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1.
18-fluorodeoxyglucose positron emission tomography in predicting survival of patients with pancreatic carcinoma 总被引:8,自引:0,他引:8
The prediction of survival of patients with pancreatic cancer is usually based on tumor staging and grading and on the level
of tumor markers. However, accurate tumor staging can be obtained only after resection, and still there is a great difference
in survival rates among patients with the same clinicopathologic parameters. Recently the uptake of 18-fluorodeoxyglucose
(FDG) by positron emission tomography (PET) has been found to be correlated with survival in patients with pancreatic cancer.
This study evaluated the role of 18FDG PET as a prognostic factor for patients with pancreatic cancer. From June 1996 to July 2002, a total of 118 patients underwent
PET for pancreatic cancer. The standardized uptake value (SUV) of 18FDG was calculated in 60 of them, and these patients were divided into high (>4) and low (≦4) SUV groups. They were also evaluated
according to the tumor node metastasis (TNM) classification system of the International Union Against Cancer, and by tumor
grade, medical or surgical treatment, diabetes, age, sex, and CA19-9 serum levels. Twenty-nine cancers showed high and 31
showed low SUVs. Survival was significantly influenced by tumor stage (P = 0.0001), tumor grade (P = 0.01), and SUV (P = 0.005). Multivariate analysis showed that only stage (P = 0.001) and SUV (P = 0.0002)were independent predictors of survival. When patients who were analyzed for SUV were stratified according to the
other variables, FDG uptake was related to survival also after stratification for the following: stage III to IVa (P = 0.002), stage IVb (P = 0.01), tumor resection (P = 0.006), moderately differentiated tumors (P = 0.01), age less than 65 years (P = 0.006), CA 19–9 levels greater than 300 kU/L (P = 0.002), and absence of diabetes (P = 0.0001). The SUV calculated with 18FDG PET is an important prognostic factor for patients with pancreatic cancer and may be useful in selecting patients for
therapeutic management.
Presented at the Forty-Fourth Annual Meeting of The Society for Surgery of the Alimentary Tract, Orlando, Florida, May 17–22,
2003 (oral presentation); and the Sixth National Congress of the Italian Association of Nuclear Medicine, Genoa, Italy, November
15–19, 2002. 相似文献
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Positron emission tomography (PET) is a functional imaging modality that has made the transition from the research enviroment to the clinical enviroment over the last 10 years. Its major role is in the field of oncology where it is being used increasingly in the management of several tumour types including colorectal cancer. This review aims to outline the current and future role of PET scanning in the field of colorectal cancer. 相似文献
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Zhongyi Yang Lingling Pan Jingyi Cheng Silong Hu Junyan Xu Dingwei Ye Yingjian Zhang 《International journal of urology》2012,19(7):639-644
Objectives: To investigate the value of whole‐body fluorine‐18 2‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography/computed tomography for the detection of metastatic bladder cancer. Methods: From December 2006 to August 2010, 60 bladder cancer patients (median age 60.5 years old, range 32–96) underwent whole body positron emission tomography/computed tomography positron emission tomography/computed tomography. The diagnostic accuracy was assessed by performing both organ‐based and patient‐based analyses. Identified lesions were further studied by biopsy or clinically followed for at least 6 months. Results: One hundred and thirty‐four suspicious lesions were identified. Among them, 4 primary cancers (2 pancreatic cancers, 1 colonic and 1 nasopharyngeal cancer) were incidentally detected, and the patients could be treated on time. For the remaining 130 lesions, positron emission tomography/computed tomography detected 118 true positive lesions (sensitivity = 95.9%). On the patient‐based analysis, the overall sensitivity and specificity resulted to be 87.1% and 89.7%, respectively. There was no difference of sensitivity and specificity in patients with or without adjuvant treatment in terms of detection of metastatic sites by positron emission tomography/computed tomography. Compared with conventional imaging modality, positron emission tomography/computed tomography correctly changed the management in 15 patients (25.0%). Conclusions: Positron emission tomography/computed tomography has excellent sensitivity and specificity in the detection of metastatic bladder cancer and it provides additional diagnostic information compared to standard imaging techniques. 相似文献
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Youpei Lin Huanhuan Chong Guohe Song Chenhao Zhang Liangqing Dong Ling Aye Fei Liang Shuaixi Yang Mengsu Zeng Guangyu Ding Shu Zhang Jieyi Shi Aiwu Ke Xiaoying Wang Jian Zhou Jia Fan Qiang Gao 《肝胆外科与营养》2022,11(5):684
BackgroundIntrahepatic cholangiocarcinoma (ICC) is a highly metastatic cancer. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) enables sensitive tumor and metastasis detection. Our aim is to evaluate the influence of pre-treatment PET/CT on the N- and M-staging and subsequent clinical management in ICC patients.MethodsBetween August 2010 and August 2018, 660 consecutive ICC patients, without prior anti-tumor treatments nor other malignancies, were enrolled. The diagnostic performance of PET/CT on the N- and M-staging was compared with conventional imaging, and the preoperative staging accuracy and treatment re-allocation by PET/CT were retrospectively calculated. Survival difference was compared between patients receiving PET/CT or not after propensity score matching.ResultsPatients were divided into group A (n=291) and group B (n=369) according to whether PET/CT was performed. Among 291 patients with both PET/CT and conventional imaging for staging in group A, PET/CT showed significantly higher sensitivity (83.0% vs. 70.5%, P=0.001), specificity (88.3% vs. 74.9%, P<0.001) and accuracy (86.3% vs. 73.2%, P<0.001) than conventional imaging in diagnosing regional lymph node metastasis, as well as higher sensitivity (87.8% vs. 67.6%, P<0.001) and accuracy (93.5% vs. 89.3%, P=0.023) in diagnosing distant metastasis. Overall, PET/CT improved the accuracy of preoperative staging from 60.1% to 71.8% (P<0.001), and modified clinical treatment strategy in 5.8% (17/291) of ICC patients, with unique roles in different tumor-node-metastasis (TNM) stages. High tumor-to-non-tumor ratio (TNR) predicted poor overall survival [hazard ratio (HR) = 2.17; 95% confidence interval (CI): 1.49–3.15; P<0.001]. Furthermore, patients performing PET/CT had longer overall survival compared with those without PET/CT (HR =0.74; 95% CI: 0.58–0.93; P=0.011) after propensity score matching.ConclusionsPET/CT was valuable for diagnosing regional lymph node metastasis and distant metastasis in ICC patients, and facilitated accurate tumor staging and optimal treatment allocation. 相似文献
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The value of FDG positron emission tomography in the management of patients with breast cancer 总被引:2,自引:0,他引:2
Increasing experience with positron emission tomography (PET) scanning in breast cancer patients is revealing a significant role for this imaging modality. This report summarizes the experience of 2-[F18]fluoro-2-deoxy-D-glucose (FDG) PET scanning in 165 breast cancer patients from the BC Cancer Agency, British Columbia, Canada, and reviews the literature on this topic. Using the database at PETSCAN Vancouver, we identified imaged patients with a diagnosis of breast cancer. We then conducted a retrospective review of these patients' BC Cancer Agency charts to extract demographic and follow-up information. Between November 2000 and March 2003 we identified 165 patients with histologically confirmed breast cancer who had undergone PET scanning, were registered at the BC Cancer Agency, and had follow-up information. The median patient age was 52 years. The sensitivity of PET in detecting axillary metastases was 28%, and the specificity was 86%. At diagnosis, 5% of patients were diagnosed with distant metastases. In patients undergoing PET scanning because of suspected recurrence, the sensitivity and specificity for detecting recurrence were 89% and 88%, respectively. Distant metastases were demonstrated in 30% of patients who were thought only to have local-regional recurrence. The results suggest that there are two clinical situations in which PET appears to be particularly valuable. The first is in the evaluation of patients who are suspected of having a tumor recurrence. The other is in identifying patients with multifocal or distant sites of malignancy who otherwise appear to have an isolated, potentially curable, local-regional recurrence. 相似文献
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Berg WA Weinberg IN Narayanan D Lobrano ME Ross E Amodei L Tafra L Adler LP Uddo J Stein W Levine EA;Positron Emission Mammography Working Group 《The breast journal》2006,12(4):309-323
We sought to prospectively assess the diagnostic performance of a high-resolution positron emission tomography (PET) scanner using mild breast compression (positron emission mammography [PEM]). Data were collected on concomitant medical conditions to assess potential confounding factors. At four centers, 94 consecutive women with known breast cancer or suspicious breast lesions received 18F-fluorodeoxyglucose (FDG) intravenously, followed by PEM scans. Readers were provided clinical histories and x-ray mammograms (when available). After excluding inevaluable cases and two cases of lymphoma, PEM readings were correlated with histopathology for 92 lesions in 77 women: 77 index lesions (42 malignant), 3 ipsilateral lesions (3 malignant), and 12 contralateral lesions (3 malignant). Of 48 cancers, 16 (33%) were clinically evident; 11 (23%) were ductal carcinoma in situ (DCIS), and 37 (77%) were invasive (30 ductal, 4 lobular, and 3 mixed; median size 21 mm). PEM depicted 10 of 11 (91%) DCIS and 33 of 37 (89%) invasive cancers. PEM was positive in 1 of 2 T1a tumors, 4 of 6 T1b tumors, 7 of 7 T1c tumors, and 4 of 4 cases where tumor size was not available (e.g., no surgical follow-up). PEM sensitivity for detecting cancer was 90%, specificity 86%, positive predictive value (PPV) 88%, negative predictive value (NPV) 88%, accuracy 88%, and area under the receiver-operating characteristic curve (Az) 0.918. In three patients, cancer foci were identified only on PEM, significantly changing patient management. Excluding eight diabetic subjects and eight subjects whose lesions were characterized as clearly benign with conventional imaging, PEM sensitivity was 91%, specificity 93%, PPV 95%, NPV 88%, accuracy 92%, and Az 0.949 when interpreted with mammographic and clinical findings. FDG PEM has high diagnostic accuracy for breast lesions, including DCIS. 相似文献
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Contribution of 18F-fluorodeoxyglucose positron emission tomography to the diagnosis of early pancreatic carcinoma 总被引:1,自引:0,他引:1
Seo S Doi R Machimoto T Kami K Masui T Hatano E Ogawa K Higashi T Uemoto S 《Journal of Hepato-Biliary-Pancreatic Surgery》2008,15(6):634-639
Background/Purpose Pancreatic carcinoma has a poor prognosis, and early detection is essential to allow potentially curative resection. Despite
the wide array of diagnostic tools available, the detection of small pancreatic tumors remains difficult. The aim of this
study was to investigate the contribution of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to the diagnosis of early pancreatic cancer.
Methods FDG-PET was performed in 56 patients with pancreatic cancer who underwent curative surgery. The standardized uptake value
(SUV) for FDG was calculated in each patient and the relationships between the SUV and various clinicopathological factors
were analyzed.
Results The tumors ranged from 0.8 to 6.5 cm in diameter. When the cutoff value for the SUV was set at 2.5, 51 of the 56 patients
(91%) had a positive FDG-PET study. The SUV did not show a significant difference in relation to tumor differentiation or
pTS and pT factors. There was also no correlation between the SUV and the maximum tumor diameter (r = 0.22; P = 0.1). Five tumors had an SUV below the cutoff value, and all of these lesions had intermediate or scirrhous stroma rather
than medullary stroma.
Conclusions These results indicate that FDG-PET is useful for the detection of small early pancreatic cancers. 相似文献
13.
Local resectability assessment of head and neck cancer: Positron emission tomography/MRI versus positron emission tomography/CT
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Tetsuro Sekine MD PhD Felipe de Galiza Barbosa MD Gaspar Delso PhD Irene A. Burger MD Paul Stolzmann MD Edwin E. ter Voert MS Gerhard F. Huber MD Spyros S. Kollias MD Gustav K. von Schulthess MD PhD Patrick Veit‐Haibach MD Martin W. Huellner MD 《Head & neck》2017,39(8):1550-1558
14.
Summary Positron emission tomography (PET) uses the shortlived positron-emitting radioisotopes of elements such as oxygen, nitrogen, and carbon as tracers both to image and to measure, non-invasively, normal regional tissue physiology and pathophysiology in man. This technique has been used to study the pathophysiology of brain tumours at the time they present and after therapeutic intervention. 相似文献
15.
F-18-fluorodeoxyglucose positron emission tomography in differentiating malignant from benign pancreatic cysts: A prospective study 总被引:5,自引:0,他引:5
Cosimo?Sperti Claudio?Pasquali Giandomenico?Decet Franca?Chierichetti Guido?Liessi Sergio?Pedrazzoli
The differential diagnosis between benign and malignant pancreatic cystic lesions may be very difficult. We recently found
that F-18-.uorodeoxyglucose positron emission tomography (18-FDG PET) was useful for the preoperative work-up of pancreatic
cystic lesions. This study was undertaken to confirm these results. From February 2000 to July 2003, 50 patients with a pancreatic
cystic lesion were prospectively investigated with 18-FDG PET in addition to helical computed tomography (CT) and, in some
instances, magnetic resonance imaging (MRI). The validation of diagnosis was based on pathologic findings after surgery (n
= 31), percutaneous biopsy (n = 4), and according to follow-up in 15 patients. The 18-FDG PET was analyzed visually and semiquantitatively
using the standard uptake value (SUV). The accuracy of FDG PET and CT was determined for preoperative diagnosis of malignant
cystic lesions. Seventeen patients had malignant cystic lesions. Sixteen (94%) showed increased 18-FDG uptake (SUV >2.5),
including two patients with carcinoma in situ. Eleven patients (65%) were correctly identified as having malignancy by CT.
Thirty-three patients had benign tumors: two patients showed increased 18-FDG uptake, and four patients showed CT findings
of malignancy. Sensitivity, specificity, positive and negative predictive value, and accuracy of 18-FDG PET and CT in detecting
malignant tumors were 94%, 94%, 89%, 97%, and 94% and 65%, 88%, 73%, 83%, and 80%, respectively. 18-FDG PET is accurate in
identifying malignant pancreatic cystic lesions and should be used in combination with CT in the preoperative evaluation of
patients with pancreatic cystic lesions. A negative result with 18-FDG PET may avoid unnecessary operation in asymptomatic
or high-risk patients.
Presented at the Forty-Fifth Annual Meeting of The Society for Surgery of the Alimentary Tract, New Orleans, Louisiana, May
15–19, 2004 (oral presentation).
This study was supported by the Ministero Università e Ricerca Scientifica (Cofin 2001068593-001), Rome, Italy. 相似文献
16.
[目的]比较18F-FDG PET/CT与传统影像检查(胸片、彩超、CT及MRI等)为骨转移瘤患者寻找原发灶的临床价值.[方法]回顾性分析37例于2008年5月~2010年6月间本中心收治的经病理证实的骨转移瘤患者的病例资料,并随访其后续的诊治情况.以病理结果或临床随访作为原发灶确认标准.并将PET/CT与传统影像检查对原发灶的检出情况进行比较.且对治疗方案的调整进行汇总.[结果]37例患者中,PET/CT提示原发灶28例,其中正确检出原发灶27例(73%),1例为假阳性;传统影像检查正确检出原发灶17例(46%),两者原发灶正确检出率的差异有显著性(x2=5.61,P=0.018).27例经PET/CT正确检出原发灶的病例中,17例(63%)采取了针对原发灶的治疗措施.此外9例PET/CT未提示原发灶的患者中,3例经病理证实为假阴性.[结论]与传统影像检查相比,18F-FDG PET/CT可更有效、更便捷的找出骨转移瘤患者原发灶,进而为制定更合理的治疗方案提供依据. 相似文献
17.
Allen TL Kendi AT Mitiek MO Maddaus MA 《Seminars in thoracic and cardiovascular surgery》2011,23(1):43-50
We present the current optimal uses and limitations of positron emission tomography/computed tomography (PET/CT) as it relates to the diagnosis and staging of non-small cell lung cancer (NSCLC). PET/CT demonstrates increased accuracy in the workup of solitary pulmonary nodules for malignancy compared with CT alone, and we discuss its benefits and limitations. We review pitfalls in measured standardized uptake values of lung lesions caused by respiratory artifacts, the lower sensitivity for detection of small lung nodules on non-breath-hold CT, and the benefits of obtaining an additional diagnostic CT for the maximum sensitivity of lung nodule detection. There are limitations of quantitatively comparing separate PET/CT examinations from different facilities with standardized uptake values. As for staging, we describe how PET/CT supplements clinical tumor-nodes-metastases (ie, TNM) staging, as well as mediastinoscopy, endobronchial ultrasound, and endoscopic ultrasound, which are the gold standard pathologic staging methods. We touch on the 7th edition TNM staging system based on the work by the International Association for the Study of Lung Cancer, an anatomically based staging method. 相似文献
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Prognostic implication of fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography in patients with recurrent papillary thyroid cancer
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Ji‐Hun Kang MD Da‐Woon Jung MD Kyoung‐June Pak MD In‐Ju Kim MD PhD Hak‐Jin Kim MD PhD Jae‐Keun Cho MD Sung‐Chan Shin MD Soo‐Geun Wang MD PhD Byung‐Joo Lee MD PhD 《Head & neck》2018,40(1):94-102
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Fluorodeoxyglucose positron emission tomography integrated with computed tomography to determine resectability of primary lung cancer 总被引:1,自引:0,他引:1
Nakamura H Taguchi M Kitamura H Nishikawa J 《General thoracic and cardiovascular surgery》2008,56(8):404-409
PURPOSE: Fluorodeoxyglucose positron emission tomography integrated with computed tomography (FDGPET/CT) was evaluated as a routine staging technique for primary lung cancer. MATERIALS AND METHODS: We prospectively compared FDG-PET/CT in determining clinical stage and surgical indication with conventional staging not including positron emission tomography (PET). A total of 50 consecutive patients diagnosed with primary lung cancer by cytological or histological examination were studied; 20 of them underwent surgery. RESULTS: Discrepancies between the two staging methods were observed in 14 patients (28%). The stage assigned by PET increased in 12 cases (24%) and decreased in 2 (4%). PET staging was accurate in eight cases with otherwise undetected distant metastases (M1) but was incorrect in six cases, including five where it overdiagnosed nodal metastases (N). Two clinical N3 patients (4%) would have missed a chance of surgery if the surgical indication had been determined by PET staging alone. According to our criteria for surgery, other patients were assigned correctly to surgery by PET staging. The maximum standard uptake value (maxSUV) of all primary lesions ranged from 0 to 23.0 (mean +/- SD, 8.0 +/- 4.4). The mean maxSUV among surgical cases (5.8 +/- 3.6) was significantly smaller than among nonsurgical cases (9.5 +/- 4.2) (P < 0.05). CONCLUSION: Staging examination including FDG-PET/CT and brain magnetic resonance imaging ordinarily can determine the clinical stage and resectability of primary lung cancer. False-positive findings in regional lymph nodes, possibly reflecting past infectious disease, are the most important remaining problem. 相似文献
20.
Lawrentschuk N Poon AM Foo SS Putra LG Murone C Davis ID Bolton DM Scott AM 《BJU international》2005,96(4):540-546
OBJECTIVE: To assess renal tumours for hypoxic regions using 18F-fluoromisonidazole (18F-FMISO) positron emission tomography (PET), a recognized noninvasive method for detecting hypoxia in tumours, as renal cell carcinoma (RCC) can be potentially cured with nephrectomy but recurrence develops in most patients, who then respond poorly to treatments such as chemotherapy, and hypoxia is known to confer resistance to radiotherapy and chemotherapy in many solid tumours. PATIENTS AND METHODS: In all, 17 patients had 18F-FMISO PET scans before nephrectomy for presumed RCC. Specimens were examined histologically, and immunohistochemistry was used to compare the microvessel density (MVD) as an indicator of angiogenesis in the tumour and normal parenchyma, in 15 patients. Tumour oxygenation was measured invasively in three patients using a polarographic oxygen sensor probe. RESULTS: Of the 15 patients with histological results, 11 had RCC and four had other tumours. Although there was a trend there was no statistically significant (P = 0.14) difference in the maximum standardized uptake value (SUV(max)) when comparing the region of the kidney involved with RCC; the mean (95% confidence interval) SUV(max) in the tumours was 1.3 (0.15), whilst that in the normal contralateral kidney was 1.1 (0.22). The MVD was greater in RCC, at 13.7 (3.1) mean vessels per high-power field than in normal tissue, at 6.9 (1.9). Hypoxia as measured polarographically was detected in three RCCs (median pO2 9.6 mmHg) compared to normal parenchyma at 37.6 mmHg. CONCLUSIONS: Although 18F-FMISO scans showed significant uptake in other solid tumours, there was only mild 18F-FMISO uptake in the present RCCs. The invasive measurements indicated that there was hypoxia in RCC, but the median pO2 did not fall below 9.5 mmHg. Further direct studies of renal tumour oxygenation combined with therapies directed towards hypoxia may allow a better understanding of the relationship between 18F-FMISO results and the biological significance of hypoxia in RCC. 相似文献