盐酸多西环素联合阿奇霉素治疗女性生殖道支原体感染155例临床观察

目的 观察盐酸多西环素联合阿奇霉素治疗女性生殖道支原体感染的临床疗效.方法 将314例有临床症状及支原体酶联免疫检测阳性患者随机分为2组,治疗组采用盐酸多西环素联合阿奇霉素治疗,对照组仅采用阿奇霉素治疗,2组均治疗1个疗程后观察疗效.结果 治疗组治愈率及总有效率分别为83.87％,95.48％,对照组分别为56.60％,76.73％,2组治愈率和总有效率比较,差异均有统计意义(P＜0.05),治疗组疗效显著优于对照组.结论 采用盐酸多西环素联合阿奇霉素治疗女性生殖道支原体感染临床疗效显著,值得推广.     

国产多西环素粉针剂治疗泌尿生殖道感染的临床疗效观察

目的:观察国产多西环素粉针剂治疗泌尿生殖系统感染的临床疗效及安全性.方法:采用随机对照临床观察,以阿奇霉素注射剂为对照药.60例患各类泌尿生殖系统感染的病人入组,纳入疗效分析60例,安全性分析60例.结果:多西环素组病人30例,治疗后痊愈率76.67%,有效率93.33%,不良反应33.33%.阿奇霉素组病人30例,痊愈率66.67%,有效率93.33%,不良反应发生率26.67%.结论:国产多西环素粉针剂治疗常见泌尿生殖道感染疗效与阿齐霉素注射剂相似.     

盐酸多西环素联合阿奇霉素对围手术期生殖道支原体感染的疗效观察

目的探讨盐酸多西环素联合阿奇霉素对围手术期生殖道支原体感染的治疗效果。方法选取新乡市第二人民医院2013年2月至2014年2月收治的95例妇产科围手术期生殖道支原体感染患者,随机分为观察组(48例)和对照组(47例)。对照组采用阿奇霉素进行治疗,观察组采用盐酸多西环素联合阿奇霉素进行治疗,观察对比两组疗效。结果观察组感染发生率为10.4%,低于对照组40.4%(P<0.05)。观察组宫颈管外口黏膜充血消失时间、糜烂创面恢复时间与对照组比较,均明显缩短(P<0.05)。两组药物不良反应发生率差异无统计学意义(P>0.05)。结论盐酸多西环素联合阿奇霉素对围手术期生殖道支原体感染治疗效果显著,安全性较高,值得临床推广。     

多西环素治疗非淋菌性尿道炎96例疗效分析

目的:探讨多西环素治疗非淋菌性尿道炎(NGU)的疗效.方法:收集门诊NGU患者192例,按就诊先后顺序随机分为治疗组和对照组,对照组给予阿奇霉素片治疗,治疗组口服盐酸多西环素.结果:治疗组总有效率95.83%,对照组总有效率83.33%(P<0.05),差别有统计学意义.结论:多西环素作为治疗NGU的一种药物疗效确切而且易被患者接受.     

注射用阿奇霉素治疗细菌性感染临床观察

目的 :评价国产注射用阿奇霉素治疗细菌性感染的临床疗效和安全性。方法 :采用随机对照方法 ,将 43例下呼吸道感染和 33例泌尿道感染分验证组和对照组。 43例验证组给予注射用阿奇霉素 0 .2 5 g静脉滴注 ,每天 1次 ;33例对照组给予注射用头孢呋辛 1.5g静脉滴注 ,每天 2次 ,两组疗程均为 5天。结果 :验证组有效率为 83.7% ,细菌清除率为 72 .5 % ,药物敏感率为 80 .8% ;对照组有效率为 81.8% ,细菌清除率为 77.4% ,药物敏感率为 82 .2 % ,两组差异均无显著性 (P >0 .0 5 )。两组不良反应轻微。结论 :注射用阿奇霉素是一种有效、安全的治疗细菌性感染的抗生素     

多西环素和阿奇霉素治疗支原体感染76例临床观察

目的 探讨多西环素、阿奇霉素治疗支原体感染的疗效比较.方法 采用完全随机对照试验研究方法,将2006年6月至2007年6月在本院妇科门诊宫颈分泌物支原体(UU或MH)培养阳性者76例,随机分成2组,每组38例.观察纽:口服多西环素0.1g,每天2次,14d.对照组:口服阿奇霉素,0.25g,每天2次,3d.治疗和观察期间避免性生活或工具避孕.根据药敏试验结果配偶或性伴侣同时治疗,停药1周后进行支原体复查.结果 观察组和对照组的临床有效率分别为89.47%和63.16%,观察组与对照组比较差异性有统计学意义(P<0.05).结论 多西环素治疗支原体感染较阿奇霉素效果好,疗程短,使用方便.     

注射用盐酸多西环素治疗非淋菌性尿道炎及宫颈炎的临床效果分析

目的:探讨分析采用注射用盐酸多西环素治疗非淋菌性尿道炎及宫颈炎的临床效果。方法:选取潢川县人民医院2012年1月至2013年12月收治的110例非淋菌性尿道炎、宫颈炎患者为研究对象,将其随机分成两组,观察组60例患者给予注射用盐酸多西环素治疗,对照组50例患者给予阿奇霉素治疗,观察两组临床疗效。结果:观察组患者治疗总有效率为95.0%,显著高于对照组76.0%,且观察组患者症状控制时间及用药时间显著短于对照组,差异均具有统计学意义(P<0.05)。结论:采用注射用盐酸多西环素治疗非淋菌性尿道炎、宫颈炎的临床效果较显著,能有效改善患者临床症状,提高患者生活质量,值得应用推广。     

盐酸多西环素配合阿奇霉素治疗女性生殖道支原体感染疗效观察

目的探讨盐酸多西环素联合阿奇霉素治疗女性生殖道支原体(UU)感染的临床疗效。方法将2010年1月-2012年1月在合浦妇幼保健院门诊的314例女性生殖道UU感染的患者,年龄19～47岁,平均38岁,按照治疗方法的不同分为治疗组155例和对照组159例,对照组单纯采用阿奇霉素治疗,治疗组在对照组的基础上采用盐酸多西环素治疗,比较两组的UU转阴率、症状消失情况及不良反应。结果治疗组的UU转阴率为90.96%,显著高于对照组的61.63%(P<0.05)。治疗组泌尿系感染症状外阴不适的消失比率显著高于对照组(P<0.05)。两组患者的不良反应的发生率差异无统计学意义(P>0.05)。结论盐酸多西环素联合阿奇霉素能够快速消除UU感染,缓解患者的临床症状,不良反应少,值得临床推广。     

左氧氟沙星联合阿奇霉素治疗呼吸道感染的临床疗效

目的:为了探讨左氧氟沙星联合阿奇霉素治疗呼吸道感染的临床疗效。方法:选取120例呼吸道感染患者,试验组给予左氧氟沙星联合阿奇霉素治疗,对照组单独给予阿奇霉素,密切观察两组患者的临床疗效。结果:试验组呼吸道感染患者的临床总有效率(98.3%)明显高于对照组的临床总有效率(91.7%)。结论:阿奇霉素联合左氧氟沙星对于治疗小儿呼吸道感染具有较好的疗效和安全性。     

非淋菌性尿道炎/宫颈炎经注射用盐酸多西环素治疗的临床效果观察

目的：对应用注射用盐酸多西环素对患有非淋菌性尿道炎/宫颈炎的患者实施治疗的临床效果进行研究。方法：将我院收治的74例患有非淋菌性尿道炎/宫颈炎的患者随机分为对照组和治疗组,每组37例。采用阿奇霉素对对照组患者实施治疗,采用阿奇霉素与注射用盐酸多西环素联合对治疗组患者实施治疗。结果：治疗组患者非淋菌性尿道炎/宫颈炎病情治疗效果明显优于对照组;症状表现彻底消失时间、病原菌检测结果转阴时间、接受药物治疗总时间明显短于对照组;停药后病情再次复发率明显低于对照组;两组均未出现任何药物不良反应。结论：应用注射用盐酸多西环素对患有非淋菌性尿道炎/宫颈炎的患者实施治疗的临床效果非常明显。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.