评价氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床价值

目的：观察氨氯地平阿托伐他汀钙片对高血压合并冠心痛的临床治疗价值。方法：选取60例高血压伴冠心病的患者,分为实验组及对照组。实验组使用氨氯地平阿托伐他汀钙片治疗,对照组使用硝苯地平控释片治疗,治疗6周后比较两组患者治疗前后的血压、心绞痛改善情况、硝酸甘油片的用量、心电图的改变及不良反应情况。结果：治疗后两组的血压均有明显下降,且实验组的降压效果心绞痛改善情况、硝酸甘油片的用量、心电图变化的疗效有效率均比对照组好,差异有统计学意义（P〈0．05）。不良反应发生率差异无统计学意义（P〉0．05）。结论：氨氯地平阿托伐他汀钙片对治疗高血压合并冠心病的疗效显著,其安全性高,不良反应少。     

氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的疗效观察

目的 评价氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床价值.方法 将90例高血压伴冠心病患者分为观察组和对照组,观察组给予口服氨氯地平阿托伐他汀钙片,给药剂量为5～10 mg/次,1次/d,对照组给予硝苯地平控释片30 mg/次,1次/d,疗程均为6周.比较治疗前后两组血压、心绞痛改善情况、硝酸甘油片使用量、心电图...     

氨氯地平阿托伐他汀钙片对高血压合并冠心病的治疗价值探讨

目的 探讨氨氯地平阿托伐他汀钙片对高血压合并冠心病的治疗价值.方法 选取高血压合并冠心病患者80例,随机将80例患者分为对照组和观察组,各40例,对照组予以硝苯地平控释片治疗,观察组予以氨氯地平阿托伐他汀钙片治疗,对比两组患者的治疗结果 .结果观察组的治疗有效率为95.0%,对照组的治疗有效率为75.0%,察组的治疗效果优于对照组(P<0.05);观察组对照组的不良反应分别为10.0%、7.5%,观察组的不良反应情况与对照组相比差异无统计学意义;治疗前两组患者的血压及血脂情况差异无统计学意义;治疗后两组的血压及血脂情况均优于治疗前,且观察组优于对照组,差异具有统计学意义(P<0.05).结论 氨氯地平阿托伐他汀钙片对高血压合并冠心病,能够显著改善患者的血压及血脂情况,且不良反应少,值得临床推广.     

氨氯地平阿托伐他汀钙片治疗高血压合并冠心病55例疗效观察

目的:观察氨氯地平阿托伐他汀钙片治疗高血压合并冠心病疗效。方法:选择2016年1月-2017年2月我院收治的高血压合并冠心病患者110例为研究对象,采用随机信封法将其分为对照组、观察组均为55例,对照组给予常规药物治疗;观察组给予氨氯地平阿托伐他汀钙片治疗,对比分析两组患者的血压水平、血脂指标、心电图改善情况、并发症发生率。结果:观察组患者血压水平、并发症发生率明显低于对照组,血脂指标明显优于对照组,且心电图改善情况明显高于对照组,P0.05。结论:在高血压合并冠心病患者的临床治疗中,给予氨氯地平阿托伐他汀钙片治疗,既可改善患者的血压水平、血脂指标及心电图情况,又可减少并发症,值得临床推广应用。     

氨氯地平联合阿托伐他汀钙片治疗高血压合并冠心病的效果分析

目的：对氨氯地平联合阿托伐他汀钙片治疗高血压合并冠心病的效果进行分析。方法选取80例高血压合并冠心病患者,随机均分为对照组与观察组（n=40）,对照组采用阿托伐他汀钙片治疗,观察组采用氨氯地平联合阿托伐他汀钙片治疗,对比2组患者心电图以及血压变化。结果2组患者治疗前后舒张压降低较为显著(P＜0.05)。在血压治疗有效概率以及心电图改善有效概率方面,观察组显著优于对照组（P＜0.05）。对照组患者发生不良反应概率为5.00%,观察组为2.50%,2组间差异无统计学意义。结论对于高血压合并冠心病患者采用氨氯地平阿托伐他汀钙片进行治疗,疗效理想、安全、不良反应较小,具有临床应用价值。     

氨氯地平阿托伐他汀钙片在治疗高血压合并冠心病中的临床效果分析

目的分析氨氯地平阿托伐他汀钙片治疗高血压合并冠心病患者的临床效果。方法选取高血压合并冠心病患者116例,随机均分为两组,其中对照组使用氨氯地平进行治疗;研究组使用氨氯地平阿托伐他汀钙片治疗,疗程结束后比较两组降血压临床疗效情况、心绞痛缓解情况。结果研究组和对照组均能有效降压,研究组降压有效率高于对照组,差异具有统计学意义(P0.05);研究组和对照组均能有效缓解心绞痛,研究组心绞痛缓解有效率高于对照组,差异具有统计学意义(P0.05)[1]。结论氨氯地平阿托伐他汀钙片治疗高血压合并冠心病患者,能有效降低血压、缓解心绞痛症状。     

氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的疗效

目的探讨氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床效果。方法选取于本院诊治的高血压合并冠心病患者120例并随机分为观察组和对照组,每组各60例。对照组给予氨氯地平治疗,观察组氨氯地平阿托伐他汀钙片口服治疗。观察并记录两组患者的血压控制情况、血脂控制情况以及临床治疗效果。结果两组患者经治疗后血压均有所降低(P0.05),观察组显著低于对照组(P0.05);观察组血脂整体控制情况优于对照组(P0.05);临床治疗总有效率高于对照组(P0.05)。结论氨氯地平阿托伐他汀钙片治疗高血压合并冠心病可有效控制血压以及血脂,值得临床推广。     

氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的效果分析

目的:研究和观察治疗高血压合并冠心病患者时使用氨氯地平阿托伐他汀钙片的治疗效果.方法:收集高血压合并冠心病患者共110例,随机分为观察组与对照组,各55例,对照组患者使用阿托伐他汀进行治疗,观察组的治疗药物为氨氯地平阿托伐他汀钙片,将两组患者的临床治疗效果进行观察和对比.结果:观察组患者血压水平变化显著优于对照组,观察组患者心绞痛治疗有效率显著高于对照组(P均<0.05).结论:在高血压合并冠心病患者的治疗过程中,使用氨氯地平阿托伐他汀钙片能够有效改善患者的血压和血脂水平量,提高患者心绞痛的治疗效果,值得推广应用.     

氨氯地平阿托伐他汀钙片治疗高血压合并冠心病疗效观察

目的:观察氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床效果及不良反应。方法:收集高血压合并冠心病患者128例,按照简单数字表法随机分为对照组和观察组各64例。对照组服用阿托伐他汀片,观察组服用氨氯地平阿托伐他汀钙片。治疗8周后,比较两组患者治疗前后血压、血脂水平、心电图改善情况及不良反应发生情况。结果:两组患者治疗后的收缩压及舒张压均明显下降,观察组下降较对照组更为显著,差异具有统计学意义;观察组TC、TG、LDL-C降幅均显著高于对照组,差异具有统计学意义;HDL-C升高幅度高于对照组,差异具有统计学意义;观察组心电图改善情况显著优于对照组,差异具有统计学意义;两组患者均未出现严重不良反应。结论:氨氯地平阿托伐他汀钙片对高血压合并冠心病有较好的治疗效果,且安全性高。     

氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的疗效观察

目的:观察对高血压合并冠心病应用氨氯地平阿托伐他汀钙片治疗的临床效果。方法:研究开展于2015年1月—2017年1月,随机选取我院心血管内科在此期间收治的600例高血压合并冠心病患者,平均分为对照组与观察组,每组患者300例。对照组患者予以阿托伐他汀钙片治疗,对观察组患者予以氨氯地平阿托伐他汀钙片治疗,对比治疗效果。结果:对比观察组与对照组患者治疗前后血压、血脂变化,治疗前,两组患者的收缩压和舒张压差异无统计学意义;治疗后,组间比较差异有统计学意义;治疗前,两组患者的血脂情况差异无统计学意义;治疗后,两组间比较差异有统计学意义。对比两组患者治疗前后不良反应,差异无统计学意义。讨论:氨氯地平阿托伐他汀钙片治疗高血压合并冠心病,可显著改善患者的血压、血脂情况,不良反应小,安全性高,适合临床推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.