幽门螺杆菌dupA基因与十二指肠溃疡关系的Meta分析

目的探讨幽门螺杆菌(H.pylori)dupA基因与十二指肠溃疡的关系。方法检索国内万方数据库、中国知网、维普中文科技期刊数据库及国外Science Direct、Pubmed等数据库,根据纳入与排除标准筛选文献,提取资料和评价质量后采用Revman 5.3软件对纳入研究的文献进行Meta分析。结果共纳入24篇文献,合计疾病组1 499例,对照组1 827例。Meta分析结果显示幽门螺杆菌dupA基因阳性率与十二指肠溃疡呈正相关(合并OR值为1.82,95%CI:1.37~2.42)。亚组分析显示,亚洲地区dupA基因与十二指肠溃疡的相关性(合并OR值为2.14,95%CI:1.52~3.02)高于西方国家(合并OR值为1.16,95%CI:0.82~1.64)。结论幽门螺杆菌dupA基因与十二指肠溃疡呈正相关,在亚洲人种中相关性比西方国家人种更显著。     

自身免疫性甲状腺疾病与幽门螺杆菌感染关系的系统评价

目的系统评价自身免疫性甲状腺疾病(Autoimmune thyroid diseases,AITDs)与幽门螺杆菌(Helicobacter pylori,Hp)感染是否有关,为AITDs的预防和治疗提供新的途径,为AITDs患者是否应积极根除Hp提供参考。方法由2名研究人员独立检索各大型数据库2019年3月之前发表的关于AITDs与Hp感染关系的中英文文献,用Stata 11软件分析,计算合并OR值及其95%CI。结果纳入16项研究进入Meta分析。发现Hp感染与AITDs的发生具有相关性(OR=2.122,95%CI:1.455～3.096);Hp细胞毒素相关蛋白(Hp-CagA)阳性菌株感染增加AITDs发生风险(OR=2.171,95%CI:1.245～3.786);格雷夫斯(Graves)病和桥本甲状腺炎(Hashimoto's thyroiditis,HT)患者更易感染Hp(GD:OR=3.738,95%CI:2.181～6.405;HT:OR=2.056,95%CI:1.513～2.794)。结论 Hp感染与AITDs的发生具有相关性,根除Hp感染可能降低甲状腺自身抗体水平。     

幽门螺杆菌粪便抗原免疫卡诊断幽门螺杆菌感染的Meta分析

目的 评价幽门螺杆菌粪便抗原免疫卡诊断幽门螺杆菌感染的精确性.方法 计算机检索Medline(1966-2007年4月)、EMbase(1985-2007年4月)和中国期刊全文数据库(1994-2007年)有关幽门螺杆菌粪便抗原免疫卡诊断幽门螺杆菌感染的临床试验,按Cochrane协作网推荐的方法进行Meta分析.结果 共11篇文献被纳入评价.合并敏感性和合并特异性分别为0.93(95%CI:0.91～0.94)、0.93(95%CI:0.90～0.95),合并阳性似然比和合并阴性似然比分别为12.01(95%CI:8.90～16.19)、0.08(95%C/:0.07～0.11).合并诊断优势比为160.14(95%CI:100.43～255.34).SROC曲线下面积为0.974±0.005.结论 幽门螺杆菌粪便抗原免疫卡是一种精确无创的诊断成年人幽门螺杆菌感染方法.     

反流性食管炎与幽门螺杆菌感染相关性的Meta分析

目的 用Meta分析法探讨幽门螺杆菌(Hp)与反流性食管炎(RE)的关系。方法 检索中外文电子数据库，按纳入排除标准筛选文献,利用Stata 12.0行Meta分析。结果 纳入文献23篇,RE患者8754人。(1)RE发生与Hp感染相关（I²=90.4%;OR=0.62;95%CI=0.47~0.83;P=0.001）。(2)亚组分析结果:亚洲地区RE发生与Hp相关（OR=0.60;95%CI=0.44~0.82;P<0.001）,欧洲地区不相关（OR=0.86;95%CI=0.50~1.46;p=0.645);对照组为正常、NERD或其他消化道疾病时，结果均显示RE发生与Hp感染相关（OR=0.588,95%CI=0.396~0.874,P<0.001；OR=0.947,95%CI=0.380~2.360,P=0.024;OR=0.401,95%CI=0.466~0.876,P=0.041）(3)RE发生与性别无关（I²=94.9%；OR= 1.325；95%CI= 0.876~2.003;P=0.183）。(4)RE分级与Hp感染无关（OR=1.59;95%CI=0.94~2.69;P=0.083)。结论 反流性食管炎的发生与幽门螺杆菌感染相关,与性别无关。不同地区反流性食管炎与幽门螺杆菌感染的相关性不同,反流性食管炎病情程度不受幽门螺杆菌影响。     

中国儿童青少年视屏时间与健康风险的Meta分析

目的 综合分析视屏时间与中国儿童青少年健康风险之间的关系。方法 检索中国知网（CNKI）、维普（VIP）、万方数据、PubMed、Web of Science和Embase数据库关于中国儿童青少年视屏时间与健康风险的关联性的中英文文献，包括观察研究和实验研究，检索时限均为建库至2022年3月1日，采用Comprehensive Meta Analysis V3软件进行Meta分析。结果 最终纳入文献68篇，累计样本量757 509人。Meta分析结果显示，综合视屏时间过长是我国儿童青少年超重肥胖（OR=1.47,95%CI:1.01～2.15）、近视（OR=1.52,95%CI:1.33～1.75）、自伤行为（OR=1.40,95%CI:1.31～1.50）、抑郁（OR=1.62,95%CI:1.37～1.91）、心理亚健康（OR=1.58, 95%CI:1.07～2.34）、情绪行为问题（OR=1.37, 95%CI:1.11～1.84）以及品行问题（OR=1.62,95%CI:1.14～2.32）的危险因素。此外，电脑时间与近视风险也呈较稳定的相关性（OR=1.45,95%CI:1...     

失效模式与效应分析预防ICU获得性感染的Meta分析

目的 系统评价失效模式与效应分析(FMEA)在预防重症监护病房(ICU)获得性感染中的有效性。方法 2名研究人员独立检索外文数据库和中文数据库相关文献,检索截止时间为2022年7月15日,根据纳入和排除标准独立筛选文献、提取数据和评估总体质量,并应用RevMan 5.4软件对纳入文献的预防效果进行Meta分析。结果 共纳入了19篇文献。Meta分析结果显示,运用FMEA方法降低了ICU患者呼吸机相关肺炎发病率[OR=0.40,95%CI(0.31～0.51),P<0.01]、导尿管相关尿路感染发病率[OR=0.29,95%CI(0.17～0.51),P<0.01]、中央血管导管相关血流感染发病率[OR=0.28,95%CI(0.18～0.46),P<0.01]、多重耐药菌感染发生率[OR=0.46,95%CI(0.37～0.58),P<0.01]、ICU医院感染发病率[OR=0.46,95%CI(0.37～0.59),P<0.01],提高了ICU患者及家属满意度[OR=2.34,95%CI(1.72～3.17),P<0.01]。结论 FMEA能有效预...     

幽门螺杆菌感染与胃癌不同关联强度的循证分析

[目的]综合分析幽门螺杆菌(Helicobacter pylori,Hpylori)感染与胃癌的关系. [方法]计算机检索1995年1月～2006年12月CNKI中国期刊、维普中文科技期刊全文数据库、OVID、PubMed外文期刊数据库,纳入Hp感染与胃癌关系的病例对照研究,用Meta分析方法其定量综合分析,估计合并OR值及其95%可信区间(95%CI).[结果]纳入的20个研究存在异质性,采用RevMan 4.2分析软件选择随机效应模型(D-L法)进行Meta分析,OR合并=2.35,OR合并95%CI(1.64,3.36).并将纳入的研究按对照来源、胃癌的部位、检测Hp感染的方法及胃癌病例来自高低发区对其进行亚组分析,探讨各研究结果不一致的原因. [结论]Hp感染与胃癌相关,各研究结果不一致的原因主要与胃癌的部位、对照的类型和胃癌病例来自高发区还是低发区有关. 例对照研究,用Meta分析方法其定量综合分析,估计合并OR值及其95%可信区间(95%CI).[结果]纳入的20个研究存在异质性,采用RevMan 4.2分析软件选择随机效应模型(D-L法)进行Meta分析,OR合并=2.35,OR合并95%CI( .64,3.36).并将纳入的研究按对照来源、胃癌的部位、检测Hp感染的方法及胃癌病例来自高低发区对其进行亚组分析,探讨各研究结果不一致的原因. [结论]Hp感染与胃癌相关,各研究结果不一致的原因主要与胃癌的部位、对照的类型和胃癌病     

幽门螺杆菌感染与胃癌关系的Meta分析

[目的]探讨幽门螺杆菌(Helicobacter pylori,H pylori)感染与胃癌的关系. [方法]采用Meta分析方法对国内外有关幽门螺杆菌与胃癌的关系的病例对照研究结果进行定量综合分析,估计合并OR值(OR合并)及其95%可信区间(95%CI). [结果]纳入的20个研究存在异质性,选择随机效应模型进行Meta分析,采用SAS8.0软件分析,OR合并值为2.15,OR合并95%CI(1.39,3.33),采用RevMan4.2软件分析,OR合并=2.35,OR合并95%CI(1.64,3.36).敏感性分析结果显示无论是换用固定效应模型、加入未发表的4篇文献还是去除小样本的5个研究,都说明胃癌与幽门螺杆菌感染有关联,幽门螺杆菌感染是胃癌的危险因素;在以20个研究绘制的漏斗图中,散点分布对称,计算失安全系数(Nfx)均较大,说明发表偏倚小,结论被阴性结果推翻的可能性较小,结果稳定. [结论]Hp感染与胃癌相关,Hp感染是胃癌发生的危险因素.     

幽门螺杆菌感染与大肠癌关系的Meta分析

目的 应用Meta分析方法对国内外已发表的有关幽门螺杆菌(Hp)感染与大肠癌(包括结直肠腺瘤)关系的研究进行综合评价.方法 对符合纳入标准的14篇文献用Review manager4.2软件进行Meta分析,计算比值比(OR)、95%可信区间(95%CI)并做出几何漏斗图.结果 纳入总样本量为3165例,其中病例组为1330例,对照组为1835例;Meta分析合并OR=I.36,95%CI:1.01～1.82.几何的漏斗图形虽不对称,但经敏感性分析和失效安全数分析结果显示,发表偏倚对研究结果影响较小.结论 Hp感染可导致大肠癌发生的危险性增加.     

极低和超低出生体重儿颅内出血危险因素Meta分析

目的系统分析我国极低体重儿(VLBWI)和超低出生体重儿(ELBWI)颅内出血(ICH)的危险因素,为早期预防和临床决策提供参考依据。方法通过计算机检索了建库至2020年9月18日在中国知网、中国生物医学文献数据库(CBM)、万方数据库、VIP数据库、Cochrane图书馆、PubMed、Web of Science、EMBASE等数据库发表的文献,并手动检索相关参考文献。按照文献的纳入和排除标准,纳入较高质量文献,最后采用RevMan5.3对其进行Meta分析。结果 13篇文献符合纳入标准,累计ICH人数790例,无ICH人数1 871例,经Meta分析结果显示,VLBWI和ELBWI颅内出血的危险因素为:宫内窘迫或窒息(OR=2.52,95%CI:1.98～3.21)、应用机械通气(OR=3.35,95%CI:2.56～4.38)、机械通气时间>3 d(OR=10.29,95%CI:3.69～28.66)、凝血机制障碍(OR=3.42,95%CI:1.80～6.48),新生儿坏死性小肠结肠炎(OR=3.79,95%CI:1.92～7.50),胎龄<29周(OR=2.45...     

Iron deficiency and Helicobacter pylori infection in the United States

Using data from the current National Health and Nutrition Examination Survey (1999-2000), the authors assessed whether Helicobacter pylori infection is associated with iron deficiency and iron-deficiency anemia (IDA) in the United States. Iron deficiency was defined as at least two abnormal results out of three biomarkers of iron stores. IDA was defined as a low hemoglobin level in the presence of iron deficiency. H. pylori infection was measured by serology. Complex survey estimators were used in the analysis. For 7,462 survey participants aged >or=3 years, H. pylori infection was associated with decreased serum ferritin levels (percent change = -13.9%, 95% confidence interval (CI): -19.5, -8.0) but not with levels of free erythrocyte protoporphyrin, transferrin saturation, or hemoglobin (percent change = 1.5%, -2.8%, and -1.1%, respectively). Multinomial logistic regression analyses indicated that H. pylori infection was associated with the prevalence of IDA (prevalence odds ratio (POR) = 2.6, 95% CI: 1.5, 4.6) and, to a lesser degree, other types of anemia (POR = 1.3, 95% CI: 1.0, 1.7). H. pylori infection was associated with a 40% increase in the prevalence of iron deficiency (POR = 1.4, 95% CI: 0.9, 2.0) after controlling for relevant covariates. In the United States, H. pylori infection was associated with iron deficiency/IDA regardless of the presence or absence of peptic ulcer disease.     

不同口服铁剂治疗儿童缺铁性贫血安全性的网络Meta分析

目的 应用网络Meta分析评价8种口服铁剂治疗儿童缺铁性贫血安全性。方法 检索收集2015年7月之前国内外发表有关口服铁剂与儿童缺铁性贫血文献。采用Microsoft Excel 2013软件加载NetMetaXL宏命令调用WinBUGS 1.4.3软件选择随机效应模型进行统计分析,系统评价8种口服铁剂之间的OR值及优劣顺序。结果 纳入文献31篇,3 417例缺铁性贫血儿童。与右旋糖酐铁相比,硫酸亚铁、铁叶绿素钠、琥珀酸亚铁、葡萄糖酸亚铁、多维铁复合物、多糖铁复合物、富马酸亚铁的OR值及95% CI分别为0.00（0.00~0.03）、0.03（0.00~0.39）、0.02（0.00~0.23）、0.01（0.00~0.07）、0.01（0.00~0.11）、0.02（0.00~0.19）、0.01（0.00~0.12）。右旋糖酐铁发生不良反应风险最小（SUCRA=0.999 4）,而硫酸亚铁的风险最高（SUCRA=0.034 1）。结论 硫酸亚铁发生不良反应的风险较高,临床医生和患者在选择硫酸亚铁治疗儿童IDA时需慎重。     

IL-1B基因多态性在十二指肠溃疡发病中的作用

目的探讨幽门螺杆菌(Hp)感染与IL-1B-511位点单核苷酸多态性(SNP)在十二指肠溃疡(DU)发病中的作用。方法用病例-对照研究方法,调查某院54例DU患者及94例同院同期非DU患者(对照),用ELISA方法检测其血清Hp IgG抗体,PCR扩增IL-1B-511,限制片段长度多态性分析(RFLP)检测其SNP。结果DU组Hp阳性率为90.74%(49/54),而对照组则为54.26%(51/94),病例组高于对照组,OR为8.26(95%CI为3.02~22.59)。DU组IL-1B-511基因T/T、C/T和C/C基因型频率分别为31.48%,35.19%,33.33%;而在对照组则分别为38.30%,46.81%,14.89%,IL-1B-511 C/C型能增加DU的患病危险,OR为3.05(95%CI为1.23~7.57),但按有无Hp感染进行分层后,则IL-1B-511 C/C只在有Hp感染时才有作用,OR为4.60(95%CI为1.40~15.12)。结论Hp感染时IL-1B-511 C/C能增加十二指肠溃疡病的患病风险,机体的遗传基因与Hp共同影响Hp感染者的临床结局。     

幽门螺杆菌感染与儿童缺铁性贫血关系的临床研究

目的探讨幽门螺杆菌(Hp)感染与儿童缺铁性贫血(IDA)之间的关系。方法从因再发性腹痛就诊的患儿中,抽取13C呼气试验阳性者26例为观察组,13C呼气试验阴性者22例为对照组。两组分别检测血清铁蛋白(SF)和血常规。结果观察组和对照组比较SF、血红蛋白、红细胞计数、平均红细胞体积和平均血红蛋白浓度差异有统计学意义(P<0.05或<0.01)。白细胞数和血小板数两组差异无统计学意义(P>0.05)。结论Hp感染与儿童IDA发病有关,Hp感染可能是IDA的发病因素之一。     

Prevalence and possible risk factors of Helicobacter pylori infection among children attending Damanhour Teaching Hospital

Helicobacter pylori (H. pylori) is a major cause of gastrointestinal disease in children. The factors influencing the acquisition and prevalence of H. pylori infection remain incompletely understood. In the present study, the prevalence and possible risk factors of H. pylori infection were studied among children aged 1.5-16 years who were attending the pediatric outpatient clinic of Damanhour Teaching Hospital. Blood samples were drawn and IgG seroprevalence of H. pylori among the studied children was determined using ELISA kits. A specially designed questionnaire inquired about personal, socioeconomic, household characteristics, feeding history during infancy and the child's health data was completed for every child. Results revealed that the overall seroprevalence of H. pylori infection was 50.5 %. The prevalence was widely age dependent: it was 60.6% among those age > or = 5 years and only 25.9% among those < 5 years (OR = 4.4; 95% CI = 1.6-11.9). Increased crowding in bed was also an associated factor; the prevalence among children where > or = 3 share a bed was 59.7% compared to only 26.9% among those where < 3 persons share a bed (OR = 4.1; 95% CI = 1.5-10.9). The prevalence among children who were breast fed for < 1 year was 64.7% compared to only 42.4% among those who were fed for > or =1 year (OR = 2.5; 95% CI = 1.1-5.9). After controlling for possible confounding in a Stepwise Multiple Logistic Regression model, independent predictors for H. pylori infection were: increasing age (> or = 5 years), overcrowding in bed (> or = 3/ bed) and shorter duration of breast-feeding (< 1 year) during infancy. It could be concluded that, H. pylori was highly prevalent among the sampled children and the possible risk factors are related to the community. So, there is a need to early diagnose, treat and eradicate infection during childhood to prevent its complications during adulthood.     

儿童幽门螺杆菌感染危险因素的病例对照研究

目的 探讨学龄前儿童幽门螺杆菌(Helicobactre pylori，H．pylori)感染的危险因素。方法 以2001年5～6月在浦城县实验幼儿园所检查中确诊的H．pylori感染儿童64例为病例组，以同期检查的未感染H．pylori儿童为对照组。进行1：2配对的病例对照研究。结果 条件Logistic回归分析筛选出学龄前儿童H．pylori感染的5个危险因素：即平时照顾小孩的人有胃病史(OR=4．95)；平时有啃手指、玩具、具的习惯(OR=4．74)；低人均居住面积(OR=3.73)；襁褓中接受口嚼食物喂养(OR=3．36)和与成人共用一个刷牙口杯(OR=2．40)。结论 儿童幽门螺杆菌感染呈现家庭内聚集。且与儿童个人卫生习惯、居住条件呈密切相关。积极防治成人的H．pylori感染、改善生活居住状况、教育小儿从小养成良好的饮食和卫生习惯对降低儿童H．pylori感染起重要作用。     

Association between obesity and helicobacter pylori infection

ObjectivesThe relationship between obesity and helicobacter pylori infection has been extensively reported; however, evidence from existing literature showing conflicting data. This current meta-analysis sought to assess the association between obesity and the risk of helicobacter pylori infection by summarizing all available data.MethodsPubMed, Embase, Web of Science, Cochrane databases were screened to identify relevant literature that assessed the association between obesity and helicobacter pylori infection in participants before the end of May, 2022. Data extraction and quality assessment were performed. The odds ratio (OR) and 95% confidence interval (95% CI) were used to estimate the association between obesity and helicobacter pylori infection by using a random-effects model. In addition, sensitivity analysis and publication bias were conducted.ResultsA total of twenty-one studies with 307,462 participants were included in this meta-analysis. Pooled estimates showed that obesity is associated with an increased risk of helicobacter pylori infection compared to non-obese counterparts (21 studies; OR:1.34; 95% CI: 1.17–1.52; I² = 91%). We also conducted subgroup analysis according to sex and study design, respectively. We found that males were more likely to have helicobacter pylori infection than females (OR: 1.59; 95% CI: 1.28–1.97; I² = 94.7% for male percent > 50%; OR:1.14; 95% CI: 0.94–1.38; I² = 75.2% for male percent < 50%). Furthermore, pooled studies of case-control study (OR: 1.20; 95% CI:1.05, 1.37; I² = 82.4%) showed that the people with obesity had a significantly higher prevalence of helicobacter pylori infection.ConclusionThis comprehensive quantitative analysis provides an affirmation that obesity is associated with an increased risk of helicobacter pylori infection. From this point of view, the prevention of obesity is important in the treatment of helicobacter pylori infection.     

Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women

Prenatal anemia and iron deficiency are associated with adverse birth outcomes, but no previous studies have examined the relation between preconception anemia, iron deficiency, and pregnancy outcome in healthy women. We measured hemoglobin (Hb), ferritin, transferrin receptor (TfR), and vitamins B-6, B-12, and folate concentrations before pregnancy in 405 Chinese women (median time from sample collection to gestation end = 316 d). Both mild (95 /=60 microg/L) ferritin were also significantly associated with lower birthweight (106 and 123 g, respectively). The risks of low birthweight (LBW) and fetal growth restriction (FGR) were significantly greater among women with moderate anemia compared with nonanemic controls [odds ratio (OR): 6.5; 95% CI: 1.6, 26.7; P = 0.009 and OR: 4.6; 95% CI: 1.5, 13.5; P = 0.006, respectively]. TfR and low ferritin were not associated with adverse birth outcome, but elevated ferritin, which could be a marker of inflammation, was associated with increased risk of LBW (OR: 2.2; 95% CI: 0.9, 5.7; P = 0.09) and FGR (OR: 2.7; 95% CI: 1.3, 5.6; P = 0.008). Preconception anemia, particularly iron-deficiency anemia, was associated with reduced infant growth and increased risk of adverse pregnancy outcome in Chinese women.     

Association of Iron-Deficiency Anemia and Non-Iron-Deficiency Anemia with Neurobehavioral Development in Children Aged 6–24 Months

(1) Background: Anemia has comprehensive adverse effects on the growth and development of children. In this study, we analyzed the potential effects of different types of anemia on early-life neurobehavioral development. (2) Methods: A total of 2601 children aged 6–24 months, whose parents agreed to participate in this study, underwent routine blood tests and neurobehavioral development assessment. The children’s parents or other primary caregivers were interviewed with a face-to-face questionnaire at the time of enrollment in the study. Anemia was determined by hemoglobin < 110 g/L and classified into iron-deficiency and non-iron-deficiency anemia according to the levels of serum ferritin, C-reactive protein, and alpha-1-acid glycoprotein. Neurobehavioral development was assessed by the China Developmental Scale for Children and divided into five domains: gross motor, fine movement, adaptability, language, and social behavior. The development quotient (DQ) was used to measure the level of total neurobehavioral development and each domain of neurobehavioral development. (3) Results: The prevalence of anemia in children aged 6–24 months was 26.45%, of which iron-deficiency anemia only accounted for 27.33%. Compared with children without anemia, those with iron-deficiency anemia had a significantly lower developmental quotient (DQ) for total neurobehavioral development and gross motor and adaptability development. The partial regression coefficients were −1.33 (95% CI −2.36, −0.29; p = 0.012), −1.88 (95% CI −3.74, −0.03; p = 0.047), and 1.48 (95% CI −2.92, −0.05; p = 0.042), respectively. Children with non-iron-deficiency anemia had significantly lower DQ for total neurobehavioral development and gross motor and fine movement development than those without anemia. The partial regression coefficients were −0.94 (95% CI −1.64, −0.25; p = 0.008), −1.25 (95% CI −2.48, −0.03; p = 0.044), and −1.18 (95% CI −2.15, −0.21; p = 0.017), respectively. There were no statistically significant differences in total neurobehavioral development and the five domains of neurobehavioral development between children with non-iron-deficiency and iron-deficiency anemia. The partial β values were 0.40 (95% CI −1.53, 2.33; p = 0.684), 0.21 (95% CI −1.39, 1.81; p = 0.795), 0.63 (95% CI −1.03, 2.28; p = 0.457), 0.16 (95% CI −1.78, 2.10; p = 0.871), 0.35 (95% CI −1.32, 2.01; p = 0.684), and 0.34 (95% CI −0.77, 1.46; p = 0.545), respectively. (4) Conclusions: Both iron-deficiency anemia and non-iron-deficiency anemia were negatively correlated with the neurobehavioral development of children. Negative correlations were found between iron-deficiency anemia and gross motor and adaptability development and between non-iron-deficiency anemia and gross motor and fine movement development.     

太行山食管癌高发区农村高危人群上消化道癌及癌前病变筛查结果及影响因素分析

目的 了解太行山食管癌高发区农村高危人群上消化道癌及癌前病变的检出情况,探讨其影响因素。方法 采用整群抽样的方法确定调查对象。 采用问卷调查、体格检查、内窥镜检查和病理学检查对调查对象进行上消化道癌及癌前病变的筛查。结果 共筛查出上消化道癌高危人群1 200名,根据内窥镜检查条件,共筛查高危人群865名,其中共检出阳性病例111例,总阳性病检出率12.8% 。多因素 logistic 回归分析结果表明,≥60岁（OR = 1.411,95%CI:1.1470～2.192）、腌制食品 (OR = 1.736,95% CI:1.149 ～ 2.625)、饮用水来源为井水（OR = 1.789,95%CI:1.119～2.861）或其他水源（OR = 2.143,95%CI:1.086～4.228）、幽门螺旋杆菌感染 （OR = 1.850,95%CI:1.219～2.8077）是上消化道癌及癌前病变发生的独立危险因素。结论 本地区上消化道癌及癌前病变的检出率仍然较高,年龄大、吃腌制食品、饮用水来源为井水、河水、雨水等,以及感染幽门螺旋杆菌是本地区农村居民上消化道癌及癌前病变发生的危险因素。