糖尿病患者肾内动脉血流参数变化的临床意义

目的　探讨糖尿病患者肾内动脉血流参数变化的临床意义。方法　将 64例糖尿病肾病患者按 2 4小时尿白蛋白排泄率 ( UAE)分为三组 ,采用美国 Acuson-As Pen彩色多谱勒能量图 ( CDEI) ,检测其肾内动脉血流分布情况及相关参数。结果　 1组 ( 3 0例 ;UAE<10 ug/ min,运动后升高 )段间动脉收缩期峰值血流速度( Vm ax)、舒张末期血流速度 ( Vmi)、阻力指数 ( RI)与正常对照组 ( 3 0例健康人 )比较 ,均无显著性差异( P>0 .0 5) ;2组 ( 2 5例 ,UAE15～ 2 0 ug/ min)和 3组 ( 9例 ,UAE>2 0 0 ug/ min)以上各参数均明显高于对照组 ( P<0 .0 1) ,随肾损害程度的加重 ,肾彩色血流显像逐渐减少 ,阻力指数 ( RI)及脉动指数 ( PI)增高。结论　肾动脉血流参数为判断糖尿病肾病血管损害程度的主要依据     

子宫动脉多普勒阻力指数及搏动指数预测异常妊娠结局的价值

目的 应用ROC曲线评价子宫动脉多普勒较高阻力指数(RI)、较低RI、平均RI、较高搏动指数(PI)、较低PI、平均PI预测异常妊娠结局的价值.方法 定群分析妊娠期高血压疾病80例,并随访至产后,以妊娠异常结局即早产、小于孕龄儿(SGA)、剖宫产为"金标准",绘制子宫动脉血流多普勒参数不同RI及PI对异常结局的ROC曲...     

体外授精-胚胎移植治疗周期中HCG应用的时机

1999年 7月～ 2 0 0 0年 4月 ,我们施行体外受精 -胚胎移植 ( IVF- ET)治疗 1 75例 ( 1 82个周期 ) ,并采用阴道超声显像的监测 ,辅以血、尿黄体生成素测定 ,预测 ( HGG)注射及取卵的时间。现报告如下。1　资料与方法1 .1　观察对象　不育者 1 75例 ,年龄 2 5～ 45岁。不育原因包括输卵管因素 1 0 9个周期、多囊卵巢综合征、子宫内膜异位征及不明原因不育 73个周期。1 .2超促排卵方案　 1短方案 ( Decapepty,Busere-lin/FSH/h MG/h CG) :共 52个周期。于月经第 2天开始肌注 Decapepty0 .1 mg或 Buserelin喷鼻给药 ,至注射 HCG时停…     

妊娠早期双侧子宫动脉血流参数和舒张早期切迹评估复发性流产孕妇不良妊娠结局的效能分析

目的 探讨妊娠早期双侧子宫动脉血流参数和舒张早期切迹评估复发性流产孕妇发生不良妊娠结局的效能。方法 选择2020年8月至2021年8月莆田市妇幼保健院收治的复发性流产者40例为观察组,另选择同期正常妊娠者40名为对照组。均使用Voluson 730 Pro彩色多普勒超声诊断仪进行检查,获取双侧子宫动脉血流参数[双侧子宫动脉收缩期峰值流速/舒张末期流速(S/D)值、子宫动脉搏动指数(PI)值、子宫动脉阻力指数(RI)值],并观察舒张早期切迹的出现情况。比较两组双侧子宫动脉血流参数水平和舒张早期切迹发生率。分析舒张早期切迹与不良妊娠结局的关联性。采用ROC曲线法评估双侧子宫动脉血流参数预测复发性流产孕妇发生不良妊娠结局的效能。结果 观察组S/D值、PI值和RI值均高于对照组,差异有统计学意义(P<0.05),出现舒张早期切迹的人数比例大于对照组(90.00%vs 10.00%;χ²=48.050,P=0.000)。出现舒张早期切迹者的妊娠期高血压、妊娠期糖尿病、子痫和早产发生率均显著高于无舒张早期切迹者,差异有统计学意义(P<0.05)。ROC分析结果显示...     

妊娠期高血压疾病子宫动脉、脐动脉血流对胎儿生长发育的影响

目的探讨妊娠期高血压疾病(HDP)孕妇妊娠早、中、晚期子宫动脉、脐动脉血流动态变化规律与胎儿生长发育的关系。方法选择接受产前检查的妊娠期高血压疾病孕妇213例为观察组,同期行产前检查的正常孕妇1689例为对照组,观察两组孕妇子宫动脉、脐动脉搏动指数(PI)、阻力指数(RI)和脐动脉收缩压最大血流速度(S)与舒张末期最大血流速度(D)的比值(S/D),以及胎儿生长发育的情况。结果对照组子宫动脉PI值、RI值、S/D值随着孕周的进展逐渐降低,而观察组随着孕周的进展则逐渐升高(P0.05);观察组与对照组相比,妊娠中期、晚期PI值、RI值、S/D值明显升高(P0.05)。两组孕妇妊娠中、晚期脐动脉PI值、RI值、S/D值随着孕周的进展均逐渐降低(P0.05),但两组比较差异无统计学意义。对照组、妊娠期高血压组与子痫前期组胎儿双顶径、股骨长、头围、腹围及出生时体重比较,差异有统计学意义。结论随妊娠的进展,正常孕妇子宫动脉血流阻力逐渐下降,舒张末期血流增加;妊娠期高血压疾病孕妇子宫动脉血流阻力明显升高;而两组孕妇随妊娠的进展胎儿脐动脉血流阻力均明显下降。妊娠期高血压疾病由于胎盘血液供应障碍影响胎儿的生长发育。     

卵巢过度刺激综合征22例临床分析

卵巢过度刺激综合征 (OHSS)是辅助生殖技术诱导超排卵过程中出现的一种并发症。我们在行体外受精 -胚胎移植(IVF- ET)中发生 OHSS2 2例。现报告分析如下。临床资料 :选择 2 0 0 2年 4月至 2 0 0 3年 4月间我院生殖中心的 OHSS患者 2 2例 ,年龄 2 6～ 37岁 ,平均 33岁 ;均为不孕症 ,不孕时间 3～ 15年 ,平均 8年。原发不孕 14例 ,其中 5例合并多囊卵巢综合征 (PCOS) ,继发不孕 8例。 16例常规行IVF- ET,6例行卵细胞浆内单精子注射 (ICSI)。 2 2例均接受促性腺激素释放激素激动剂 (Gn RHa)、卵泡刺激素 (FSH )、绒毛膜促性腺激…     

不同黄体酮给药方案对行胚胎植入前遗传学检测的冻融胚胎移植患者的影响及治疗成本分析

［摘要］　目的　分析不同黄体酮给药方案对行胚胎植入前遗传学检测的冻融胚胎移植（PGT-FET）患者的影响及治疗成本。方法　回顾性分析2020年8月至2022年7月在十堰市太和医院生殖医学中心进行PGT-FET的169例不孕患者的临床资料,根据患者采用的黄体酮给药方案将其分为A组（黄体酮胶囊口服,82例）和B组（黄体酮软胶囊阴道上药,87例）。比较两组注射人绒毛膜促性腺激素（HCG）日激素指标及获卵情况、注射HCG日和移植日子宫内膜厚度及容受性指标［阻力指数（RI）、搏动指数（PI）和收缩期峰值流速/舒张末期流速（S/D）］、囊胚移植、妊娠结局、阴道出血情况及成本-效果比。结果　两组注射HCG日促黄体生成素（LH）、注射HCG日雌二醇（E₂）、注射HCG日孕酮（P）、获卵数、MⅡ卵子数,注射HCG日和移植日子宫内膜厚度及子宫动脉S/D、RI、PI,移植囊胚数、移植优质囊胚率、生化妊娠率、临床妊娠率、早期流产率及继续妊娠率比较差异无统计学意义（P>0.05）。A组阴道早期出血率和晚期出血率显著低于B组（P<0.05）。A组成本-效果比为6.72,低于B组的8.41。结论　PGT-FET患者采用黄体酮胶囊口服治疗与黄体酮软胶囊阴道上药治疗所获临床效果及对子宫内膜容受性的保护作用较为接近,但前者可以降低阴道出血率和治疗成本。     

中老年高血压患者肾内动脉血流动力学变化与动态动脉硬化指数和脉压的相关性分析

目的探讨通过对肾内动脉阻力指数(RI)与动态动脉硬化指数(AASI)和脉压的相关性分析, 判断高血压性肾血管损害程度。方法回顾性病例对照研究, 选取2018年5月至2023年5月首都医科大学附属北京朝阳医院综合科高血压患者1 226例, 行肾动脉血流动力学检查, 血流异常患者187例, 其中肾动脉狭窄组78例, 无肾动脉狭窄组109例;肾动脉血流正常患者(对照组)1 039例。对比高血压患者不同程度肾血流阻力增高的AASI、脉压;采用Spearman秩和相关分析评估老年高血压患者AASI、脉压与肾损伤程度的相关性;高血压患者肾血流动力学异常者肾动脉狭窄和RI、AASI、脉压检查结果的受试者工作特征曲线(ROC)分析。结果肾动脉狭窄组、无肾动脉狭窄组和对照组患者RI[(0.83±0.05)、(0.78±0.02)、(0.71±0.03)]、AASI[(0.61±0.05)、(0.58±0.06)、(0.37±0.05)]、脉压[(1.71±0.15)、(1.44±0.22)、(0.88±0.25)]比较, 差异有统计学意义(F值分别为410.44、734.77、968.99, 均P<...     

妊娠期糖尿病患者脐动脉血流监测指标的变化

目的探讨脐动脉血流监测对妊娠期糖尿病患者(GDM)血糖控制情况以及妊娠结果的意义。方法回顾性分析2013年6月至2014年6月在我院建卡并且分娩的281例GDM孕妇与同期的281例非GDM资料,其中能通过饮食或适当药物等血糖稳定控制者206例,血糖控制不良者75例。分别调取其孕期胎儿的脐动脉血流频谱,并与同期的非妊娠期糖尿病胎儿脐血流进行对比研究,对其在收缩期末和舒张期末的比值(S/D)、阻力指数(RI)进行分析,并对妊娠结局进行随访。结果 (1)GDM血糖控制不良组脐动脉血流值均高于血糖控制稳定组与非GDM组,且差异有统计学意义(P0.05)。(2)GDM血糖控制不良组发生胎儿宫内窘迫、脐带异常及早产等妊娠风险增加。结论对GDM孕妇的脐动脉血流监测能及时反映血糖控制情况,了解胎盘功能及胎儿的发育情况、预测围产儿预后。当脐动脉血流增高时,尤其出现舒张末期缺失及反向时应引起高度的重视并及时干预,改变妊娠结局,降低围产儿风险。     

经阴道彩色超声监测早期输卵管妊娠保守治疗效果的价值

目的探讨阴道彩色超声(TVS)监测早期输卵管妊娠保守治疗效果的价值。方法对57例行药物保守治疗的未破裂输卵管妊娠患者根据治疗效果分为成功组46例与失败组11例。采用TVS血流显像及频谱技术监测两组治疗前后异位妊娠病灶滋养动脉血流频谱参数:收缩期峰值流速(PSV)、舒张末期流速(EDV)和阻力指数(RI)。结果成功组治疗后PSV、EDV明显低于、RI明显高于治疗前及失败组,P均0.05。结论 TVS可通过监测异位妊娠病灶滋养动脉血流频谱参数判断早期输卵管妊娠保守治疗的效果。     

多囊卵巢综合征患者卵泡液白细胞介素-1β水平与体外受精-胚胎移植结局关系的研究

目的探讨体外受精-胚胎移植（IVF-ET）中GnRH拮抗剂治疗多囊卵巢综合征（PCOS）对患者卵泡液中白细胞介素-1β（IL-1β）的影响及与助孕结局的关系。方法选择2011-08～2012-09在该院生殖医疗中心行IVF-ET的PCOS不孕患者76例,随机分为A组（GnRH拮抗剂组）28例（研究组）,B组（GnRH激动剂长方案组）48例（对照组）,比较分析两组患者的卵泡液中IL-1β水平及其与助孕结局的关系。结果两组卵泡液中IL-1β浓度比较差异无统计学意义（P〉0.05）;子宫内膜厚度、获卵数、成熟卵率、受精率、卵裂率、优胚率、种植率、临床妊娠率方面,两组比较差异无统计学意义（P〉0.05）;A组的Gn总用量、Gn用药天数明显比B组少（P〈0.01）;A组绒毛膜促性腺激素（HCG）日E2水平低于B组（P〈0.05）;两组的卵巢过度刺激综合征（OHSS）发生率差异无统计学意义（P〉0.05）;A组的周期取消率明显低于B组（P〈0.01）。结论 IVFET中GnRH拮抗剂治疗PCOS不会改变卵泡液中的IL-1β水平,不影响卵泡的发育、卵母细胞的成熟、受精、卵裂能力及胚胎的着床,故GnRH拮抗剂方案是安全有效的。     

Factors affecting clinical outcomes after IVF-ET for infertile young patients with ovarian endometrioma: A 5-year retrospective cohort study

This study aimed to compare ovarian reserve function and outcomes after in vitro fertilization and embryo transfer (IVF-ET) for young women with pelvic endometriosis with or without ovarian endometrioma. We explored the main factors influencing pregnancy outcomes in young patients with endometrioma.A total of 619 patients ≤38 years of age who underwent IVF-ET in our reproductive center between January 2011 and December 2015 were recruited. Among these patients, 398 had pelvic endometriosis with ovarian endometrioma and 221 had pelvic endometriosis without ovarian endometrioma. Patients underwent ovulation induction during IVF-ET. The general conditions and clinical outcomes of IVF-ET treatment were compared. Key factors affecting the success of IVF-ET treatment for endometriomas were analyzed.During IVF-ET treatment, the numbers of retrieved oocytes and 2-pronuclei (2PN) embryos in all age groups (P < .01), and the number of 2PN high-quality embryos in patients under 30 years of age was lower in the pelvic endometriosis with ovarian endometrioma group than in the pelvic endometriosis alone group (P < .05). Logistic regression analysis showed the number of antral follicles, basal follicle-stimulating hormone (bFSH) levels, number of oocytes, number of 2PN embryos, and number of 2PN high-quality embryos were significantly related to the successful outcome of IVF-ET. Among these, the number of 2PN high-quality embryos was the only independent predictive factor.Ovarian endometrioma significantly impairs ovarian reserve function and ultimately affects the therapeutic efficacy of IVF-ET. Obtaining more 2PN high-quality embryos was important for IVF-ET treatment of young patients with ovarian endometriomas.     

Inhibin and estradiol responses to ovarian hyperstimulation: effects of age and predictive value for in vitro fertilization outcome

We have compared the time courses of serum inhibin and estradiol responses to ovarian hyperstimulation in patients undergoing in vitro fertilization and embryo transfer as well as their predictive value for outcome of intermediate variables and pregnancy in in vitro fertilization and embryo transfer. Blood samples (n = 749) were collected for up to 6 days before hCG administration in 100 consecutive treatment cycles, of which 44 resulted in pregnancy, as defined by elevated luteal phase serum hCG beta levels. Inhibin and estradiol levels increased markedly in parallel during hyperstimulation and were highly correlated (r = 0.89; P less than 0.001). Inhibin responses were significantly lower in women 35 yr of age or older (P less than 0.001), although estradiol responses were not influenced by age. Gravidity and tubal disease also had marginal effects on the time course of inhibin responses, but not on overall mean inhibin levels or estradiol responses. The time course of hormonal responses to hyperstimulation was not influenced by any other demographic or etiological factors. Peak values of both hormones correlated with the total number of follicles (inhibin, r = 0.70; estradiol, r = 0.65; P less than 0.001) and oocytes retrieved per cycle (inhibin, r = 0.49; estradiol, r = 0.39; P less than 0.001). The time course and peak values of inhibin and estradiol responses to hyperstimulation did not differ significantly between conception or nonconception cycles whether judged by biochemical (luteal hCG beta) or clinical (viable ongoing pregnancy) criteria. Luteal phase serum inhibin, estradiol, progesterone, and hCG levels were significantly higher in conception than in nonconception cycles (P less than 0.001). These data suggest that the rises in serum inhibin and estradiol levels during hyperstimulation have similar predictive properties for IVF-ET outcomes and could, therefore, be used interchangeably to monitor hyperstimulation regimens. The age-related reduction in inhibin, but not estradiol, responses suggests that these two hormones reflect different granulosa cell functions and that serum inhibin responses to maximal ovarian stimulation may be a sensitive and early index of declining ovarian function with advancing age.     

妇女超重与低体重对其体外受精治疗的影响

回顾性分析1 107名妇女体重对体外受精与胚胎移植(IVF-ET)治疗中超排卵和妊娠结局的影响.超重组与正常体重组相比,卵巢刺激所需的促性腺激素剂量更多[(36.87±11.18对33.57±10.96)支,P<0.01],注射绒毛膜促性腺激素日的血雌二醇浓度更低[(1 846.6±1 390.3对2 337.2±1490.6)pg/ml,P<0.01],由于卵巢反应不良取消周期率更高(6.5%对2.8%,P<0.05),以及自然流产率更高(10.5%对5.4%,P<0.05),胚胎实验室参数、种植率、妊娠率及活产率差异无统计学意义.低体重组与正常体重组相比,在卵巢刺激以及妊娠结局方面差异无统计学意义.     

Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle

The effects of physiological changes in estrogens and androgens on the erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase enzyme activities during the menstrual cycle were investigated in healthy eumenorrheic women. Blood samples were taken on alternate days from twelve normally cyclic women (age range: 20 to 27 years; mean age: 24.1 years) from the first day of one menstrual cycle until the first day of the subsequent one. Plasma was analyzed for FSH, LH, estradiol, progesterone, testosterone, free testosterone and androstenedione concentrations. Erythrocyte superoxide dismutase, catalase and glutathione peroxidase activities were evaluated on the same days and cycle length was standardized on the basis of the preovulatory estradiol peak. Significant cyclic phase-related changes were observed in glutathione peroxidase (P<0.05), with higher glutathione peroxidase activity levels from the late follicular to the early luteal phase compared with those found in the early follicular phase (P<0.001 and P<0.002 respectively). A significant positive correlation was observed between mean estradiol and glutathione peroxidase cycle-related variations (r=0.80, P<0.001), whereas no significant cycle phase-dependent changes were seen in superoxide dismutase and catalase. No effect of progesterone and androgens on the erythrocyte antioxidant enzyme system was documented. The findings indicate that physiological ovarian estradiol production during the menstrual cycle may have an important role in regulating erythrocyte glutathione peroxidase activity.     

The effect of menstrual cycle on platelet aggregation in reproductive-age women

Our aim was to assess the change in platelet activity along the menstrual cycle. We conducted a prospective observational study. The study group included 16 healthy women with regular menstrual cycles, which were compared to a control group of 14 healthy males. Exclusion criteria were age <18 years or >45 years, use of oral contraceptives or any other forms of hormonal therapy and medical disorders or medications that might affect platelet aggregation. Blood samples were taken from each of the women at four different phases of the menstrual cycle: day 1 ± 1, day 7 ± 1, day 14 ± 1, and day 21 ± 1. A single blood sample was taken from the males. Platelet aggregation was assessed in whole blood samples using the Multiplate? analyzer with three different agonists (ADP, arachidonic acid (AA), and thrombin-receptor activating peptide (TRAP)). Platelet aggregation for each of the women at each of the phases of the menstrual cycle was expressed as the percentage change from the day 1 ± 1 value. A total of 390 aggregation assays were performed. The mean aggregation activity was significantly higher in females compared with males, irrespective of the agonist used. For the TRAP and the ADP agonists, the relative platelet activity decreased along the menstrual cycle from day 1 towards day 21 and from day 7 towards day 21, respectively, although differences reached statistical significance only for day 21 (?12.4% ± 3.2%, P < 0.05 for TRAP, and ?9.5% ± 3.9%, P < 0.05 for ADP). When using AA to induce platelet aggregation, the relative platelet activity was highest around the time of ovulation (11.0% ± 4.7%) and was significantly lower on day 21 (?8.5% ± 6.7%, P < 0.05). In conclusion, platelet aggregation activity is higher in females compared with males. The association between the phase of the menstrual cycle and platelet activity appears to vary with the type of agonist, but platelet aggregation is consistently lowest in the mid-luteal phase irrespective of the agonist used.     

脑积水患者行经颅多普勒检测的意义

目的明确脑积水患者经颅多普勒（TCD）监测结果与颅内压的关系。方法选择我院32例行脑室腹腔分流术的脑积水患者（观察组），分别于术前1d和术后5d行大脑中动脉（MCA）的TCD监测；另选择27名门诊体检健康个体为对照组，行大脑中动脉TCD监测，并与观察组作对照。结果观察组患者行分流手术前TCD监测显示MCA收缩期血流速度（Vs）、舒张期血流速度（Vd）以及平均血流速度（Vm）较对照组明显下降（P〈0．05）；而搏动指数H和阻抗指数砌却明显高于对照组（P〈0．01）。观察组患者治疗前、后MCA的PI、RI、Vd、Vm间差异有显著性意义（P〈0．05）。结论经颅多普勒中RI和PI值可作为评价脑积水患者颅内高压的有效手段。     

Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

Abstract:  We investigated the relationship between oxidative stress and poor oocyte quality and whether the antioxidant melatonin improves oocyte quality. Follicular fluid was sampled at oocyte retrieval during in vitro fertilization and embryo transfer (IVF-ET). Intrafollicular concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in women with high rates of degenerate oocytes were significantly higher than those with low rates of degenerate oocytes. As there was a negative correlation between intrafollicular concentrations of 8-OHdG and melatonin, 18 patients undergoing IVF-ET were given melatonin (3 mg/day), vitamin E (600 mg/day) or both melatonin and vitamin E. Intrafollicular concentrations of 8-OHdG and hexanoyl-lysine adduct were significantly reduced by these antioxidant treatments. One hundred and fifteen patients who failed to become pregnant with a low fertilization rate (50%) in the previous IVF-ET cycle were divided into two groups during the next IVF-ET procedure; 56 patients with melatonin treatment (3 mg/day) and 59 patients without melatonin treatment. The fertilization rate was improved by melatonin treatment compared to the previous IVF-ET cycle. However, the fertilization rate was not significantly changed without melatonin treatment. Oocytes recovered from preovulatory follicles in mice were incubated with H₂O₂ for 12 hr. The percentage of mature oocytes with a first polar body was significantly reduced by addition of H₂O₂ (300  μ m ). The inhibitory effect of H₂O₂ was significantly blocked by simultaneous addition of melatonin. In conclusion, oxidative stress causes toxic effects on oocyte maturation and melatonin protects oocytes from oxidative stress. Melatonin is likely to improve oocyte quality and fertilization rates.     

Hormonal pattern of adolescent menstrual cycles.

Serum FSH, LH, PRL, estradiol, pregnenolone, progesterone, 17-hydroxyprogesterone, androstenedione, testosterone, 5 alpha-dihydrotestosterone, and androsterone were measured radioimmunologically in 20 normal girls aged 13-17 yr. Samples were taken every day or every second day during one menstrual cycle. The cycles recorded could be divided into three groups. The first and oldest group consisted of 10 girls with a mean gynecological age (years since menarche) of 2.9 yr. The luteal phase was at least 11 days and the progesterone concentration was at least 5 ng/ml. The testosterone rise (mean, 55%) on the day of LH surge correlated well with the simultaneous progesterone rise (mean, 270%) and the following luteal progesterone secretion. A negative correlation was seen between the FSH concentration on days 3-4 of the cycle and the length of the follicular phase. The second group consisted of 4 girls who had a mean gynecological age of 1.5 yr. The luteal phase was of 4- to 8-day duration and the progesterone secretion was lower than in group I. The follicular phase testosterone concentration was lower in group II as compared to group I. No "periovulatory" testosterone increases were seen, although every cycle displayed an LH and FSH peak. The third group consisted of 6 girls with a mean gynecological age of 1.1 yr. These cycles were anovulatory, as the serum progesterone concentration never exceeded 1.0 ng/ml. In two cycles, signs of follicular maturation were seen. In the four others, the androgen levels tended to be elevated. In two cases, the testosterone and androstenedione concentrations were 2-4 times elevated from the beginning of these two cycles. Thus, the hormonal pattern of adolescent menstrual cycles is far from uniform. It is very likely that in addition to gonadotropins, estradiol and progesterone, androgens may also have a role in the development and maintenance of normal menstrual function in the female.     

GONADOTROPHIN SECRETION IN THE SECOND HALF OF THE MENSTRUAL CYCLE: A COMPARISON OF WOMEN WITH NORMAL CYCLES, LUTEAL PHASE DEFECTS AND DISTURBED FOLLICULAR DEVELOPMENT

In order to study the relationship between episodic gonadotrophin secretion and alterations of ovarian hormone secretion, we examined women with normal menstrual cycles (n = 26), luteal phase defects (n = 10) or disturbed follicular oestradiol secretion (n = 8) as established by daily (except weekends) determinations of oestradiol and progesterone. Pulsatile gonadotrophin secretion was studied during the luteal phase or the second half of the menstrual cycle sampling at 15 min intervals for 12 h. LH and FSH mean concentrations and LH pulse frequency were significantly (P less than 0.01) increased in the group with disturbed follicular development in the presence of decreased oestradiol (E2) and progesterone (P4) levels. In women with luteal phase defects mean LH and FSH concentrations and pulsatile LH secretion showed a nonsignificant trend to lower values in the presence of significantly decreased P4 concentrations during the luteal phase.