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PCNA在垂体腺瘤中的表达及临床意义 总被引:1,自引:0,他引:1
目的 :探讨增殖细胞核抗原 (PCNA)在人脑垂体腺瘤中的表达及临床意义。方法 :采用免疫组化 SP法对 2 5例侵袭性垂体腺瘤、2 2例非侵袭性垂体腺瘤病理蜡块和 4例正常脑垂体标本。检测 PCNA的表达及侵袭性垂体腺瘤复发情况作统计学分析。结果 :侵袭性垂体腺瘤中 PCNA表达显著大于非侵袭性腺瘤 (P <0 .0 5 ) ;侵袭性垂体腺瘤中复发组 PCNA表达明显高于非复发组 (P <0 .0 5 )。结论 :腺瘤组织中的 PCNA的异常表达能够准确地反映垂体腺瘤细胞的增殖状态及侵袭潜能 ,可为临床上评价垂体腺瘤侵袭性、复发、治疗及预后提供重要的参考指标 相似文献
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垂体腺瘤微血管定量与增殖细胞核抗原表达的临床研究 总被引:1,自引:0,他引:1
目的:探讨垂体腺瘤组织中微血管定量(MVC)与增殖细胞核抗原(PCNA)蛋白表达的临床意义。方法:应用免疫组化ABC法对50例侵袭性垂体腺瘤进行回顾性研究。结果:MCV、PCNA蛋白表达在侵袭性腺瘤组明显高于非侵袭组(P<0.05),复发组明显高于非复发组(P<0.05),而且肿瘤组织内MVC与PCNA阳性表达强度呈显著正相关(γ=0.718,P<0.01),结论:肿瘤的血管形成和PCNA过度表达可能与垂体腺瘤发生,发展有关,MVC和PCNA表达可作为临床评价肿瘤侵袭性的指标。 相似文献
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目的探讨血管内皮生长因子(VEGF)及其特异性受体(KDR)蛋白和mRNA在垂体腺瘤中的表达与肿瘤血管形成和侵袭性的关系。方法采用免疫组织化学S-ABC法和RT-PCR检测58例人垂体腺瘤中的VEGF及KDR蛋白和mRNA的表达,并对血管进行染色及计数。将肿瘤的侵袭程度分为0、1、2、3级,分别为5例、14例、20例和19例。结果VEGF阳性蛋白主要位于胞浆,血管内皮很少表达,KDR蛋白主要表达在垂体腺瘤微血管内皮细胞胞浆中。随侵袭性程度的增加,VEGF和KDR蛋白、mRNA的表达相应增加,1级与0级、3级与2级比较P〈0.01,但1级与2级比较,P〉0.05。以VEGF和KDR表达的中位数为界分成高、低表达组,VEGF和KDR高表达组中的微血管密度明显高于低表达组(P〈0.01)。结论VEGF以旁分泌、自分泌形式,通过KDR协同促进垂体腺瘤血管的生成,并与垂体腺瘤的侵袭性密切相关。 相似文献
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目的 研究基质金属蛋白酶9(MMP-9)在C端的血红素样结构域(MMP-9-PEX)和MMP-9在垂体腺瘤侵袭性生长中的作用及其相关性。方法 用RT-PCR法检测116例垂体腺瘤标本的MMP-9-PEX mRNA和MMP-9mRNA表达,免疫组化检测MMP-9蛋白表达;分析其与侵袭性垂体腺瘤的关系及两者之间的相关性。结果 侵袭性垂体腺瘤组MMP-9-PEX mRNA表达较非侵袭性垂体腺瘤组降低(P<0.05);侵袭性垂体腺瘤组MMP-9的mRNA及蛋白表达均高于非侵袭性垂体腺瘤组(P<0.05);侵袭性垂体腺瘤组中MMP-9-PEX mRNA表达与MMP-9mRNA表达呈负相关(r=-0.66,P<0.05)。结论 MMP-9-PEX低表达及MMP-9高表达可能与垂体腺瘤的侵袭性生长密切相关;MMP-9-PEX及MMP-9可以作为垂体腺瘤侵袭性的参考指标,对诊断、治疗和预后判断有重要价值。 相似文献
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目的分析HSP70在垂体腺瘤中的表达,探讨HSP70与垂体腺瘤侵袭性之间的关系,研究以HSP70的表达水平作为判断垂体腺瘤侵袭性和预后指标的可能性.方法取经手术切除且病理诊断为垂体腺瘤、具有完整内分泌资料的患者50例,根据Hardy-Wilson及Knosp分级、分期标准,结合病理活检判断其肿瘤侵袭性,用免疫组化方法分别检测每例肿瘤HSP70的表达水平.结果50例病人中HSP70蛋白表达的阳性率为86.0%(43/50),PRL腺瘤和无功能腺瘤之间的HSP70蛋白表达阳性率在统计学上无显著性差异(P>0.05), HSP70蛋白表达水平与垂体腺瘤侵袭性之间的关系在统计学上存在正相关关系(P<0.05).结论HSP70的表达水平与垂体腺瘤侵袭性有关,其表达水平有可能作为判断垂体腺瘤侵袭性和预后的指标. 相似文献
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目的 探讨乳腺癌组织中血管内皮生长因子 ( VEGF)的表达及肿瘤血管形成与乳腺癌侵袭、转移的关系。方法 对 1 1 0例乳腺癌标本应用免疫组化 S- P法检测其微血管数 ( MVC)和 VEGF蛋白的表达 ,分析 MVC和 VEGF的表达与乳腺癌临床病理因素的关系。结果 1 1 0例中 VEGF表达阳性率为 6 7.3% ,VEGF的表达与淋巴结转移、肿瘤脉管侵犯呈密切正相关 ( P<0 .0 1 ) ;乳腺癌的微血管数 ( MVC) X± S为 97.7± 4 2 .5个 ,MVC与淋巴结转移、肿瘤脉管侵犯呈密切正相关 ( P<0 .0 1 ) ;本组乳腺癌的 VEGF表达与 MVC呈密切正相关 ( P<0 .0 1 )。结论 乳腺癌组织由于 VEGF等血管形成因子的明显增加 ,肿瘤血管大量形成 ,微血管数显著增加 ,促进肿瘤的侵袭和转移。故检测乳腺癌组织中 MVC和 VEGF的表达状况有助于进一步了解乳腺癌的生物学行为 ,为指导乳腺癌术后综合治疗提供新的分子生物学指标 相似文献
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目的提高对垂体微腺瘤的MRI诊断。方法回顾性总结分析64例垂体微腺瘤的病例,包括临床表现、影像学检查。所有患者均采用Philips 1.5T核磁共振扫描机扫描,垂体平扫加动态增强扫描。结果全部患者表现不一,基本病程1月至3年。月经紊乱者40例,其中28例合并头昏、头痛,5例有四肢乏力,50例有泌乳素增高。垂体微腺瘤的MRI表现为垂体大小正常或较饱满,微腺瘤病灶动态增强无明显强化,延时扫描有轻度强化,经药物治疗后病灶可缩小或消失。结论 MRI诊断垂体微腺瘤敏感性高、准确率高,影像表现有特征性,可以多方位成像,图像直观,直接显示病灶大小、形态,是垂体微腺瘤常用的影像诊断方法,为临床提供帮助。 相似文献
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目的探讨肾脏后肾腺瘤(metanephric adenoma,MA)的临床病理特征及鉴别诊断方法。方法应用常规病理及免疫组化方法观察近年诊断的1例MA病理组织学表现,结合相关临床资料及文献复习分析其病理特点。结果本例16岁女性,大体标本为类圆形黄褐色肿块,大小约10cm,有薄层包膜,与周围组织分界清楚组织学上具有独特的形态结构特点:瘤细胞较小,核大质少,深染,圆形到椭圆形,核仁不明显,细胞大小较一致,无异型性,无核分裂像。间质疏松水肿样,无细胞。由规则排列的圆形小管和含有圆形细胞巢的实性区域相间构成,偶可见肾小球样结构,免疫组化分析:瘤细胞角蛋白(CK)呈阳性表达,波形蛋白(Vimentin)弱阳性表达,WT1,CK7,EMA,CD10,CD99,CK34βE12,CgA,SYN,RCC,P53及Bcl-2呈阴性,Ki-67仅约2%阳性。结论后肾腺瘤是一种少见的肾脏胚胎性上皮源性良性肿瘤,MA在形态学上具有独特的组织结构特点,免疫表型表现为Vimentin恒定出现,WT1、CD57、CK多有表达,其中WT1、CD57、CK表达强度和范围各有不同,而EMA、CK7、CgA、CD10多无表达;要注意与Wlims瘤、肾乳头状细胞癌等进行鉴别。 相似文献
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目的探讨肾上腺Conn腺瘤的MSCT表现及其诊断价值。方法回顾19例经手术病理证实的肾上腺Conn腺瘤患者的CT资料,分析病变的形态、大小、密度及强化特征。结果19例患者均表现为与肾上腺相连的类圆形结节影,均为单侧病变,17例边缘清楚,2例病灶边缘模糊;18例病灶直径小于2cm,1例大于2cm;18例病灶内密度较均匀,1例表现欠均匀;19例患者结节病灶均呈低密度。增强扫描动脉期17例病灶轻度强化,2例无明显强化,16例强化较均匀,门脉期均持续强化,延迟期18例肿块保持强化。结论肾上腺Conn腺瘤有特征性的MSCT表现,MSCT对肾上腺Conn腺瘤定性诊断有重要价值。 相似文献
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Ocampo-Candiani J Vázquez-Martínez O Regalado-Briz A Barboza-Quintana O Méndez-Olvera N 《Journal of drugs in dermatology : JDD》2005,4(5):642-645
We present a case of cutaneous leiomyomas (CL) arising in a pleomorphic adenoma (PA) of the parotid gland. PA and CL are benign tumors arising from the parotid gland and the erector pilli muscle, respectively. They both have a benign clinical course and in most cases leiomyomas are multiple in nature. PAs of the parotid are the most frequent benign tumors of the major salivary glands. To our knowledge this is the first case of PA with CL. 相似文献
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A report from a medium-sized community hospital of 4 additional cases of hepatocellular adenoma is presented. Of these, 3 were pedunculated tumors. A 29-year-old woman, gravida 7, had been taking Enovid-E for 8 years. After 3 attacks of epigastric pain a mass was detected in her right upper abdomen. Surgical exploration revealed the mass pedunculated from the right hepatic lobe. The mass was excised. 3 years later a liver scan was normal. The histological appearance of the tissue resembled mature hepatic architecture without protal areas or bile ducts. A 34-year-old woman, gravida 4, para 2, had been taking Enovid-E for 6 years. She previously had had a partial thyroidectomy for carcinoma of the thyroid and later radical neck dissection for metastatic thyroid carcinoma. A mass was detected in the right abdomen. At operation, a pedunculated mass was found attached to the right hepatic lobe with 2 smaller nodules. All lesions were excised. The microscopic picture was similar to that of the other patient. A 24-year-old woman, gravida 4, para 3, had been taking Oracon for 1 year. Upper abdominal pain, vomiting, and diarrhea were complained of. An upper abdominal mass was present. At operation, a 9 cm mass was excised. The histology was the same as in the previous cases. A 28-year-old woman, gravida 2, para 1, had been taking Ovulen for 5 years. An abdominal mass was present. Surgical exploration revealed a nodular mass pedunculated from the left lobe of the liver. The mass was excised. Histological appearance was similar to the other 3 tumors. Of 42 other reported cases of similar tumors, the mean age was 27.3 years. About 40% had been admitted as emergency cases with hemoperitoneum. Almost 20% had complained of upper abdominal pain. A palpable mass was usually present. Multiple nodules were found in 13% of cases. For nonemergency cases, selective hepatic angiography has been a reliable method of diagnosis. The treatment has been resection of the tumor when feasible. However, regression of tumors has occurred when exogenous hormone influence ceased. The outcome has been fatal in 8 cases. The low incidence of this tumor is not considered sufficient cause to justify discontinuing use of oral contraceptives. 相似文献