Effect of the synthetic antiheparin agent quaternary ammonium salt of oligomer 25-conidine on liver regeneration

Single injection of quaternary ammonium salt of oligomer-25 conidine to rats with acute CCI₄-induced hepatitis promotes normalization of morphological and biochemical markers of hepatic injury in comparison with untreated animals. On day 3 postinjection the number of mitosis increased 2–3-fold. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 7, pp. 56–60, July, 1998     

Acoustic assessment of skin grafts in children with burn contractures

The outcome of skin plasty is assessed quantitatively with the use of an acoustic skin analyzer, which allows one to measure the rate of the propagation of a surface acoustic wave in the skin. An objective criterion is proposed for evaluating the efficiency of grafting. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 478–480, October, 1996     

Effect of dexamethasone on the composition of skin phospholipids in laboratory animals

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ^o 4, pp. 378–380, April, 1993     

In vivo electrical characteristics of human skin, including at biological active points

The aim is to compare the mean values of the in vivo electrical characteristics of bioiogical active points (BAPs) with those of the surrounding human skin. The impedance measurements at BAPs and on the surrounding skin are carried out in vivo on ten young, healthy people. The results of the measurements show that the BAP resistance R_P is smaller, and the capacitance C_P is higher, than the corresponding values for skin, R_S and C_S, respectively, these differences are larger at low frequencies (at f=3 Hz, R_S/R_P=3.19 and C_P/C_S=3.2). The mean values of the impedance measurements at the BAPs are different from those measured on the skin. The dependence of R_P and C_P on the pressing force, in the range of about 1–5 N, for the BAPs, has a smaller slope than that observed for the surrounding skin. An equivalent circuit for the BAPs is proposed that describes sufficiently well the experimental results obtained. These results show that the large dispersion in the observed impedance characteristics of the human body measurements in different body regions can be related to the influence of the BAPs present under the electrodes.     

Effect of low-intensity infrared laser on the healing of dermatome wounds

Changes in the microvessels, consisting in their dilatation and accelerated formation, and a shift of the peak of epitheliocyte proliferative activity are found to be the structural basis of the stimulating effect of infrared magnetic laser. Morphologic changes in connective-tissue cells determine both the proper development of the connective-tissue carcass, primarily of the fibroblasts, and the barrier protective and regulatory function of such cells as macrophages, neutrophils, plasma cells, eosinophils, and, last but not least, mast cells. Morphologic changes occurring during irradiation according to optimal schemes indicate activation of specific cell functions and are observed at earlier times. Translated fromByulleten' Eksperimental'noi Biologi i Meditsiny, Vol. 119, N ^o 2, pp. 218–224, February, 1995 Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences     

Electron microscopic autoradiographic investigation of burn injury healing after treatment with Levosin ointment

Translated fromByulleten' Experimental'noi Biologii i Meditsiny, Vol. 115, No. 1, pp. 77–79, January, 1993     

Lipid spectrum of the skin in psoriasis

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N ^o 9, pp. 271–272, September, 1993     

Levels of the thymic factor thymalin in human and murine skin epithelia during ontogeny

Skin specimens from humans, CBA mice, and nude mice are studied during ontogeny using antithymalin and antithymosin α₁ antisera in order to reveal extrathymic thymalin-positive cells and to collect more information on the involution of these cells with age. Thymalin is identified in young actively proliferating skin cells. In humans and mice, the number of thymalin-containing cells decreases with age. It is concluded that thymalin-positive cells not only of the thymic epithelial stroma but also of the epidermis involute with age. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 11, pp. 574–577, November, 1996     

Effect of low-intensity luminescence on reparative processes in skin wounds in the rat

Low-intensity noncoherent luminescent radiation stimulates reparative processes in soft tissue wounds of rats. The stimulation is dependent on the frequency of light pulsation and the luminescence spectrum. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 6, pp. 665–667, June, 1994 Presented by B. A. Korolev, Member of the Russian Academy of Medical Sciences     

Dynamics of changes in skin lipids after stress: Effects of exogenous melatonin

Changes in the skin lipid composition induced by water-immersion stress in rats treated and untreated with melatonin were studied by thin-layer chromatography. Skin lipids showed a delayed reaction to stress. Melatonin exerted a protective effect which was manifested on the 2nd day after treatment in restoration of the level of total lipids and the absolute content of the majority of lipid fractions. The data suggest modification of, the metabolic relationships between skin lipids as well as lipids of the blood and subcutaneous adipose tissue. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 519–522, May, 1999     

Immunological characteristics of skin preparations

Effects of three preparations from porcine skin on the number of antibody-producing mouse splenocytes at the peak of primary immune response and on the restoration of the sensitivity of background rosette-forming splenocytes to inhibitory effect of azathioprine were studied in thymectomized mice. All three preparations were active in the first test, while in the second test only the preparation with molecular weight below 1.4 kD was active. The effects of preparations on B and T immunity have been demonstrated. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 2, pp. 194–197, February, 2000     

Skin lipids in rats administered with melatonin

Effects of the pineal hormone melatonin on skin lipids in Wistar rats were studied by thinlayer chromatography. The reaction was shown to be delayed. Contents of total lipids and the majority of fractions increased over 24 h after administration of melatonin. Concentrations of triglycerides and phospholipids decreased, while the contents of cholesterol, cholesterol esters, and free fatty acids increased by the end of the second day. Our findings indicate that the blood and subcutaneous fat, as well as changed metabolic interrelations of skin lipids are involved in the skin response to increased melatonin concentration. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 4, pp. 463–465, April, 1999     

Effects of fibroblasts, collagen, and laminin on healing of superficial split wounds

Application of cultured fibroblasts on a superficial split wound accelerates its healing: 3–4 daysvs. 5–7 days with type I collagen or laminin and 7–10 days with conventional dressings and wound-healing means. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 229–322, August, 1997     

Steroid hormones modulate lipid spectrum in lysosomal membranes of skin fibroblasts

It is shown that estradiol and hydrocortisone modulate lipid composition and affect lipidprotein interaction in fibroblast lysosome membranes, which can promote enzyme release from lysosomes. These effects are particular mechanisms of hormone regulation of functional lysosome activity in the skin. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 2, pp. 165–167, February, 1998     

Characteristics of the skin lactate dehydrogenase isozyme spectrum after thermal injuries

Activity of lactate dehydrogenase (LD) and its isozymes in the injured zone and in adjacent areas of the skin was investigated at various times after infliction of burns in rats. On the 1st–8th day after burning total LD activity was reduced in the zone of the scab and in the underlying tissues by 70–80% and in the border and intact skin by 50%. These changes were accompanied by changes in the LD isozyme spectrum in the injured tissue: On the 1st day the activity of fraction 5 was sharply increased and activity of fractions 2 and 3 reduced; by the 8th day, on the other hand, some decrease in activity of fraction 5 and an increase in activity of fractions 2 and 3 were observed. By the 14th–22nd day after burning total LD activity remained low, the LD isozyme spectrum in the border and scab was largely restored to normal, whereas in the underlying tissue changes in the relative proportions of LD isozymes were still present (a decrease in activity of fractions 1–3 and an increase in activity of fraction 5).Laboratory of Biochemistry, A. V. Vishnevskii Institute of Surgery, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR M. I. Kuzin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 9, pp. 294–297, September, 1977.     

Two mechanisms of progesterone action on the skin (Results of biochemical analysis)

Effects of progesterone on functional activity of lysosomes and lipid peroxidation are measured in the skin of rats in relation to its dose, duration of exposure to it, and skin tissue type (epidermis and dermis). This hormone is shown to regulate both lipid peroxidation intensity and lysosomal activity. It is concluded that these two affects represent two mechanisms through which progesterone exerts its anti-inflammatory effect on the skin. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 8, pp. 173–176, August, 1996