服清血糖浆,50 m L/次,3次/d;对照组70例采用依巴斯丁片口服,10 mg/次,1次/d,2组均外用炉甘石洗剂。2周为1个疗程。2组均用1个疗程。结果治疗组基本痊愈率和有效率分别为73.08%和97.44%,对照组分别为55.71%和81.43%,治疗组和对照组痊愈率及有效率差异有统计学意义。结论清血糖浆治疗夏季皮炎疗效显著,复发率低,治疗过程中无明显不良反应。     

咪唑斯汀治疗皮炎湿疹68例临床分析

目的评价咪唑斯汀治疗皮炎湿疹的临床疗效。方法118例皮炎湿疹患者随机分为两组,咪唑斯汀组68例口服咪唑斯汀10mg,氯雷他定组50例口服氯雷他定10mg,均1次/d。结果咪唑斯汀治疗急慢性湿疹和异位性皮炎3周有效率为90.7%,氯雷他定组为60.0%,两组差异有显著性(P<0.01);咪唑斯汀与氯雷他定对接触性皮炎的1周有效率均为100%,差异无显著性(P>0.05)。结论咪唑斯汀是治疗皮炎湿疹等过敏性疾病的理想药物。     

中药清暑止痒汤治疗夏季皮炎

我们根据中医理论应用六一散加蝉蜕等药组成清暑止痒汤和赛庚啶对照治疗夏季皮炎共66例,现报告如下.     

祛风止痒口服液对皮炎湿疹患者Th_1/Th_2的调节作用

目的探讨祛风止痒口服液对皮炎湿疹患者的治疗作用机制。方法选择50例皮炎湿疹患者随机分为祛风止痒口服液治疗组和对照组,治疗前后分别采用ELISA法检测PBMC培养上清液中白细胞介素4(IL-4)、γ-干扰素(IFN-γ)含量,采用RIA法检测白细胞介素10(IL-10)含量。结果皮炎湿疹患者上清液中IL-4和L-10含量均显著增高,而IFN-γ含量显著减少。治疗组经祛风止痒口服液治疗后,上清液IL-4和IL-10含量均显著下降,而IFN-γ含量显著增高。对照组治疗前后上述指标差异均无显著性。结论祛风止痒口服液能显著抑制皮炎湿疹患者T细胞和B细胞的活化,纠正体内Th1和Th2细胞因子的失衡状态。     

复方氟米松软膏联合炉甘石洗剂治疗皮炎湿疹的疗效观察

目的观察复方氟米松软膏联合炉甘石洗剂治疗皮炎湿疹患者的疗效。方法以2018年6月～2019年6月本院收治的80例皮炎湿疹患者为观察对象,按照数字法进行随机分组,常规组(40例)实施炉甘石洗剂治疗,治疗组(40例)在常规组治疗的基础上使用复方氟米松软膏治疗,比较两组皮炎湿疹患者的临床治疗效果。结果治疗组患者的治疗有效率(92.50%)、不良反应发生率(2.50%)均显著优于常规组的治疗有效率(70.00%)和不良反应发生率(15.00%),组间差异明显,(P 0.05);两组患者接受治疗前的症状变化比较,组间差异无显著性(P 0.05),具有可比性;治疗后治疗组患者的瘙痒程度以及皮损面积均显著低于常规组,组间差异明显,(P 0.05)。结论皮炎湿疹患者使用复方氟米松软膏联合炉甘石洗剂治疗效果更为显著,同时还可以降低其不良反应的发生率。     

Airborne contact dermatitis induced by parthenium: a study of 50 cases in South India

Airborne contact dermatitis (ABCD) is a commonly occurring form of allergic contact dermatitis with varied aetiology, often posing a diagnostic challenge in management. A study was carried out on patients with a clinical picture and history consistent with ABCD due to exposure to Parthenium hysterophorus (parthenium weed), who were patch tested. There were 50 patients with parthenium-induced ABCD (36 men and 14 women; age range 24–75 years). The majority (90%) of the patients were farmers and most of the patients (74.5%) had exacerbations during summer. The most common type of dermatitis was the classic pattern (46%) followed by the mixed pattern (30%), erythroderma (14%) and chronic actinic dermatitis (10%). Of the 40 cases patch tested with the Indian standard series of antigens, 36 (90%) cases had patch-test results positive for parthenium.     

Some atypical forms of eczema in children (author's transl)]

Among 466 children under the age of 12 years who presented with eczema in a 5-year period, 68 p. 100 were atopic. 136 had various atypical signs of atopy. 44 suffered from pityriasis alba of sufficient intensity to justify referral for this reason; 10 had the typical features of seborrhoeic dermatitis of infants. 27 suffered from "forefoot" eczema ("juvenile plantar dermatosis"). The course and characteristics of this condition are discussed and compared with the series recently described in the West of Scotland. Our cases were exactly similar except for an aggravation in the summer months and the fact that our cases responded poorly to topical corticosteroids alone though improved with coal tar. Atopy and contact sensitivity to shoe materials are rare in both groups. We feel that this may be classified as "frictional" dermatitis and agree with our Scottish colleagues that the introduction of nylon socks during the last ten years may be important.     

Efficacy and safety of combination ointment "fluticasone propionate 0.005% plus mupirocin 2.0%" for the treatment of atopic dermatitis with clinical suspicion of secondary bacterial infection: an open label uncontrolled study

BACKGROUND: The skin of patients with atopic dermatitis is colonized with Staphylococcus aureus. Reduction of bacterial colonization has been reported to be effective in the treatment of atopic dermatitis. AIM: To assess the efficacy and safety of a combination of fluticasone propionate 0.005% and mupirocin 2.0% ointment twice daily for 2 weeks in patients with atopic dermatitis clinically suspected of secondary bacterial infection. METHODS: An open-label, non-randomized study of 122 patients (64 males and 58 females) from 20 centers was conducted. Atopic dermatitis was diagnosed by clinical assessment and scoring was done on the visual analogue scale (VAS). Clinical evaluation of the lesions was done on day 1 (baseline), day 8 and on day 15 of study visits. RESULTS: At baseline, many patients had moderate itching (41.8%), moderate dryness (41.8%) and mild weeping lesions (49.2%). The baseline proportions of the clinicians' global impressions (CGI) scale for mild, moderate and severe atopic dermatitis lesions were 19.7%, 55.7% and 12.2% respectively. At the end of the treatment period, 67.2% patients had mild disease, whereas only 9% and 0.8% patients had moderate and severe disease respectively. At baseline, only 33.65% patients were comfortable with the existing lesions when assessed on visual analog scale (VAS). However, after the treatment, this proportion increased to 51.77% and 78.60% patients on day 8 and on day 15 respectively. CONCLUSION: Twice daily topical application of a fluticasone propionate 0.005% and mupirocin 2.0% ointment is an effective and safe therapeutic regimen in atopic dermatitis.     

Treatment of dyshidrotic hand dermatitis with intradermal botulinum toxin

BACKGROUND: Botulinum toxin (Btx A) has recently been used in the treatment of focal hyperhidrosis. Hyperhidrosis is also an aggravating factor in nearly 40% of patients with dyshidrotic hand eczema. OBJECTIVE: The objective of this study was to evaluate the effect of intradermal injections of Btx A on dermatitis in patients with vesicular hand dermatitis. METHODS: Ten patients with vesicular dermatitis were treated on one hand with intradermal Btx A (mean, 162 U BOTOX, Allergan Pharmaceuticals, Irvine, Calif) with the untreated side as a control. RESULTS: Self-assessment at follow-up 5 to 6 weeks after injection on a 5-point scale (none, slight, moderate, good, or very good effect) showed that 7 of 10 patients experienced good or very good effect. A decrease in itching was shown with a visual linear analogue scale (VAS) for itching, with mean 39% on the treated side compared with an increase by 52% on the untreated side. These findings were supported by the evaluation of clinical signs. Six of 7 patients who experienced good or very good effect also had aggravating hand sweating or worsening during the summer. CONCLUSION: Btx A can be a valuable alternative for patients with treatment-refractory hand eczema of the vesicular type, especially with hyperhidrosis or worsening during the summer.     

地奈德乳膏联合尿素乳膏治疗手部湿疹疗效和患者生活质量观察

目的评价地奈德乳膏联合尿素乳膏治疗手部湿疹的疗效和生活质量。方法将入选的91例患者按随机区组法分为对照组(40例)和治疗组(51例),对照组予丁酸氢化可的松乳膏(天津药业集团有限公司生产)联合10%尿素乳膏治疗,治疗组予地奈德乳膏(重庆华邦制药股份有限公司生产)联合10%尿素乳膏(本所自制)治疗,均2次/d,连续用药2周。记录治疗过程中的不良反应,分别于初诊当日和用药2周后记录临床表现,并进行皮肤病患者生活质量指数(DLQI)问卷调查。结果治疗结束治疗组和对照组的有效率分别为92.16%和67.50%,差异有统计学意义(P=0.003)。DLQI问卷调查表明治疗组患者生活质量改善程度优于对照组,差异有统计学意义(P<0.001)。结论地奈德乳膏联合尿素乳膏治疗手部湿疹安全有效,能明显改善患者的生活质量。     

Prospective aetiological study of diaper dermatitis in the elderly

BACKGROUND: The different causes of diaper dermatitis (DD) in the elderly are not well known and the treatment is often empirical. OBJECTIVES: To determine the causes of DD in the elderly and to evaluate the efficacy of antifungal treatments in this indication. METHODS: Consecutive patients presenting with DD were included. Clinical evaluation, skin swabs for bacterial and mycological cultures, patch testing and skin biopsy were performed at inclusion. This was followed by 1 month of topical antifungal cream and, if needed, by oral fluconazole for the second month. RESULTS: Forty-six patients were included (mean age 85 years). Causes of DD were established for 38 patients: 24 had candidiasis (63%), six irritant dermatitis (16%), four eczema (11%) and four psoriasis (11%). After 2 months of treatment, 27 of 37 (73%) patients were cured and five of 37 were improved. CONCLUSIONS: Mycoses and irritant dermatitis are the main causes of DD in the elderly, and emollient skin care and topical antifungal treatment can be considered a first-line therapy for this indication.     

Nickel-elicited systemic contact dermatitis

20 patients with systemic contact dermatitis due to nickel are described. Of these patients, 15 were female and 5 were male. Their mean age was 24.8 years (16-51 years). All had experienced contact dermatitis in the umbilical area due to continual contact with metal belt-buckles or buttons. Then, with long- or short-term aggravation of such periumbilical dermatitis, commonly in summer, lesions spread to other sites such as the side of the neck, the flexures of the extremities, etc. All patients showed a positive patch test to nickel sulphate (2.5% in petrolatum) and the dimethylglyoxime test demonstrated the presence of free nickel on metal buttons or belt-buckles. Punch biopsies performed in 7 patients showed subacute dermatitis. After avoidance of continual exposure to objects containing nickel and foods rich in nickel, as well as treatment with oral antihistamines and topical corticosteroids, all patients improved or cleared. It has been reported that nickel can cause systemic contact dermatitis by some internal systemic route, such as oral intake, transfusion, inhalation, implantation of metal medical devices, etc. In our patients, we found that continual local skin contact could also elicit systemic contact dermatitis.     

Periorbital dermatitis--a recalcitrant disease: causes and differential diagnoses

Background Periorbital dermatitis is common and frequently recalcitrant to treatment. Due to the exposed and visible location, patients often suffer severely from periorbital dermatitis. Objectives To determine the frequency and causes of periorbital dermatitis including contact sensitizers. Methods We investigated two cohorts of patients (Erlangen and IVDK without Erlangen) between 1999 and 2004. Results The differences between the two cohorts with periorbital dermatitis [Department of Dermatology at University Hospital Erlangen (n = 88) and the German Information Network of Departments of Dermatology (IVDK) collective (n = 2035)] were determined by the MOAHLFA (male, occupational dermatosis, atopic eczema, hand dermatitis, leg dermatitis, facial dermatitis, age ≥ 40 years) index. Statistically significant factors for periocular eczema are female sex, atopic skin diathesis and age ≥ 40 years. In both cohorts allergic contact dermatitis was the main cause of periorbital eczema (Erlangen 44·3%, IVDK 31·6%), followed by periorbital atopic dermatitis (Erlangen 25%, IVDK 14·1%), airborne dermatitis (Erlangen 10·2%, IVDK 1·9%), irritant contact dermatitis (Erlangen 9·1%, IVDK 7·6%), periorbital rosacea (Erlangen 4·5%, IVDK 2·2%), allergic conjunctivitis (Erlangen 2·3%, IVDK included in ‘others’) and psoriasis (Erlangen 2·3%, IVDK included in ‘others’). The most relevant allergens/allergen sources inducing periorbital eczema were consumers’ products (facial cream, eye shadow and ophthalmic therapeutics) (31%), fragrance mix (19%), balsam of Peru (10%), thiomersal (10%) and neomycin sulphate (8%); 12·5% of patients with allergic periocular dermatitis could be exclusively elucidated by testing patients’ own products. Conclusions Our data demonstrate the multiplicity of causes for periorbital eczematous disease manifestation, which requires patch testing of standard trays as well as consumers’ products to elucidate the relevant contact sensitization.     

Tinea pedis in Korean children

BACKGROUND: Tinea pedis is an infrequent disease in children before the age of puberty. There are few epidemiologic and clinical data regarding cases of tinea pedis observed in children. Materials and methods We prospectively collected all cases of tinea pedis in children diagnosed during the years 1995-1997. Only those showing a positive result with potassium hydroxide preparation were included in the study. We performed fungal cultures in Sabouraud's agar in all cases to document the etiologic fungi. The clinical characteristics were investigated. RESULTS: A total of 21 children, aged 3 months to 14 years, were included. Fifteen patients were boys and six were girls. The mean age was 7.1 years. All the children were otherwise healthy. Prior to the establishment of the diagnosis of tinea pedis, 17 patients (80.9%) were treated for eczema without improvement. The intertriginous type was most common (53.3%). The first or second toe-webs were the sites of predilection (32.3%). Eighteen children (86%) had a family history of tinea pedis and more than half of cases (52.4%) showed occurrence in the summer. The results of fungal cultures were positive in 13 patients (57%). Trichophyton rubrum was the most commonly isolated pathogen (69.2%). The other associated dermatoses were onychomycosis (33.3%), atopic dermatitis (14%), plantar warts (10%), and chronic urticaria (5%). Tinea pedis and onychomycosis cleared after treatment with topical antifungals with or without systemic antifungals in all cases. CONCLUSIONS: Tinea pedis in children can occur more frequently than suspected. Our study shows the strong association with a family history and the seasonal relationship with occurrence in summer in more than half of cases. We suggest that tinea pedis should be considered in the differential diagnosis of foot dermatitis in children.     

The profile of atopic dermatitis in a tertiary dermatology outpatient clinic in Singapore

BACKGROUND: Atopic dermatitis is a common, chronic, relapsing, pruritic, eczematous skin condition occurring in patients with a personal or family history of atopy. The aim of this study is to describe the profile of atopic dermatitis seen at a tertiary referral skin center in a tropical multiracial country. METHODS: A retrospective chart review was conducted of all the patients with atopic dermatitis seen during the first six months of 1994. RESULTS: There were 492 patients, age range from 1 month to 74 years, with an equal sex ratio. The prevalence was 2%. The onset of the disease occurred before the age of 10 years in 61.2% of patients. In 13.6% of patients, the onset was after the age of 21 years. Two hundred and fifty four patients (52%) had "pure" atopic dermatitis without concomitant respiratory allergies; 238 patients (48%) suffered from a "mixed" type, with 23% having allergic rhinitis, 12% having asthma, and 13% having both asthma and allergic rhinitis; 231 patients (47%) had at least one first-degree family member with atopy: atopic dermatitis (17%), asthma (15%), and allergic rhinitis (15%). Most of the patients, 416 (84.5%), had subacute dermatitis at presentation. Ichthyosis vulgaris was present in 38 patients (8%) and pityriasis alba in 13 patients (3%). The most common infective complication was bacterial infection (impetiginized dermatitis, folliculitis, cellulitis) present in 95 patients (19%), followed by viral infections (dermatitis herpeticum, viral warts, and molluscum contagiosum) in 17 patients (3%). Allergies were noted in 43 patients (9%). The most common was drug allergy (penicillin and cotrimoxazole) in 28 patients, followed by food allergy in 11 patients. Common aggravating factors reported included heat, sweating, stress, thick clothing, and grass intolerance. Most patients could be controlled with a fairly simple regimen of moisturizers, topical steroids, and antibiotics for acute flares. Short courses of systemic steroids were used in 78 patients (16%). Three patients were treated with phototherapy: two on combined UVA and UVB (UVAB) and one on oral psoralen photochemotherapy (PUVA). CONCLUSIONS: The pattern of atopic dermatitis in Singapore is similar to that reported in the Western literature, except for a lower prevalence and a significant proportion of adult-onset atopic dermatitis.