Kikuchi Disease with Facial Rash and Erythema Multiforme

Kikuchi disease, or histiocytic necrotizing lymphadenitis, is a benign illness characterized by fever and cervical lymphadenopathy predominantly in young women. It has a self-limiting course. Skin changes occur in about one-third of patients and are of a nonspecific nature. A case of Kikuchi disease with cutaneous involvement in the guise of erythema multiforme and a facial rash is reported. The differential diagnosis with systemic lupus erythematosus and Rowell syndrome is discussed.     

A Case of Herpetic Whitlow Associated with Erythema Multiforme

Abstract: We report a 6-month-old girl with erythema multiforme minor occurring during the course of a herpetic whitlow. Erythema multiforme minor is unusual in infants, and in this population herpes simplex virus has not been reported as a significant etiologic factor. The clinical coexistence of erythema multiforme minor and the herpetic lesion is also atypical. To our knowledge, this is the first report of erythema multiforme minor associated with a concomitant HSV infection in an infant.     

Erythema Multiforme in Childhood and Early Infancy

Erythema multiforme is said to be rare in childhood and especially in early infancy. Three infants, none older than 1 year, were seen with this condition; all showed typical clinical features. In one of the three infants, no distinctive etiological factor(s) could be found. One was suffering from congenital hepatitis (cause unknown) and another from a staphylococcal infection.     

Neonatal Erythema Multiforme: A Case Report

Erythema multiforme (EM) is an extremely rare condition in infancy. To the best of our knowledge, there have been only three cases of neonatal EM described in the literature, and no such cases have been reported in Korea. A preterm neonate born at 35 weeks and six days of gestation presented with multiple annular erythematous patches with a targetoid shape over his entire body at 36 days of age (corrected age of 7 days). He had no systemic symptoms except for transient mild fever. No triggering factor except for hepatitis B and BCG vaccination was found. Neutropenia was noted upon laboratory analysis. Skin biopsy specimens showed findings suggestive of erythema multiforme. The skin lesions improved rapidly upon administration of intravenous methylprednisolone; however, neutropenia continued for a much longer period. The significance of neutropenia with respect to the development of EM was not clarified. There has been no recurrence of skin lesions over a one-year follow-up period.     

多形红斑与HLA相关性研究

目的 研究多形红斑与ＨＬＡ相关性。方法 采用血清学技术和聚合酶链式反应－序列特异性引物技术,检测多形红斑患者ＨＬＡＩ类抗原和ＨＬＡⅡ类基因。结果 在３０例多形红斑患者中,ＨＬＡ－Ａ３０＋３１、Ｂ１３抗原频率较对照组明显增高（Ａ３０＋３１：Ｐｃ〈０．０１,ＲＲ＝６．６４;Ｂ１３：Ｐｃ〈１０＾－３,ＲＲ＝７．８８）。ＨＬＡ－ＤＱＢＩ＊０４基因频率在多形红斑患者较正常人对照组明显增高（ＤＱＢＩ＊０４：Ｐ     

Erythema Multiforme in a Newborn Associated with Acute Acquired Cytomegalovirus Infection

Abstract: Erythema multiforme is exceptional in newborns, and none of the few available reports has revealed a clear etiologic agent, not even herpes simplex virus. Immunocompetent patients rarely present with cutaneous cytomegalovirus involvement, and few cases of cytomegalovirus‐associated erythema multiforme have been described, none of them in newborns. We report the first case of erythema multiforme in a newborn associated with cytomegalovirus infection.     

Linear IgA Bullous Dermatosis Mimicking Erythema Multiforme in Adult

This report describes a 49-year-old woman with an erythema multiforme--like rash and direct immunofluorescence showing linear IgA deposits at the dermoepidermal junction. Light microscopy revealed features of bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme; immunoelectron microscopy demonstrated IgA deposition beneath the lamina densa about anchoring fibrils. These data provide additional information about the variable clinical and histologic manifestations of the adult linear IgA bullous dermatosis and emphasize the diagnostic dilemmas of light microscopy, which are resolved by immunohistochemical methods.     

Persistent Annular Erythema of Infancy

Abstract: Annular erythema of Infancy is an uncommon, nonpruritic, figurate erythema that begins in the first year of life. Biopsy specimens reveal a perivascular and interstitial lymphocytic infiltrate with numerous eoslnophils. The cause of the disorder is unknown, but a hypersensitivity response to unrecognized antigens is suspected. The disorder is selflimited, but may last for many months. In our patient the eruption continued 19 months after its onset.     

A Case of Herpes-associated Erythema Multiforme in a Japanese Child

A case of a five-year-old Japanese boy with herpes-associated erythema multiforme (HAEM) was reported. The patient had eleven recurrences of herpes labiaris within one year; four of these recurrences were accompanied by erythema multiforme. A study of the human leukocyte antigens revealed the presence of HLA-DQW3, which has been reported to be significantly frequent in Caucasian patients with HAEM. Oral administration of acyclovir at the onset of herpes labialis was effective in preventing HAEM. Early administration of oral steroids at the onset of HAEM also prevented its exacerbation.     

多形红斑型药疹40例临床分析

目的　分析多形红斑型药疹增多原因,探讨如何提高疗效及减少发生。方法　对 40例多形红斑型药疹致敏药物、临床表现、实验室检查及治疗进行分析。结果　①致敏药物多为青霉素类、解热镇痛类及中药类;②临床常见,重型较多;③以糖皮质激素为主综合治疗,疗效高。结论　多形红斑型药疹增多与多用、滥用及伪劣药品相关;糖皮质激素为主、全身治疗与局部治疗结合能显著提高疗效;规范用药,加强监管能减少其发生。     

Varicella Zoster with Erythema Multiforme in a Young Girl: A Rare Association

Erythema multiforme (EM) is an acute, self-limited, mucocutaneous disorder regarded as a hypersensitivity reaction which is triggered by various factors like infection, drugs, and food. Infectious agents are considered to be a major cause of EM other than idiopathic cause. A young girl presented with fluid-filled lesions all over the body of 3 days duration with history of similar lesions with fever in her sibling 2 weeks prior to admission. This was followed by large fluid-filled lesions with halo 3 days thereafter over the trunk, extremities suggesting target lesions of EM. The diagnosis was confirmed by cytology and positive serology. Varicella zoster virus (VZV) has rarely been reported as an etiological agent, despite its high incidence in childhood. VZV as an etiology of EM in a young girl has not been reported so far. This case was reported for its rare association of EM and varicella zoster and also for its rare presentation in a young girl.