干扰素α-1b治疗扁平疣50例疗效分析

目的观察干扰素α-1b（运德素）治疗扁平疣的临床疗效。方法将98例扁平疣患者随机分为治疗组50例和对照组48例,治疗组采用干扰素α-1b肌肉注射,对照组口服转移因子胶囊,两组均用药1个月,分别观察两组的疗效。结果治疗组50例与对照组48例总有效率分别为82．0％和29．2％,两组比较差异有统计学意义（P〈0．005）。结论干扰素α-1b治疗扁平疣疗效肯定,可在临床推广应用。     

转移因子与伊可尔联合治疗扁平疣疗效观察

目的观察转移因子与伊可尔联合治疗扁平疣的临床疗效。方法将66例扁平疣患者随机分成2组,2组患者均给予转移因子皮下注射。治疗组（n=34）局部用伊可尔稀释液湿敷;对照组（n=32）用0．025％维A酸乳膏外涂。2组疗程均为8周。结果治疗组总有效率明显高于对照组（94．11％VS．59．38％,P〈0．05）。结论转移因子联合伊可尔治疗扁平疣疗效满意,疗程短,毒副作用少,安全可靠,患者的依从性好。     

转移因子联合抗痨药物治疗老年肺结核的疗效观察

目的观察和评价转移因子胶囊联合抗痨药物治疗老年肺结核的疗效。方法将210例老年肺结核病人随机分为治疗组和时照组各105例,对照组采用2HRZE／4HR方案治疗,治疗组采用上述方案治疗的同时加用转移因子胶囊口服观察痰菌阴转、肺部病灶吸收、空洞闭合等情况。结果1个月后治疗组痰菌阴转82例（78．1％）,对照组57例（54．3％）;2个月后治疗组95例（90．5％）,对照组78例（74．3％）;两组比较差异均有统计学意义（P〈0．01）;3个月后治疗组104例（99．0％）,对照组101例（96．2％）,两组比较差异无统计学意义（P〉0．05）。病变吸收在2、4、6个月显著有效及有效病例：治疗组分别为41、76、102例,对照组分别为22、57、79例,两组比较差异有统计学意义（P〈0．01）。空洞闭合在2、4、6个月显著有效及有效病例：治疗组分别为20、33、38例,对照组分别为11、25、31例,两组比较差异有统计学意义（P〈0．05）。结论转移因子胶囊联合抗痨药物治疗老年肺结核有显著疗效。     

P-转移因子口服液治疗扁平疣31例疗效观察

目的：观察P－转移因子口服液治疗扁平疣的有效性和安全性。方法：对31例扁平疣患者分别口服P－转移因子口服液治疗，同时设对照组20例用聚肌胞注射液治疗，连续1个月进行疗效观察比较。结果：治疗组31例患者痊愈16例，显效7例，好转5例，总有效率90．3％，对照组总有效率仅为65％。结论：P－转移因子口服液服用方便，疗效较高，是治疗扁平疣有效药物之一。     

水飞蓟宾胶囊治疗酒精性脂肪肝40例临床观察

目的：探讨水飞蓟宾胶囊治疗酒精性脂肪肝的临床疗效。方法：用水飞蓟宾胶囊治疗观察酒精性脂肪肝40例，并设立对照组20例，给予口服护肝片及脂必妥治疗，疗程均为3个月。结果：观察组在降ALT，AST作用明显优于对照组（P＜0．01），治疗酒精性脂肪肝综合疗效也优于对照组（P＜0．05）。结论：水飞蓟宾胶囊在治疗酒精性脂肪肝有良好疗效。     

胃康胶囊治疗胃癌前病变的临床研究

目的：探讨胃康胶囊对癌前期病变的治疗作用。方法：治疗组128例,硫糖铝对照组128例。全部病例均经胃镜和胃黏膜活组织病理检验确诊。治疗期间停服其他药物,2个月为1个疗程,连服2个疗程。结果：治疗组与对照组相比较,两组总有效率分别为70．31％、43．39％（P〈0．01）;治疗组脾胃虚弱型与气阴两虚型总有效率分别为77．78％、44．37％（P〈0．01）。胃康胶囊能提高患者的血色素,细胞免疫功能和血浆cAMP含量,并有抑制幽门螺杆菌的作用。结论：胃康胶囊有治疗胃癌前期病变和预防胃癌发生的作用。     

一清胶囊治疗出血性肛肠疾病的临床疗效评估

目的：观察一清胶囊治疗痔、肛裂、直肠出血的临床疗效。方法：308例病例随机分为三组：一清胶囊组（Ⅰ组，118例），云南白药组（Ⅱ组，90例），安络血组（Ⅲ组，100例）。治疗方法均1日3次，每次2粒，口服，7天为一疗程，观察各组临床疗效及血浆比粘度、出、凝血时间。结果：一清胶囊组总有效率为89．0％，云南白药组有效率为60．0％，安络血组有效率为44．0％，一清胶囊且疗效高于其他两组且血浆比粘有所增加，出血时间有所缩短（P＜0．05）。结论：一清胶囊能有效治疗出血性肛肠疾病。     

阿维A联合转移因子口服治疗80例扁平疣的疗效观察

目的探讨阿维A联合转移因子治疗扁平疣的疗效。方法采用阿维A胶囊每日一次,餐后顿服,转移因子胶囊口服,每次两颗,一日二次,两个月后判定疗效。结果80例扁平疣患者两个月后痊愈率达60．00％,总有效率达93．75％。结论阿维A联合转移因子口服是治疗扁平疣的一种有效方法。     

养血清脑颗粒与西比灵合用治疗偏头痛的临床观察

目的 观察养血清脑颗粒与西比灵联合治疗偏头痛的临床疗效。方法 将90例偏头痛患者随机分为3组（每组各30例），中药组用养血清脑颗粒，西药组用西比灵胶囊，联合组使用养血清脑颗粒和西比灵胶囊，疗程均为3个月，观察治疗前后各组患者头痛发作次数、头痛程度、头痛持续时间和伴随症状的变化情况。结果 中药组控制显效率57．0％，西药组控制显效率54．0％，联合组控制显效率87．0％。结论 养血清脑颗粒联合西比灵胶囊治疗偏头痛的疗效明显优于西药单独一组应用的疗效。     

乌体林斯联合抗痨药物治疗老年肺结核疗效观察

目的观察和评价乌体林斯联合抗痨药物治疗老年肺结核的疗效。方法将120例老年肺结核病人随机分为治疗组和对照组各60例。对照组采用2HRZE／4HR方案治疗。治疗组采用上述方案治疗的同时,加用乌体林斯肌肉注射观察痰菌阴转、肺部病灶吸收、空洞闭合等情况。结果痰菌阴转情况：1个月后治疗组46例,阴转率76．7％,对照组32例,阴转率53．3％,两组比较差异有统计学意义（P〈0．01）;2个月后治疗组55例,阴转率91．7％,对照组43例,阴转率71.7％,两组比较差异有统计学意义（P〈0．01）;3个月后治疗组60例,阴转率100％,对照组58例,阴转率96．7％,两组比较无差异。病变吸收情况：2个月、4个月、疗程结束后显效病例,治疗组分别为27、48、52例,对照组分别为14、32、40倒,两组比较差异有统计学意义（P〈0．01）。空洞闭合情况：2个月、4个月、疗程结束后,治疗组分别为11、19、21例,对照组分别为4、13、19例,两组比较差异有统计学意义（P〈0．05）。结论乌体林斯联合抗痨药物治疗老年肺结核有显著性疗效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.