中西医结合治疗慢性胃炎

目的观察中西医结合治疗对慢性胃炎的疗效；以便临床更好地选择用药。方法病例选择55例确诊为慢性胃炎的患者，运用中西药结合进行治疗。结果55例慢性胃炎中西医结合治疗后，临床症状，体征完全消失46例，5例症状减轻，4例无改变。总有效率92．73％。结论中西医结合治疗对慢性胃炎疗效较好，且副作用较少，是治疗慢性胃炎的有效方法之一。     

中西医治疗慢性胃炎5例临床体会

目的观察中西医结合治疗慢性胃炎的疗效。方法对5例慢性胃炎患者应用中医辨证，按中医分型，分别行中西医治疗，对用中西医治疗的病例2个疗程后进行疗效评定。结果两者比较，其中中医治疗有效率为97．14％，西医治疗的有效率为87．88％。结论通过临床治疗方法及治疗效果的分析，认为中西医结合疗法治疗慢性胃炎的疗效尚佳。     

中西医结合治疗慢性胃炎的临床观察与分析

目的：分析研究中西医结合治疗慢性胃炎的疗效。方法：根据中医辨证论治，选用对慢性胃炎有特别疗效的中药方剂加减，配合西药综合治疗。结果：1周后治愈10例，2周后治愈20例，3周后治愈22例，共计治愈52例。3周后症状改善4例，无效2例，其中1例症状加重。总有效率96．42％。结论：中西医结合是治疗慢性胃炎的有效办法。且经济实用，副作用少，复发率低。     

中西医结合治疗慢性胃炎临床观察

目的：探讨中西医结合治疗慢性胃炎的疗效。方法：选择符合诊断标准病例320例。分为治疗组和对照组，对照组常规给予西沙比利、枸橼酸铋钾胶囊，复方尿囊素等口服，治疗组在对照组基础上加用自拟健脾理中汤口服。结果：治疗组痊愈80例，显效64例，有效36例，总效率为90％；对照组痊愈32例，显效28例，有效24例，总有效率为70％，经统计学处理P〈0．05。结论：中西医结合治疗慢性胃炎疗效确切。     

中西医结合根除幽门螺杆菌感染临床疗效观察

目的：观察中西医结合根除幽门螺杆菌（Hp）感染的疗效。方法：选择有上消化道症状，1个月内未用过抗生素或抑酸药，胃镜诊断为慢性胃炎、消化性溃疡或反流性食管炎患者。快速尿素酶试验或组织学Hp阳性，^14 C-尿素呼气试验（^14C—UBT）阳性患者。共85例，随机分成两组。中西医结合组42例，给予灭幽散，1天1剂，分3次餐前服用，同时口服奥美拉唑胶囊，1次20mg，1天2次，连续4周；西药三联组43例，给予克拉霉素片，1次0．25g，甲硝唑片，1次0．4g，奥美拉唑胶囊，1次20mg，1天2次，均口服，连续1周。疗程结束后4周，复查^14C-UBT。结果：治疗2周后症状消失率，中西医结合组80．9％，西药三联组83．7％；Hp根除率，中西医结合组66．6％，西药三联组72．0％。差异无显著性意义（P〉0．05）。因药物不良反应中断治疗，中西医结合组4．76％，西药三联组16．2％（P〉0．05）。结论：中西医结合根除幽门螺杆菌感染疗效确切，不良反应较少，特别适用于对抗生素耐药或有严重不良反应的患者。也可作为一种二线治疗方案。     

自拟活血通脉冠心汤治疗冠心病心绞痛临床疗效观察

目的：探讨中西医结合治疗冠心病的临床效果。方法：运用活血通脉冠心汤治疗冠心病心绞痛。结果：43例患者按心绞痛疗效分级评定,显效28例,显效率65．12％,有效40例,有效率93．03％。按心电图疗效评定,显效27例,显效率62．79％,有效39例,有效率90．70％。结论：运用中西医结合治疗该病症状体征较单纯西药治疗,疗效好,复发率少。     

中西医结合治疗骨质疏松症62例疗效观察

目的：观察中西医结合治疗骨质疏松症的临床疗效。方法：124例病例随机分为两组，每组62例。对照组采用阿法D3和乐力治疗，治疗组在上述治疗的基础上配合肝肾同治、气血并重、温阳补阴中药治疗。结果：对照组治疗后总有效率为82．3％，治疗组治疗后总有效率为93．5％，两组病例治疗后总有效率比较差异有统计学意义（P〈0．05）。结论：中西医结合治疗骨质疏松症疗效显著，值得在临床上推广应用。     

中西医结合治疗糖尿病坏疽21例

目的：观察中西医结合治疗糖尿病坏疽的临床疗效。方法：21例病例均采用中西医结合治疗。结果：21例病例治疗后治愈15例，好转4例，无效2例，总有效率为90．48％。结论：中西医结合治疗糖尿病坏疽疗效显著，值得在临床上推广应用。     

中西医结合治疗慢性胃炎的疗效观察

目的探讨中西医结合治疗慢性胃炎的临床疗效。方法选择2010年1月～2011年1月来我院经胃镜确诊的90例慢性胃炎患者,随机分为西医组和中西医结合治疗组各45例,比较两组的疗效及不良反应。结果90例患者经治疗后,食欲均恢复正常,胃酸分泌正常,胃镜见黏膜组织学改变基本恢复正常治愈。77例临床症状基本消失或减轻,13例效果不显著。与西医治疗组的总有效率比较,中西医结合治疗组的总有效率明显高于西医治疗组．差异有统计学意义（P〈0．05）。结论中西医结合治疗慢性胃炎疗效明显优于单纯西医治疗,副作用小,具有显著的优势,值得基层医院推广和应用。     

子宫动脉栓塞治疗子宫肌瘤的临床应用

目的：探讨子宫动脉栓塞治疗子宫肌瘤的临床应用价值。方法：对16例症状性子宫肌瘤患行双侧子宫动脉栓塞，复查随访观察瘤体变化以及出血症状、贫血等改善情况。结果：除1例完成单侧子宫动脉栓塞外，其余均治疗成功，随访3—20个月，瘤体缩小31．6％-72．4％，本组病例临床症状明显改善，月经恢复正常，血红蛋白恢复正常范围，本组病例无严重并发症发生。结论：子宫动脉栓塞治疗子宫肌瘤疗效好，值得临床选择应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.