消痔液治疗肛周炎性疾患267例

目的观察消痔液治疗肛周炎性疾病的疗效;方法自拟薰洗剂消痔液治疗肛周炎性疾病患者267例,连用7 d;结果显效231例,有效33例,无效3例,总有效率为98.87%。结论中药薰洗剂消痔液治疗肛周炎性疾患有显著疗效。     

骨外洗剂薰洗、热敷治疗膝关节骨性关节炎82例的疗效观察

目的 观察骨外洗剂薰洗、热敷治疗膝关节骨性关节炎的疗效.方法 以骨外洗剂薰洗、热敷治疗膝关节骨性关节炎.结果 临床治愈12例,显效53例,有效13例,无效4例,总有效率97.56%.结论 骨外洗剂薰洗、热敷治疗膝关节骨性关节能有效缓解症状、改善膝关节功能、延缓进程,提高生活质量.     

自拟毓液消痔汤治疗炎性外痔67例临床疗效观察

目的：观察自拟毓液消痔汤熏蒸坐浴治疗炎性外痔的临床效果.方法：每天用毓液消痔汤500ml熏蒸坐浴2次,5～7d为1个疗程.结果：总病例数67例,显效48例,占71.6％;有效18例,占26.8％;无效1例,占1.5％,总有效率98.5％.结论：毓液消痔汤熏蒸坐浴治疗炎性外痔,可使症状明显改善,值得临床推广使用.     

中草药薰洗在治疗扁平疣中的疗效观察

目的 观察中草药薰洗在治疗扁平疣中的作用，提高扁平疣的临床治疗效果。方法以中药煎汤薰洗疣体为主，同时用病毒唑片、维生素C注射液混合成糊状外擦，连用10天。结果48例扁平疣，痊愈38例(79．2％)，显效6例(12．5％)，总有效率91．7％。结论中草药薰洗效果良好，疗程短，治愈率高。     

妇炎清汤治疗盆腔常见疾患200例效果观察

对２００例盆腔常见疾患（卵巢囊肿、炎性包块、液性占位）早期用妇炎清汤加减治疗，结果为：早期卵巢囊肿３６例，显效５８．３３％，有效３３．３０％，无效８．４％，总有效率９１．６３％。炎性包块８４例，显效６１．８０％，有效３５．８％，无效２．４％，总有效率９７．６％。液性占位８０例，显效６７．５％，有效２８．７５％，无效３．７５％，总有效率９６．２５％。     

痔清冲剂治疗痔疮的临床研究

用痔清冲剂内服加外薰洗治疗痔疮223例,总有效率为97．8％;其中1期内痔、Ⅱ期内痔、外痔、混合痔的有效率分别为97％、96％、100％、100％,与单用痔清冲剂内服比较有显著性差异（P＜0．05）。内服外洗组在提高疗效、改善症状,缩短疗程等方面明显优于内服组,说明采用痔清冲剂内服外洗符合标本同治、内外兼治的治疗原则。     

洛丁新佐治慢性肺心病难治性心力衰竭32例疗效观察

对３２例慢性肺心病心力衰竭患者采用洛丁新治疗，结果显效２３例，有效６例，无效２例，死亡１例，总有效率为９０．６％，观察表明，洛丁新对慢性肺心病心力衰     

青黛散油膏外敷配合中药熏洗治疗肛门湿疹213例

[目的]观察青黛散油膏治疗肛门湿疹的疗效。[方法]用青黛散油膏外敷配合中药熏洗治疗肛门湿疹213例,每日1次,10日为1个疗程,治疗1-2个疗程,观察疗效。[结果]急性、亚急性肛门湿疹共82例,显效71例,有效11例,无效0例,总有效率100％,慢性肛门湿疹共131例,显效69例,有效41例,无效21例,总有效率83．9％。[结论]青黛散油膏配合中药熏洗能有效地治疗肛门湿疹。     

复方毛冬青液肛门灌肠治疗慢性前列腺炎107例

以中药煎剂复方毛冬青液肛门灌肠治疗慢性前列腺炎１０７例，结果治愈３２例，占２９．９０％；显效３０例，占２８．０４％；好转２７例，占２５．２３％；总有效率为８３．１７％，疗效满意。笔者认为中药煎剂复方毛冬青液谨守慢性前列腺炎病机湿热瘀滞，采用扶正祛邪，消肿止痛，活血通络的法则组方，通过经肛门灌肠使药物直达病所，又有局部热疗作用，不失为治疗前列腺炎的一种有效方法。     

复方黄柏液治疗肛门瘙痒症的临床疗效观察

目的 观察复方黄柏液治疗肛门瘙痒症的临床疗效.方法 将88例肛门瘙痒症患者随机分为两组,治疗组46例,给予复方黄柏液外洗;对照组42例,给予荆芥熏洗剂外洗,10d为一疗程,共治疗2个疗程.结果 治疗组总有效率（86.96％）较对照组（54.76％）有显著性差异（P＜0.05）,症状改善率治疗组优于对照组.结论 复方黄柏液治疗肛门瘙痒症疗效满意.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.