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Elseviers MM De Broe ME 《Kidney international》2001,59(6):2370, author reply 2372-2370, author reply 2373
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Seven female patients hospitalized in the Surgery Ward of Warsaw's Hospital for Children are described. Nonspecific abdominal pains, recurrent urinary tract infections, and voiding disorders (difficulty in voiding commencement) were the primary causes of hospitalization. Urodynamics and cystoscopy with a histopathology section of the urothelium achieved the diagnosis of nonkeratizing squamous cell metaplasia of the urothelium. The topic is not new, although the diagnosis is particularly rare in the pediatric patient. Until now, the existing world literature has described only a few cases of this kind of metaplasia in children. These findings may be helpful in differential diagnosis of urinary bladder disease. It is postulated that nonkeratizing squamous cell metaplasia of the urothelium, in the future, may lead to malignant changes in the urothelium. Therefore, the therapeutic process merits close monitoring. 相似文献
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N. Liu T. Ono T. Kawamura I. Kobayashi E. Muso S. Sasayama 《Clinical and experimental nephrology》2001,5(4):268-271
We report a patient who had nephropathy of toxemia of pregnancy associated with membranous glomerulonephritis, which deteriorated
3 months after delivery. Electron microscopy revealed electron-dense deposits on the subepithelial surface of the glomerular
basement membrane and finely granular/fibrillar materials in the subendothelial space. As a result of treatment with prednisolone
and anticoagulants, marked alleviation of both proteinuria and edema was achieved. We therefore consider that the change from
subclinical to clinical membranous nephropathy could be attributed to pregnancy.
Received: February 22, 2001 / Accepted: July 12, 2001 相似文献
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Lyophilized human dura was used for augmentation cystoplasty in a woman who had a scarred bladder because of multiple resections and fulgurations of superficial bladder tumors. Thirty months later, two sessile tumors developed from the urothelium regenerated over the dura patch, together with infiltrating recurrences elsewhere in the bladder, and a radical cystectomy was performed. This case supports the concept that implantation of tumor cells is a factor in the recurrence of superficial bladder carcinoma. 相似文献
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IgA nephropathy associated with sarcoidosis 总被引:1,自引:0,他引:1
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In this report we describe the development of idiopathic nephrotic syndrome with an IgM nephropathy in a 53-year-old patient undergoing treatment for active rheumatoid arthritis with D-penicillamine. The use of D-penicillamine in the treatment of rheumatoid arthritis is known to be complicated by the development of various glomerulonephritides. However, in this report we describe for the first time the development of IgM glomerular alterations consistent with a nephropathy in a patient undergoing D-penicillamine therapy. 相似文献
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The association between phenacetin abuse and renal papillary necrosis is widely known. Recently, reports in the European literature indicated a possible correlation between phenacetin abuse and the development of transitional cell carcinoma of the renal pelvis and bladder. A case of transitional cell carcinoma associated with phenacetin abuse is presented. The pharmacology of phenacetin metabolites is discussed, and the world literature is reviewed. The data available warrant careful reappraisal of the ready availability of phenacetin. 相似文献
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Pulmonary tuberculosis associated with membranous nephropathy 总被引:1,自引:0,他引:1
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Shima Y Nakanishi K Togawa H Obana M Sako M Miyawaki M Nozu K Iijima K Yoshikawa N 《Pediatric nephrology (Berlin, Germany)》2009,24(3):605-608
A 6-year-old previously healthy Japanese girl was found to have dipstick 2+ proteinuria and a goiter based on the results
of a routine school medical examination. Her serum free-thyroxine level was 4.98 ng/dL (normal range 0.95–1.74 ng/dL), thyroid-stimulating
hormone (TSH) was less than 0.003 μU/mL (0.34–3.88 μU/mL), anti-microsomal (anti-thyroid-peroxidase) antibody was 1600 T (up
to 100), anti-thyroglobulin antibody was 400 T (up to 100), and TSH-receptor antibody was 84% (up to ±10%). These results
are consistent with a diagnosis of Graves’ disease. Electron microscopy examination of a renal biopsy specimen revealed electron-dense
deposits located in the subepithelial spaces, and immunofluorescence microscopy examination demonstrated bright granular stainings
of immunoglobulin G along the glomerular capillary walls. These findings are characteristic of membranous nephropathy. To
investigate the relationship between the membranous nephropathy and Graves’ disease, we carried out a second immunofluorescence
study, which revealed that the immunoglobulin G granular deposits corresponded to glomerular granular staining of thyroid-peroxidase,
whereas staining for thyroglobulin was absent. It was therefore assumed that the deposition of immune complexes mediated by
thyroid-peroxidase had caused the membranous nephropathy in this patient. This is the first report of membranous nephropathy
associated with Graves’ disease in which deposits of thyroid-peroxidase, rather than thyroglobulin, have been confirmed in
the kidney.
This study was presented in the 14th congress of International Pediatric Nephrology Association (IPNA), Budapest, Hungary,
2007. 相似文献
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3 cases of enteric fever (2 paratyphoid and 1 typhoid) associated with IgA nephropathy were reported. Salmonella Vi antigen was demonstrated in the glomeruli. The clinical syndrome disappeared after enteric fever was treated. Possible pathogenesis was discussed relating this intestinal infection to IgA nephropathy. 相似文献
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Membranous nephropathy associated with childhood sarcoidosis 总被引:1,自引:0,他引:1
Costa Dimitriades Avinash K. Shetty Matti Vehaskari Randall D. Craver A. Gedalia 《Pediatric nephrology (Berlin, Germany)》1999,13(5):444-447
Sarcoidosis is a chronic multisytemic granulomatous disease of unknown etiology. It is relatively rare in children. Renal
involvement in sarcoidosis is described less commonly than other organ involvement such as pulmonary, eye, musculoskeletal,
and skin. We report a 13-year-old girl with sarcoidosis and nephrotic syndrome. Renal biopsy showed findings of membranous
nephropathy. She received intravenous pulse methylprednisolone and oral cyclophosphamide with resolution of the symptoms of
fever and edema, and improvement of the proteinuria. Her condition is stable with no progression of her renal disease. To
the best of our knowledge, this is the first report of membranous nephropathy associated with childhood sarcoidosis.
Received: 27 March 1998 / Revised: 31 August 1998 / Accepted: 31 August 1998 相似文献
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Membranous nephropathy associated with thyroid disorders 总被引:7,自引:0,他引:7
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Ohtomo Y Nagaoka R Watanabe H Kaneko K Ohyama S Yamashiro Y 《Pediatric nephrology (Berlin, Germany)》2000,15(1-2):136-138
Renal biopsy was performed in a 12-year-old girl with hematuria and proteinuria which was first detected at the age of 7,
and the findings were the mesangial proliferative glomerulonephritis with IgG and C3 deposits. The routine blood examination
for the biopsy disclosed the presence of the prolonged activated partial thromboplastin time and the biological false positive
reaction in the syphilis test. These results led us to the further investigation, which revealed the presence of high titers
of anticardiolipin antibodies. Since this girl presented no extra-renal symptoms of systemic lupus erythematosus (SLE) and
had negative serologic tests for SLE, we hypothesize that her nephritis is closely related to antiphospholipid antibodies.
Received: 24 January 2000 / Revised: 16 May 2000 / Accepted: 18 May 2000 相似文献
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A 61-year-old male patient had secondary polycythemia associated with idiopathic nephrotic syndrome. Renal biopsy revealed membranous nephropathy. Polycythemia did not change in spite of partial remission of proteinuria. Serum erythropoietin determined by an enzyme-linked immunosorbent assay was 7.2 mU/ml. His serum erythropoietin maintained at a constant level during polycythemia was higher than it was before the appearance of renal ischemia, so he was kept in a polycythemic state. Whether decreasing proteinuria can improve renal ischemia requires future study. We must observe the patient for the occurrence of thromboembolism. Renal ischemia possibly induced by nephrotic syndrome is likely to cause secondary polycythemia. 相似文献
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Watanabe Y Eguchi A Kamio M Yamaguchi K Ohara M Mochizuki T 《Nihon Jinzo Gakkai shi》2005,47(5):547-551
We experienced a case of membranous nephropathy associated with argyria. The patient was a 78-year-old woman who had noticed blue skin of the face and azure lunulae for 8 years. She was admitted to our hospital for edema and proteinuria. She was diagnosed as membranous nephropathy by needle renal biopsy, and treated with prednisolone. Her proteinuria disappeared after 63 days. We investigated the blue skin of her face and azure lunulae. Skin biopsy was performed and black granules deposited in the upper layer of the corium were observed. The granules were identified with silver by EDS (energy-dispersive X-ray spectroscopy) analysis. Membranous nephropathy associated with gold or mercury has been reported, but association with silver has not been reported. We considered that this is a rare case of membranous nephropathy associated with silver. 相似文献
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Membranous nephropathy is the most common cause of adult-onset idiopathic nephrotic syndrome. Glomerular disease has been reported to occur in association with a wide variety of malignancies, particularly carcinomas and lymphomas. With the case reported here, we relate acute myeloid leukemia with membranous glomerulonephritis, depending on the previous literature reports about the association of malignancies and glomerulopathies. 相似文献
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A 35-year-old woman who had been suffering from ascites more than 3 months after the delivery of her first baby, developed generalized edema, pyrexia, pleural effusion, and right lower abdominal pain. The laboratory data revealed 5.6 g of 24-hour urinary protein, increased ESR and CRP, a positive skin test for tuberculosis, and a positive culture fortuberculous bacilli from pleural effusion. A renal biopsy showed mild proliferative glomerulonephritis, IgA and C3 depositions along the capillary loop, in the mesangium and also in the focal tubular basement membrane, and scattered membranolysis of the glomerular basement membrane in addition to paramesangial and intramembranous electron-dense deposits. A positive culture of tuberculous bacilli led anti-tuberculous drugs resulted in the complete disappearance of proteinuria, inflammation, and various organ manifestations. As far as we know, the association of tuberculosis with glomerulonephritis is an uncommon occurrence. In addition to describing this case, we also discussed the role of tuberculosis in the pathogenesis of glomerulonephritis, and reviewed the pertinent literature. 相似文献