Medicinal properties and conservation of Pelargonium sidoides DC.

Ethnopharmacological relevance

Pelargonium sidoides DC. (Geraniaceae), a popular medicinal plant used in traditional medicine in the treatment of gastrointestinal ailments has been transformed into a phytopharmaceutical (EPs^® 7360) for treating respiratory tract infections. The increasing international demand for Pelargonium sidoides has led to localised overexploitation of its wild populations in southern Africa. The aim of the review is to provide a synthesis of the current state of scientific knowledge on the phytochemical, pharmacological and toxicological properties of Pelargonium sidoides as well as the potential role of plant biotechnology in its conservation. The review highlights knowledge gaps in these research areas.

Materials and Methods

A comprehensive literature search involving mainly electronic and library sources of information were used to collate and synthesise published data.

Results

Experimental results from in vitro studies indicate that bioactive phytochemical constituents of Pelargonium sidoides may not possess a direct antimicrobial effect, but instead act by interfering with microbial binding to host cell receptors, inhibition of key enzymes and the production of antimicrobial effector molecules such as nitric oxide and interferons (IFNs) by the host cells. Furthermore, clinical evaluations in randomised, double-blind, placebo-controlled trials have demonstrated the beneficial effect of Pelargonium sidoides in the treatment of respiratory tract infections with few side effects. However, there is lack of adequate information on the safety evaluation of the plant. On the other hand, the increasing demand for Pelargonium sidoides has led to localised illegal harvesting of wild plants.

Conclusions

Pharmacological data reported in literature suggest that Pelargonium sidoides shows a beneficial effect in the treatment of respiratory tract infections. However, more studies are required to elucidate the mode of action of the active constituents exhibited in the treatment of respiratory tract infections and other health conditions caused by microbial attack. Furthermore, the pharmacological usefulness of Pelargonium sidoides must take cognisance of the broader context involving the need for conservation-friendly approaches in its utilisation. In this regard, plant biotechnology applications can play a meaningful role in a holistic conservation strategy.     

Conservation strategy for Pelargonium sidoides DC: Phenolic profile and pharmacological activity of acclimatized plants derived from tissue culture

Ethnopharmacological relevance

Pelargonium sidoides DC (Geraniaceae), a popular medicinal plant used in folk medicine in the treatment of respiratory-related infections has gained international prominence due to its usage in several herbal formulations. This has led to high demand and the subsequent decimation of wild populations.

Aim of the study

Using plant tissue culture techniques, Pelargonium sidoides plants were cloned in vitro, acclimatized under greenhouse conditions and evaluated for their phytochemical content and pharmacological activity.

Methods

Phenolic content in extracts of in vitro-derived, greenhouse-acclimatized and wild Pelargonium sidoides plants were analyzed using UPLC-MS/MS. The oxygen radical absorbance capacity (ORAC), 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging activity and minimum inhibitory concentration (MIC) of the extracts against bacterial and fungal strains were evaluated.

Results

Similarities in phenolic profiles were identified confirming the chemical signatures that characterize Pelargonium sidoides plants. Extracts of greenhouse-acclimatized and wild plants exhibited comparable antimicrobial and antioxidant properties.

Conclusions

Overall, the study highlights the potential of integrating plant tissue culture technologies in conservation strategies of medicinal plants. In particular, the results strongly suggest the feasibility of both large-scale cultivation and plant part substitution as alternative solutions to the current destructive overharvesting practices of wild Pelargonium sidoides populations.     

South African Helichrysum species: a review of the traditional uses, biological activity and phytochemistry

Aims of the study

In South Africa, the genus Helichrysum is widely used in traditional medicine. The uses are well documented although renaming of species and the resulting confusing taxonomic nomenclature may cause uncertainty as to which specific species was referred to in some reports. The aim of this paper is to present a collated and coherent overview of the documented traditional uses of Helichrysum species and to update the botanical identity of previously studied species.

Materials and methods

Databases (Scifinder, ISI Web of Knowledge) and several books were used to collect in information on South African Helichrysum species.

Results

The traditional uses, chemistry and biological activity of Helichrysum species have been summarized. It was attempted to give clarity as to exactly which species is refer to in the ethnobotanical literature.

Conclusions

Although a large number of ethnopharmacological uses have been documented and the chemistry of the genus has been studied extensively, only a few South African species have been investigated for their biological activity.     

Ethnobotanical survey for potential anti-malarial plants in south-western Nigeria

Aim of study

The ethnobotanical study surveyed the different types of medicinal plants used for the treatment of malaria in the south-western region of Nigeria.

Materials and methods

Information was collected by interviewing indigenous people, using a semi-structured questionnaire. Collected plant samples were identified and authenticated in Forestry Research Institute of Nigeria, Ibadan, Nigeria.

Results

A total of 151 respondents were interviewed of which 64% were females and 36% males. This population comprised of herbal medicine sellers (39%), traditional doctors (15%), housewives (24%) and farmers (22%). Twenty two plants species used in the treatment of malaria belonging to 18 families were identified and compiled detailing information such as common and vernacular names, parts used, methods of preparation and previous scientific reports. Of the plants identified during the survey, Azadirachta indica (12.9%), Alstonia congensis (11.9%) and Cymbopogon citratus (11.3%) showed the highest incidence of encounter whereas Nauclea latifolia recorded the lowest incidence of encounter (0.2%). The traditional usage of Persea americana and Ludwigia peruviana in the treatment of malaria is reported here for the first time.

Conclusion

Though a large number of traditionally used plants for the treatment of malaria were identified, scientific validation of the traditional claims of anti-malarial properties is imperative. This would establish their candidature for any possible future research for active principles and the possible development of new cheaper and more effective anti-malarial drugs, as well as in the conservation of this rich diversity of anti-malarial plants.     

Ethnobotany of medicinal plants used in Eastern Mallorca (Balearic Islands, Mediterranean Sea)

Ethnopharmacological relevance

This paper represents the first large-scale ethnobotanical study in the island of Mallorca, and provides significant information on pharmaceutical plant uses, built up from interviews with native people from this touristic hotspot, demonstrating its ethnopharmacological importance.

Aim of the study

To collect, analyse and evaluate the ethnobotanical knowledge concerning medicinal plants in a north-eastern Mallorcan area (municipalities of Artà, Capdepera and Son Servera; 298 km², 31,764 inhabitants).

Materials and methods

We performed semi-structured interviews with 42 informants (mean age 77; 40% women, 60% men), identified the plant taxa reported and analysed the results, comparing them with those found in the current Mallorcan ethnobotanical information and in other territories.

Results

The informants reported data on 121 human medicinal plants representing 64 botanical families. Around 45 medicinal uses reported, concerning 37 species, have not or have very rarely been cited as medicinal. An index of medicinal importance is proposed.

Conclusions

All efforts addressed to compiling ethnobotanical information in industrialised or touristised areas such as Eastern Mallorca are still valuable. New possibilities can be explored to give practical value to Mallorcan ethnobotanical data in the frame of considering traditional plant knowledge as part of the islanders’ lifestyle and healthy habits.     

Ethnobotanical survey of Purulia district, West Bengal, India for medicinal plants used against gastrointestinal disorders

Ethnopharmacological relevance

An ethnobotanical survey was conducted in the remote hills, forests and rural areas of Purulia, one of the tribal rich districts of the West Bengal state of eastern India. Purulia is a part of the biogeographic zone Deccan Peninsula Chhotonagpur. The authors have reported the use of medicinal plants by nine tribes of the district against various gastrointestinal disorders.

Materials and methods

Semi structured questionnaire was used during the interview with the informants having traditional botanical knowledge. Bhumijs, Birhor, Gond, Ho, Kharia, Mal Pahariya, Mundas, Oraon and Santhali represent the various aboriginal groups present in the district. The use of medicinal plants were documented using an interview data sheet mentioning the names, age, profession and gender of the informants and scientific and vernacular names, families, part(s) used, disease(s) treated, method of preparation, mode of administration of the botanicals and the preparations.

Results

A total number of 56 plants belonging to 29 families have been reported to be used against different types of gastrointestinal disorders viz. indigestion, stomach pain, vomiting tendency, constipation, piles, diarrhea, dysentery, cholera, loss of appetite, liver complaints, intestinal worms etc. Fabaceae and Apocynaceae were found to be the dominant families of medicinal plants used to treat such ailments.

Conclusion

Age, gender, literacy and profession of the aboriginals were found to be the significant factors when the traditional knowledge of medicinal botanicals was concerned. Due to urbanization and loss of biodiversity, the authors have noted a significant decrease in the ethnic knowledge as well as the botanicals. Preservation of folklore should be given utmost importance in this region to prevent the rapid loss of ethnobotanical wealth.     

Ethnobotanical and phytomedical knowledge in the North-Western Ligurian Alps

Ethnopharmacological relevance

The ethnobotany of European alpine regions is much diversified and scarcely investigated. These regions retain a well-developed heritage culture and botanical traditional knowledge, favored by the isolated montane location. We carried out a study of therapeutic and traditional uses of native plants of a poorly explored area of the Western Italian Alps in the Ligurian region (NW Italy). The area has been the object of human activities since prehistoric ages, and an obliged crossroad for people moving across Provence, Liguria and Piemonte.

Methodology

The investigation was conducted in the upper Tanarello and Arroscia Valleys by using semi-structured, open interviews. Data were summarized by different indices – Relative Frequency of Citation (RFC), Cultural Value Index (CV), Ethnobotanicity Index (EI) and Informant Consensus Factor (F_ic).

Results and discussion

A group of 65 informants were interviewed, yielding an inventory of 199 botanical taxa from 64 families, and a total of 2661 citations. A total of 13 categories of use were found, of which the most frequent ones were medicinal and food. In addition, 12 main medicinal subcategories were recorded. Botanicals were mainly used to treat digestive system, respiratory system, and the skin. A relevant role was played by plants with digestive and remineralizing properties. On the basis of quantitative analysis (RFC and CV indices) among the 30 most relevant plants are included rare and/or protected species, such as Achillea ligustica, Arnica montana, Gentiana ligustica, Gentiana lutea, and Achillea erba-rotta.

Conclusions

An exhaustive prospect of the ethnobotanical knowledge in North-Western Ligurian Alps has been achieved through the recording of a large number of data. About 50% of the recorded uses have survived in the area. A great traditional importance is retained by species such as Artemisia absinthium, Lavandula angustifolia and Arnica montana which were formerly cultivated and marketed for their therapeutic virtues. A substantial role is also attributable to the tree species Pinus sp. pl., Castanea sativa and Olea europaea that have been exploited as sources of wood/food since long ago. These plants are a natural resource deserving reevaluation among local agriculture and commercial activities.     

Is aristolochic acid nephropathy a widespread problem in developing countries?: A case study of Aristolochia indica L. in Bangladesh using an ethnobotanical–phytochemical approach

Ethnopharmacological relevance

Species of Aristolochia are associated with aristolochic acid nephropathy (AAN), a renal interstitial fibrosis and upper urinary tract cancer (UUC). Aristolochic acid nephropathy has been reported in ten countries but its true incidence is unknown and most likely underestimated. By combining an ethnobotanical and phytochemical approach we provide evidence for the risk of AAN occurring in Bangladesh. More specifically, we assess the intra-specific variation of aristolochic acid analogues in medicinally used Aristolochia indica samples from Bangladesh.

Materials and methods

Ethnobotanical information was collected from 16 kavirajes (traditional healers) in different study locations in Bangladesh. Plant samples were obtained from native habitats, botanical gardens, herbal markets and pharmaceutical companies. The samples were extracted using 70% methanol and were analysed using LC-DAD-MS and ¹H-NMR.

Results

Roots as well as leaves are commonly used for symptoms such as snake bites and sexual problems. Among the informants knowledge about toxicity or side effects is very limited and Aristolochia indica is often administered in very high doses. Replacement of Aristolochia indica with other medicinal plants such as Rauvolfia serpentina (L.) Benth. ex Kurz was common. Aristolochia indica samples contained a variety of aristolochic acid analogues such as aristolochic acid I, aristolochic acid II, cepharadione A and related compounds.

Conclusions

AAN cases are likely to occur in Bangladesh and more awareness needs to be raised about the health risks associated with the use of Aristolochia indica and other species of Aristolochia as herbal medicines.     

Therapeutic uses of Aloe L. (Asphodelaceae) in southern Africa

Ethnopharmacological relevance

The African-Arabian succulent genus Aloe L. (Aloaceae/Asphodelaceae) is represented by approximately 120 infrageneric taxa in southern Africa, including A. ferox Mill., a species long used in commercial natural products.

Aims of the study

To assess the documented ethnobotanical knowledge and biocultural value of utility in the genus in southern Africa.

Materials and methods

A survey of over 350 multidisciplinary publications was undertaken.

Results

Local uses for medicine and wellbeing were identified for over half the species of Aloe occurring in the Flora of Southern Africa region. The most frequently cited medicinal uses were the treatment of infections and internal parasites, digestive ailments and injuries. Numerous species were recorded for their social uses, notably as ingredients in tobacco snuff.

Conclusion

The exceptional infrageneric diversity of Aloe, and extensive therapeutic uses in southern Africa, indicate its cultural importance in the subcontinent. These factors highlight the need for the conservation of the species as well as their potential as a source of natural products.     

Medicinal plants and their uses by the people in the Region of Randa,Djibouti

Ethnopharmacological relevance

The article presents the local knowledge on medicinal plants and their relevance in managing health problems. Important ethnobotanical leads are given with priority species and disease categories, casting insight on future phytochemical and pharmacological studies.

Aim of the study

The use of traditional medicinal plants has been an integral part of the traditional healthcare systems in Djibouti. However, scientific studies on the traditional herbal healing systems of the various cultural groups have never been undertaken. This study has, therefore, aimed at assessing plant-related ethnomedicinal knowledge of the people in Randa Region; prioritising the plants with respect to common disease categories and inferring about prospects of new pharmacological products.

Materials and methods

Interview-based ethnobotanical field study was carried out to document the plant-based ethnomedicinal knowledge handed down to the present by the oral tradition of people living in 24 villages in Tadjourah District of Randa Region (north Djibouti). Informant Consensus Factors (ICF) and Fidelity Level (FL) values of the medicinal plants were calculated to check the level of informant agreement and the healing potentials of the species.

Results

A total of 91 plant species that belong to 72 genera and 40 families were documented. Most of these species (92%) were collected from non-cultivated areas. Their local names and traditional uses in medicine were also studied. The plant family Fabaceae was represented by the highest number of taxa (17 species). Strong informant agreements hinted at good healing potentials of some species as shown by high values of consensus factors for eye diseases (0.98), mouth diseases (0.93), kidney problems (0.89) and microbial infections (0.84). Dodonea angustifolia, Solanum cordatum, Grewia erythraea, Acalypha indica, Acacia etbaica, Fagonia schweinfurthii, Solanum coagulans, Senna alexandrina and Grewia tembensis scored high FL values emerging as promising priority species for future pharmacological screening against microbial infections.

Conclusion

The results of this study may inspire further ethnobotanical and ethnopharmacological research and investigations toward drug discovery in Djibouti and beyond.     

The effectiveness of jewelweed, Impatiens capensis, the related cultivar I. balsamina and the component, lawsone in preventing post poison ivy exposure contact dermatitis

Ethnopharmacological relevance

Impatiens capensis (jewelweed) is native to the Eastern and Midwestern US and Canada. Many Native American tribes used I. capensis and its close relatives to treat/prevent rash from plant sources particularly Toxicodendron radicans and Urtica dioica. I. balsamina (garden balsam) a native of China was used by the indigenous people of Asia for similar purposes.

Aim of study

This study aims to validate ethnopharmacological use of jewelweed in poison ivy (PI) dermatitis prevention and to refute scientific papers denying this efficacy. Additionally, the content of lawsone, the purported effective agent in jewelweed preparations, was measured to see if its concentration correlated with jewelweed preparation efficacy.

Material and methods

Poison ivy was brushed onto forearms of volunteers in 6 locations and exposed areas were treated with jewelweed extracts, fresh plant mashes, soaps made of plant extracts, water and Dawn® dish soap. Rash development was scored on a scale of 0–14.

Results

Jewelweed mash was effective in reducing poison ivy dermatitis, supporting ethnobotanical use. However, jewelweed extracts were not effective; and soaps made of these extracts were effective but no more so than jewelweed-free soaps. Lawsone content varied with harvest season and did not appear to affect rash development.

Conclusion

Jewelweed is an efficacious plant for preventing development of dermatitis following poison ivy contact, but soap is more effective. Lawsone content does not correlate with PI rash prevention. Perhaps saponins, the soapy component of jewelweed are the effective agents.     

Assessment of in vitro pharmacological effect of Neotropical Piperaceae in GABAergic bioassays in relation to plants traditionally used for folk illness by the Yanesha (Peru)

Ethnopharmacological relevance

A previous pilot ethnobotanical and ethnopharmacological study with the Q‘echi? Maya identified the family Piperaceae, as an important taxonomic group traditionally used for the treatment of epileptic and culture-bound anxiety disorders and possessing activity in the GABA system. Following that lead, a botanical survey was conducted in Peru, where 47 species of Piperaceae were collected including 21 plants traditionally used for folk illnesses by the Yanesha of Peru, an indigenous Amazonian group.

Materials and methods

Two high throughput bioassays were used to quantify the in vitro activity of botanical extracts on the GABA system.

Results

Plant extracts demonstrated moderate to high affinity to the γ-aminobutyric acid benzodiazepine (GABA-BZD) receptor. In addition, extracts demonstrated low to moderate activity in the inhibition of the GABA-transaminase, with select plants exhibiting significant activity. Plants indicated by the Yanesha showed comparable activity to the other Piperaceae plants collected. Piper cremii was the most active plant in the GABA-BZD receptor assay, and Drymaria cordata (Caryophyllaceae) in the GABA-T assay.

Conclusion

The study provides evidence that there is a pharmacological basis behind the use of plants in the treatment of susto and mal aire in both Central and South America, and we propose that the possible mechanism of action includes an interaction with the GABA-T enzyme and/or the GABA_A-BZD receptor.     

Ethnobotanical survey of malaria prophylactic remedies in Odisha,India

Aim of the study

To investigate the plants traditionally used for prevention of malaria in Cuttack, Gajapati and Koraput districts of Odisha state, eastern India.

Materials and methods

An ethnobotanical survey was carried out among 20 traditional healers who were sampled based on recommendations of local elders and local non-government organizations. Data were collected through semi-structured interview.

Results

The study revealed the use of 16 traditional plant species belonging to 12 families for prevention of malaria. Andrographis paniculata, Azadirachta indica, Nyctanthes arbor-tristis, Ocimum sanctum, Piper nigrum, Zingiber officinale were the most commonly reported plants for their malaria prophylactic use by the healers of three districts of Odisha. Most of the remedies were used in decoction form.

Conclusions

Findings of this study provide a lead to explore traditional plants for malaria preventive potential through further pre-clinical and clinical studies.     

Medicinal mosses in pre-Linnaean bryophyte floras of central Europe. An example from the natural history of Poland

Ethnopharmacological relevance

The paper presents information about the earliest botanical work from Poland, Warsavia physice illustrata which takes bryophytes into account. It was elaborated by a German physician Christian Heinrich Erndtel and issued in 1730 in Dresden. That time understanding of bryophytes was imprecise and in many cases they were confused with lichens and club mosses.

Materials and methods

Bryophyte taxa polynomials (18 names) were identified using pre- and post-Linnaean botanical monographs from years 1590 to 1801. Their current names and pharmacological value are provided, as well as the old ethnobotanical data about bryophytes (cited from 18th-century sources).

Results

Altogether 18 bryophyte species were identified from the vicinity of Warsaw (17 mosses and 1 liverwort). Some of them are still abundant in this area (for example Climacium dendroides, Plagiomnium undulatum and Polytrichum juniperinum) while some other are rare or extinct (for example Neckera crispa and Rhodobryum roseum).

Conclusions

Despite the technical ability to observe specific microscopic differences among bryophytes, physicians of 18th century were hardly interested in using any of them as medicinal stock. It may be concluded that the competences in pre-Linnaean bryology did not put into practice using moss-derived materia medica of 18th century (the only exceptions were Fontinalis antipyretica and Polytrichum spp.).     

The importance of botellas and other plant mixtures in Dominican traditional medicine

Ethnopharmacological relevance

Plant mixtures are understudied in ethnobotanical research.

Aim of the study

To investigate the importance of plant mixtures (remedies consisting of at least two plants) in Dominican traditional medicine.

Materials and methods

A Spanish language questionnaire was administered to 174 Dominicans living in New York City (NYC) and 145 Dominicans living in the Dominican Republic (DR), including lay persons (who self-medicate with plants) and specialists (traditional healers). Plants were identified through specimens purchased in NYC botánica shops and Latino grocery shops, and from voucher collections.

Results

The percentage of mixtures as compared to single plants in plant use reports varied between 32 and 41%, depending on the geographic location (NYC or DR) and participant status (lay person or specialist). Respiratory conditions, reproductive health and genitourinary conditions were the main categories for which Dominicans use plant mixtures. Lay persons reported significantly more mixtures prepared as teas, mainly used in NYC to treat respiratory conditions. Specialists mentioned significantly more botellas (bottled herbal mixtures), used most frequently in the DR to treat reproductive health and genitourinary conditions. Cluster analysis demonstrated that different plant species are used to treat respiratory conditions as compared to reproductive health and genitourinary conditions. Interview participants believed that combining plants in mixtures increases their potency and versatility as medicines.

Conclusions

The present study demonstrates the importance and complexity of plant mixtures in Dominican traditional medicine and the variation in its practices influenced by migration from the DR to NYC, shedding new light on the foundations of a particular ethnomedical system.     

A review of Khoi-San and Cape Dutch medical ethnobotany

Ethnopharmacological context

Cape herbal medicine as a distinct and unique healing system is conceptualized for the first time, together with a first compilation of the authentic materia medica of the system.

Materials and methods

The early literature on Khoikhoi (Hottentot), San (Bushman) and Cape Dutch medicinal plants and medical practices is reviewed, with a focus on the Cape Floristic Region (from Namaqualand to the Eastern Cape). To avoid recent additions and modern cultural influences in the results, the date of publication of the last volume of Marloth's Flora of South Africa (1932) was chosen as a cut-off date.

Results

The recorded Cape materia medica (up to 1932) is briefly summarized, giving the scientific names, vernacular names (in Afrikaans or Khoi-San/Nama) and main uses. It comprises about 170 items and includes mainly indigenous and endemic plant species, some exotic (garden) plants, and a few other items (fungi, seaweeds, lichens, hyraceum and natural potassium nitrate). Most of the plants (and hyraceum) are still widely used today, especially in rural areas.

Conclusions

The combination of unique cultural practices and a diverse, highly endemic flora has led to the development of a distinct herbal healing system, here called Cape herbal medicine, but hitherto rather vaguely and inaccurately referred to as Khoi-San medicine, Cape Dutch medicine or boererate (farm remedies). The data allows for a more informed consideration of indigenous knowledge and intellectual property rights associated with particular plants (e.g. Hoodia and Pelargonium). It also offers opportunities for linking modern ethnobotanical field studies with historical data.     

Ethnobotanical investigation on wild medicinal plants in the Monti Sicani Regional Park (Sicily,Italy)

Ethnopharmacological relevance

The area of the “Monte Sicani Regional Park” (Central Western Sicily, southern Italy) has been quantitatively and extensively investigated in an ethnobotanical study for the first time. A total of 108 wild species are used for medicinal purposes, while, according to our study, the uses of 9 species have not previously been reported in ethnobotanical studies in Italy (e.g., the use of Kickxia elatine (L.) Dumort. for the treatment of hyperhydrosis of the feet, the use of Lavatera agrigentina Tineo for cough and bronchitis). Aim of the study: The aim of this paper is to analyze, through quantitative indicators, the extent of the current knowledge on medicinal uses of plants in the area, evaluating also the features of uniqueness and commonality of this knowledge in comparison with other Italian and Mediterranean areas.

Methodology

Semi-structured interviews were carried out in the local communities between 2009 and 2010 within the Monti Sicani Regional Park with local people retained experts in rural traditions. A total of 230 people were interviewed about their knowledge on medicinal plant uses. Local plant uses were evaluated using ethnobotanical indices (e.g., cultural importance index, ethnobotanicity index, informant consensus factor) and then compared with uses in other localities in Sicily, Italy and the Mediterranean basin.

Results

Local communities currently use a total number of 108 wild species (43 families) as remedies for human and livestock ailments. The majority of plants are used in the treatment of articular, skin and gastrointestinal problems. The use of some species is limited to Sicily (e.g., Rhus coriaria L., Athamanta sicula L., Senecio delphinifolius Vahl).

Conclusions

The research shows an ongoing process of cultural erosion in an advanced stage, but results still highlight an interesting cultural identity as regards the local folk medicine.     

Management of diabetes in Guinean traditional medicine: An ethnobotanical investigation in the coastal lowlands

Ethnopharmacological relevance

This survey was carried out in the coastal lowlands of Guinea–Conakry in order to make an inventory of plants used by traditional healers, herbalists and diabetic patients for the management of diabetes mellitus.

Materials and methods

Frequent ethnomedical and ethnobotanical investigations were conducted from June 2008 to December 2009 in Conakry, Kindia, Forécariah, Dubréka, Boke, Fria and Boffa. It is a cross-sectional survey and data collection is based on the interactive method. During this period a total of 112 people aged from 39 to 76 years old were interviewed.

Results

During this investigation 146 plant species belonging to 55 families were collected. The most cited plants were Anacardium occidentale L. and Ficus spp., while the Fabaceae family was the most represented, followed by the Euphorbiaceae and Rubiaceae. The most frequently plant parts used by the traditional healers and the herbalists were the stem-bark and decoctions the most common preparation mode.

Conclusions

It is clear that a variety of plants is used in the management and treatment of diabetes. Due to the increasing prevalence of type 2 diabetes, there is an urgent need for scientific investigations to rationalise the use of these traditional remedies, which could represent accessible alternative medicines for the Guinean populations.     

Pharmacological potential and conservation prospect of the genus Eucomis (Hyacinthaceae) endemic to southern Africa

Ethnopharmacological relevance

The genus Eucomis (Hyacinthaceae) consists of 10 species that are extensively used in African traditional medicine. This review is an appraisal of current information on the distribution and morphology, traditional uses, pharmacology, toxicology and approaches devised to enhance the conservation of the genus.

Methods

A systematic and comprehensive literature search using electronic searches such as Scopus, Google Scholar, Web of Science and ethnobotanical books was conducted.

Results

Evidence from traditional medicine usage shows wide utilization of this genus for ailments such as respiratory, venereal diseases, rheumatism as well as kidney and bladder infections. Pharmacological screening reported antimicrobial, antiplasmodial, antitumor, cytotoxic, phytotoxic and anti-inflammatory properties.

Conclusions

The potential of the genus Eucomis especially in terms of pharmacology cannot be overemphasized. Apart from the anti-inflammatory properties, the antifungal activity of Eucomis remains a valuable reservoir with potential application in the agriculture sector as a source of an affordable biocontrol agent. Based on the speculated toxic constituents in the genus Eucomis, it will be valuable to conduct detailed toxicological studies. Extensive utilization of members of the genus Eucomis is causing severe strain on wild populations. Although conventional propagation has been relatively effective in the alleviation of the declining status, micropropagation of members may be vital to guarantee the conservation of wild populations.     

What is in a name? The need for accurate scientific nomenclature for plants

Ethnopharmacological relevance

To avoid ambiguities and error, ethnopharmacological and any other research on plants requires precise and appropriate use of botanical scientific nomenclature.

Aims

This paper explores problems and impacts of ambiguous or erroneous use of botanical scientific nomenclature in ethnopharmacological studies. It suggests how the frequency and impact of such errors can be reduced.

Approach and methods

We assessed 214 articles published in the three first volumes of the Journal of Ethnopharmacology in 2012: 140(1) to 141 (3) and 214 articles in Phytomedicine (2012–2013): 19 (5) to 20 (7).

Results

Amongst the articles reviewed 308 articles cited plant names incorrectly. Among the articles studied 9178 Latin scientific names were cited and 3445 were incorrect in some respect. Simple principles applied in a systematic way and used together with open-access reference resources could help authors, referees and editors of ethnopharmacological, phytochemical, toxicological and clinical studies to reduce ambiguity about the identity and name of the species involved and thus significantly improve the quality of the final publication.

Conclusions

We have identified a series of key steps needed to solve the taxonomic ambiguities and errors. Aside from reinforcing existing policies, journals will have to implement better tools to ensure the proper authentication of materials. The new electronic publishing environments offer novel ways to develop such botanical-taxonomic tools.