口腔粘膜扁平苔藓危险因素的Logistic回归分析

目的：探讨引起口腔粘膜扁平苔藓的危险因素。方法：对口腔粘膜扁平苔藓危险因素作出相关性的分析。应用Logistic回归分析方法研究口腔粘膜扁平苔藓与发病因素之间的数量关系。结果：年龄，性别，胃炎，焦虑是口腔粘膜扁平苔藓发病的危险因素。口腔粘膜扁平苔藓的发病情况用Logistic回归分析计算结果的总判别率为95％。结论：年龄，性别，胃炎，焦虑是导致口腔扁平苔藓的危险因素。     

口腔粘膜扁平苔藓危险因素的Logistic回归分析

目的 :探讨引起口腔粘膜扁平苔藓的危险因素。方法 :对口腔粘膜扁平苔藓危险因素作出相关性的分析。应用Logistic回归分析方法研究口腔粘膜扁平苔藓与发病因素之间的数量关系。结果 :年龄、性别、胃炎、焦虑是口腔粘膜扁平苔藓发病的危险因素。口腔粘膜扁平苔藓的发病情况用Logistic回归分析计算结果的总判别率为95 %。结论 :年龄、性别、胃炎、焦虑是导致口腔扁平苔藓的危险因素。     

口腔鳞状细胞癌淋巴结转移危险因素的Logistic回归分析

目的选择常用的临床及病理指标,通过多因素分析,筛选出与口腔鳞癌淋巴结转移密切相关的指标,建立预测方程,为临床预测口腔鳞癌淋巴结转移提供参考。方法选择100例口腔鳞癌患者,记录性别、年龄、发病部位、T分期、N分期、病程等6个临床指标;选择肿瘤细胞浸润深度、浸润方式、淋巴细胞浸润程度、肿瘤的粘附力、基底膜的连续性、血管生成、肿瘤增殖等病理指标,进行Logistic逐步回归分析。结果浸润深度、平均血管密度、VEGF和E—CD染色阳性细胞率具有统计学意义。得出预测方程：P=exp（-6．5689＋1．5309XDEPTH＋3．8116XMVD＋2．8066XVEGF＋5．5917XE—CD）／1＋exp（-6．5689＋1．5309XDEPTH＋3．8116XMVD＋2．8066XVEGF＋5．5917XE—CD）。经回代分析,预测方程的准确性为95％。结论口腔鳞癌细胞的浸润深度、E-CD和VEGF的表达程度、肿瘤血管平均密度是与口腔鳞癌淋巴结转移密切相关的危险因素,通过预测方程得出的概率值可为手术方案的制定提供参考。     

前牙桩冠脱落危险因素的logistic回归分析

目的探讨前牙桩冠脱落的危险因素。方法对123位前牙桩冠修复患者（131颗患牙）进行病例-对照研究，并用单因素和多因素非条件logistic回归模型分析，探讨前牙桩冠修复脱落的危险因素。结果最终进入logistic回归模型的因素有深覆[牙合]、食物嵌塞、咬合习惯、牙列缺损未修复、患牙缺损达龈下，OR值分别为7．386、8．121、7．084、13．258和15．583。结论提示以上因素可能与桩冠修复脱落的发生有关，并且是其危险因素。     

儿童龋病发病现状及相关危险因素的Logistic回归分析

目的分析儿童龋病发病现状及相关危险因素Logistic回归分析。方法选择来我院体检以及就诊儿童为研究对象,采用问卷调查方式搜集儿童资料,分析儿童龋病发病现状和相关危险因素。结果共检查322例儿童,其中患龋病132例,总体患龋率为41.0%,上颌患龋率(29.5%)显著低于下颌患龋率(70.5%),P<0.05。龋病组患儿年龄、性别无统计学差异(P>0.05),嗜好甜食、睡前刷牙习惯以及刷牙频率等因素差异明显(P<0.05),Logistic回归分析显示嗜好甜食、口腔保健知识缺乏、刷牙时间过短是引起儿童龋病危险因素(P<0.05)。结论儿童患病水平较高,口腔卫生行为较差,建议定期组织小儿进行口腔检查,普及口腔保健教育。     

门诊患者根面龋危险因素的Logistic回归分析

目的：探讨引起门诊口腔患者根面龋的危险因素。方法：对根面龋危险因素作出相关性的分析。应用Logistic回归分析方法研究根面龋与危险因素之间的数量关系。结果：牙龈退缩、菌斑指数、放疗指数与年龄是根面龋产生的危险因素。根面龋的发病情况用Logistic回归分析计算结果判别的总正确率为93．24％。结论：牙龈退缩、口腔卫生、放疗与年龄是导致根面龋的危险因素。     

老年人牙齿楔状缺损危险因素的Logistic回归分析

目的：分析老年人牙齿楔状缺损的患病情况并探讨其相关因素。方法：采用分层随机抽样，对大连市631例60岁以上老年人，使用Smith和Knight牙齿磨损指数（TWI）进行楔状缺损患病情况的调查，数据应用SPSS13．0统计软件进行Logistic多因素回归分析。结果：该组人群楔状缺损患病率为86．67％，52例147颗患牙舌侧有不同程度的楔状缺损。年龄、牙龈退缩、近中错骀、咬合面磨损、偏侧咀嚼、横向刷牙方法，以及刷牙频率是该病形成和发展的危险因素。结论：老年人牙齿形成楔状缺损受多因素影响，其危险因素是年龄、牙龈退缩、近中错[牙合]、咬合面磨损、偏侧咀嚼、横向刷牙方法以及刷牙频率。     

2型糖尿病患者罹患口腔假丝酵母菌感染危险因素的Logistic回归分析

目的通过多因素分析,筛选出与2型糖尿病患者伴发口腔假丝酵母菌感染密切相关的指标,建立预测方程,分析2型糖尿病患者口腔假丝酵母菌感染的危险因素。方法选择140例2型糖尿病患者,记录性别,年龄,病程,吸烟史,空腹血糖值及系统并发症（包括肾病、神经病变和高血压）;并对患者进行口腔检查,记录口腔卫生状况、口腔黏膜情况及义齿修复情况。运用标准含漱浓缩法检测患者口腔假丝酵母菌的检出率和负载量,并采用CHROM agar显色培养基进行初步生物分型。应用Logistic回归分析方法研究2型糖尿病患者口腔假丝酵母菌感染与上述11项临床指标之间的关系。结果140例2型糖尿病患者中有69例检出口腔假丝酵母菌,检出率为49.3%,检出的假丝酵母菌菌种以白假丝酵母菌为主。以上述11项临床指标作为自变量,口腔假丝酵母菌感染发生与否作为因变量,进行Logistic回归分析,建立Logistic回归方程,方程的总判断率为82.1%。经回归分析,空腹血糖值、口腔卫生状况和黏膜干燥是2型糖尿病患者伴发口腔假丝酵母菌感染的危险因素。结论空腹血糖值、口腔卫生状况、黏膜干燥是2型糖尿病患者伴发口腔假丝酵母菌感染的危险因素;通过回归方程得出的概率值可为2型糖尿病患者口腔假丝酵母菌感染的预测及口腔护理保健提供参考。     

乳牙反相关危险因素的Logistic回归分析

目的通过对儿童乳牙反畸形各种可能致病因素的逐步回归分析,探讨引起乳牙反畸形的主要危险因素。方法对100例乳牙反畸形患儿和100例正常儿童做问卷调查,将结果用Logistic回归法分析,提取有效因素,研究乳牙反畸形与相关危险因素之间的关系。结果按其贡献大小,共有喂养方式、家族史及咬上唇三种危险因素进入方程。结论喂养方式、家族史及咬上唇是导致乳牙反畸形的主要危险因素。     

口腔扁平苔藓的精神发病因素与神经免疫的研究进展

口腔扁平苔藓(OLP)存在多种发病机制假说,其中精神因素发病机制认为,精神因素可以通过应激轴引起神经免疫反应导致OLP的发生,本文就对精神因素以及神经免疫与OLP的关系等研究进展作一综述。     

OLP糜烂症状急性发作相关危险因素调查

目的：探讨口腔扁平苔藓（OLP）患者及其糜烂症状急性发作发生的流行病学特征和临床特点。方法：对上海交通大学医学院附属第九人民医院口腔黏膜科就诊并随访存档的OLP病例档案进行回顾性分析研究,筛选影响OLP糜烂症状急性发作的相关因素。结果：通过对出现OLP糜烂症状急性发作病例的临床特征多因素Logistic回归分析,筛选出对糜烂发作最具影响的危险因素依次为：刺激性饮食、饮酒、吸烟、高血糖、精神因素、年龄。结论：OLP患者中有刺激性饮食习惯、吸烟习惯、饮酒习惯、情绪波动、血糖升高以及60岁以上老年患者易出现糜烂症状急性发作。     

Psychological profile in oral lichen planus

AIM: Oral lichen planus (OLP) is an oral lesion with an enigmatic etiology. To explore the possibility of psycho-somatization, we evaluated the psychological personality profiles of OLP patients. METHODS: Twenty patients with reticular; 20 with erosive form of OLP, and 25 controls were tested with the psychological Minnesota Multiphasic Personality Inventory (MMPI)-202 test. Eight clinical scales (hypochondriasis, depression, hysteria, psychopathic deviate, paranoia, psychasthenia, schizophrenia, and hypomania) as well as cortisol level, CD3, CD4, CD8, and CD16 markers by group were compared. Psychosomatization was evaluated by the use of internalization ratio (IR) Index. RESULTS: A characteristic MMPI profile was noted in the OLP groups with high IR index value. Significant differences among the groups were detected for cortisol, CD4, CD8, and CD16 counts. Mean values for hypochondriasis, depression, and hysteria were all significantly different with significantly higher mean scores for both reticular and erosive OLP subjects compared with controls. CONCLUSIONS: Prolonged emotive stress in many OLP patients may lead to psychosomatization and may contribute to the initiation and clinical expression of this oral disorder. Clinical significance: If additional research involving a larger and more diverse sample of patients confirms these findings, clinical trials will be needed to determine whether adjunctive psychological intervention provides a benefit in treating patients with OLP.     

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口腔扁平苔藓(orallichenplanus,OLP)是一种累及口腔黏膜且可反复发作的慢性炎症疾病,患病率为0.51%,在口腔黏膜疾病中居第2位,属常见病。皮肤和黏膜可单独或同时发病,病理表现相似:主要以口腔黏膜不同程度的角化异常、基底层细胞液化变性、上皮下结缔组织中淋巴细胞呈带状浸润为典型表现。     

OSF并存OLP34例回顾性分析

目的：总结口腔黏膜下纤维性变（OSF）并存口腔扁平苔藓（OLP）的临床特征,提高对该病的诊断和治疗水平。方法：对34例OSF并存OLP患者的临床资料进行回顾性分析。结果：34例OSF并存OLP患者表现为青壮年男性居多,均有进食刺激性食物和咀嚼槟榔史,29例（85.29%）有吸烟史,27例（79.41%）有饮酒史,28例（82.35%）OSF的病理分期为早期,6例（17.65%）为中期,发病部位以颊部和舌部为主,所有患者均无糜烂和张口受限,治疗后疼痛症状缓解,但白色条纹或斑点始终未消退,已消失的丝状乳头、菌状乳头亦未见恢复。结论：OSF并存OLP并非两种疾病的简单叠加,而是具有其特异性的表现,必要时可行两个典型部位活检进行诊断,治疗中及治疗后须戒烟、戒槟榔。     

Th1 cytokines in oral lichen planus

BACKGROUND: Cell-mediated immune responses in oral lichen planus (OLP) may be regulated by cytokines and their receptors. METHODS: In situ cytokine expression and in vitro cytokine secretion in OLP were determined by immunohistochemistry and ELISA. RESULTS: The majority of subepithelial and intraepithelial mononuclear cells in OLP were CD8+. In some cases, intraepithelial CD8+ cells were adjacent to degenerating keratinocytes. CD4+ cells were observed mainly in the deep lamina propria with occasional CD4+ cells close to basal keratinocytes. Mononuclear cells expressed IFN-gamma in the superficial lamina propria and TNF-alpha adjacent to basal keratinocytes. Basal keratinocytes expressed TNF-alpha as a continuous band. TNF R1 was expressed by mononuclear cells and basal and suprabasal keratinocytes. There was variable expression of TGF-beta1 in the subepithelial infiltrate while all intraepithelial mononuclear cells were TGF-beta1-. Keratinocytes in OLP stained weakly for TGF-beta1. Unstimulated OLP lesional T cells secreted IFN-gamma in vitro. TNF-alpha stimulation down-regulated IFN-gamma secretion and up-regulated TNF-alpha secretion. IL-4, IL-10 and TGF-beta1 secretion were not detected. CONCLUSIONS: These data suggest the development of a T helper 1 immune response that may promote CD8+ cytotoxic T-cell activity in OLP.     

Pathogenesis of oral lichen planus – a review

J Oral Pathol Med (2010) 39 : 729–734 Oral lichen planus (OLP) is a T‐cell‐mediated chronic inflammatory oral mucosal disease of unknown etiology. OLP presents as white striations, white papules, white plaques, erythema, erosions, or blisters affecting predominantly the buccal mucosa, tongue and gingiva. Both antigen‐specific and non‐specific mechanisms are hypothesized to be involved in the pathogenesis of oral lichen planus (OLP). Antigen‐specific mechanisms in OLP include antigen presentation by basal keratinocytes and antigen‐specific keratinocyte killing by CD8⁺ cytotoxic T cells. Non‐specific mechanisms include mast cell degranulation and matrix metalloproteinase activation in OLP lesions. These mechanisms may combine to cause T cell accumulation in the superficial lamina propria, basement membrane disruption, intra‐epithelial T cell migration and keratinocyte apoptosis in OLP. The various hypotheses proposed for pathogenesis of oral lichen planus are discussed in this review.     

Immunohistochemical study of oral keratoses including lichen planus

Biopsies of non-ulcerated oral mucosa from 13 patients with oral lichen planus and 12 patients with leukoplakia were immunohistochemically stained using monoclonal antibodies to pan T, pan B, T helper and T suppressor/cytotoxic cells and the stained lymphocytes enumerated using an image analyser. The results show the preponderance of T cells infiltrating both oral lichen planus and leukoplakia. The T helper: T suppressor/cytotoxic cell ratio was the same (1:2) for both oral lichen planus and leukoplakia. A similar proportion of T suppressor/cytotoxic cells was found infiltrating the epithelium. These data indicate that T cell subset analysis is of no value in distinguishing oral lichen planus from other oral keratoses.     

The frequency of Candida in oral lichen planus

ABSTRACT – Histologic material of typical lichen planus lesions from 43 patients was studied. Two sections of each specimen were stained with hematoxylin-eosin and 10 sections by the PAS method. Only 1 of 43 biopsies was invaded by Candida, and hyphae were present in all of the 10 PAS-stained sections of this case. The results show that oral lichen planus has a considerably lesser susceptibility than oral leukoplakia to invasion by Candida albicans.