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Objective: The main purpose of the present systematic review was to evaluate the efficacy of enamel matrix derivative Emdogain in healing of replanted teeth in humans.

Materials and Methods: This review conducted in adherence to PRISMA standards and was registered in PROSPERO with registration number CRD42017062736. We graded the methodological quality of the studies by means of Cochrane's tool of risk of bias in non-randomized studies – of interventions (ROBINS-I).

Results: In total, 65 studies were identified for screening, and five studies were eligible. The uneventful healing of replanted teeth was varied from 20% to 75%. Two controlled trials found Emdogain treatment significantly reduced resorption of replanted teeth and improved the healing of periodontal ligament compared with controls. Two studies showed high recurrent resorption in Emdogain treated teeth.

Conclusions: To conclude, the number of publications that met all inclusion criteria were limited and did not allow for drawing evidence for Emdogain being effective in supporting healing of replanted teeth.  相似文献   

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Diet is one of the most important factors driving the process of natural selection in evolution. The dentition is adapted for the diet, contributing to the diversification and adaptation of extant vertebrates. Importantly, the structure of the molar shows marked variation in extant mammals to facilitate the processing of many kinds of food and support the occlusal force effectively. A tooth root is an important element, connecting a tooth with the jaw to support the occlusal force. However, morphological studies on teeth mainly focus on the crown, whereas there has been an insufficient accumulation of information on the morphogenic control mechanism of tooth root structures. There have been some reports on the root form in humans due to clinical demand, and recent studies on Hertwig's epithelial root sheath (HERS), which plays an important role in root development, have progressed rapidly. However, studies on the regulatory mechanism of the tooth root structure in relation to the jaw and crown are still awaited. In this paper, we highlight the following three issues : the morphological relevance of the tooth root and crown, and developmental mechanisms and phylogenetic aspects of the tooth roots. HERS produces several signaling molecules including bone morphogenic protein (BMP), Sonic Hedgehog (Shh), Wnt, ectodysplasin (Eda), and fibrobast growth factor (FGF). These factors regulate the closure of the pulp chamber floor to determine the numbers and width of the tooth roots, and then regulate the fusion, curve, and length. The tooth root differentiates and develops in conjunction with its crown. However, few studies have examined the tooth root from an evolutionary perspective. We need to advance research on the tooth root including the whole tooth in developmental biology, evolutionary biology, and comparative odontology.  相似文献   

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Objectives : This paper analyzes the impact of a 7‐year interruption in water fluoridation on the prevalence of enamel fluorosis in Jaú, state of São Paulo, Brazil. Methods : Fluorosis prevalence (TF index) was evaluated in permanent maxillary central incisors of children (9–14 years old) that were 36 (n=81; cohort ‐36), 27 (n=81; cohort ‐27), and 18 months old (± 1 month; n=89; cohort—18) in October 1991, when the break started, and 18 months old (± 1 month; n=70; cohort 18) after that date. Children brushed their teeth prior to examination, which was conducted under natural light by three calibrated examiners (agreement 87.8–93.8%, kappa 0.72–0.85). Results : The fluorosis prevalence (TF≥1) was 7.41 percent, 3.70 percent, 7.87 percent, and 18.57 percent, respectively, for cohorts ‐36, ‐27, ‐18, and 18. The difference between cohort 18 and the other groups was statistically significant (Kruskall‐Wallis test, P=.05). Conclusions : These results suggest that the fluoridated water is not an important risk factor for enamel fluorosis, since the prevalence of enamel fluorosis was low in the cohorts ‐36, ‐27, and ‐18 when fluoridated water was used. [J Public Health Dent 2004;64(4):205–8].  相似文献   

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《Journal of endodontics》2020,46(8):1120-1124
IntroductionThis study aimed to assess whether ultrasonic activation (UA) or the EasyClean (EC; BassiEndo, Belo Horizonte, BH, Brazil) or EDDY (ED; VDW, Munich, Germany) systems used to promote agitation of the irrigating solutions during the final irrigation step can lead to smear layer formation in the apical third of the root canal.MethodsThirteen premolars were instrumented with the Reciproc R40 file (VDW) and embedded in silicone, forming a closed irrigation/aspiration system. The teeth were cleaved, and 4 indentations were made on the inner buccal wall of the canal to standardize the observation sites. All the specimens were cleaned in an ultrasonic bath and evaluated under environmental scanning electron microscopy, thus constituting the control group. The same specimens were reassembled, submitted to final irrigation using UA or the ED or EC systems, and classified using a 4-level scoring system. The data were analyzed using the kappa, Pearson, and Kruskal-Wallis tests (P < .05).ResultsSmear layer formation occurred in all of the experimental groups and at all apical levels. At 3 and 4 mm, all of the experimental groups had significantly higher levels of smear layer formation than the control group. At 2 mm, the level of smear layer formation in the UA group was significantly higher than that of the control group, and there were no significant differences among the EC, ED, and control groups. At 1 mm, there were no significant differences between the ED and control groups, and the levels of smear layer formation in the EC and UA groups were significantly higher than that of the control group. There were no significant differences between the ED and EC groups at any of the apical levels.ConclusionsThe smear layer formation occurred in all of the specimens submitted to final irrigation, irrespective of the technique used.  相似文献   

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Clinical Relevance A significant reduction in bond strength of restorative materials to dentin and enamel after home-use bleaching treatment has been reported. Antioxidizing agents may be a procedure to increase bond strength values. Although no reversal of bond strength values was found for sodium ascorbate, alpha-tocopherol formulated in solution resulted in a significant increase in bond strength of bleached enamel.  相似文献   

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Introduction

The aim of the present study was to evaluate the frequency of dentinal microcracks observed after root canal preparation with HyFlex CM (Coltène/Whaledent, Altstätten, Switzerland), HyFlex EDM (Coltène/Whaledent), Vortex Blue (Dentsply Tulsa Dental Specialties, Tulsa, OK), and TRUShape (Dentsply Tulsa Dental Specialties) systems using micro–computed tomographic (micro-CT) analysis.

Methods

Forty human mandibular incisors with 1 and straight root canals were randomly assigned to 4 experimental groups (n = 10) and 1 control group for root canal preparation: group 1, HyFlex CM; group 2, HyFlex EDM; group 3, Vortex Blue; and group 4, TRUShape. The specimens were scanned using high-resolution micro-CT imaging before and after root canal preparation. Afterward, preoperative and postoperative cross-sectional images of the teeth were screened to identify the presence of dentinal defects. The number of microcracks was determined as a percentage for each group.

Results

Before and after canal preparation, 36,152 cross-sectional images were examined. Four thousand four hundred fifty-two (12.31%) dentinal defects were observed. No new microcracks were observed after root canal instrumentation with the tested systems.

Conclusions

Root canal preparation with the HyFlex CM, HyFlex EDM, Vortex Blue, and TRUShape systems did not induce the formation of new dentinal microcracks on straight root canals of mandibular incisors.  相似文献   

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《Journal of endodontics》2021,47(8):1314-1320
IntroductionThis study aimed to compare root dentinal microcrack formation after root canal shaping using rotary, reciprocating, and adaptive instruments at different working lengths using micro–computed tomographic imaging.MethodsOne hundred eighty extracted mature mandibular molar mesial roots with 2 separate canals were selected. The mesial roots were resected at the cementoenamel junction and randomly divided into 4 groups (n = 45) based on the nickel-titanium file system used: ProTaper Universal (Dentsply Maillefer, Ballaigues, Switzerland), ProTaper Gold (Dentsply Maillefer), Twisted File Adaptive (SybronEndo, Orange, CA), and Reciproc Blue (VDW, Munich, Germany). Each of the 4 groups were then subdivided into 3 groups (n = 15) depending on the working length used for root canal preparation (ie, instrumentation 1 mm short, flush, and 1 mm beyond the major apical foramen). The roots were imaged with micro–computed tomographic scanning before and after root canal preparation. The cross-sectional images generated were screened to detect the presence of new microcracks.ResultsThe ProTaper Universal system significantly increased the number of postinstrumentation microcracks at all working lengths (P ≤ .05). No significant increase (P > .05) in postinstrumentation microcracks was observed in the ProTaper Gold, Twisted File Adaptive, or Reciproc Blue groups.ConclusionsRotary instrumentation induced a higher number of dentinal microcracks compared with reciprocating and adaptive instruments. Instrumentation at different working lengths did not significantly influence the formation of dentinal microcracks.  相似文献   

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Background: Maxillary sinus floor‐augmentation techniques are frequently used to increase the bone volume in the posterior edentulous maxilla to enable placement and integration of titanium implants. Purpose: The purpose of this report is to document an unexpected healing pattern after maxillary sinus surgery and to discuss the implications for future bone‐augmentation techniques. Materials and Methods: In a patient referred for sinus augmentation, an intrasinus mucosal cyst was removed 3 months prior to the planned augmentation procedure. A replaceable bone window was prepared in the lateral aspect of the sinus wall. The cyst was removed, the ruptured mucosa was sutured, and the bone window was replaced, resulting in a secluded space in the sinus. Results: After 3 months of healing, the space between the replaced bony window and the lifted sinus membrane was filled with newly formed bone. The surgical technique was repeated in a second patient and resulted in a similar bone reformation pattern. Conclusion: Surgical trauma and the creation of a secluded space between the bone surfaces and the sinus mucosa result in spontaneous bone formation in the maxillary sinus. The surgical approach described may be used to achieve bone reformation to enable placement of dental implants without the addition of any grafting material.  相似文献   

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<正> 下颌—眼—面—颅骨发育不全综合征又名Hallerman—Streiff综合征或Francois综合征,是一组具有侏儒症、头颅骨发育不良伴有先天性白内障或毛发稀少为特征的综合征。国内报道较少。我院最近收治一例,现报告如下:  相似文献   

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