冠心病患者血浆高半胱氨酸和血脂水平的关系

应用高效液相色谱仪、荧光检测仪测定40例冠心病（CHD）患者的血浆总高半胱氨酸（tHcy）水平，自动生化分析仪测定甘油三酯（TG）、总胆固醇（C）、低密度脂蛋白胆固醇（LDL－C）和高密度脂蛋白胆固醇（HDL－C）水平，并以40例正常人作对照，以探讨CHD患者血浆tHcy和血脂的关系。结果显示：CHD组血浆tHcy水平显著高于对照组（P＜0．001）；CHD组血浆tHcy水平男性显著高于女性（P＜0．05）；CHD组女性的TG、TC、LDL－C水平均显著高于男性（P＜0．01）；CHD组男、女和对照组男、女性的血浆tHcy水平与TG、TC、LDL－C和HDL－C水平均无显著相关性（P＞0．05）。     

低脂膳食对广西巴马老年人血脂水平的影响

目的：了解低脂膳食对老年人血脂的影响,探讨长寿的相关因素,方法：测定171例广西长寿地区巴马县农村老年人血清总胆固醇（TC）,甘油三酯（TG）,高密度脂蛋白胆固醇（HDL－C）的的水平,结果：巴马组血清TC,TG及HDL－C均极显著低于南宁组（P＜0．05）,各年龄组的TC,TG均显著极低于高宁市相应年龄组（P＜0．05）,女性老年人TC及TG水平显著高于男性（P＜0．05）,高TC和高TG的例数均显著低于城市老年人（P＜0．00001及P＜0．001）。结论：低脂膳食可降低老年人的血脂浓度,减少高脂血症的发生,合理膳食,保持能量平衡对于老年人的健康长寿尤为重要。     

女性系统性红斑狼疮初治患者骨密度变化及其与疾病活动性的相关性

目的：研究女性系统性红斑狼疮（ SLE）初治患者骨密度变化及其与疾病活动性的相关性。方法选择女性SLE患者90例,其中初治45例（初治组）,已接受治疗45例（治疗组）,另择45例月经正常的健康者作为对照组。检测各组双侧股骨颈、大转子、髋部及腰椎的骨密度,分析各部位骨密度与疾病活动性的相关性。结果初治组和治疗组的双侧股骨颈、大转子及全髋的骨密度均低于对照组（P均＜0．05）。治疗组的右侧股骨颈、双侧大转子及全髋的骨密度均低于初治组（P均＜0．05）。各组腰椎各处骨密度比较差异无统计学意义（P均＞0．05）。双侧股骨颈、大转子及全髋关节的骨密度均与疾病活动性呈负相关（r分别为－0．694、－0．705、－0．779、－0．813、－0．654、－0．669,P均＜0．01）,腰椎的骨密度与疾病活动性无明显相关性。结论女性SLE患者存在一定程度的骨密度改变,腰椎外的其他各处骨密度和疾病活动性呈负相关。     

老年急性心肌梗死临床特点

目的：探讨老年人急性心肌梗死（AMI）临床特点，方法：对比分析59例老年人和41例青年人AMI临床资料。结果：老年组与对照组相比，女性患者较对照组多（P＜0．01），其余危险因素比例无差别（P＞0．05）；老年AMI无明显诱发因素者明显多于对照组（P＜0．01），老年组曾有心肌梗死和脑梗死者多（P＜0．05－P＜0．01）；老年组症不典型者多，且心衰、房颤发生率高（P＜0．05－P＜0．01），死亡率亦高（P＜0．05），而两组相比室速，室颤、房室传导阻滞无差别（P＞0．05）老年组广泛前壁，前壁，无Q波性心肌梗死多于对照组（P＜0．05）。结论：老年人AMI诱发因素及临床症不典型，心衰发生率及近期死亡率高。     

2型糖尿病患者伴骨质疏松与血脂的关系

目的探讨2型糖尿病（type 2 diabetes，T2DM）患者骨质疏松（osteoporosis，OP）和血脂的相关性。方法将296例2型糖尿患者按性别分为两组，男106例，女190例。再按其是否合并OP，将上述2组患者再分成2组。比较各组骨密度（BMD）与血脂的相关性。并用二元logist逐步回归方法分析血脂和其他相关因素与OP之间的相关性。结果合并OP的女性T2DM患者甘油三酯（TG）与LI、k、L4的BMD值成正相关（r1=0．302、P1=0．004、r3=0．221、P3=0．039、r4=0．208、P4=0．045），高密度脂蛋白胆固醇（HDL-c）与L1、Neck骨密度成负相关（r1=-0．237、P1：0．026、rN=-0．265、P2=0．013）。未合并OP的女性T2DM患者及男性患者未得到相同的结论，但上述结果在校正年龄和BMI因素后相关关系消失。应用二元logistic回归方法进行分析，只有年龄、性别、体重指数（body mass index，BMI）与OP有关。结论未观察到OP和血脂之间有必然的联系。     

高血压冠心病与骨质疏松骨量的相关性研究

目的探讨高血压冠心病与骨质疏松骨量的关系。方法93例骨质疏松及骨量减少的绝经后女性，其中无高血压和冠心病组（A组）53例，有高血压或冠心病组（B组）40例，经双能X线骨密度仪测定腰椎、髋部骨密度．生化检测各项血脂指标即总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）。比较2组血脂及各部位骨密度的相关性变化。结果2组患者TC、LDL-C及腰椎骨密度有显著性差异（P〈0．05），A组TC、LDL．C均高于B组，腰椎骨密度低于B组；Ward三角、左侧股骨近端总骨密度、TG、HDL．C2组间无显著性差异。结论心血管疾病与骨质疏松之间存在一定的相关性。     

醋柳黄酮治疗老年冠心病的疗效观察

目的：观察醋柳黄酮治疗老年冠心病心肌缺血的临床疗效。方法：78例冠心病，随机分为治疗组（40例）与对照组（38例）。对照组常规治疗应用硝酸异山梨酯与阿司匹林。治疗组在常规治疗基础上，加用醋柳黄酮15mg，3次／d，连续3个月。每例于治疗开始前1日与结束次日，进行血脂、血液流变学与动态心电图（Holter）检测。结果：服醋柳黄酮3个月，血清总胆固醇（TC），甘油三酯（TG），低密度脂蛋白-胆固醇（LDL—C）水平明显下降（P〈0．01），高密度指蛋白-胆固醇（HDL—C）水平明显上升（P〈0．05），较对照组显著（P〈0．01）；血液流变学指标如全血粘度、血浆比粘度等均显著下降（P〈0．01或〈0．05），且优于对照组（P〈0．05）。Holter监测示心肌缺血的发作次数及其持续时间，两组均明显减少（P〈0．01、〈0．05），但治疗组减少更著（P〈0．05）。醋柳黄酮治疗未见不良反应。结论：醋柳黄酮有调脂与改善血液流变性作用，治疗老年冠心病安全、有效。     

高血压对2型糖尿病患者血脂的影响

目的：观察高血压对2型糖尿病患者血脂的影响。方法：将429例住院病人分为高血压病组（EH，171例）、糖尿病合并高血压病组（DM＋EH，117例），糖尿病组（DM，141例），比较三组患者血脂变化情况，并做分层分析，结果：血浆总胆固醇（Tc)，甘油三酯（TG）、低密度脂蛋白胆固醇（LDL－c）水平在高血压病例≤55岁男性患者中明显高于＞55岁男性患者（P＜0．01），女性患者的血浆TC、TG、LDL明显于男性患者（P＜0．01），在高血压合并糖尿病组≤55岁男性患者中主要表现为TG增高，同样＞55岁女性患者为TC、TG、LDL也明显高于男性患者（P＜0．01）；在糖尿病组中，血脂变化与性别和年龄关系不大。结论：年龄和性别对高血压病和糖尿病合并高血压者血脂影响较大，糖尿病和高血压时血脂异常的类型有所不同，但高血压对血脂紊乱的程度无明显叠加作用。     

北京市社区最低生活保障老年人群血脂情况调查及分析

目的研究北京市社区最低生活保障老年人群血脂特点及流行病学特征。方法对2012年9月至2012年11月,来我院进行健康体检的≥60岁北京市社区最低生活保障老年人进行血脂调查,共计582人,检测其血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）及高密度脂蛋白胆固醇（HDL-C）水平,并进行实验室诊断,诊断结果与北京市社区普通老年居民血脂异常发生情况进行比较。同时,按年龄分为3组：60—69岁组、70—79岁组和80—90岁组,进行男性、女性组内血脂异常发生情况比较。结果北京市社区最低生活保障老年人群TC、TG及LDL—C异常比例均高于北京市社区普通老年人群（P〈0．05）,而HDL—C异常比例低于北京市社区普通老年人群（P〈0．05）。低保老年人各年龄组男性LDL—C异常比例均低于女性（P〈0．05）;60—69岁组及80-90岁组,男性TC异常比例低于女性（P〈0．05）;60—69岁组及70～79岁组男性TG及HDL—C异常比例高于女性（P〈0．05）：80。90岁组男性TG异常比例低于女性（P〈0．05）;低保老年人群总体血脂异常比例明显高于北京市社区普通老年人群（P〈0．05）,其中男性70～79岁组、女性60～69岁组血脂异常发生比例最高。结论北京市社区最低生活保障老年人群血脂异常比例较高,是北京市血脂异常防治的重点人群,而通过提高其生活水平,改善膳食结构,开展相关疾病的宣传教育,定期体检,合理药物控制,可降低该人群血脂水平,防止其心脑血管疾病的发生和发展。     

老年人动脉硬化指标和骨密度的相关性研究

目的通过踝肱脉搏波传导速度（baPWV）、脚踝上臂血压比（ABI）和骨密度T值之间的相关性分析,探讨老年人动脉硬化和骨质疏松之间的相关性。方法老年科门诊就诊的60岁及以上老年患者87例,以全自动动脉硬化诊断装置对其进行baPWV和ABI的测定,根据baPWV结果将其分为动脉硬化组和非动脉硬化组,根据ABI结果将其分为动脉狭窄组和非动脉狭窄组。同时对所有患者进行血糖、血脂、肌酐清除率、骨密度T值等测定,比较baPWV、ABI和骨密度T值之间的关系。结果动脉硬化组的骨密度T值降低（P〈0．05）,baPWV和骨密度T值呈负相关;而ABI和骨密度T值之间无明显相关关系。结论：早期动脉硬化指标和骨密度之间存在相关性,有动脉硬化的老年人也存在骨密度降低风险,对其早期进行骨密度测定,可能对防治骨质疏松有重大意义。     

老年人身体脂肪分布与骨密度关系的研究

目的 研究中国宁波市老年人骨密度(BMD)与年龄、体质指数(BMI)、身体脂肪(体脂)、肌肉的关系. 方法 选择宁波市老年男性61例,用双能X线吸收法测量法(DXA)测定腰椎BMD、全身BMD和体脂、肌肉分布,并与63例老年女性进行对照. 结果 老年男性腰椎BMD与年龄呈负相关(r=-0.401,P<0.01),与BMI、全身肌肉比例、躯干肌肉比例、全身脂肪比例及躯干脂肪比例呈正相关(分别为r=0.560,P<0.01;r=0.249,P<0.05;r=0.214,P>0.05;r=0.276,P<0.05;r=0.217,P<0.01);全身BMD与年龄呈负相关(r=-0.423,P<0.01),与BMI、全身肌肉比例、躯干肌肉比例、全身脂肪比例和躯干脂肪比例呈正相关(分别为r=0.542,P<0.01;r=0.314,P<0.05;r=0.197,P>0.05;r=0.253,P<0.05;r=0.191,P>0.01).老年女性腰椎BMD及全身BMD与年龄(r=0.364,P<0.01;r=0.412,P<0.01)、BMI(r=0.413,P<0.01;r=0.49,P<0.01)、全身肌肉比例(r=0.246,P<0.05;r=0.246,P<0.01)、躯干肌肉比例(r=0.215,P<0.05;r=0.320,P<0.01)、全身脂肪比例(r=0.361,P<0.01;r=0.507,P<0.01)及躯干脂肪比例(r=0.434,P<0.01;r=0.422,P<0.01)呈正相关. 结论 老年女性体脂与BMD相关性较男性更为密切;躯干脂肪与腰椎BMD呈正相关,提示向心性肥胖可能对腰椎BMD有保护作用.     

Significance of body weight status for bone density in the elderly and very old

Reduced bone density and osteoporosis are significant health problems and contributors to disability and mortality among older women and men. Therefore the decline of bone mineral content (BMC) and bone mineral density (BMD) are aspects of ageing with great medical and social significance. In recent years a low body weight was declared to be an important risk factor for the development of osteoporosis. In the present study the impact of weight status, defined by the categories of the WHO, on BMC of the whole body and BMD of the proximal femur end, determined by dual energy x-ray absorptiometry (DEXA), were studied in 77 female and 62 male probands aged between 60 and 92 years (x = 71.7 yrs). With increasing weight status (BMI categories), BMC and BMD increased significantly (p < 0.001). This was true of both sexes. Even moderate overweight women and men (BMI 25.0-29.99) showed a significantly higher bone density than their normal weight counterparts (BMI < 25.0). In the present study a marked positive impact of body weight on bone density of old-aged women and men could be shown.     

611例汉族人维生素D受体基因多态性与骨密度关系研究

采用PCR-RFLP分析了611名上海地区汉族人的维生素D受体(VDR)基因型,并测量其骨密度(BMD),统计分析发现男女性VDR基因分布差异存在统计学意义,Bb基因型在男性中的分布频率(26.9%)高于女性(12.7%,P<0.01)。不同基因型的人群BMD差异无统计学意义。     

Reduced bone mineral density in human immunodeficiency virus-infected patients and its association with increased central adiposity and postload hyperglycemia

Reduced bone mineral density (BMD) and abnormalities in fat redistribution, glucose homeostasis, and lipid metabolism are prevalent among HIV-infected patients on highly active antiretroviral therapy (HAART). The relationship between the metabolic and skeletal complications of HIV is unclear. Fifty-one HIV patients on HAART (aged 30-54 yr, 86% male) and 21 HIV-negative control subjects (aged 31-51 yr, 82% male) were examined with oral glucose tolerance testing, a fasting lipid profile, and dual x-ray absorptiometry, and markers of bone formation (serum osteocalcin) and resorption (urinary deoxypyridinoline). HIV-infected subjects had a higher prevalence of either osteopenia or osteoporosis (World Health Organization criteria) at the spine, hip, or forearm, compared with HIV-negative controls (63% vs. 32%, P = 0.02) and evidence of increased bone resorption (urine deoxypyridinoline, 14.7 +/- 6.5 vs. 10.9 +/- 2.5 nmol/mmol creatinine, P = 0.012). Among the HIV-infected patients, those with reduced bone mineral density (n = 32) were similar to the group with normal BMD (n = 19) in the use of protease inhibitors, duration of HAART therapy, or other demographic variables. Plasma glucose 2 h after a glucose load (odds ratio 1.02 per 1 mg/dl increase, 95% confidence interval 1.01-1.05, P = 0.009) and central adiposity (trunk fat/total fat) (odds ratio 1.09 per 1% ratio increase, 95% confidence interval 1.00-1.18, P = 0.012) were associated with reduced BMD. These associations remained significant in a multivariate model including age and body mass index. Bone resorption was associated with female gender (P < 0.001) and non-high-density lipoprotein cholesterol (P = 0.034) in a multivariate linear regression model controlling for age, body mass index, protease inhibitor use, duration of HAART, and extremity fat. Reduced BMD is prevalent in HIV-infected patients on HAART and is related to central adiposity and postload hyperglycemia. Bone resorption is independently associated with female gender and dyslipidemia. HIV-infected patients with metabolic abnormalities may represent a population that would benefit from bone density screening.     

Correlation between bone mineral density and plasma lipids in Taiwan

Many studies showed that depression is correlated with osteoporosis, while others showed that low cholesterol level is also related to depression. However, these relationships still remain controversial. Since the bone mineral density (BMD) is related to depression and depression is related to hypocholesterolemia, there might exist a correlation between BMD and plasma cholesterol levels. To prove this, we enrolled 5000 individuals, 2170 males, and 2830 females, who had health check-ups at a private clinic between 1998 and 1999. They were divided into three groups. Group 1 was composed of male subjects; Group 2, female subjects; and Group 3, females aged over 50 to exclude pre-menopausal females. Each subject had a routine physical examination, fasting blood drawing, BMD measured by dual energy x-ray absorptiometry (DEXA) over the wrist, and was given a questionnaire to answer. Between Groups 1 and 2, the females were significantly younger, had higher body mass index (BMI), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), and platelet, but lower BMD, fasting plasma glucose (FPG), triglycerides (TG), hemoglobin (Hgb), and white blood cell (WBC) count. As for Groups 1 and 3, all the aforementioned findings still remained the same except that the systolic blood pressure (SBP) was higher and diastolic blood pressure (DBP) was lower in Group 3. Our results showed that BMD is negatively related to age in males. In females, it is negatively correlated with age, FPG, PPG, SBP, DBP, TC, LDLC, TG, and Hgb, but positively related to BMI and platelet. However, for females in Group 3, BMD is only negatively related to age, FPG, SBP, and TG but positively related to BMI. Stepwise multiple regression analysis showed that the BMD is negatively related to age but positively related to BMI in both males and females. In Group 3, BMD is negatively related to age and FPG but positively related BMI. In conclusion, no correlation exists between BMD and cholesterol. This implies that the depression is not significantly related to cholesterol and/or BMD. This might be due to various confounding factors, which could affect their relationships. The negative correlation between BMD and FPG is only observed in females older than 50 years. Further studies are needed to clarify these relationships.     

Das gemeinsame Auftreten von Osteoporose und Arthrose und der Nutzen der Knochenstoffwechselmarker

OBJECTIVE: Increasing bone mineral density (BMD) has been found in several studies in patients with osteoarthritis. Therefore, many clinicians deny the simultaneous occurrence of osteoporosis (OP) and osteoarthritis (OA). Because of our clinical impression however, we suggested that we have to consider a common occurrence. Furthermore, the value of markers of bone turn over with a view to early diagnosis of OP and or as an assessment for bone metabolism in OA is still a matter debate and their clinical use has not been clearly defined in the management of the individual patient. METHOD: The BMD of the lumbar spine and the proximal femur of 119 OA patients (83 postmenopausal female patients aged 50-83 and 35 male patients aged 36-86 years) who subsequently required hip or knee replacements, but were otherwise healthy, were measured by dual energy X-ray absorption (DXA), Hologic QDR-2000. We also measured biochemical markers of bone turn over, i. e., CICP, ICTP, DPD, PTH, estrogen, testosterone, bAP, hydroxy vitamin D and the normal blood count. RESULTS: There was a high occurrence of a low BMD among the patients. A total of 28.9% of women were affected by OP and 52.9% by osteopoenie. This reflects the normal distribution of OP in the female population. Of the male patients 20% had OP and 38.8% osteopoenie. This is astonishing high. Age proved to be a significant factor in the degree of BMD. An association between disuse osteoporosis and degree of BMD in the OA affected joint could not be proven. The use of the biochemical markers for an earlier diagnosis or to assess bone metabolism in OP and OA was not possible. CONCLUSION: We can not support the hypotheses that OA prevents OP. Moreover, the occurrence of OP in our study reflected the incidence of OP in the average female and the astonishingly high incidence in the male population; however does not mean that the two conditions are mutually exclusive. We did not find that the biochemical markers of bone turn over could deliver additional information with respect to bone metabolism and an earlier diagnosis of OP.     

Serum lipid profile: its relationship with osteoporotic vertebrae fractures and bone mineral density in Turkish postmenopausal women

The effect of the serum lipid levels on vertebral fractures and bone mineral density is not clear. A total of 107 postmenopausal women aged 45–79 examined by lumbar spine, hip and radius bone mineral density (BMD) measurements, lateral dorsal and lumbar spine radiographies, routine blood tests and serum lipids [total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, VLDL-C]. Demographic and lifestyle characteristics were collected. Eighty-nine radiographies with good technical properties were scored by the Kleerekoper method. Patients with vertebrae fractures had lower levels of TC, TG, LDL-C than the patients without vertebrae fractures. Total cholesterol level was the most prominent factor affecting the vertebral fracture existence. An increase of 1 mg/dl total cholesterol decreases the risk of vertebrae fracture by 2.2%. The existence of osteoporosis due to T score was not influencing the lipid values. TC and LDL-C were weakly associated with BMD at the forearm UD region after the adjustment for the possible confounders. This study shows that the serum lipids have impact on vertebrae fracture existence rather than BMD alterations.     

Osteoporosis in treated adult coeliac disease.

Forty five women and 10 men with coeliac disease diagnosed in adult life, who were already on a gluten free diet, had serial bone mineral density measurements at the lumbar spine and femoral neck over 12 months. Osteoporosis, defined as a bone mineral density (BMD) < or = 2 SD below the normal peak bone mass was found in 50% of male and 47% of female coeliac patients. Patients with a BMD < or = 2 SD below age and sex matched normal subjects, had a significantly lower body mass index (21.3 kg.m-2 compared with 25.2 kg.m-2, p < 0.02 Wilcoxon rank sum test) and lower average daily calcium intake (860 mg/day compared with 1054 mg/day, p < 0.05 Wilcoxon rank sum test) than patients with normal bone mineral density. In postmenopausal women with coeliac disease there was a strong correlation between the age at menopause and BMD at both the lumbar spine (r = 0.681, p < 0.01, Spearman's rank correlation) and femoral neck (r = 0.632, p < 0.01). No overall loss of bone was shown over the 12 months of follow up, and relative to the reference population there was a significant improvement in BMD at the lumbar spine in women (p < 0.025, paired t test) and at the femoral neck in men (p < 0.05, paired t test). There was a significant negative correlation between the annual percentage change in BMD at the lumbar spine and the duration of gluten free diet (r = -0.429, p<0.01, Spearman's rank correlation), with the largest gain in BMD in patients with most recently diagnosed coeliac disease. Osteoporosis was shown in 47% of patients with treated adult coeliac disease. Recognised risk factors for osteoporosis in the general population including low body mass index, dietary calcium intake, and early menopause are particularly important in coeliac disease. Treatment of coeliac disease with a gluten free diet probably protects against further bone loss, and in the early stages is associated with a gain in bone mineral density.     

2型糖尿病患者颈动脉粥样硬化斑块与骨密度的相关性分析

目的探讨住院2型糖尿病(T2DM)患者不同性别骨量减少(包括骨质疏松与低骨量)相关影响因素及其与颈动脉粥样硬化斑块之间的关系。方法回顾性分析720例T2DM患者的临床资料,将入选对象分为男性组和女性组,每组再分为骨量正常组和骨量减少组,颈动脉有斑块组和颈动脉无斑块组。结果在男性骨量减少组(77例)中,存在粥样斑块68例(88.31%),与骨量正常组(164例)比较,骨量减少组粥样斑块的发生率明显升高(P0.05);斑块形成组骨密度(BMD)明显减低(P0.05)。在女性骨量减少组(255例)中,存在粥样斑块191例(74.90%),与骨量正常组(224例)比较,骨量减少组粥样斑块的发生率明显升高(P0.05);斑块形成组骨密度明显减低(P0.05)。二元Logistic回归分析显示,男性骨量减少的影响因素有年龄(OR=1.059,P=0.002),体质指数(BMI)(OR=0.853,P=0.004),空腹血糖(FBG)(OR=1.138,P=0.044),有无颈动脉斑块(OR=2.514,P=0.035)。女性骨量减少的影响因素有年龄(OR=1.117,P=0.000),绝经年龄(OR=0.946,P=0.031),BMI(OR=0.910,P=0.003)。结论 T2DM患者颈动脉粥样硬化斑块与骨量减少密切相关。女性患者由于增龄等共同危险因素的存在,二者常相伴发生,然而在男性患者中,颈动脉粥样硬化斑块的形成是骨质疏松的危险因素,因此,颈动脉硬化的发展常伴有骨量变化,易发生骨质疏松。     

苏州地区1931名健康成人腰椎骨密度调查分析

目的了解苏州地区正常成年人群腰椎骨密度(BMD)的正常参考值及其变化规律。方法应用双能X线骨密度仪,对1931名成年健康男女进行腰椎(L_(1-4))骨密度测量,并将所得结果标准化处理后进行统计学分析。结果①男性腰椎(L_(1-4))BMD值在20～29岁达到峰值,女性在30～39岁达到峰值,女性较男性晚10年;②男性BMD值在30岁以后逐渐降低,但无明显加速丢失期;女性BMD在40岁以后开始丢失,且存在迅速丢失现象;苏州地区健康成年人腰椎BMD峰值:男性为(1.084±0.135)g/cm~2,女性为(1.096±0.119)g/cm~2,男性腰椎BMD峰值略低于女性。结论初步明确苏州地区健康人群腰椎BMD峰值,发现不同性别和不同年龄组人群骨密度的变化规律及其差异,为本地区骨质疏松的预防和诊治提供了有用的信息。