共查询到20条相似文献,搜索用时 46 毫秒
1.
Macgowan CK Kellenberger CJ Detsky JS Roman K Yoo SJ 《Journal of magnetic resonance imaging : JMRI》2005,21(3):297-304
PURPOSE: To compare in vivo real-time Fourier velocity encoding (FVE), spectral-Doppler ultrasound, and phase-contrast (PC) magnetic-resonance (MR) imaging. MATERIALS AND METHODS: In vivo velocity spectra were measured in the suprarenal and infrarenal aorta and the hepatic segment of the inferior vena cava of eight normal volunteers using FVE, and compared to similar measurements using Doppler ultrasound and gated PC MR imaging. In vivo waveforms were compared qualitatively according to flow pattern appearance (number, shape, and position of velocity peaks) and quantitatively according to peak velocity. RESULTS: Good agreement was obtained between peak velocities measured in vitro using FVE and PC MR imaging (R(2) = 0.99, P = 2.10(-6), slope = 0.97 +/- 0.05). Qualitatively, the FVE and ultrasound measurements agreed closely in the majority of in vivo cases (excellent or good in 21/24 cases) while the PC MR method resolved fewer velocity peaks due to the inherent temporal averaging of cardiac-gated studies (excellent or good agreement with FVE in 13/24 cases). Quantitatively, the FVE measurement of peak velocity correlated strongly with both ultrasound (R(2) = 0.71, P = 2.10(-7), slope = 0.81 +/- 0.08) and PC MR (R(2) = 0.85, P = 2.10(-10), slope = 1.04 +/- 0.08). CONCLUSION: Real-time MR assessment of blood-flow velocity correlated well with spectral Doppler ultrasound. Such new methods may allow hemodynamic information to be acquired in vessels inaccessible to ultrasound or in patients for whom respiratory compensation is not possible. 相似文献
2.
The study was approved by the local ethical committees, and informed consent from each participant was obtained. The purpose of the study was to compare accelerated magnetic resonance (MR) Fourier velocity encoding (FVE), MR phase-contrast velocity mapping, and echocardiography with respect to peak velocity determination in vascular or valvular stenoses. FVE data collection was accelerated by using the k-space and time sensitivity encoding, or k-t SENSE, technique. Peak velocities were evaluated in five healthy volunteers (one woman, four men; mean age, 28 years; range, 23-34 years), three patients with stenotic aortic valves (two women, one man; mean age, 67 years; range, 39-82 years), two patients with pulmonary valvular stenosis (a 14-year-old girl and a 36-year-old man), and two patients with aortic stenosis (two women aged 18 and 27 years). In volunteers, peak velocity determined by the different methods agreed well. In patients, similar peak velocities were obtained by using accelerated MR FVE and echocardiography, while phase-contrast MR imaging results tended to underestimate these values. 相似文献
3.
Lin HY Bender JA Ding Y Chung YC Hinton AM Pennell ML Whitehead KK Raman SV Simonetti OP 《Magnetic resonance in medicine》2012,68(3):703-710
Phase-contrast magnetic resonance imaging (PC-MRI) is used routinely to measure fluid and tissue velocity with a variety of clinical applications. Phase-contrast magnetic resonance imaging methods require acquisition of additional data to enable phase difference reconstruction, making real-time imaging problematic. Shared Velocity Encoding (SVE), a method devised to improve the effective temporal resolution of phase-contrast magnetic resonance imaging, was implemented in a real-time pulse sequence with segmented echo planar readout. The effect of SVE on peak velocity measurement was investigated in computer simulation, and peak velocities and total flow were measured in a flow phantom and in volunteers and compared with a conventional ECG-triggered, segmented k-space phase-contrast sequence as a reference standard. Computer simulation showed a 36% reduction in peak velocity error from 8.8 to 5.6% with SVE. A similar reduction of 40% in peak velocity error was shown in a pulsatile flow phantom. In the phantom and volunteers, volume flow did not differ significantly when measured with or without SVE. Peak velocity measurements made in the volunteers using SVE showed a higher concordance correlation (0.96) with the reference standard than non-SVE (0.87). The improvement in effective temporal resolution with SVE reconstruction has a positive impact on the precision and accuracy of real-time phase-contrast magnetic resonance imaging peak velocity measurements. 相似文献
4.
Julie C DiCarlo Brian A Hargreaves Krishna S Nayak Bob S Hu John M Pauly Dwight G Nishimura 《Magnetic resonance in medicine》2005,54(3):645-655
In areas of highly pulsatile and turbulent flow, real-time imaging with high temporal, spatial, and velocity resolution is essential. The use of 1D Fourier velocity encoding (FVE) was previously demonstrated for velocity measurement in real time, with fewer effects resulting from off-resonance. The application of variable-density sampling is proposed to improve velocity measurement without a significant increase in readout time or the addition of aliasing artifacts. Two sequence comparisons are presented to improve velocity resolution or increase the velocity field of view (FOV) to unambiguously measure velocities up to 5 m/s without aliasing. The results from a tube flow phantom, a stenosis phantom, and healthy volunteers are presented, along with a comparison of measurements using Doppler ultrasound (US). The studies confirm that variable-density acquisition of kz-kv space improves the velocity resolution and FOV of such data, with the greatest impact on the improvement of FOV to include velocities in stenotic ranges. 相似文献
5.
Three-directional myocardial phase-contrast tissue velocity MR imaging with navigator-echo gating: in vivo and in vitro study 总被引:1,自引:0,他引:1
The study protocol was HIPAA compliant and institutional review board approved. Informed consent was obtained from all participants. The purpose of the study was to prospectively validate the capability of navigator-echo-gated phase-contrast magnetic resonance (MR) imaging for measurement of myocardial velocities in a phantom and to prospectively use the phase-contrast MR sequence to measure three-directional velocity in the myocardium in vivo in volunteers and in patients scheduled for cardiac resynchronization therapy. An excellent correlation between the measured velocity and the true phantom motion (R = 0.90 for longitudinal velocity, R = 0.93 for circumferential velocity) was observed. Myocardial velocities were successfully measured in 17 healthy volunteers (11 male, six female; mean age, 27.5 years +/- 6.5 [standard deviation]) and 28 patients with heart failure (18 male, 10 female; mean age, 63.9 years +/- 15.0). Velocity values were significantly lower in the patients than in the volunteers. The time to peak velocity in the lateral wall of the patients, as compared with that in the volunteers, was delayed. Phase-contrast MR imaging can be combined with navigator-echo gating to measure three-directional myocardial tissue velocities in vivo. 相似文献
6.
Seitz J Strotzer M Wild T Nitz WR Völk M Lenhart M Feuerbach S 《Investigative radiology》2001,36(11):642-647
RATIONALE AND OBJECTIVES: To compare blood flow velocities in the carotid arteries measured with three different magnetic resonance (MR) phase-contrast imaging techniques and with percutaneous Doppler ultrasound. METHODS: Fourteen healthy male volunteers with a mean age of 33 +/- 3.8 years were studied. Ultrasound and MR phase velocity mapping of both common carotid arteries (n = 28) was performed within 5 hours. A two-dimensional fast low-angle shot sequence with retrospective cardiac gating, a sequence with prospective cardiac triggering, and a breath-hold sequence with prospective cardiac triggering were used. Resistance indexes and pulsatility indexes were calculated for all modalities. RESULTS: The comparison of flow velocities obtained with ultrasound and the different MR techniques led to a moderate correlation of the retrospective gated and prospective triggered MR techniques (eg, r = 0.73 for maximum systolic velocity). The worst correlation was found between the breath-hold technique and retrospective cardiac gating (eg, r = 0.004 for pulsatility index). There was a weak correlation of all three MR sequences compared with ultrasound (r = 0.19-0.60) CONCLUSIONS: A moderate correlation was found between velocities and indexes measured with the prospective cardiac-triggered phase-contrast MR technique and the retrospective cardiac-gated phase-contrast MR technique. A weak correlation was found between the three different MR techniques and ultrasound, as well as between the breath-hold prospective cardiac-triggered MR sequence and both of the other MR sequences. The influence of temporal and spatial resolution on MR phase-contrast velocity mapping was confirmed. 相似文献
7.
Right and left lung perfusion: in vitro and in vivo validation with oblique-angle, velocity-encoded cine MR imaging 总被引:6,自引:0,他引:6
G R Caputo C Kondo T Masui S J Geraci E Foster M M O'Sullivan C B Higgins 《Radiology》1991,180(3):693-698
Quantification of pulmonary flow is clinically important in the evaluation of both congenital and acquired heart disease. Velocity-encoded cine magnetic resonance (MR) is a promising technique for measuring velocity and volume of blood flow. The authors report validation of the accuracy of velocity-encoded cine MR for measurement of oblique-angle flow in vitro, with use of a constant-flow phantom, and in vivo, with nine healthy volunteers in whom velocities were measured separately in the main, right, and left pulmonary arteries. Findings at MR were compared with findings at Doppler echocardiography. Velocity measurements in a flow phantom with cine MR correlated well with direct measurements at Doppler echocardiography. Velocity-encoded cine MR enabled accurate and reproducible measurement of absolute blood flow in healthy subjects. Oblique-gradient flow encoding (ie, flow-encoding direction coinciding with the true direction of flow) was the method of choice for velocity measurements in the right and left pulmonary arteries. 相似文献
8.
Velocity spectra can be derived from velocity-encoded nuclear magnetic resonance (NMR) images. Velocity spectra are histograms showing the amounts of fluid flowing at different velocities in the sensitive volume of the measurement. Velocity spectra may prove to be useful in characterizing the flow of blood in small vessels, for example, in detecting the presence of stenoses and in evaluating their severity. NMR velocity spectra acquired in vivo are sufficiently complicated that a model system was designed and tested to investigate the velocity spectra of pulsatile flow. This study measured the NMR velocity spectra of pulsatile flow in a rigid tube and compared them to velocity spectra derived from Doppler ultrasound measurements and to velocity spectra inferred from a theoretical model driven by the measured pressure difference function. The experimental results from each technique agree. 相似文献
9.
P J Kilner D N Firmin R S Rees J Martinez D J Pennell R H Mohiaddin S R Underwood D B Longmore 《Radiology》1991,178(1):229-235
For measurement of poststenotic jet velocities with magnetic resonance (MR) imaging, the authors reduced the echo time (TE) of the field even-echo rephasing (FEER) velocity mapping sequence from 14.0 to 3.6 msec, so minimizing the problem of MR signal loss from turbulent fluid. In vitro use of rotating disk and stenotic flow phantoms confirmed that the 3.6-msec TE sequence enables accurate measurement of jet velocities of up to 6.0 m/sec (r = .996). Peak jet velocity measurements were made with MR imaging in 36 patients with stenosis of native heart valves (n = 9), conduits (n = 19), or Fontan connections (n = 2) or with aortic coarctation (n = 6). Peak velocity measurements made with MR imaging agreed well with measurements made with Doppler ultrasound (US), which were available in 18 cases (standard deviation = 0.2 m/sec). Velocity mapping with fast-echo MR imaging is likely to have considerable importance as a noninvasive means of locating and evaluating stenoses, particularly at sites inaccessible to US, but care must be taken to prevent errors caused by malalignment, signal loss, phase wrap, or partial-volume effects. 相似文献
10.
11.
Petter Dyverfeldt Andreas Sigfridsson John-Peder Escobar Kvitting Tino Ebbers 《Magnetic resonance in medicine》2006,56(4):850-858
Turbulent flow, characterized by velocity fluctuations, is a contributing factor to the pathogenesis of several cardiovascular diseases. A clinical noninvasive tool for assessing turbulence is lacking, however. It is well known that the occurrence of multiple spin velocities within a voxel during the influence of a magnetic gradient moment causes signal loss in phase-contrast magnetic resonance imaging (PC-MRI). In this paper a mathematical derivation of an expression for computing the standard deviation (SD) of the blood flow velocity distribution within a voxel is presented. The SD is obtained from the magnitude of PC-MRI signals acquired with different first gradient moments. By exploiting the relation between the SD and turbulence intensity (TI), this method allows for quantitative studies of turbulence. For validation, the TI in an in vitro flow phantom was quantified, and the results compared favorably with previously published laser Doppler anemometry (LDA) results. This method has the potential to become an important tool for the noninvasive assessment of turbulence in the arterial tree. 相似文献
12.
G. Bruce Pike Craig H. Meyer Thomas J. Brosnan Norbert J. Pelc 《Magnetic resonance in medicine》1994,32(4):476-483
Time-resolved velocity imaging using the magnetic resonance phase contrast technique can provide clinically important quantitative flow measurements in vivo but suffers from long scan times when based on conventional spin-warp sequences. This can be particularly problematic when imaging regions of the abdomen and thorax because of respiratory motion. We present a rapid phase contrast sequence based on an interleaved spiral k-space data acquisition that permits time-resolved, three-direction velocity imaging within a breath-hold. Results of steady and pulsatile flow phantom experiments are presented, which indicate excellent agreement between our technique and through plane flow measurements made with an in-line ultrasound probe. Also shown are results of normal volunteer studies of the carotids, renal arteries, and heart. 相似文献
13.
Arterial MR imaging phase-contrast flow measurement: improvements with varying velocity sensitivity during cardiac cycle 总被引:3,自引:0,他引:3
To reduce noise in velocity images of magnetic resonance (MR) phase-contrast measurements, the authors implemented and evaluated a pulse sequence that enables automatic optimization of the velocity-encoding parameter V(enc) for individual heart phases in pulsatile flow on the basis of a rapid prescan. This sequence was prospectively evaluated by comparing velocity-to-noise ratios with those from a standard MR flow scan obtained in the carotid artery in eight volunteers. This sequence was shown to improve velocity-to-noise ratios by a factor of 2.0-6.0 in all but the systolic heart phase and was determined to be an effective technique for reducing noise in phase-contrast velocity measurements. 相似文献
14.
Andreas Stadlbauer PhD Wilma van der Riet Sebastian Globits MD Gerard Crelier PhD Erich Salomonowitz MD 《Journal of magnetic resonance imaging : JMRI》2009,29(4):817-824
Purpose
To evaluate differences in velocity and flow measurements in the aorta between accelerated phase‐contrast (PC) magnetic resonance imaging (MRI) using SENSE and k‐t BLAST and in peak velocity to Doppler ultrasound.Materials and Methods
Two‐dimensional PC‐MRI perpendicular to the ascending and descending aorta was performed in 11 volunteers using SENSE (R = 2) and k‐t BLAST (2‐, 4‐, 6‐, and 8‐fold). Peak velocity, mean velocity, and stroke volume of the accelerated PC‐MRI experiments were correlated. Peak velocities were compared to Doppler ultrasound.Results
All acceleration techniques showed significant correlations for peak velocity with Doppler ultrasound. However, k‐t BLAST 6 and 8 showed a significant underestimation. Strong correlations between SENSE and k‐t BLAST were found for all three parameters. Significant differences in peak velocity were found between SENSE and all k‐t BLAST experiments, but not for 2‐fold k‐t BLAST in the ascending aorta, and 2‐ and 4‐fold k‐t BLAST in the descending aorta. For mean velocity no significant differences were found. Stroke volume showed significant differences for all k‐t BLAST experiments in the ascending and for 6‐ and 8‐fold k‐t BLAST in the descending aorta.Conclusion
Peak velocity of accelerated PC‐MRI correlated with CW Doppler measurements, but high k‐t BLAST acceleration factors lead to a significant underestimation. SENSE with R = 2 and 2‐fold k‐t BLAST are most highly correlated in phase‐contrast flow measurements. J. Magn. Reson. Imaging 2009;29:817–824. © 2009 Wiley‐Liss, Inc. 相似文献15.
Machida H Komori Y Ueno E Shen Y Hirata M Kojima S Sato M Okazaki T Masukawa A Morita S Suzuki K 《Japanese journal of radiology》2010,28(8):571-577
Purpose
We compared the accuracy of magnetic resonance imaging (MRI) measurements of pulsatile flow velocity in a small tube phantom using different spatial factors versus those obtained by intraluminal Doppler guidewire examination (as reference).Materials and methods
We generated pulsatile flow velocities averaging about 20–290 cm/sec in a tube of 4 mm diameter; we performed phase-contrast cine MRI on pixels measuring 1.002–2.502 mm2. We quantified spatial peak flow velocities of a single pixel and a cluster of five pixels and spatial mean velocities within regions of interest enclosing the entire lumen in the phantom’s cross-section. Finally, we compared the measurements of temporally mean and maximum flow velocity with the Doppler measurements.Results
Linear correlation was excellent between both measurements of spatial peak flow velocities in one pixel. The highest spatial resolution using spatial peak flow velocities of a single pixel allowed the most accurate MRI measurements of both temporally mean and maximum pulsatile flow velocity (r = 0.97 and 0.99, respectively: MRI measurement = 0.95x + 8.9 and 0.88x + 24.0 cm/s, respectively). Otherwise, MRI measurements were significantly underestimated at lower spatial resolutions.Conclusion
High spatial resolution allowed accurate MRI measurement of temporally mean and maximum pulsatile flow velocity at spatial peak velocities of one pixel. 相似文献16.
Szarf G Dori Y Rettmann D Tekes A Nasir K Amado L Foo TK Bluemke DA 《Journal of magnetic resonance imaging : JMRI》2006,23(1):42-49
PURPOSE: To validate partial Fourier phase contrast magnetic resonance (PC MR) with full number of excitation (NEX) PC MR measurements in vitro and in vivo. MATERIALS AND METHODS: MR flow measurements were performed using a partial Fourier and a full NEX PC MR sequence in a flow phantom and in 10 popliteal and renal arteries of 10 different healthy volunteers. Average velocity, peak velocity, and flow results were calculated and compared with regression analysis. RESULTS: Excellent correlations in average velocities (r = 0.99, P < 0.001), peak velocities (r = 0.99, P < 0.001), and flow rates (r = 0.98, P < 0.001) were demonstrated in vitro between the two different acquisitions. For the popliteal arteries there was excellent correlation between peak velocities for both acquisitions (r = 0.98, P < 0.0001); the correlation of average velocity measurements when using all data points in the cardiac cycle for all volunteers was 0.96 (P < 0.001). For the renal arteries the same comparison resulted in a good correlation for average velocity (0.93, P < 0.001) and peak velocity measurements (r = 0.91, P = 0.002), although the correlation coefficient for flow rates was 0.88 (P = 0.004). Blurring of the vessel margins was consistently observed on magnitude images acquired with the partial Fourier method, causing overestimation of the vessel area and some error in the flow measurements. CONCLUSION: Partial Fourier PC MR is able to provide comparable average and peak velocity values when using 1 NEX PC MRI as a reference. 相似文献
17.
Gatehouse PD Keegan J Crowe LA Masood S Mohiaddin RH Kreitner KF Firmin DN 《European radiology》2005,15(10):2172-2184
A review of cardiovascular clinical and research applications of MRI phase-contrast velocity imaging, also known as velocity mapping or flow imaging. Phase-contrast basic principles, advantages, limitations, common pitfalls and artefacts are described. It can measure many different aspects of the complicated blood flow in the heart and vessels: volume flow (cardiac output, shunt, valve regurgitation), peak blood velocity (for stenosis), patterns and timings of velocity waveforms and flow distributions within heart chambers (abnormal ventricular function) and vessels (pulse-wave velocity, vessel wall disease). The review includes phase-contrast applications in cardiac function, heart valves, congenital heart diseases, major blood vessels, coronary arteries and myocardial wall velocity. 相似文献
18.
Lars Sondergaard Carsten Thomsen Freddy Stahlberg Erik Gymoese Knud Lindvig Per Hildebrandt Ole Henriksen 《Journal of magnetic resonance imaging : JMRI》1992,2(3):295-302
When magnetic resonance phase mapping is used to quantitate valvular blood flow, the presence of higher-order-motion terms may cause a loss of phase information. To overcome this problem, a sequence with reduced encoding for higher-order motion was used, achieved by decreasing the duration of the flow-encoding gradient to 2.2 msec. Tested on a flow phantom simulating a severe valvular stenosis, the sequence was found to be robust for higher-order motion within the clinical velocity range. In eight healthy volunteers, mitral and aortic volume flow rates and peak velocities were quantified by means of phase mapping and compared with results of the indicator-dilution technique and Doppler echocardiography, respectively. Statistically significant correlations were found between phase mapping and the other two techniques. Similar studies in patients with valvular disease indicate that phase mapping is also valid for pathologic conditions. Phase mapping may be used as a noninvasive clinical tool for flow quantification in heart valve disease. 相似文献
19.
Visualization of flow patterns distal to aortic valve prostheses in humans using a fast approach for cine 3D velocity mapping 总被引:1,自引:0,他引:1
Kozerke S Hasenkam JM Pedersen EM Boesiger P 《Journal of magnetic resonance imaging : JMRI》2001,13(5):690-698
The fluid dynamic performance of mechanical heart valves differs from normal valves and thus is considered related to late clinical complications in patients. Since flow patterns evolving around heart valves are complex in space and time, flow visualization based on time-resolved 3D velocity data might add important information regarding the performance of specific valve designs in vivo. However, previous cine 3D techniques for three-directional phase-contrast velocity mapping suffer from long scan duration and therefore might hamper assessment in patients. A hybrid 3D phase-contrast sequence combining segmented k-space acquisition with short EPI readout trains is presented with its validation in vitro. The technique was applied to study flow patterns downstream from a bileaflet aortic prosthesis in six patients. Navigator echoes were incorporated for respiratory motion compensation. Before flow visualization, spurious phase errors due to concomitant gradient fields and eddy currents were corrected. Flow visualization was based on particle paths and animated velocity vector plots. Dedicated algorithms for particle path integration were implemented to account for the considerable motion of the ascending aorta during the cardiac cycle. A distinct flow pattern reflecting the valve design was observed closest to the valve during early flow acceleration. Reverse flow occurred adjacent to high velocity jets and above the hinge housings. Later in systole, flow became confined to the central vessel area and reverse flow along the inner aortic curvature developed. Further downstream from the valve, flow patterns varied considerably among patients, indicating the impact of varying aortic anatomy in vivo. It is concluded that MR velocity mapping is a potential tool for studying 3D flow patterns evolving around heart valve prostheses in humans. J. Magn. Reson. Imaging 2001;13:690-698. 相似文献
20.
Dieter H. Szolar Hajime Sakuma Charles B. Higgins 《Journal of magnetic resonance imaging : JMRI》1996,6(1):78-89
With recent developments of MR techniques for blood flow measurements, qualitative and quantitative information on both flow volume and flow velocity in the major vessels can be obtained. MR flow quantitation uses the phase, rather than the amplitude of the MR signal, to reconstruct the images. Previous validation studies have demonstrated the accuracy of the phase shift techniques for measuring flow velocities. This technique is now being applied successfully in the cardiovascular system to quantify global and regional ventricular function, valvular heart disease, pulmonary artery disease, thoracic aortic disease, congenital heart disease, and ischemic heart disease. 相似文献