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1.
We proposed to assess serum antioxidant vitamins and magnesium (Mg) levels in patients with fibromyalgia (FM) in comparison
to healthy controls. Additionally, the association between the serum antioxidant vitamins, magnesium levels, and clinical
parameters in FM patients was also investigated. Forty female patients, aged between 30 and 50 years, were diagnosed with
FM according to ACR-1990 criteria, and 40 healthy controls were included in the present study. Socio-demographic characteristics
of participants, accompanying symptoms, and number of tender points (TP) of the patients were recorded. The intensity of pain
was measured using the visual analogue scale (VAS). The functional status and depression levels were evaluated with Fibromyalgia
Impact Questionnaire (FIQ) and Beck Depression Inventory (BDI), respectively. Serum vitamins A, C, and E and Mg levels were
measured. There were no significant differences in the levels of vitamins A, C, and E and Mg between control subjects and
patients with fibromyalgia (p > 0.05). In addition, no statistically significant correlations were found between mean levels of serum vitamins A, C, and
E, and Mg and number of TP, scores of VAS, FIQ, and BDI in patients with FM (p > 0.05). According to the results of this study, it was asserted that other complex mechanism may play an important role
in the pathophysiology of FM without plasma antioxidant vitamins and Mg levels. 相似文献
2.
A pragmatic community-based intervention of multimodal physiotherapy plus deep water running (DWR) for fibromyalgia syndrome: a pilot study 总被引:1,自引:0,他引:1
Evidence-based recommendations support the use of multimodal therapy and hydrotherapy for fibromyalgia syndrome; however,
there is little standardisation of such programmes. The aim of the study was to assess the effectiveness of a pool-based exercise
using deep water running (DWR) as part of a multimodal physiotherapy programme for patients with fibromyalgia syndrome. For
a non-randomised clinical study, 44 patients diagnosed with fibromyalgia were recruited from primary care. Patients in the
experimental group received a multimodal programme incorporating pool-based exercise using DWR three times a week for an 8-week
period. The control group received a leaflet containing advice and continued with normal activities. Patients were evaluated
for physical function (Fibromyalgia Impact Questionnaire, FIQ), pain, general health (Short Form-12 Health Survey) and quality
of life (European Quality of Life Scale-5D) pre- and post intervention. Statistically significant results were found for the
experimental group for FIQ total score, incorporating physical function, pain, fatigue, stiffness and psychological variables
(p < 0.05). Statistically significant differences between the experimental group and control were also found for general health
(p < 0.05) and quality of life (p < 0.05). The results of this pilot study and the high level of compliance and adherence and low level of attrition suggest
that this multimodal programme incorporating DWR is a safe and effective intervention for fibromyalgia syndrome that is acceptable
to patients. 相似文献
3.
Cecilia P. Chung Dina Titova Annette Oeser Margaret Randels Ingrid Avalos Ginger L. Milne Jason D. Morrow C. Michael Stein 《Clinical rheumatology》2009,28(4):435-438
Oxidative stress is thought to play a role in the pathogenesis of fibromyalgia. We examined the hypothesis that oxidative
stress was increased in patients with fibromyalgia and related to the severity of symptoms. Urinary F2-isoprostane excretion was measured in 48 patients with fibromyalgia and compared to those of 96 control subjects. In patients,
we examined the association between oxidative stress and symptoms. Patients with fibromyalgia were significantly more symptomatic
than control subjects, but urinary F2-isoprostane excretion did not differ significantly (2.3 ± 1.9 vs. 2.8 ± 2.2 ng/mg creatinine, p = 0.16). In patients with fibromyalgia, F2-isoprostane excretion was associated with fatigue visual analog scale (rho = 0.30, p = 0.04) but not with pain, quality of life, functional capacity, depression, number of tender points, or overall impact of
fibromyalgia. Oxidative stress is not increased in patients with fibromyalgia, but as was previously found in patients with
systemic lupus erythematosus, oxidative stress was associated with fatigue.
Jason D. Morrow: deceased 相似文献
4.
The objective of the study was to analyse the impact of fibromyalgia (FM) on health-related quality of life (HRQOL) and to
identify clinical and psychological factors associated with the disease. A cross-sectional study was conducted with adult
Portuguese women with FM. Analysed data were demographic, clinical and psychological variables and HRQOL: SF-36 and Fibromyalgia
Impact Questionnaire (FIQ). The relationship between HRQOL and the other variables was made with a bivariate analysis. To
assess the relative contribution of clinical and psychological variables, a series of multiple regression analyses were designed
and made. The study sample consisted of 76 women with FM (49.61 ± 10.07 years). All dimensions of HRQOL were affected in FM,
especially Physical Functioning, Physical Role Functioning and General Health. The mean FIQ total score was 68.59 ± 17.54,
and 40 patients (53%) presented scores ≥70. Pain intensity, assessed by a 10-cm visual analogue scale (VAS), was a significant
predictor of HRQOL in expressing association with FIQ and all dimensions of SF-36, except Emotional Role Functioning. Anxiety
(Hospital Anxiety and Depression Scale (HADS)) was a significant predictor of the Mental Component and General Health (SF-36).
Depression (HADS) was related with Vitality, Mental Health and FIQ. Emotion-focused coping was related with General Health
and Emotional Role Functioning, and social support (Satisfaction with Social Support Scale (ESSS)) was related with the Social
Functioning. These clinical and psychological variables explained an acceptable proportion of variability (R
2), ranging from 31.3% on Emotional Role Functioning to 70.6% on FIQ, except for Physical Role Functioning (R
2 = 6.1). FM has a negative impact on both general and specific dimensions of HRQOL, especially the physical dimensions. Pain
intensity, anxiety and depression symptoms and the emotion-focused coping are the most relevant explanatory variables of the
impact of FM on HRQOL. 相似文献
5.
Ottaviani S Bernard JL Jean-Luc B Bardin T Thomas B Richette P Pascal R 《Clinical rheumatology》2012,31(3):531-534
Joint lavage for knee osteoarthritis is an invasive procedure that can be stressful and painful. We aimed to assess the impact
of music therapy on perioperative anxiety, pain and tolerability of the procedure in patients undergoing joint lavage performed
with two needles. We randomized all patients diagnosed with knee osteoarthritis and undergoing joint lavage in our department
from November 2009 to October 2010 to an experimental group listening to recorded music or a control group receiving no music
intervention. Perioperative anxiety and pain related to the procedure were self-reported on a visual analogic scale (0–100 mm
visual analog scale [VAS]), and heart rate and blood pressure were measured during the procedure. Tolerability was assessed
on a four-grade scale directly after the procedure. We included 62 patients (31 in each group). Mean age was 68.8 ± 12.6 years
(72% females). As compared with the control group, the music group had lower levels of perioperative anxiety (40.3 ± 31.1
vs. 58.2 ± 26.3 mm; p = 0.046) and pain related to the procedure (26.6 ± 16.2 vs. 51.2 ± 23.7 mm; p = 0.0005). Moreover, heart rate was lower in the music group (69.5 ± 11.4 vs. 77.2 ± 13.2; p = 0.043) but not diastolic or systolic blood pressure. Tolerability was higher in the music group (p = 0.002). Music is a simple and effective tool to alleviate pain and anxiety in patients undergoing joint lavage for knee
osteoarthritis. 相似文献
6.
The validity and reliability of the Turkish version of the Revised Fibromyalgia Impact Questionnaire
Levent Ediz Ozcan Hiz Murat Toprak Ibrahım Tekeoglu Songul Ercan 《Clinical rheumatology》2011,30(3):339-346
The Revised Fibromyalgia Impact Questionnaire (FIQR) attempts to address the limitations of the Fibromyalgia Impact Questionnaire
(FIQ). As there is no Turkish version of the FIQR available, we aimed to investigate the validity and reliability of a Turkish
translation of the FIQR in Turkish female fibromyalgia (FM) patients. After translating the FIQR into Turkish, it was administered
to 87 female patients with FM. All of the patients filled out the questionnaire together with a Turkish version of the FIQ,
hospital anxiety and depression scales (HADS), short form-36 (SF-36). The tender-point count (TPC) was also calculated from
tender points identified by thumb palpation. One week later, FM patients filled out the Turkish FIQR at their second visit.
The test–retest reliability of the Turkish FIQR questions ranged from 0.714 to 0.898. The test and retest reliability of total
FIQR score was 0.835. Cronbach's alpha was 0.89 for FIQR visit 1 (the first assessment) and 0.91 for FIQR visit 2 (the second
assessment), indicating acceptable levels of internal consistency for both assessments. The total scores of the FIQR and FIQ
were significantly correlated (r = 0.87, P < 0.01). Significant correlations for construct validity were also obtained between the FIQR total and domain scores and
the FIQ, the HADS and the subscales of the SF-36 (FIQR total versus SF-36 physical component score and mental component score
were r = −0.63, P < 0.01 and r = −0.51, P < 0.01, respectively). The Turkish FIQR is a reliable and valid instrument for measuring health status in FM, showing sufficient
reliability and construct validity. It may be utilized for both clinical practice and research use in the Turkish-speaking
population in place of FIQ, since its Turkish version has problems in the wording, omissions, concepts, and scoring from the
original FIQ. 相似文献
7.
Expiratory pressure relief (C-Flex) technology monitors the patient’s airflow during expiration and reduces the pressure in
response to the patient. Increased comfort levels associated with C-Flex therapy have potential to improve patient adherence
to therapy. The purpose of this study was to assess the combination of autoadjusting CPAP (APAP) and C-Flex in terms of (1)
treatment efficacy, and (2) patient preference when compared to standard CPAP. Fifteen patients who had previously undergone
formal CPAP titration polysomnography were treated with either one night of the APAP with C-Flex or one night of conventional
CPAP, in a crossover trial. Patient satisfaction levels were recorded using visual analog scales (VAS) on the morning after
the study. Mean patient age was 50 ± 12 years, body mass index (BMI) was 36 ± 6 kg/m2, baseline AHI was 53 ± 31 events/h, and CPAP Pressure was 11 ± 2 cm/H2O. APAP with C-Flex was as effective as CPAP, with no differences detected in sleep latency (17 ± 5 vs 12.3 ± 3 min, p = 0.4), or respiratory indices (AHI of 4.2 ± 2 vs 2.4 ± 0.7 events/h, p = 0.1). VAS scores (scale 0–10) indicated a trend towards increased patient satisfaction while using APAP with C-Flex (7.9
vs 7.2, p = 0.07). 10 patients expressed a preference for APAP with C-Flex (VAS, 0 to10) over standard CPAP (total positive score of
68, mean score of 4.8 ± 4.3). One patient expressed no preference. Four patients expressed a preference for CPAP (total positive
score of 13, mean score of 0.9 ± 1.9) (APAP with C-Flex vs standard CPAP, p < 0.01 paired t test). APAP with C-Flex eliminates sleep disordered breathing as effectively as standard CPAP. Patients indicated a preference
for APAP with C-Flex suggesting a possible advantage in terms of patient adherence for this mode of treatment. 相似文献
8.
The objective was to determine the relationship between symptoms of fibromyalgia (FM) and early menopause and hysterectomy.
We included 115 postmenopausal patients with FM (mean age 54.6 ± 7.6) and 67 rheumatoid arthritis (RA) patients (mean age
55.5 ± 9) into our study. All patients were questioned about the severity of their symptoms of FM, anxiety, and depression
by using a visual analog scale and FM impact questionnaire. Patients’ history of menopause and hysterectomy were recorded.
Menopause (≤45 years) was accepted to be early. The frequencies of early menopause (38.3% vs. 13.4%, p = 0.001) and hysterectomy (16.5% vs. 6%, p = 0.039) in FM patients were significantly higher than in RA patients. While chronic widespread pain and other FM-related
symptoms started after menopause in 58.3% of FM patients, the disease started after menopause in 64.2% of RA patients (p > 0.05). FM-related symptoms started in 30 patients (26.1%) with FM with menopause or within the first postmenopausal year.
When the clinical features of FM patients whose symptoms started within the first menopausal year were compared to other FM
patients; it was observed that the frequency of early menopause was higher in the former group (p = 0.048). Duke anxiety and depression score was higher in patients with hysterectomy whose FM symptoms started within the
first year of post-hysterectomy than other FM patients (9.1 ± 2.7 vs. 6.7 ± 2.7, p = 0.022). Early menopause and hysterectomy may be one of the factors contributing to the development of FM. 相似文献
9.
Di Minno MN Iervolino S Peluso R del Puente A Russolillo A Coppola A Ruosi C Guida A Scarpa R Di Minno G 《Clinical rheumatology》2011,30(7):915-919
Because of joint haemorrhages, severe haemophilia subjects often have limitations in their daily activities. Current orthopaedic
scores (OJS) in haemophilia miss mild joint impairments and only pick up severe alterations. Twelve young severe haemophiliacs
(20.25 ± 1.9 years of age), were evaluated for OJS as well as for indices employed in rheumatoid arthritis [28-joint Disease
Activity Score (DAS-28), Ritchie index, Health Assessment Questionnaire (HAQ), visual analogue scale (VAS)], spondyloarthritis
[Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), HAQ, VAS] and osteoarthritis [Knee injury and Osteoarthritis
Outcome Score (KOOS), VAS]. Twenty-four matched apparently healthy subjects and 29 subjects with psoriatic arthritis (PsA)
with oligoarticular involvement (one to three swollen joints) served as controls. In addition to the impairment of target
joints (elbow, in five of five in those on-demand treatment; three, elbows; four, knee in those on secondary prophylaxis),
HAQ (mean 0.71 ± 0.95) and VAS (3.12 ± 2.36) documented a quality of life and a perception of pain in haemophiliacs similar
to that of PsA subjects (p = 0.061 and p = 0.063, respectively). Their Ritchie index did not differ from that of subjects with psoriatic arthritis (5.75 ± 8.1 vs
7.73 ± 9.22; p = 0.408), nor did the BASDAI score with respect to psoriatic arthritis patients (p = 0.105). Six of 12 haemophiliacs (50%) had KOOS values from 70 to 50 (significant function joint impairment); 3 of 12 (25%)
showed DAS-28 values >3.2 (moderate disease activity), 2 of 12 (16.6%) severe disease activity (>5.1). All these indices significantly
correlated with VAS and HAQ in haemophilia subjects. A rheumatologic assessment may help identify early polyarticular disease
and subclinical abnormalities involving joints not usually studied (not target joint) in haemophiliacs. These pilot data provide
the rationale for testing a systemic involvement in haemophiliacs by means of high-tech imaging and to start early-onset prophylaxis/treatment
in this setting. 相似文献
10.
DeLea SL Chavez-Chiang NR Poole JL Norton HE Sibbitt WL Bankhurst AD 《Clinical rheumatology》2011,30(6):805-813
Scleroderma is associated with intractable hand pain from vasospasm, digital ischemia, tenosynovitis, and nerve entrapment.
This study investigated the effect of hydrodissection of the carpal tunnel followed by corticosteroid injection for the painful
scleroderma hand. Twenty-six consecutive subjects [12 with painful scleroderma hand and 14 with rheumatoid arthritis and carpal
tunnel syndrome (RA/CTS)] underwent sonographically observed carpal tunnel hydrodissection with 3 ml of 1% lidocaine administered
with a 25-gauge 1-in. needle on a 3-ml RPD mechanical syringe (reciprocating procedure device). After hydrodissection, a syringe
exchange was performed, and 80 mg of triamcinolone acetonide was injected. Baseline pain, procedural pain, pain at outcome,
responders, therapeutic duration, and reinjection interval were determined. Hydrodissection and injection with corticosteroid
significantly reduced pain scores by 67% in scleroderma (p < 0.001) and by 47% in RA/CT (p < 0.001). Scleroderma and RA/CTS were similar in outcome measures: injection pain (p = 0.47), pain scores at outcome (p = 0.13), responders (scleroderma, 83.3%; RA/CTS, 57.1%, p = 0.15), pain at 6 months (p = 0.15), and therapeutic duration (p = 0.07). Scleroderma patients responded better in time to next injection (scleroderma, 8.5 ± 3.0 months; RA/CTS, 5.2 ± 3.1
months, p = 0.03). Reduced Raynaud’s attacks and healing of digital ulcers occurred in 83% of subjects. There were no complications.
Hydrodissection with lidocaine followed by injection of triamcinolone reduces pain and vasomotor changes in the scleroderma
hand. The mechanism may be a combination of hydrodissection-mediated mechanical freeing of entrapped arteries, nerves, and
tendinous structures and corticosteroid-induced reduction of inflammatory vasospasm. 相似文献
11.
The aims of this randomized controlled trial were to evaluate the efficacy of intra-articular Hylan G-F 20 on the pain, pinch
strength, and functional status in patients with thumb base osteoarthritis (OA). Sixty-six hands of 33 female patients (mean
age, 62.6 ± 6.4 years) with bilateral clinical and radiological thumb base OA were included into this study. Hands of the
same patient were divided to Hylan G-F 20 and saline-injection groups. VAS pain 100 mm, pinch strength (key, tripod and pulp
to pulp pinch) and functionality (Dreiser functional index) were assessed at baseline, at sixth and 24th weeks. Statistically
significant improvements were detected in function (p = 0.001), VAS pain (p = 0.002), and pinch strength (p = 0.004) at the 24th week in the Hylan G-F 20 group. However, only VAS pain scores decreased temporarily in control hands
at the 6th week (p = 0.02). Although short-term placebo analgesic effect could not be ignored, intra-articular hylan was effective on pain,
pinch strength, and function at the 24th week. 相似文献
12.
Tarakci E Yeldan I Kaya Mutlu E Baydogan SN Kasapcopur O 《Clinical rheumatology》2011,30(11):1415-1420
The aim of this study was to assess the relationships between physical activity level and anxiety, depression, and functional
ability in children and adolescents with juvenile idiopathic arthritis (JIA). Cross-sectional study design including patients
with JIA aged between 8 and 17 years and healthy controls was used. Sociodemographic data and clinical features were assessed.
Physical activity level and energy expenditure were assessed with a 1-day activity diary. Anxiety was screened by The Screen
for Child Anxiety Related Emotional Disorders (SCARED) questionnaire. Depressive symptoms were assessed by the Children’s
Depression Inventory (CDI). Functional ability was assessed with the Childhood Health Assessment Questionnaire (CHAQ). Pain
and overall well-being were measured using a visual analog scale (VAS). Fifty-two patients and 48 controls were included with
a mean age of 12.13 ± 2.92 and 11.27 ± 1.59 years, respectively. The mean disease duration was 64 months. The JIA group had
significantly less time in physical activity (p = 0.000), decrease in energy expenditure (p = 0.04), and higher CHAQ scores (p = 0.000) compared with the control group. In the JIA group, significant relationships were found between the number of active
joint and disease duration (r = 0.44, p = 0.000) and VAS pain (r = 0.30, p = 0.02), between SCARED and CDI (r = 0.54, p = 0.000). Significant relationships were found between VAS overall well-being and CDI (r = 0.29, p = 0.03), CHAQ (r = 0.37, p = 0.000), and VAS pain (r = 0.41, p = 0.000). Correlation between CHAQ and CDI (r = 0.34, p = 0.01) was significant. The result of our study suggested that only depression was related to anxiety, functional ability,
and well-being in children and adolescents with JIA. 相似文献
13.
Mehves Buyukkose Erkan Kozanoglu Sibel Basaran Ozlem Bayramoglu Fugen Yarkin 《Clinical rheumatology》2009,28(3):305-309
This study was aimed to evaluate the seroprevalence of parvovirus B19 in patients with fibromyalgia syndrome (FS). Seventy-five
patients with FS (44.3 ± 8.3) and 75 healthy controls (44.2 ± 8.1) were evaluated. Serum anti-B19 IgM and IgG antibodies were
measured by ELISA technique. Patients were questioned about duration of symptoms, characteristic features of FS, and symptoms
related with viral infection preceding the onset of FS. No significant difference was found regarding the prevalence of anti-B19
IgM antibodies between the groups (p = 0.494). Seropositivity of anti-B19 IgG of the patients was significantly higher than control group (81.3% vs. 64% respectively,
p = 0.027). No statistically significant differences were found regarding to the clinical features between fibromyalgia patients
with IgG antibody compared to those without IgG antibody. Parvovirus B19 IgG seropositivity was found to be significantly
higher in patients with FS. Parvovirus B19 infection might have a role in the etiopathogenesis of FS or might act as a triggering
factor. 相似文献
14.
The aim of the study was to assess iron serum levels and markers of iron stores in non-anemic fibromyalgia (FM) patients and
to evaluate their impact on the prevalence and clinical manifestations of FM patients. Eighty-four patients with primary FM
and 87 controls were investigated. Demographic and clinical data were collected from all participants. All patients completed
the fibromyalgia impact questionnaire (FIQ). Patients evaluated the effect of the disease on their daily activity (DA) and
judged the severity (DS) of the disease on a 0–10 scale. Venous blood was tested for serum iron, transferrin, ferritin, and
soluble transferrin receptors (sTfR). Iron deficiency was defined if any of the following were present: serum iron <40 μg/dL,
serum ferritin levels <10 ng/mL, or sTfR levels >28.1 nmol/L. Analysis at a cutoff level of serum ferritin levels ≤30 ng/mL
and sTfR/ferritin ratio was also performed. Hemoglobin, iron, transferrin, sTfR, ferritin levels, and sTfR/ferritin ratios
did not differ between the groups. The mean FIQ score was 57.13 ± 20.21 and the DA and DS scores were 6.79 ± 2.97 and 6.74 ± 3.09,
respectively. No correlations were found between the parameters studied and the FIQ or its ten individual items. Thirty-eight
controls (43.7%) and 23 FM patients (27.4%) had ferritin levels of ≤30 (p < 0.04). Within the FM group, lower levels were associated with lower total FIQ score and FIQ subscale scores. Patients with
FM do not have reduced serum levels of iron or surrogate markers of iron stores. At present, there is no evidence to support
iron supplementation in the treatment of FM. 相似文献
15.
Yu-Hua Chao Ching-Tien Peng Horng-Jyh Harn Chin-Kan Chan Kang-Hsi Wu 《Annals of hematology》2010,89(7):715-723
The pathogenesis of severe aplastic anemia (SAA) has not been completely understood, and insufficiency of the hematopoietic
microenvironment can be an important factor. Here, we compared the basic properties of mesenchymal stem cells (MSCs), a major
component of bone marrow microenvironment, from five SAA children with those of MSCs from five controls. Although MSCs from
SAA children and controls were similar in morphology and immunophenotypic profile, SAA MSCs had slower expansion rate and
smaller cumulative population doubling (1.83 ± 1.21 vs 3.36 ± 0.87; p = 0.046), indicating lower proliferative capacity. After osteogenic induction, SAA MSCs showed lower alkaline phosphatase
activity (optical density, 1.46 ± 0.04 vs 2.27 ± 0.32; p = 0.013), less intense von Kossa staining, and lower gene expression of core binding factor α1 (0.0015 ± 0.0005 vs 0.0056 ± 0.0017;
p = 0.013). Following adipogenic induction, SAA MSCs showed less intense Oil red O staining (optical density, 0.86 ± 0.22 vs
1.73 ± 0.42; p = 0.013) and lower lipoprotein lipase expression (0.0105 ± 0.0074 vs 0.0527 ± 0.0254; p = 0.013). These findings provided evidence that defects in bone marrow MSCs of SAA children do exist. 相似文献
16.
F. Piarulli G. Sartore A. Ceriello E. Ragazzi R. Reitano L. Nollino C. Cosma D. Fedele A. Lapolla 《Diabetologia》2009,52(7):1419-1425
Aims/hypothesis This study examined the relationship, if any, between glucose-induced oxidative stress, antioxidant status and microalbuminuria
in patients with type 2 diabetes.
Methods The study involved 99 consecutive type 2 diabetic patients (57 men, 42 women). Patients with persistent microalbuminuria were
identified and the following variables evaluated: fasting plasma glucose, HbA1c, malonyldialdehyde (MDA), pentosidine, AGE, the total radical-trapping antioxidant parameter (TRAP), vitamin E, creatinine,
estimated GFR and lipid profile.
Results Patients were divided into two groups, i.e. 37 individuals without microalbuminuria (AER <20 μg/min) and 62 with microalbuminuria
(AER ≥20 μg/min). The following variables were significantly higher in patients with microalbuminuria than in those without
microalbuminuria (mean ± SD): fasting plasma glucose 9.41 ± 2.88 vs 8.19 ± 1.93 mmol/l, p < 0.05; HbA1c 7.97 ± 1.51 vs 7.39 ± 1.03%, p < 0.05; MDA 1.18 ± 0.35 vs 1.02 ± 0.29 μmol/l, p < 0.05; pentosidine 98.5 ± 24.6 vs 82.9 ± 20.9 pmol/ml, p < 0.005; and AGE 13.2 ± 4.8 vs 10.6 ± 3.8 μg/mg protein, p < 0.01. However, vitamin E and TRAP did not differ between the two groups. Serum creatinine values and estimated GFR were
similar in the two groups. Only in patients with microalbuminuria were significant linear correlations seen between AER and
both oxidation (HbA1c
r = 0.33, p < 0.01; MDA r = 0.59, p < 0.001; pentosidine r = 0.48, p < 0.001; and AGE r = 0.44, p < 0.001) and antioxidation variables (vitamin E r = −0.55, p < 0.001; TRAP r = −0.49, p < 0.001). Considering all variables together, multiple regression revealed a correlation between microalbuminuria and vitamin
E, TRAP, HbA1c and MDA, but not pentosidine or AGE.
Conclusions/interpretation Our data suggest that microalbuminuria in type 2 diabetic patients might be promoted by an insufficient counter-regulation
of the antioxidant system in the event of increased glyco-oxidation/glycation. 相似文献
17.
Risk factors for cardiovascular disease and endothelin-1 levels in Takayasu arteritis patients 总被引:1,自引:0,他引:1
Alexandre Wagner Silva de Souza Henrique Ataíde Mariz Edgard Torres Reis Neto Anne Elizabeth Diniz Arraes Neusa Pereira da Silva Emília Inoue Sato 《Clinical rheumatology》2009,28(4):379-383
The objective of this study was to evaluate traditional risk factors for cardiovascular disease (CVD) and endothelin-1 (ET-1)
levels in Takayasu arteritis (TA) patients. Twenty-two TA patients and 37 controls were evaluated. TA patients had a higher
prevalence of hypertension (63.6% vs. 21.6%, p = 0.001) and higher levels of triglycerides (129.5 mg/dL ± 70.8 vs. 88.4 mg/dL ± 60.8, p = 0.017) than controls. Mean number of CVD risk factors was 1.64 ± 1.22 in TA patients and 1.03 ± 1.44 among controls, p = 0.030. More TA patients presented at least one CVD risk factor when compared to controls (77.2% vs. 51.3%, p = 0.048). ET-1 levels were higher in patients than in controls (1.49 pg/mL ± 0.45 vs. 1.27 pg/mL ± 0.32, p = 0.034), however no significant difference was found between patients with active and inactive disease. In this study, TA
patients presented a higher prevalence of hypertension, higher levels of triglycerides, and ET-1 than controls. 相似文献
18.
Højberg PV Zander M Vilsbøll T Knop FK Krarup T Vølund A Holst JJ Madsbad S 《Diabetologia》2008,51(4):632-640
Aims/hypothesis The ability of glucagon-like peptide-1 (GLP-1) to enhance beta cell responsiveness to i.v. glucose is impaired in patients
with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near normalisation of
blood glucose (BG) improves the potentiation of glucose-stimulated insulin secretion by GLP-1.
Methods Nine obese patients with type 2 diabetes and inadequate glycaemic control (HbA1c 8.0 ± 0.4%) were investigated before and after 4 weeks of near normalisation of BG using insulin treatment (mean diurnal
blood glucose 6.4 ± 0.3 mmol/l, HbA1c 6.6 ± 0.3%). Nine matched healthy participants were also studied. Beta cell function was investigated before and after insulin
treatment using stepwise glucose infusions and infusion of saline or GLP-1 (1.0 pmol kg−1 min−1), resulting in supraphysiological total GLP-1 concentrations of approximately 200 pmol/l. The responsiveness to glucose or
glucose+GLP-1 was expressed as the slope of the linear regression line relating insulin secretion rate (ISR) and plasma glucose
concentration (pmol kg−1 min−1 [mmol/l]−1).
Results In the diabetic participants, the slopes during glucose+saline infusion did not differ before and after insulin treatment
(0.33 ± 0.07 and 0.39 ± 0.04, respectively; p = NS). In contrast, near normalisation of blood glucose improved beta cell sensitivity to glucose during glucose+GLP-1 infusion
(1.27 ± 0.2 before vs 1.73 ± 0.31 after; p < 0.01). In the healthy participants, the slopes during the glucose+saline and glucose+GLP-1 infusions were 1.01 ± 0.14 and
4.79 ± 0.53, respectively.
Conclusions/interpretation A supraphysiological dose of GLP-1 enhances beta cell responses to glucose in patients with type 2 diabetes, and 4 weeks of
near normalisation of blood glucose further improves this effect.
ClinicalTrials.gov ID no.: NCT00612625 相似文献
19.
《Modern rheumatology / the Japan Rheumatism Association》2013,23(6):943-947
Aim: The aim of this study was to analyze the effect of 18-week functional training (FT) program consisting in two sessions a week of in-water exercise and one of on-land exercise on pain, strength, and balance in women with fibromyalgia.Methods: A sample consisting of 36 fibromyalgia patients was included in the study. The patients were allocated randomly into the experimental group (EG, n = 20), and control group (CG, n = 16). Standardized field-based fitness tests were used to assess muscle strength (30-s chair stand and handgrip strength) and agility/dynamic balance and static balance. Fibromyalgia impact and pain were analyzed by Fibromyalgia Impact Questionnaire (FIQ), tender points (TPs), visual analog scale (VAS).Results: We observed a significant reduction in the FIQ (p = 0.042), the algometer scale of TP (p = 0.008), TP (p < 0.001), and VAS (p < 0.001) in the EG. The EG shows better results in leg strength (p < 0.001), handgrip strength (p = 0.025), agility/dynamic balance (p = 0.032) and balance (p = 0.006).Conclusions: An 18-week intervention consisting in two sessions of in-water exercise and one session of on-land exercise of FT reduces pain and improves functional capacity in FM patients. These results suggested that FT could play an important role in maintaining an independent lifestyle in patients with FM. 相似文献
20.
Kabitz HJ Sonntag F Walker D Schwoerer A Walterspacher S Kaufmann S Beuschlein F Seufert J Windisch W 《Diabetologia》2008,51(1):191-197
Aims/hypothesis Diabetes has a major negative effect on intensive care unit outcome. This has been partly attributed to impaired respiratory
neuromuscular function. However, data on respiratory neuromuscular involvement in diabetes are lacking. This study therefore
aimed to assess respiratory neuromuscular function related to diabetic polyneuropathy in patients with type 2 diabetes.
Methods Respiratory neuromuscular function was assessed by the use of volitional tests and twitch mouth (TwPmo) and twitch transdiaphragmatic
(TwPdi) pressures during non-volitional bilateral anterior magnetic phrenic nerve stimulation in 21 male type 2 diabetic patients
without pulmonary disease and in 23 healthy, well-matched controls (forced expiratory volume in 1 s 103 ± 11 vs 103 ± 12%
predicted; p = 0.9).
Results Both volitionally assessed maximal inspiratory and expiratory mouth pressures, and sniff nasal and transdiaphragmatic pressures
were comparable between diabetic patients and controls (p > 0.1 for all). TwPmo was reduced in diabetic patients compared with controls (1.3 ± 0.5 vs 1.0 ± 0.4 kPa; p = 0.04), while TwPdi was comparable (1.7 ± 0.5 vs 1.6 ± 0.7 kPa; p = 0.6). Following subgroup analysis, patients with no or mild polyneuropathy (n = 10) as assessed by neurological disability scoring had normal respiratory neuromuscular function, whereas patients with
moderate or severe polyneuropathy (n = 11) presented with markedly impaired respiratory neuromuscular function as indicated by TwPmo (1.3 ± 0.4 vs 0.8 ± 0.3 kPa;
p = 0.01) and TwPdi (1.9 ± 0.6 vs 1.1 ± 0.4 kPa; p < 0.01).
Conclusions/interpretation With regard to volitional tests, diabetes does not affect respiratory neuromuscular function. In contrast, the application
of non-volitional phrenic nerve stimulation provides strong evidence that diabetic polyneuropathy, as simply assessed by neurological
disability scoring, is associated with substantially impaired respiratory neuromuscular function in type 2 diabetic patients. 相似文献