宫腔内人工授精治疗男性不育的护理

对161例不孕症患者行宫腔内人工授精,结果38例获得临床妊娠,35例流产。尽管其妊娠率较低,但对药物治疗无效,少、弱畸形精子症不育者是重要的治疗方法之一。     

宫腔内人工授精治疗男性不育的护理

对161例不孕症患者行宫腔内人工授精,结果38例获得临床妊娠,35例流产。尽管其妊娠率较低,但对药物治疗无效,少、弱畸形精子症不育者是重要的治疗方法之一。     

宫腔内人工授精治疗男性不育的护理

对161例不孕症患者行宫腔内人工授精,结果38例获得临床妊娠,35例流产。尽管其妊娠率较低,但对药物治疗无效,少、弱畸形精子症不育者是重要的治疗方法之一。     

夫精宫腔内人工授精的最佳时机探讨

200例患者行夫精宫腔内人工授精(IUI)344个周期,妊娠69例,妊娠率为34.5%,周期妊娠率为20.1%.IUI在排卵后24小时内1次、排卵前1次、排卵前后各1次的周期妊娠率分别为26.8%、14.8%、14.5%,前者与后两者相比有显著性差异.排卵后24小时内是IUI的最佳时机.     

不同促排卵方案用于宫腔内人工授精临床结局比较

目的 比较不同促排卵方案用于宫腔内人工授精（IUI）的临床结局.方法 回顾性分析589例不孕症患者行1 238个周期宫腔内人工授精的临床资料,对自然周期（NC）人工授精及氯米芬（CC）、氯米芬/尿促性素（CC/HMG）、来曲唑（LE）、来曲唑/尿促性素（LE/HMG）、尿促性素（HMG）促排卵方案行宫腔内人工授精的临床结局进行比较分析.结果 NC、CC、CC/HMG、LE、LE/HMG、HMG临床妊娠率分别为9.98％、13.46％、15.96％、21.21％、23.75％、15.14％,促排卵妊娠率均高于NC（P＜0.05）.LE、LE/HMG方案临床妊娠率高于CC、CC/HMG、HMG促排卵方案（P＜0.05）.结论 促排卵治疗增加IUI妊娠率,LE或LE/HMG方案促排卵IUI安全、有效,妊娠率高于其他促排卵方案.     

114例夫精宫腔内人工授精患者健康教育需求调查报告

夫精宫腔内人工授精(IUI)是一种简单经济的辅助生育技术[1],成功率目前一直不高。但不孕症患者对助孕技术普遍期望过高,在接受治疗时往往背负着很大的精神压力。研究表明,不孕对患者的心理、情感可造成一定影响[2,3],这种负性心理反过来又影响不孕症的治疗结果。为使健康教育更具有针对性、可行性和实效性,2011年1～12月,我们对     

宫腔内蝇蛆寄生1例报告

患者，女性，23岁，已婚，未生育，贵州人。因停经1月余，于2004年11月5日前往广东番禺化龙镇医院就诊。妇科诊断为早孕。该患者希望终止妊娠，而行人工流产手术。术中清理出宫腔内组织约10g，内含长度约为0．5cm的灰白色能蠕动的小虫．共20多条，部分虫体黏附于官腔组织上。病理切片被转送至本教研室检查，将制作该切片的蜡块熔化．分解组织后检获了2条虫体。     

宫腔镜诊治宫腔内病变441例效果分析

1999年 3月至 2 0 0 0年 6月 ,我们采用宫腔镜诊断宫腔内病变患者 4 4 1例 ,其中 117例接受宫腔镜电切手术 ,取得满意效果 ,现报告如下。资料与方法 :本组年龄 2 6～ 6 2岁 ,平均 4 3岁。妇科检查及B超扫描或阴道分泌物化验诊为不孕症 312例 ,异常阴道流血10 6例 ,反复流产 2 0例 ,其它 3例。117例行宫腔镜电切手术其中子宫内膜切除 8例 ,子宫内膜息肉切除 2 5例 ,粘膜下子宫肌瘤切除 4 0例 ,宫腔粘连分离 2 8例 ,子宫纵隔切除 16例。方法 :于月经干净后 3～ 5天行宫腔镜检查和手术 ,阴道流血者不受限制。按董建春等的方法进行操作 ,用 5 %…     

精液处理前后精液参数对夫精人工授精妊娠结局的影响

目的：探讨精液处理前、后精液参数对以男性因素为主的宫腔内人工授精（ IUI）妊娠结局的影响。方法回顾性分析530个以男性因素为适应证在我中心接受IUI治疗的临床资料,按处理前、后的精子前向运动数和精子回收率进行分组,比较各组临床妊娠率。结果（1）根据处理前前向运动数分成三组：＜20×106/ml组、＞20～＜100×106/ml组和≥100×106/ml组,各组周期临床妊娠率分别为10.08％、12.79％和12.50％,各组妊娠率比较差异无统计学意义（P＞0.05）;（2）根据处理后前向运动数分成三组：＜10×106/ml组、＞10～＜20×106/ml组和≥20×106/ml组,各组周期临床妊娠率分别为8.42％、10.59％和12.57％,各组妊娠率比较差异无统计学意义（P＞0.05）;（3）根据处理后精子回收率分成两组：＜25％组和≥25％组,两组周期临床妊娠率分别为10.45％和12.76％,两组妊娠率比较差异无统计学意义（ P＞0.05）。结论 IUI的妊娠率随着精液处理前、后前向运动精子数和精子回收率的升高逐渐提高,但差异无统计学意义。     

磁场对兔生殖内分泌及宫腔内环境的影响

为探讨磁场对生殖系统的影响,并将其用于女性避孕,我们做了以下试验。1 材料及方法 使用武汉冶金研究所提供的钐钴合金永磁棒(直径2mm,长4mm,表面磁场强度400～800高斯)。试验动物为健康成熟雌     

瘦素与男性不育症的关系

瘦素是由肥胖基因编码的一种蛋白质产物,属于Ⅰ型细胞因子,瘦素受体广泛分布于下丘脑、脂肪、睾丸、胎盘等组织,具有不同的生物功能.瘦素需与靶细胞膜上的瘦素受体结合,并通过多种信号转导途径才能发挥多种生物学效应.瘦素缺乏及瘦素受体的异常均可使生殖器官形态异常和导致与生殖相关的性激素分泌异常,进而引起男性不育症.目前研究发现,瘦素水平升高与精索静脉曲张、慢性前列腺炎、肥胖引起的男性不育,以及免疫相关性不育有关.     

Genetic causes of male infertility

Male infertility, affecting around half of the couples with a problem to get pregnant, is a very heterogeneous condition. Part of patients are having a defect in spermatogenesis of which the underlying causes (including genetic ones) remain largely unknown. The only genetic tests routinely used in the diagnosis of male infertility are the analyses for the presence of Yq microdeletions and/or chromosomal abnormalities. Various other single gene or polygenic defects have been proposed to be involved in male fertility. Yet, their causative effect often remains to be proven. The recent evolution in the development of whole genome-based techniques may help in clarifying the role of genes and other genetic factors involved in spermatogenesis and spermatogenesis defects.     

活性氧与男性不育相关性的研究进展

研究发现活性氧与男性不育具有一定相关性,如何预防过量活性氧的产生和清除过量的活性氧是近年研究的热点之一。该文主要综述活性氧对精子的生理及病理作用、精液活性氧的来源及检测方法、活性氧对辅助生殖的影响等方面的相关研究进展。     

精液沙眼衣原体感染与男性不育的关系

目的研究精液沙眼衣原体（CT）感染与男性不育的关系。方法选择精液CT阳性的男性不育者57例作为CT阳性组,另选择正常对照组15例。检测精液常规,免疫层析法检测CT感染情况,末端脱氧核苷酸转移酶（TdT）介导的TUNEL法及瑞—姬染色检测细胞凋亡,常规细胞形态学和透射电镜检测凋亡精子形态。结果CT阳性组精子凋亡率（33.03±14.98）%,正常对照组为（9.68±2.78）%,CT阳性组精子凋亡率增高（P〈0.01）。CT阳性组精子凋亡率与不育时间呈正相关,与精液量、精液活力、精子密度及正常形态率呈负相关（P均〈0.01）。结论精液CT感染诱导精子凋亡率增加。不育时间越长、精子数量越少、活力越差、正常形态率越低,精子凋亡率越高。     

COVID-19 and male infertility: An overview of the disease

Since SARS-CoV-2 infection was first discovered in December 2019 in Wuhan City in China, it spread rapidly and a global pandemic of COVID-19 has occurred. According to several recent studies on SARS-CoV-2, the virus primarily infects the respiratory system but may cause damage to other systems. ACE-2, the main receptor for entry into the target cells by SARS-CoV-2, was reported to abundantly express in testes, including spermatogonia, Leydig and Sertoli cells. Nevertheless, there is no clinical evidence in the literature about whether SARS-CoV-2 infection has an impact on male reproductive health. Therefore, this review highlights the effect of SARA-CoV-2 infection on male reproductive health, including the reproductive system and its functioning, as well as gamete and male gonadal function that might be affected by the virus itself or secondary to immunological and inflammatory response, as well as drug treatments and the psychological stress related to panic during the COVID-19 outbreak.     

Efficacy and safety of moxibustion in the treatment of infertility with polycystic ovary syndrome: A protocol of systematic review and meta-analysis

Background:Polycystic ovary syndrome (PCOS) is one of the common diseases of reproductive endocrine metabolism in gynecology, and it is also a common and difficult disease affecting female reproductive endocrine health. PCOS characterized by insulin resistance and hyperandrogenemia, the clinical manifestations are polychaemia, acne, obesity, infertility, menstrual disorders and so on. Clinical treatment of patients with PCOS ovulatory dysfunction infertility is mainly treated with ovulation-promoting drugs, insulin sensitizer, hyperandrogenemia drugs and other drugs Healing. It is found that the sensitivity of patients to ovulation promotion is poor, and it is often necessary to increase the dosage of drugs to increase ovulation rate, thus increasing the risk of ovarian hyperstimulation syndrome, and the recurrence rate is higher after withdrawal. Moxibustion therapy has shown strong advantages in the treatment of PCOS, and the curative effect is accurate. Therefore, this paper will carry out a systematic evaluation and meta-analysis of the efficacy and safety of moxibustion therapy in the treatment of PCOS.Methods:We will search 8 electronic databases, including PubMed, Embase, Web of Science, Cochrane Library, the China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), Wanfang Database (WF), and Chinese Biomedical Literature Database (CBM). We will search above electronic databases from the beginning to January 2021, without any language restriction. Ovulation rate and pregnancy rate will be accepted as the primary outcomes. The changes of Sex hormone levels, including Luteinizing hormone, follicle-stimulating hormone, serum estradiol, total testosterone will be used as secondary outcomes. RevMan 5.3 software will be used for statistical analysis. The result about the curative effect and safety of moxibustion therapy for PCOS will be presented as risk ratio for dichotomous data and mean differences with a 95% confidence interval for continuous data.Results:Only when we finish this meta-analysis can we get the result.Conclusions:The results of this study will provide reliable evidence for the efficacy and safety of moxibustion therapy in the treatment of PCOS.     

Effects of chromosomal abnormalities on pregnancy outcomes in female undergoing artificial insemination with donor's sperm

This study aimed to evaluate the clinical characteristics, pregnancy outcomes and prognostic factors for pregnancy of female with chromosomal abnormalities (CAs) after artificial insemination with donor''s sperm (AID) treatment.A retrospective case–control study was analyzed by using the data of 29 female patients with CA and 116 controlled patients with normal karyotype (1:4 ratio) who underwent AID cycles at Guangdong Family Planning Special Hospital from January 2011 to December 2017. In all cases, reproductive histories were collected, and the cytogenetic analysis was performed by Trypsin-Giemsa banding and karyotyping. The embryos were fertilized via intracervical or intrauterine insemination. Clinical characteristic variables were compared.The prevalence of CA was found to be 0.29% in the whole AID population. The live birth rates of CA group and controlled group were 41.4% and 31.0% (P = .29) respectively. Compared to normal karyotype group, patients with CA showed higher rate of primary infertility (93.1% vs 75.9%, P = .049); Multivariate analysis demonstrated that ovarian stimulation (odds ratio, 3.055; 95% confidence interval, 1.421–6.568; P = .004) was associated with adverse pregnancy outcomes in female patients with AID treatment.For the infertility CA patients who were phenotypically normal, AID was a suitable choice, whereas ovarian stimulation results in an improvement in the pregnancy rate.     

不同不育类型患者精液质量比较及对补救卵胞浆内单精子注射术临床结局的影响分析

目的 探讨不同不育类型患者精液质量情况及其对补救卵胞浆内单精子注射术(R-ICSI)临床结局的影响.方法 回顾性研究2014-01～2018-12于广西壮族自治区人民医院生殖医学与遗传中心行常规体外受精-胚胎移植(IVF-ET)失败而进行R-ICSI治疗的98对不孕不育夫妇的临床资料.根据不育类型将98对夫妇分为原发性...     

男性不育精浆弓形虫感染与生精细胞凋亡关系的研究

目的探讨男性不育精浆弓形虫感染与生精细胞凋亡及精子凋亡与男性不育关系。方法应用末端脱氧核苷酸转移酶(TdT)介导的脱氧核苷酸原位末端标记法(TUNEL)检测正常生育、不育男性精液中的生精细胞凋亡。结果男性不育精浆弓形虫感染组生精细胞凋亡率为(14．17± 7．16)％,显著高于男性不育弓形虫感染阴性组生精细胞凋亡率(12．22±6．18)％(P<0．05)。男性不育组精子凋亡发生率为(13．76±9．19)％,显著高于正常生育组男性精子凋亡发生率(4．28± 1．67)％(P<0．01)。结论精子凋亡与男性不育有着密切关系,弓形虫感染可引起生精细胞凋亡。