An automated complex for the multiparametric analysis of galvanic skin response signals

The questions related to the design of the hardware and software means for the automation complex, which allows multiparameter analysis of the GSR signal based on IBM PC/XT microcomputer are being considered in the present article. The choice of the structure for the complex and working parameters of the separate modules is based on the experimental and printed data. Microcomputer GSR signal input and its further processing algorithms are presented. The possibility to simplify the soft- and hardware of the complex with the help of the rational choice of its structure and regarding the peculiarities of the GSR signal frequency-amplitude parameters is described.     

The immune system of the skin and stereotyped reaction patterns in inflammatory skin diseases

The clinical and histological presentation of inflammatory disease in the skin is exceedingly heterogeneous. Nonetheless, most inflammatory dermatoses can be classified according to five stereotypical tissue-reaction patterns: the spongiotic, the lichenoid, the psoriasiform, the vesiculo-bullous and the vasculopathic. By means of potent antigen-presenting cells, cytokine and chemokine cascades and a skin-specific cutaneous lymphocyte antigen (CLA)-positive lymphocyte population, the skin is able to respond very efficiently to pathogens that threaten the individual. Inflammatory skin diseases follow the rules and routes of the physiological reaction to inflammation but however for various reasons the immune response may be inadequate, enhanced or chronic. In allergic contact dermatitis, which is a prototype of the spongiotic reaction pattern, the inflammation is directed against an otherwise harmless antigen, for which the body is sensibilized. Lichenoid dermatitis (like erythema multiforme, graft versus host disease or lupus erythematodes) is based on a primary cytotoxic reaction against the basal epithelial cell, due to alterations in its antigenic make-up or due to an altered immune response. In psoriasis, an example of psoriasiform dermatitis, the interaction between inflammatory cells, antigen presenting cells and epithelial cells is disturbed.     

Automated system for processing medical rhythmic information

The computer-aided (ES computer) system for acquisition, storage and sampling for any set of signs and processing of rhythm-based data is developed. The software is based on the operation system ES computer by using a time share system and a system for database control "Spektr". The informative database contains "The map of chronobiological examinations" and "The meteorologic map".     

Automated system for individual selection of hearing aids

The automated system based on the computer CM-4 and the algorithm for selecting hearing aids are described. From the audiometry data (a hearing threshold, discomfort, etc.) the acoustic characteristics of hearing aids are calculated allowing a low hearing person to improve the speech perception. Then, according to the developed fitting criteria the system selects the required hearing aid from the available set (acoustic characteristics are preliminary loaded into the computer memory). Consequently, an audiologist has the important information on the most adequate hearing aid for a patient along with the data on the unit operating modes and the validate compliance between the rated and computed values. The high efficiency of the system has been demonstrated while selecting hearing aids for low hearing persons in clinical practice, the selection time being considerably reduced.     

Automated analysis of the parameters of myocardial cells

To determine the quantitative influence of electromagnetic radiation factor on the ultrastructure of cardiomyocytes, use was made of automated morphometry of the electronomograms. The system of automated analysis of the images obtained on the basis of electron microscopy is intended for computation of the test parameters by means of tracking the image structure. The data are continuously processed by computer and printed. The measurements were made in accordance with the theory of experimental design. The obtained equations simulated the influence of the test factors. The general view of the model that takes into consideration the response of several substructures is provided.     

基于直流电刺激的细胞生长培养系统的研制

一种基于直流电刺激的细胞生长培养系统。实现了在μA级电流情况下对组织细胞进行刺激,能完成实时刺激数据的采集、特征信号的数据分析、处理和波形显示等操作。恒流源的电流的输出范围为1～100μA,相对误差小于5%。